H. Okada

发表

One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats.

H. Okada, T. Heya, Y. Ogawa, 1988, The Journal of pharmacology and experimental therapeutics.

Enhancement of gene transfection into human dendritic cells using cationic PLGA nanospheres with a synthesized nuclear localization signal.

H. Okada, T. Kanazawa, Y. Takashima, 2009, International journal of pharmaceutics.

Transdermal anti‐nuclear kappaB siRNA therapy for atopic dermatitis using a combination of two kinds of functional oligopeptide

H. Okada, T. Kanazawa, Y. Takashima, 2018, International journal of pharmaceutics.

Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide

H. Okada, T. Kanazawa, Y. Takashima, 2016, Molecules.

Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis

H. Okada, T. Kanazawa, Y. Takashima, 2015, Pharmaceutics.

Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery.

H. Okada, T. Kanazawa, Y. Takashima, 2010, International journal of pharmaceutics.

Targeted siRNA therapy using cytoplasm-responsive nanocarriers and cell-penetrating peptides

H. Okada, 2014, Journal of Pharmaceutical Investigation.

Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrating Peptide and Jet Injection

H. Okada, T. Kanazawa, 2014 .

Cell-penetrating peptide polymer nanomicelle-based cytosol-sensitive nucleotide delivery systems

H. Okada, 2014 .

Treatment of rat brain tumors using sustained-release of camptothecin from poly(lactic-co-glycolic acid) microspheres in a thermoreversible hydrogel.

H. Okada, T. Ozeki, Kosuke Hashizawa, 2010, Chemical & pharmaceutical bulletin.

Effect of physical properties of carrier particles on drug emission from a dry powder inhaler device

H. Okada, T. Ozeki, Y. Takashima, 2005 .

Insulin Fragments as a Carrier for Peptide Delivery Across the Blood–Brain Barrier

H. Okada, H. Toguchi, M. Fukuta, 1994, Pharmaceutical Research.

Biodegradable microspheres in drug delivery.

H. Okada, H. Toguchi, 1995, Critical reviews in therapeutic drug carrier systems.

Preparation of spray-dried microparticles using Gelucire 44/14 and porous calcium silicate or spherical microcrystalline cellulose to enhance transport of water-insoluble pranlukast hemihydrate across Caco-2 monolayers

H. Okada, M. Kataoka, S. Yamashita, 2011 .

New method for analysis of biodegradable polyesters by high-performance liquid chromatography after alkali hydrolysis.

H. Okada, H. Toguchi, S. Kamei, 1992, Biomaterials.

The characterization of protein release from sericin film in the presence of an enzyme: towards fibroblast growth factor-2 delivery.

H. Okada, T. Kanazawa, Y. Takashima, 2011, International journal of pharmaceutics.

Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice.

Naoyuki Murata, Hiroaki Okada, H. Okada, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Controlled-release of leuprolide acetate from polylactic acid or copoly(lactic/glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer.

H. Okada, T. Shimamoto, Y. Ogawa, 1988, Chemical & pharmaceutical bulletin.

Nose-to-brain drug delivery system with ligand/cell-penetrating peptide-modified polymeric nano-micelles for intracerebral gliomas.

H. Okada, T. Kanazawa, H. Taki, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes.

H. Okada, A. Urtti, T. Lajunen, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Sustained-release of protein from biodegradable sericin film, gel and sponge.

H. Okada, T. Kanazawa, Y. Takashima, 2011, International journal of pharmaceutics.

Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 Carcinoma

H. Okada, Kazuhiro Saito, Y. Kuge, 1995, Pharmaceutical Research.

Optimal formulation of an angiogenesis inhibitor, TNP-470, for arterial injection determined by in vitro drug release and stability, and in vivo antitumor activity

H. Okada, Kazuhiro Saito, Y. Kuge, 1995 .

Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms.

H. Okada, T. Ozeki, T. Mizoe, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution.

H. Okada, H. Toguchi, S. Kamei, 1993, The Journal of pharmacology and experimental therapeutics.

Therapeutic Effects on Atopic Dermatitis by Anti-RelA Short Interfering RNA Combined with Functional Peptides Tat and AT1002

H. Okada, T. Kanazawa, Y. Takashima, 2011, Journal of Pharmacology and Experimental Therapeutics.

Suppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG-PCL nanomicelles.

H. Okada, T. Kanazawa, Y. Takashima, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Antitumor activity of a medium-chain triglyceride solution of the angiogenesis inhibitor TNP-470 (AGM-1470) when administered via the hepatic artery to rats bearing Walker 256 carcinosarcoma in the liver.

H. Okada, Y. Kuge, H. Toguchi, 1994, The Journal of pharmacology and experimental therapeutics.

Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier

H. Okada, T. Tagami, T. Ozeki, 2012, AAPS PharmSciTech.

Versatile nuclear localization signal-based oligopeptide as a gene vector.

H. Okada, T. Kanazawa, Y. Takashima, 2015, Biological & pharmaceutical bulletin.

Functional peptide nanocarriers for delivery of novel anti-RelA RNA interference agents as a topical treatment of atopic dermatitis.

H. Okada, T. Ohgi, T. Kanazawa, 2015, International journal of pharmaceutics.

Synthesis and Transport Activities of HIV–Tat Peptide-modified Cholesterol Pullulan

H. Okada, T. Kanazawa, Y. Takashima, 2009 .

A novel, bio-reducible gene vector containing arginine and histidine enhances gene transfection and expression of plasmid DNA.

H. Okada, T. Kanazawa, Y. Takashima, 2011, Chemical & pharmaceutical bulletin.

Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors

H. Okada, T. Kanazawa, Y. Takashima, 2012, Pharmaceuticals.

One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis.

H. Okada, T. Ozeki, Katsuya Ohashi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Needle-free intravaginal DNA vaccination using a stearoyl oligopeptide carrier promotes local gene expression and immune responses.

H. Okada, T. Kanazawa, Y. Takashima, 2013, International journal of pharmaceutics.

Development of an efficient transdermal delivery system of small interfering RNA using functional peptides, Tat and AT-1002.

H. Okada, T. Kanazawa, Y. Takashima, 2011, Chemical & pharmaceutical bulletin.

One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier.

H. Okada, T. Ozeki, T. Mizoe, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Application of a Four-fluid Nozzle Spray Drier to Prepare Inhalable Rifampicin-containing Mannitol Microparticles

H. Okada, T. Ozeki, T. Mizoe, 2008, AAPS PharmSciTech.

Spray-drying preparation of microparticles containing cationic PLGA nanospheres as gene carriers for avoiding aggregation of nanospheres.

H. Okada, T. Kanazawa, Y. Takashima, 2007, International journal of pharmaceutics.

Pharmacokinetics of Once-a-Month Injectable Microspheres of Leuprolide Acetate

H. Okada, T. Heya, H. Toguchi, 1991, Pharmaceutical Research.

Vaginal DNA vaccination against infectious diseases transmitted through the vagina.

H. Okada, T. Kanazawa, Y. Takashima, 2012, Frontiers in bioscience.

Controlled Release of LHRH Agonist, Leuprolide Acetate, from Microcapsules: Serum Drug Level Profiles and Pharmacological Effects in Animals

H. Okada, T. Heya, T. Shimamoto, 1989, The Journal of pharmacy and pharmacology.

A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid.

T Yashiki, H. Okada, Y. Ogawa, 1988, Chemical & pharmaceutical bulletin.

Effective vaginal DNA delivery with high transfection efficiency is a good system for induction of higher local vaginal immune responses

H. Okada, T. Kanazawa, Y. Takashima, 2009 .

Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine.

H. Okada, T. Kanazawa, Y. Takashima, 2008, International journal of pharmaceutics.

Persistent suppression of the pituitary-gonadal system in female rats by three-month depot injectable microspheres of leuprorelin acetate.

H. Okada, Y. Ogawa, Y. Doken, 1996, Journal of pharmaceutical sciences.

One-month release injectable microspheres of leuprolide acetate inhibit steroidogenesis and genital organ growth in rats

H. Okada, T. Heya, T. Shimamoto, 1989 .

In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers.

H. Okada, Y. Ogawa, T. Shimamoto, 1988, Chemical & pharmaceutical bulletin.

Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration

H. Okada, T. Kanazawa, Y. Takashima, 2011, Pharmaceutical Research.

Cytoplasm-responsive nanocarriers conjugated with a functional cell-penetrating peptide for systemic siRNA delivery.

H. Okada, T. Kanazawa, Y. Takashima, 2013, International journal of pharmaceutics.

Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers

H. Okada, H. Toguchi, Y. Ogawa, 2004, Pharmaceutical Research.

Controlled release of drug via methylcellulose-carboxyvinylpolymer interpolymer complex solid dispersion

H. Okada, T. Ozeki, H. Yuasa, 2005, AAPS PharmSciTech.

Preparation of Polymeric Submicron Particle-Containing Microparticles Using a 4-Fluid Nozzle Spray Drier

H. Okada, T. Ozeki, Y. Takashima, 2006, Pharmaceutical Research.

Anticancer Effects of an Angiogenesis Inhibitor (TNP ·470) After Arterial Injection in Rabbits Bearing VX·2 Carcinoma

H. Okada, Y. Kuge, H. Toguchi, 1993 .

Use of silk protein, sericin, as a sustained-release material in the form of a gel, sponge and film.

H. Okada, T. Kanazawa, Y. Takashima, 2010, Chemical & pharmaceutical bulletin.

Improvement of survival in C6 rat glioma model by a sustained drug release from localized PLGA microspheres in a thermoreversible hydrogel.

H. Okada, T. Tagami, T. Ozeki, 2012, International journal of pharmaceutics.

Depot Microcapsules Containing Biologic Nanoparticles and Cytoplasm-Responsive Nanocarriers for Nucleotides

H. Okada, 2016 .

siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model.

Okio Hino, Hiroaki Okada, H. Okada, 2008, Cancer letters.

eedle-free intravaginal DNA vaccination using a stearoyl oligopeptide carrier romotes local gene expression and immune responses

H. Okada, Y. Takashima, Mamiko Yamazaki, 2013 .

Local gene expression and immune responses of vaginal DNA vaccination using a needle-free injector.

H. Okada, T. Kanazawa, Y. Takashima, 2010, International journal of pharmaceutics.

Cytoplasm-Responsive Delivery Systems for siRNA Using Cell-Penetrating Peptide Nanomicelles

H. Okada, T. Kanazawa, Y. Takashima, 2014 .

Improved Bioavailability of a Water-Insoluble Drug by Inhalation of Drug-Containing Maltosyl-β-Cyclodextrin Microspheres Using a Four-Fluid Nozzle Spray Drier

H. Okada, T. Tagami, T. Ozeki, 2012, AAPS PharmSciTech.

Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier.

H. Okada, T. Ozeki, Y. Takashima, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Combination therapy of surgical tumor resection with implantation of a hydrogel containing camptothecin-loaded poly(lactic-co-glycolic acid) microspheres in a C6 rat glioma model.

H. Okada, T. Tagami, T. Ozeki, 2012, Biological & pharmaceutical bulletin.

Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and Dogs

H. Okada, H. Toguchi, Y. Ogawa, 1994, Pharmaceutical Research.

A cytoplasm-sensitive peptide vector cross-linked with dynein light chain association sequence (DLCAS) enhances gene expression.

H. Okada, T. Kanazawa, Y. Takashima, 2011, International journal of pharmaceutics.

In vitro and in vivo evaluation of thyrotrophin releasing hormone release from copoly(dl-lactic/glycolic acid) microspheres.

H. Okada, T. Heya, Y. Ogawa, 1994, Journal of pharmaceutical sciences.

Sustained Pharmacological Activities in Rats Following Single and Repeated Administration of Once-a-Month Injectable Microspheres of Leuprolide Acetate

H. Okada, T. Heya, T. Shimamoto, 1991, Pharmaceutical Research.

Targeted siRNA therapy using cytoplasm-responsive nanocarriers and cell-penetrating peptides

H. Okada, 2014, Journal of Pharmaceutical Investigation.

Disulfide crosslinked stearoyl carrier peptides containing arginine and histidine enhance siRNA uptake and gene silencing.

H. Okada, T. Kanazawa, Y. Takashima, 2010, International journal of pharmaceutics.

Improved intestinal absorption of a poorly water-soluble oral drug using mannitol microparticles containing a nanosolid drug dispersion.

H. Okada, T. Ozeki, T. Kanazawa, 2012, Journal of pharmaceutical sciences.

Development of a novel and customizable two-solution mixing type spray nozzle for one-step preparation of nanoparticle-containing microparticles.

H. Okada, Toshiyuki Tanaka, Yusuke Akiyama, 2012, Biological and Pharmaceutical Bulletin.

One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate.

H. Okada, Okada, 1997, Advanced drug delivery reviews.

Design of rapidly disintegrating oral tablets using acid-treated yeast cell wall: A technical note

H. Okada, T. Ozeki, Y. Takashima, 2003, AAPS PharmSciTech.

Drug discovery using a novel biomaterial of oligonucleotides and innovative DDS

H. Okada, 2010 .

Versatile nuclear localization signal-based oligopeptide as a gene vector.

H. Okada, T. Kanazawa, Y. Takashima, 2015, Biological & pharmaceutical bulletin.

Electroporation-Based ex Vivo Gene Delivery into Dendritic Cells by Anionic Polymer-Coated Versatile Nuclear Localization Signal/pDNA Complex.

H. Okada, T. Kanazawa, Y. Takashima, 2021, Biological & pharmaceutical bulletin.

Improved intestinal absorption of a poorly water-soluble oral drug using mannitol microparticles containing a nanosolid drug dispersion.

H. Okada, T. Ozeki, T. Kanazawa, 2012, Journal of pharmaceutical sciences.