C. Altar

发表

Discriminatory roles for D1 and D2 dopamine receptor subtypes in the in vivo control of neostriatal cyclic GMP.

C. Altar, W. Boyar, H. Kim, 1990, European journal of pharmacology.

The Biomarkers Consortium: On the Critical Path of Drug Discovery

C. Altar, 2008, Clinical pharmacology and therapeutics.

Neurotrophin trafficking by anterograde transport

C. Altar, P. Distefano, C. Altar, 1998, Trends in Neurosciences.

Suppression of In Vivo Neostriatal Acetylcholine Release by Vesamicol: Evidence for a Functional Role of Vesamicol Receptors in Brain

C. Altar, J. Richard, C. Allaire, 1991, Journal of neurochemistry.

The dopamine autoreceptor agonist, (±)-Trans-1,3,4,4a5, 10b-hexahydro-4-propyl-2h [1]benzopyrano [3,4-b] pyridin-9-ol hydrochloride (CGS 15855A), modulates striatal dopamine metabolism and prolactin release

C. Altar, P. Wood, S. Iyengar, 1989, Neuropharmacology.

1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation.

C. Altar, M. Marien, L. Manzino, 1986, European journal of pharmacology.

Cholecystokinin attenuates basal and drug-induced increases of limbic and striatal dopamine release

C. Altar, W. Boyar, P. Wood, 1988, Brain Research.

Target Identification for CNS Diseases by Transcriptional Profiling

C. Altar, M. Vawter, S. Ginsberg, 2009, Neuropsychopharmacology.

Characterization and topography of high-affinity 125I-neurotrophin-3 binding to mammalian brain

C. Altar, P. DiStefano, R. Lindsay, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial

C. Altar, B. Frey, V. Taylor, 2022, Translational Psychiatry.

[3H]vesamicol binding in brain: Autoradiographic distribution, pharmacology, and effects of cholinergic lesions

C. Altar, M. Marien, C. Anthony Altar, 1988, Synapse.

[3H]Tryptamine Receptors in Rat Brain

C. Altar, P. Wood, L. Martin, 1985 .

Receptor localization : ligand autoradiography

C. Altar, F. Leslie, 1988 .

A prospective, randomized, double-blind study assessing the clinical impact of integrated pharmacogenomic testing for major depressive disorder.

C. Altar, B. DeChairo, Josiah D. Allen, 2013, Discovery medicine.

125I-LSD autoradiography confirms the preferential localization of caudate-putamen S2 receptors to the caudal (peripallidal) region

C. Altar, W. Boyar, M. Marien, 1986, Brain Research.

Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements.

C. Altar, P. Wood, 1988, Pharmacological reviews.

An easily constructed and inexpensive three-layer cassette for tritium-sensitive film autoradiography.

C. Altar, 1984, Journal of pharmacological methods.

Brain CCK-B receptors mediate the suppression of dopamine release by cholecystokinin

C. Altar, W. Boyar, 1989, Brain Research.

Presynaptic inhibition of nigrostriatal dopamine release in the mouse: lack of cross tolerance between apomorphine, GBL and CGS 10746B.

C. Altar, H. Kim, P. Wood, 1988, Life sciences.

Topography of substantia nigra innervation by D1 receptor-containing striatal neurons

C. Altar, K. Hauser, C. Anthony Altar, 1987, Brain Research.

Inhibition of climbing and mossy fiber input to mouse cerebellar Purkinje cells by cholecystokinin.

C. Altar, H. Kim, P. Wood, 1988, The Journal of pharmacology and experimental therapeutics.

Regional Distribution of α‐[3H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Binding Sites in Rat Brain: Effect of Chemical Modification of SH– Groups in Tissue Sections

C. Altar, C. Cotman, D. Monaghan, 1990, Journal of neurochemistry.

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523

C. Altar, M. Nakai, T. Kikuchi, 2001, Neuropharmacology.

Glucocorticoid induction of tryptophan oxygenase. Attenuation by intragastrically administered carbohydrates and metabolites.

C. Altar, A. Yuwiler, B. Bennett, 1983, Biochemical pharmacology.

Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine

C. Altar, MT Martin-Iverson, K. Todd, 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

C. Altar, P. Distefano, S. Wiegand, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Striatal dopamine uptake and swim performance of the aged rat

C. Altar, J. Marshall, 1986, Brain Research.

A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013.

C. Altar, D. Mrazek, J. Hornberger, 2014, Psychiatric services.

The social and economic burden of treatment-resistant schizophrenia: a systematic literature review

C. Altar, J. Hornberger, J. Kennedy, 2014, International clinical psychopharmacology.

Mechanism of Action of Aripiprazole Predicts Clinical Efficacy and a Favourable Side-Effect Profile

C. Altar, T. Nabeshima, T. Kikuchi, 2004, Journal of psychopharmacology.

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor.

C. Altar, Ruoyan Chen, V. Koprivica, 2002, European journal of pharmacology.

Rotational behavior induced by 8-hydroxy-DPAT, a putative 5HT-1A agonist, in 6-hydroxydopamine-lesioned rats

C. Altar, J. Liebman, R. Gerber, 2004, Psychopharmacology.

Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).

C. Altar, M. Nakai, T. Kikuchi, 2002, The Journal of pharmacology and experimental therapeutics.

Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine 1 A Receptor Agonist OPC-14523 ( 1-{ 3-[ 4-( 3-chlorophenyl )

C. Altar, M. Nakai, T. Kikuchi, 2002 .

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

C. Altar, J. Siuciak, L A Mamounas, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Modulation of In Vivo Dopamine Release by D2 but Not D1 Receptor Agonists and Antagonists

C. Altar, W. Boyar, 1987, Journal of neurochemistry.

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Christopher J. Weber, S. Haggarty, C. Altar, 2020, Alzheimer's & dementia.

Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies

C. Altar, B. DeChairo, D. Hall‐Flavin, 2015, Molecular Neuropsychiatry.

Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation

C. Altar, S. Garavaglia, G. Lavezzari, 2015, Current medical research and opinion.

Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes

C. Altar, B. DeChairo, D. Hall‐Flavin, 2015, The Pharmacogenomics Journal.

Clinical validity of cytochrome P450 metabolism and serotonin gene variants in psychiatric pharmacotherapy

C. Altar, D. Mrazek, J. Hornberger, 2013, International review of psychiatry.

Brain dopamine and serotonin receptor sites revealed by digital subtraction autoradiography.

C. Altar, J. Marshall, R. Walter, 1985, Science.

Aripiprazole Blocks Reinstatement of Cocaine Seeking in an Animal Model of Relapse

C. Altar, R. See, M. W. Feltenstein, 2007, Biological Psychiatry.

In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function.

C. Altar, V. Koprivica, T. Kikuchi, 2004, European journal of pharmacology.

Sensorimotor impairment and elevated levels of dopamine metabolites in the neostriatum occur rapidly after intranigral injection of 6-hydroxydopamine or gamma-hydroxybutyrate in awake rats

C. Altar, J. Marshall, S. O'neil, 1984, Neuropharmacology.

Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker 2-(4-phenylpiperidino)cyclohexanol (AH5183).

C. Altar, M. Marien, S. Parsons, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain

C. Altar, G. Stone, R. Neale, 1986, Brain Research Bulletin.

Short communication The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT 1A receptor

C. Altar, Ruoyan Chen, V. Koprivica, 2002 .

CGS 10746B: an atypical antipsychotic candidate that selectively decreases dopamine release at behaviorally effective doses.

C. Altar, H. Kim, J. Liebman, 1986, Life sciences.

Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-d-aspartate Receptor Antagonism

C. Altar, S. Bernales, B. Hutter-Paier, 2010, Journal of Pharmacology and Experimental Therapeutics.

Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone.

C. Altar, P. Molinoff, M. Nakai, 2003, European journal of pharmacology.

Computer imaging and analysis of dopamine (D2) and serotonin (S2) binding sites in rat basal ganglia or neocortex labeled by [3H]spiroperidol.

C. Altar, H. Kim, J. Marshall, 1985, The Journal of pharmacology and experimental therapeutics.

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor

T. Kikuchi, C. Altar, V. Koprivica, 2001, European Neuropsychopharmacology.

Computer-assisted video analysis of [3H]spiroperidol binding autoradiographs

Robert J. Walter, John F. Marshall, C. Anthony Altar, 1984, Journal of Neuroscience Methods.

Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction autoradiography

C. Altar, M. Marien, 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Dopamine neurochemical profile of atypical antipsychotics resembles that of D-1 antagonists

C. Altar, W. Boyar, J. Liebman, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

In Vivo Assessment of Dopamine and Norepinephrine Release in Rat Neocortex: Gas Chromatography‐Mass Spectrometry Measurement of 3‐Methoxytyramine and Normetanephrine

C. Altar, P. Wood, Helen S. Kim, 1987, Journal of neurochemistry.

Quantitative analysis of [3H]spiroperidol binding to rat forebrain sections: Plasticity of neostriatal dopamine receptors after nigrostriatal injury

C. Altar, K. Neve, Catherine Wong, 1984, Brain Research.

Medial-to-lateral gradient of neostriatal NGF receptors: relationship to cholinergic neurons and NGF-like immunoreactivity

C. Altar, M. Armanini, C. Bakhit, 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Dopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal cortices.

C. Altar, W. Boyar, P. Wood, 1987, The Journal of pharmacology and experimental therapeutics.

Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine

C. Altar, K. Todd, M. Martin-Iverson, 1994 .

Injections of deuterated tryptamine into the nucleus accumbens of the rat: Effects on locomotor activity and monoamine metabolism

C. Altar, W. Boyar, M. Marien, 1987, Neuropharmacology.

Autoradiographic localization and pharmacology of unique [3H]tryptamine binding sites in rat brain

C. Altar, L. Martin, A. Wasley, 1986, Neuroscience.

Novel directions in antipsychotic target identification using gene arrays.

C. Altar, L. Klimczak, D. Hook, 2002, Current drug targets. CNS and neurological disorders.

Time Course of Adaptations in Dopamine Biosynthesis, Metabolism, and Release Following Nigrostriatal Lesions: Implications for Behavioral Recovery from Brain Injury

C. Altar, J. Marshall, M. Marien, 1987, Journal of neurochemistry.

Glossary Agranulocytosis : an acute condition involving a severe and potentially fatal reduction in white blood cells

C. Altar, B. Roth, J. A. Gray, 2007 .

Supplementary Material for: Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies

C. Altar, B. DeChairo, D. Hall‐Flavin, 2016 .

Psychiatric pharmacogenomics predicts health resource utilization of outpatients with anxiety and depression

C. Altar, Josiah D. Allen, J. Winner, 2013, Translational Psychiatry.

Dopamine autoreceptor agonists including CGS 15855A decrease dopamine release and metabolism in mouse brain.

C. Altar, W. Boyar, P. Wood, 1987, European journal of pharmacology.

One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists.

C. Altar, R. Kasser, R. Y. Wang, 1990, The Journal of pharmacology and experimental therapeutics.

S.02.03 Combinatorial pharmacogenomics provides clinical validity and utility for treating major depression

C. Altar, 2015, European Neuropsychopharmacology.