G. Snyder

发表

Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine

P. Greengard, A. Nishi, G. Snyder, 1997, The Journal of Neuroscience.

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

P. Greengard, A. Nairn, H. Hemmings, 1999, Nature.

D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade.

P. Greengard, D. Surmeier, A. Fienberg, 2000, Journal of neurophysiology.

Amplification of dopaminergic signaling by a positive feedback loop.

P. Greengard, A. Nairn, A. Nishi, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and Psychostimulants In Vivo

P. Greengard, A. Nairn, A. Fienberg, 2000, The Journal of Neuroscience.

Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors

P. Greengard, G. Snyder, G. Fisone, 2006, Journal of neurochemistry.

Role of Calcineurin and Protein Phosphatase‐2A in the Regulation of DARPP‐32 Dephosphorylation in Neostriatal Neurons

P. Greengard, A. Nairn, A. Nishi, 1999, Journal of neurochemistry.

Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists

P. Greengard, A. Nairn, A. Fienberg, 2003, Neuropharmacology.

Discovery of novel alpha7 nicotinic receptor antagonists.

G. Snyder, R. Papke, Qiang Zhang, 2010, Bioorganic & medicinal chemistry letters.

DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens

A. Fienberg, G. Snyder, S. Schreiber, 2002, Nature Neuroscience.

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

Takaichi Fukuda, Paul Greengard, Diane B Miller, 2008, The Journal of Neuroscience.

DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

Paul Greengard, Steven E. Hyman, James P. O'Callaghan, 1998 .

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

P. Greengard, G. Snyder, J. Bibb, 2001, The Journal of Biological Chemistry.

Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.

G. Snyder, Qiang Zhang, A. Robichaud, 2014, Journal of medicinal chemistry.

Na+,K+-ATPase in the Choroid Plexus

P. Greengard, G. Snyder, G. Fisone, 1995, The Journal of Biological Chemistry.

The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

G. Snyder, A. Danser, I. Garrelds, 2022, Frontiers in Pharmacology.

Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

G. Snyder, I. van der Pluijm, D. Duncker, 2021, Oxidative medicine and cellular longevity.

Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals

G. Snyder, Wei Yao, I. van der Pluijm, 2021, The Journal of Pharmacology and Experimental Therapeutics.

ITI-214, A Novel Phosphodiesterase I Inhibitor for the Treatment of Parkinson’s Disease: Results from A Phase I/II Clinical Study (P2.8-051)

G. Snyder, J. Hendrick, L. Wennogle, 2019 .

Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress.

G. Snyder, M. Zigmond, E. Stricker, 1985, The Journal of pharmacology and experimental therapeutics.

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.

P. Greengard, A. Nairn, P. Svenningsson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

G. Snyder, J. Hendrick, J. O'Callaghan, 2019, Molecular and Cellular Neuroscience.

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

G L Snyder, L Meijer, D W Zaharevitz, 2000, European journal of biochemistry.

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.

Robert I. Davis, C. Heyser, G. Snyder, 2016, Journal of medicinal chemistry.

Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.

P. Greengard, H. Hemmings, G. Snyder, 1999, The Journal of clinical endocrinology and metabolism.

Spinophilin is phosphorylated by Ca2+/calmodulin‐dependent protein kinase II resulting in regulation of its binding to F‐actin

Angus C Nairn, Paul Greengard, Linda C Hsieh-Wilson, 2004, Journal of neurochemistry.

Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments*

Fabio Benfenati, Angus C Nairn, Paul Greengard, 2003, The Journal of Biological Chemistry.

Short- and long-term changes in adrenal tyrosine hydroxylase activity during insulin-induced hypoglycemia and cold stress

G. Snyder, M. Zigmond, E. Stricker, 1983, Brain Research.

Effects of lateral hypothalamic lesions on food intake of rats during exposure to cold

G. Snyder, E. Stricker, 1985 .

Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation

G. Snyder, Robert E Davis, S. Dutheil, 2022, The Journal of Neuroscience.

The Role of Phosphodiesterases in Dopamine Systems governing Motivated Behavior

A. Nishi, G. Snyder, J. Hendrick, 2014 .

Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum.

P. Greengard, T. Hökfelt, G. Snyder, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Robert I. Davis, G. Snyder, J. Hendrick, 2016, Psychopharmacology.

DARPP-32/Protein Phosphatase-1/Na+/K+ ATPase System: A Mechanism for Bidirectional Control of Cell Function

P. Greengard, G. Snyder, J. Girault, 1994 .

General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo

G. Snyder, Stacey Galdi, J. Hendrick, 2007, Neuropharmacology.

Phosphodiesterase 1B Knock-Out Mice Exhibit Exaggerated Locomotor Hyperactivity and DARPP-32 Phosphorylation in Response to Dopamine Agonists and Display Impaired Spatial Learning

P. Greengard, G. Snyder, C. Vorhees, 2002, The Journal of Neuroscience.

Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity

P. Greengard, P. Calabresi, D. Centonze, 2006, Neuroscience.

A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr 32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor

P. Greengard, A. Fienberg, R. Huganir, 1998, The Journal of Neuroscience.

Regulation of Na+, K+ ‐ATPase Isoforms in Rat Neostriatum by Dopamine and Protein Kinase C

P. Greengard, I. Dulubova, A. Nairn, 1999, Journal of neurochemistry.

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

G L Snyder, G Eisenbrand, L Meijer, 2001, The Journal of biological chemistry.

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

P. Greengard, A. Nairn, P. Svenningsson, 2001, Nature.

Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling

G. Snyder, J. Bibb, R. Greene, 2007, Brain Research.

Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons

A. Fienberg, A. Nishi, G. Snyder, 2012, Neuropharmacology.

Some aspects on the anatomy and function of central cholecystokinin systems.

T. Hökfelt, D. Blacker, G. Snyder, 2002, Pharmacology & toxicology.

PDE Inhibitors for the Treatment of Schizophrenia.

G. Snyder, K. Vanover, 2017, Advances in neurobiology.

Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past,  Present and Future

G. Snyder, K. Vanover, Peng Li, 2016, Current topics in medicinal chemistry.

Phosphorylation of Protein Phosphatase Inhibitor-1 by Cdk5*

P. Greengard, J. Ule, A. Nairn, 2001, The Journal of Biological Chemistry.

The DARPP-32/protein phosphatase-1 cascade: a model for signal integration 1 Published on the World Wide Web on 22 January 1998. 1

Angus C Nairn, Paul Greengard, Gilberto Fisone, 1998, Brain Research Reviews.

Phosphorylation of DARPP‐32 Is Regulated by GABA in Rat Striatum and Substantia Nigra

P. Greengard, G. Snyder, G. Fisone, 1994, Journal of neurochemistry.

Distribution of dopamine- and cAMP-dependent phosphoprotein (DARPP-32) in the developing and mature kidney.

G. Snyder, A. Aperia, B. Meister, 1993, Kidney international.

Production of phosphorylation state-specific antibodies.

P. Greengard, A. Nairn, J. Kebabian, 1991, Methods in enzymology.

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

P. Greengard, Y. Yanagawa, A. Nairn, 2012, Psychopharmacology.

Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission.

A. Nishi, G. Snyder, 2010, Journal of pharmacological sciences.

Oestradiol Increases Phosphorylation of a Dopamine‐ and Cyclic AMP‐Regulated Phosphoprotein (DARPP‐32) in Female Rat Brain

G. Snyder, J. Meredith, J. Blaustein, 2001, Journal of neuroendocrinology.

Dopamine efflux from striatal slices after intracerebral 6-hydroxydopamine: evidence for compensatory hyperactivity of residual terminals.

G. Snyder, M. Zigmond, R. Keller, 1990, The Journal of pharmacology and experimental therapeutics.

P. Greengard, G. Snyder, J. Blaustein, 1998, The Journal of Neuroscience.

The effects ofl-DOPA on in vitro dopamine release from striatum

G. Snyder, M. Zigmond, 1990, Brain Research.

The Dopamine/D1 Receptor Mediates the Phosphorylation and Inactivation of the Protein Tyrosine Phosphatase STEP via a PKA-Dependent Pathway

Angus C. Nairn, Marina R. Picciotto, A. Nairn, 2000, The Journal of Neuroscience.

A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia.

A. Fienberg, G. Snyder, K. Vanover, 2021, Advances in pharmacology.

Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission

G. Snyder, E. Nestler, J. Hendrick, 2014, Psychopharmacology.

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

G. Snyder, J. Hendrick, Hongwen Zhu, 2016, Psychopharmacology.

Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2a receptor signaling in the neostriatum

P. Greengard, A. Nishi, G. Snyder, 2006, Neuroscience.

Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice.

P. Greengard, A. Fienberg, P. Allen, 2000, Science.

Dopamine D1 receptor stimulation of cyclic AMP accumulation in COS-1 cells.

G. Snyder, P. Adams, R. Mackenzie, 1991, European journal of pharmacology.

Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia

P. Greengard, A. Nairn, H. Hemmings, 2000, Neuropharmacology.

ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins.

P. Greengard, I. Dulubova, A. Nairn, 2001 .

Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain

G. Snyder, Qiang Zhang, J. Hendrick, 2010, Brain Research.

ARPP‐16/ARPP‐19: a highly conserved family of cAMP‐regulated phosphoproteins

P. Greengard, A. Nairn, G. Snyder, 2001, Journal of neurochemistry.

A comparison of the electrophysiological properties of morphologically identified cells in layers 5B and 6 of the rat neocortex

G. Snyder, J. V. Brederode, 1992, Neuroscience.

Psychotherapy supported by drug treatment is the prescription for children and adolescents with post-traumatic stress disorder

A. Fienberg, G. Snyder, S. Schreiber, 2002 .

Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra.

P. Greengard, G. Snyder, K. Tsou, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Requirement for DARPP‐32 in mediating effect of dopamine D2 receptor activation

P. Greengard, A. Nairn, A. Fienberg, 1999, The European journal of neuroscience.

Choroid Plexus: Synergistic Regulation by Serotonin/Protein Kinase C and Isoproterenol/cAMP-PK/PP-1 Pathways

G. Snyder, G. Fisone, '. A. Aperia, 2007 .