J. Conboy

发表

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Joshua M. Korn, Christopher A. Miller, Derek Y. Chiang, 2008, Nature.

The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons

J. Conboy, I. Dubchak, Simon Minovitsky, 2005, Nucleic acids research.

A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing

Tyson A. Clark, A. Schweitzer, J. Blume, 2007, Nucleic acids research.

Integrated Genomic Analyses of Ovarian Carcinoma

Benjamin J. Raphael, James M. Eldred, Joshua M. Stuart, 2011, Nature.

Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer

Lior Pachter, Zhi Hu, Bahram Parvin, 2010, Molecular Cancer Research.

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges

Gene W. Yeo, T. Liang, D. Black, 2013, Nature Structural &Molecular Biology.

A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis

L. Pachter, J. Conboy, S. Gee, 2015, Nucleic acids research.

Regulation of alternative pre-mRNA splicing during erythroid differentiation

J. Conboy, V. Hou, V C Hou, 2001, Current opinion in hematology.

Glycophorin C content of human erythrocyte membrane is regulated by protein 4.1.

J. Conboy, N. Mohandas, M. Reid, 1990, Blood.

Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. I. Biochemical identification of rearrangements in the spectrin/actin binding domain and functional characterizations.

J. Conboy, D. Speicher, P. Agre, 1990, The Journal of clinical investigation.

Glycophorin C content of human erythrocyte membrane is regulated by protein 4.1.

J. Conboy, N. Mohandas, M. Reid, 1990 .

Computational Analysis of an Evolutionarily Conserved Vertebrate Muscle Alternative Splicing Program

Tyson A. Clark, A. Schweitzer, J. Blume, 2006 .

Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Computational Analysis of an Evolutionarily Conserved Vertebrate Muscle Alternative Splicing Program Permalink

Tyson A. Clark, A. Schweitzer, H. Marr, 2006 .

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis

Lior Pachter, Harold Pimentel, John G. Conboy, 2014, Nucleic acids research.

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

J. Conboy, M. DeWitt, Weiguo Zhang, 2020, bioRxiv.

RNA splicing during terminal erythropoiesis

J. Conboy, 2017, Current opinion in hematology.

Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1.

J. Conboy, D. Discher, N. Mohandas, 1993, The Journal of biological chemistry.

Molecular and Functional Characterization of Protein 4.1B, a Novel Member of the Protein 4.1 Family with High Level, Focal Expression in Brain*

J. A. Gimm, S. Snyder, J. Conboy, 2000, The Journal of Biological Chemistry.

Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells.

J. Conboy, 1993, Seminars in hematology.

Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities.

J. Conboy, V. Afzal, B. Coller, 1999, The Journal of clinical investigation.

Fox1 and Fox4 regulate muscle-specific splicing in zebrafish and are required for cardiac and skeletal muscle functions

H. Marr, J. Conboy, Joshua A. Arribere, 2010 .

Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.

J. Conboy, P. Gascard, L. Walensky, 2003, Kidney international.

Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating

R. Waugh, J. Conboy, P. Kingsley, 2017, Scientific Reports.

Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins.

J. Conboy, N. Mohandas, Y. Takakuwa, 2000, The Journal of biological chemistry.

Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.

J. Conboy, P. Gascard, L. Walensky, 1999, Molecular biology of the cell.

Differential use of protein 4.1 translation initiation sites during erythropoiesis: implications for a mutation-induced stage-specific deficiency of protein 4.1 during erythroid development.

J. Conboy, N. Mohandas, L. Coulombel, 1996, Blood.

Molecular basis of hereditary elliptocytosis due to protein 4.1 deficiency.

J. Conboy, Y. Kan, N. Mohandas, 1986, The New England journal of medicine.

Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.

S. Snyder, J. Conboy, P. Gascard, 1998, Genomics.

Lack of Protein 4.1G Causes Altered Expression and Localization of the Cell Adhesion Molecule Nectin-Like 4 in Testis and Can Cause Male Infertility

J. Conboy, G. Debnath, A. Lambert, 2011, Molecular and Cellular Biology.

Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions

J. Conboy, G. Debnath, N. Mohandas, 2010, Histochemistry and Cell Biology.

The role of alternative pre-mRNA splicing in regulating the structure and function of skeletal protein 4.1.

J. Conboy, 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1.

J. Conboy, Y. Kan, N. Mohandas, 1991, The Journal of biological chemistry.

Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.

J. Conboy, Y. Kan, J. Prchal, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.

J. Conboy, S. Gee, 1994, Gene.

Chapter title : Alternative splicing in humans

J. Conboy, I. Dubchak, 2005 .

Lawrence Berkeley National Laboratory Recent Work Title Alternative splicing in humans

J. Conboy, I. Dubchak, 2005 .

In vitro synthesis of a putative precursor of mitochondrial ornithine transcarbamoylase.

J. Conboy, L. Rosenberg, F. Kalousek, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.

H. Marr, J. Conboy, Joshua A. Arribere, 2011, Developmental biology.

Processing of pre-ornithine transcarbamylase requires a zinc-dependent protease localized to the mitochondrial matrix.

J. Conboy, W. Fenton, L. Rosenberg, 1982, Biochemical and Biophysical Research Communications - BBRC.

Energy-dependent translocation of the precursor of ornithine transcarbamylase by isolated rat liver mitochondria.

J. Conboy, W. Fenton, L. Rosenberg, 1982, The Journal of biological chemistry.

Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.

S. Snyder, J. Conboy, H. Weier, 1998, Genomics.

Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1.

L. Zon, J. Conboy, D. Discher, 1995, Blood.

Selective effects of protein 4.1N deficiency on neuroendocrine and reproductive systems

J. Conboy, C. Hillyer, N. Mohandas, 2020, Scientific Reports.

An isoform-specific mutation in the protein 4.1 gene results in hereditary elliptocytosis and complete deficiency of protein 4.1 in erythrocytes but not in nonerythroid cells.

J. Conboy, Y. Kan, N. Mohandas, 1993, The Journal of clinical investigation.

Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements.

J. Conboy, Y. Kan, P. Agre, 1990, The Journal of clinical investigation.

Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3.

D. W. Knowles, J. Conboy, D. Knowles, 1992, The Journal of clinical investigation.

A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1

R. Huganir, S. Snyder, J. Conboy, 1999, The Journal of Neuroscience.

Regulation of Protein 4.1R, p55, and Glycophorin C Ternary Complex in Human Erythrocyte Membrane*

J. Conboy, N. Mohandas, Y. Takakuwa, 2000, The Journal of Biological Chemistry.

Hereditary elliptocytosis due to both qualitative and quantitative defects in membrane skeletal protein 4.1.

J. Conboy, N. Mohandas, M. Parra, 1991, Blood.

Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening

J. Conboy, D. Discher, N. Mohandas, 1995, The Journal of cell biology.

Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis.

J. Conboy, Y. Kan, N. Mohandas, 1993, The Journal of clinical investigation.

The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1

S. Snyder, J. Conboy, P. Gascard, 1998, The Journal of cell biology.

Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation.

J. Conboy, P. Gascard, N. Mohandas, 1998, Blood.

Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.

J. Conboy, Y. Kan, N. Mohandas, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.

Tyson A. Clark, Jeong-Ah Kang, Tyson A Clark, 2009, Blood.

Keep Me Around: Intron Retention Detection and Analysis

Lior Pachter, Harold Pimentel, John G. Conboy, 2015, 1510.00696.

Fox-2 Splicing Factor Binds to a Conserved Intron Motif to Promote Inclusion of Protein 4.1R Alternative Exon 16*

J. Conboy, S. Gee, J. Chasis, 2006, Journal of Biological Chemistry.

Developmental regulation of RNA processing by Rbfox proteins

J. Conboy, 2017, Wiley interdisciplinary reviews. RNA.

High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function.

J. Conboy, N. Mohandas, Jeff S. Tan, 2006, Blood.

Evolutionarily conserved coupling of transcription and alternative splicing in the EPB41 (protein 4.1R) and EPB41L3 (protein 4.1B) genes.

J. Conboy, N. Mohandas, Jeff S. Tan, 2005, Genomics.

Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.

I-Min A. Dubchak, M S Gelfand, I Dubchak, 2001, Nucleic acids research.

FIRMA: a method for detection of alternative splicing from exon array data

Mark D. Robinson, Terence P. Speed, E. Purdom, 2008, Bioinform..

Unannotated splicing regulatory elements in deep intron space

J. Conboy, 2021, Wiley interdisciplinary reviews. RNA.

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys

James B. Brown, Gene W. Yeo, Benjamin W. Booth, 2018, bioRxiv.

Human erythroid 5-aminolevulinate synthase. Gene structure and species-specific differences in alternative RNA splicing.

J. Conboy, T. Cox, B. May, 1992, The Journal of biological chemistry.

A Deep Exon Cryptic Splice Site Promotes Aberrant Intron Retention in a Von Willebrand Disease Patient

J. Conboy, 2021, bioRxiv.

Decrease in hnRNP A/B expression during erythropoiesis mediates a pre‐mRNA splicing switch

A. Krainer, J. Conboy, S. Gee, 2002, The EMBO journal.

Molecular analysis of glycophorin C deficiency in human erythrocytes.

J. Conboy, N. Mohandas, M. Reid, 1993, Blood.

Molecular characterization of erythrocyte glycophorin C variants.

J. Conboy, Y. Kan, N. Mohandas, 1991, Blood.

A molecular study of heterozygous protein 4.1 deficiency in hereditary elliptocytosis.

J. Conboy, S. Zail, S. Lambert, 1988, Blood.

Pre-ornithine transcarbamylase. Properties of the cytoplasmic precursor of a mitochondrial matrix enzyme.

J. Conboy, J. Kraus, L. Rosenberg, 1981, The Journal of biological chemistry.

Defining of the Minimal Domain of Protein 4.1 Involved in Spectrin-Actin Binding (*)

J. Conboy, D. Discher, H. Witkowska, 1995, The Journal of Biological Chemistry.

Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene

J. Conboy, N. Mohandas, M. Parra, 2008, The EMBO journal.

Alternative splicing in humans

J. Conboy, I. Dubchak, 2005 .

Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicing.

J. Conboy, S. Rivkees, P. Gascard, 2004, Biochimica et biophysica acta.

Alternative 5' exons and differential splicing regulate expression of protein 4.1R isoforms with distinct N-termini.

J. Conboy, S. Gee, M. Koury, 2003, Blood.

The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane

S. C. Liu, P. Bryant, P. Low, 1998 .

Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1

S. Snyder, J. Conboy, E. Rubin, 1998, Current Biology.

Cell Shape-dependent Regulation of Protein 4.1 Alternative Pre-mRNA Splicing in Mammary Epithelial Cells*

J. Conboy, P. Yaswen, N. Mohandas, 1997, The Journal of Biological Chemistry.

Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.

J. Conboy, S. Gee, S. W. Krauss, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Cloning of mDEAH 9 , a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp 43

J. Conboy, S. Gee, S. W. Krauss, 1997 .

Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.

J. Conboy, I. Dubchak, S. Gee, 2004, Genomics.

Deep Intron Elements Mediate Nested Splicing Events at Consecutive AG Dinucleotides To Regulate Alternative 3′ Splice Site Choice in Vertebrate 4.1 Genes

J. Conboy, N. Mohandas, S. Amacher, 2012, Molecular and Cellular Biology.

Alternative splicing of protein 4.1R exon 16: ordered excision of flanking introns ensures proper splice site choice.

J. Conboy, S. Gee, M. Wu, 2000, Blood.

The Role of Alternative Pre-mRNA Splicing in Regulating the Structure and Function of Skeletal Protein 4.1

J. Conboy, 1999 .

Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.

J. Conboy, Y. Kan, N. Mohandas, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of β1 integrin

J. Conboy, N. Mohandas, X. An, 2011, Journal of Cell Science.

Posttranslational uptake and processing of in vitro synthesized ornithine transcarbamoylase precursor by isolated rat liver mitochondria.

J. Conboy, L. Rosenberg, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating

R. Waugh, J. Conboy, P. Kingsley, 2017, Scientific Reports.

A Dynamic Alternative Splicing Program Regulates Gene Expression In A Differentiation Stage-Specific Manner During Terminal Erythropoiesis

L. Pachter, J. Conboy, S. Gee, 2013 .

Efficient in Vivo Manipulation of Alternative Pre-mRNA Splicing Events Using Antisense Morpholinos in Mice*

J. Conboy, S. Gee, N. Mohandas, 2010, The Journal of Biological Chemistry.

Ca2+-dependent and Ca2+-independent Calmodulin Binding Sites in Erythrocyte Protein 4.1

J. Conboy, N. Mohandas, Y. Takakuwa, 2000, Journal of Biological Chemistry.

α-Globin pre-mRNA splicing, revisited.

J. Conboy, 2019, Blood.

Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.

H. Marr, J. Conboy, Joshua A. Arribere, 2011, Developmental biology.

Efficient in Vivo Manipulation of Alternative Pre-mRNA Splicing Events Using Antisense Morpholinos in Mice*

J. Conboy, S. Gee, N. Mohandas, 2010, The Journal of Biological Chemistry.

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.

Tyson A. Clark, A. Schweitzer, J. Conboy, 2009, Blood.

Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of β1 integrin

J. Conboy, N. Mohandas, X. An, 2011, Journal of Cell Science.