C. Langmead

发表

Unifying cardiovascular modelling with deep reinforcement learning for uncertainty aware control of sepsis treatment pdf

Gilles Clermont, Christopher James Langmead, Thesath Nanayakkara, 2021, PLOS digital health.

Time-Varying Gaussian Graphical Models of Molecular Dynamics Data

Arvind Ramanathan, Subhodeep Moitra, Hetunandan Kamisetty, 2010 .

Free Energy Estimates of All-Atom Protein Structures Using Generalized Belief Propagation

Eric P. Xing, Christopher James Langmead, Hetunandan Kamisetty, 2007, RECOMB.

A graphical model approach for predicting free energies of association for protein-protein interactions under backbone and side-chain flexibility

Chris Bailey-Kellogg, Hetunandan Kamisetty, Christopher J. Langmead, 2008 .

Temporal-logics as query languages for dynamic Bayesian networks: application to D. melanogaster embryo development

Sumit Kumar Jha, Edmund M. Clarke, Christopher J. Langmead, 2006 .

Symbolic Approaches for Finding Control Strategies in Boolean Networks.

Sumit Kumar Jha, C. Langmead, 2007 .

Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution

Trevor S. Frisby, C. Langmead, 2021, Algorithms Mol. Biol..

Systematic Testing of Belief-Propagation Estimates for Absolute Free Energies in Atomistic Peptides and Proteins.

C. Langmead, D. Zuckerman, Rory M. Donovan-Maiye, 2018, Journal of chemical theory and computation.

Generative models of conformational dynamics.

C. Langmead, 2014, Advances in experimental medicine and biology.

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

A. Leslie, C. Langmead, C. Tate, 2011, Nature.

Accounting for conformational entropy in predicting binding free energies of protein‐protein interactions

C. Langmead, Hetunandan Kamisetty, A. Ramanathan, 2011, Proteins.

Quantitative Analysis Reveals Multiple Mechanisms of Allosteric Modulation of the mGlu5 Receptor in Rat Astroglia

C. Langmead, R. Challiss, S. Bradley, 2011, Molecular Pharmacology.

G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

C. Langmead, P. Sexton, R. Summers, 2018, Pharmacological Reviews.

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

Jonathan S. Mason, Christopher J. Langmead, Miles Congreve, 2011, Journal of medicinal chemistry.

Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

C. Langmead, K. Gregory, I. Kufareva, 2019, British journal of pharmacology.

Functional and structural perspectives on allosteric modulation of GPCRs.

Arthur Christopoulos, Christopher J Langmead, C. Langmead, 2014, Current opinion in cell biology.

Discovering Conformational Sub-States Relevant to Protein Function

Arvind Ramanathan, Christopher J. Langmead, Pratul K. Agarwal, 2011, PloS one.

Belief Propagation Reveals Allosteric Mechanisms in Proteins

C. Langmead, Hetunandan Kamisetty, A. Ramanathan, 2009 .

MODELING AND INFERENCE OF SEQUENCE-STRUCTURE SPECIFICITY

Chris Bailey-Kellogg, Bornika Ghosh, Hetunandan Kamisetty, 2009 .

Detecting Protein-Protein Interaction Decoys using Fast Free Energy Calculations

C. Langmead, Hetunandan Kamisetty, 2007 .

The von Mises Graphical Model: Structure Learning (CMU-CS-11-108 / CMU-CB-11-100)

C. Langmead, N. Razavian, Hetunandan Kamisetty, 2011 .

Binding kinetics differentiates functional antagonism of orexin‐2 receptor ligands

C. Langmead, F. Marshall, J. Brown, 2014, British journal of pharmacology.

Characterization of the binding of [125I]‐human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor

C. Langmead, J. Chambers, P. Szekeres, 2000 .

Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists

C. Langmead, P. Sexton, A. Christopoulos, 2017, Molecular Pharmacology.

Structure-based development of a subtype-selective orexin 1 receptor antagonist

C. Langmead, P. Kolb, D. Rosenbaum, 2020, Proceedings of the National Academy of Sciences.

SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Paul W Smith, C. Langmead, J. Hagan, 2006, Neuropharmacology.

Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor

C. Langmead, C. Scott, H. Herdon, 2004, British journal of pharmacology.

Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties

M. Congreve, C. Langmead, J. Errey, 2015 .

A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

Kalyan C. Tirupula, J. Klein-Seetharaman, Subhodeep Moitra, 2012, BMC biophysics.

A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons.

C. Langmead, Gregory D. Stewart, Cassandra J Hatzipantelis, 2020, ACS chemical neuroscience.

High-Throughput 3D Homology Detection via NMR Resonance Assignment

C. Langmead, 2004 .

Molecular pharmacology of GPCRs

C. Langmead, R. Summers, 2018, British journal of pharmacology.

The Marker State Space (MSS) Method for Classifying Clinical Samples

C. Langmead, W. Tembe, R. Brand, 2013, PloS one.

Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

C. Langmead, P. Sexton, A. Christopoulos, 2018, British journal of pharmacology.

New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery.

C. Langmead, D. Riddy, Julia Park, 2020, ACS pharmacology & translational science.

Angiopoietin-2 , a Regulator of Vascular Permeability in Infl ammation , Is Associated With Persistent Organ Failure in Patients With Acute Pancreatitis From the United States and Germany

G. Clermont, C. Langmead, V. Muddana, 2010 .

Tools Needed for Automating Science : Formalizing the use of Active Machine Learning to Drive Experimentation

Joshua D Kangas, C. Langmead, R. Murphy, 2017 .

Contrasting Effects of Allosteric and Orthosteric Agonists on M1 Muscarinic Acetylcholine Receptor Internalization and Down-regulation

C. Langmead, M. Wood, R. Challiss, 2009, Journal of Pharmacology and Experimental Therapeutics.

Differential GLP-1R binding and activation by peptide and non-peptide agonists

David E. Gloriam, C. Langmead, P. Sexton, 2020, bioRxiv.

Deep Normed Embeddings for Patient Representation

Thesath Nanayakkara, G. Clermont, C. Langmead, 2022, ArXiv.

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery

Nathan Robertson, Ali Jazayeri, Christopher J. Langmead, 2011, Neuropharmacology.

Ligand properties and behaviours in an allosteric age.

C. Langmead, 2012, Trends in pharmacological sciences.

Multi-pathway in vitro pharmacological characterisation of specialised pro-resolving G protein-coupled receptors (SPM-GPCRs)

C. Langmead, S. Fabb, Jon Merlin, 2022 .

Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro

C. Langmead, A. A. Parsons, P. Strijbos, 2004, Neuroscience Letters.

Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor

Arthur Christopoulos, Patrick M. Sexton, Christopher J. Langmead, 2010, Molecular Pharmacology.

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3

C. Langmead, J. Wess, A. Christopoulos, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Gpr88 deletion impacts motivational control independently of striatal dopamine function

C. Langmead, A. Fornito, J. Nithianantharajah, 2022, bioRxiv.

2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.

C. Langmead, I. Forbes, R. Rivero, 2010, Bioorganic & medicinal chemistry letters.

2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.

C. Langmead, J. Foley, I. Forbes, 2010, Bioorganic & medicinal chemistry letters.

HIV-1 Capsid Function Is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD.

Klaus Schulten, Juan R Perilla, Christopher J Langmead, 2016, Journal of the American Chemical Society.

Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

C. Langmead, P. Sexton, A. Christopoulos, 2018, Molecular Pharmacology.

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

C. Langmead, P. Sexton, A. Christopoulos, 2016, PloS one.

The muscarinic M(4) receptor is the functionally predominant subtype in rat and mouse striatum as demonstrated using [(35)S] GTPγS binding.

C. Langmead, J. Kew, J. Watson, 2011, European journal of pharmacology.

Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.

C. Langmead, J. Chambers, P. Szekeres, 2000, British journal of pharmacology.

Bone marrow transplantation and RNAseq analysis of Gpr21−/− monocytes reveals reduced migratory function and downregulation of inflammatory genes

C. Langmead, P. Sexton, A. Murphy, 2019, Obesity Research & Clinical Practice.

Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities.

Pramod C. Nair, C. Langmead, K. Gregory, 2022, ACS pharmacology & translational science.

International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

J. Changeux, R. Neubig, C. Langmead, 2014, Pharmacological Reviews.

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

Jonathan S. Mason, Christopher J. Langmead, S. P. Andrews, 2012, Journal of medicinal chemistry.

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

David M. Shackleford, C. Langmead, P. Sexton, 2019, Neuropharmacology.

Gpr88 deletion impacts motivational control without overt disruptions to striatal dopamine

C. Langmead, A. Fornito, J. Nithianantharajah, 2022, Biological Psychiatry Global Open Science.

An Online Approach for Mining Collective Behaviors from Molecular Dynamics Simulations

Arvind Ramanathan, Christopher James Langmead, Pratul K. Agarwal, 2009, RECOMB.

A maximum entropy algorithm for rhythmic analysis of genome-wide expression patterns

Bruce Randall Donald, Christopher James Langmead, C. Robertson McClung, 2002, Proceedings. IEEE Computer Society Bioinformatics Conference.

The von Mises Graphical Model : Structure Learning

Christopher James Langmead, Hetunandan Kamisetty, C. Langmead, 2011 .

Matching models to data: a receptor pharmacologist's guide

David A Hall, Christopher J Langmead, D. A. Hall, 2010, British journal of pharmacology.

Approximating Correlated Equilibria using Relaxations on the Marginal Polytope

Eric P. Xing, Christopher James Langmead, Hetunandan Kamisetty, 2011, ICML.

Structured probabilistic models of proteins across spatial and fitness landscapes

E. Xing, C. Langmead, Hetunandan Kamichetty, 2011 .

Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

C. J. Hutchings, C. Langmead, F. Marshall, 2014, mAbs.

Structural and functional characterisation of neuronal Gq protein coupled receptors.

C. Langmead, 2006 .

Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis.

Dhiraj Yadav, Vikesh K. Singh, Faraz Bishehsari, 2012, Gastroenterology.

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior

David M. Shackleford, Shailesh N Mistry, C. Langmead, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2

C. Langmead, J. Wess, A. Christopoulos, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

C. Langmead, J. Wess, A. Christopoulos, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists

C. Langmead, M. Wood, R. Challiss, 2008, Journal of Pharmacology and Experimental Therapeutics.

G protein‐coupled receptors as anabolic drug targets in osteoporosis

C. Langmead, A. E. Cook, P. Rueda, 2017, Pharmacology & therapeutics.

Performance of Mouse Neural Stem Cells as a Screening Reagent

C. Langmead, A. Lodge, Tim D. Werry, 2010, Journal of biomolecular screening.

Muscarinic M4 and M5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol‐preferring rats

C. Langmead, C. Lindsley, A. Lawrence, 2021, British journal of pharmacology.

Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Alice E. Berizzi, C. Langmead, A. Christopoulos, 2020, Biological Psychiatry.

Neurochemical Changes in LPA1 Receptor Deficient Mice – A Putative Model of Schizophrenia

C. Langmead, P. Maycox, Z. Hughes, 2005, Neurochemical Research.

Muscarinic acetylcholine receptors as CNS drug targets.

Christopher J Langmead, Jeannette Watson, C. Langmead, 2008, Pharmacology & therapeutics.

Identifying Promising Sequences For Protein Engineering Using A Deep Transformer Protein Language Model

Trevor S. Frisby, C. Langmead, 2023, bioRxiv.

A Novel 5-Cytokine Panel Outperforms Conventional Predictive Markers of Persistent Organ Failure in Acute Pancreatitis

C. Langmead, Phil J. Greer, P. Hart, 2021, Clinical and translational gastroenterology.

A Novel 5-Cytokine Panel Outperforms Conventional Predictive Markers of Persistent Organ Failure in Acute Pancreatitis

C. Langmead, Phil J. Greer, P. Hart, 2021, Clinical and Translational Gastroenterology.

ANGIOPOIETIN-2, A REGULATOR OF VASCULAR PERMEABILITY IN INFLAMMATION IS ELEVATED IN SEVERE ACUTE PANCREATITIS AND IS ASSOCIATED WITH SYSTEMIC ORGAN FAILURE

C. Langmead, V. Muddana, D. Whitcomb, 2008 .

Serum Biomarker Panels for the Detection of Pancreatic Cancer

William E Grizzle, Christopher J Langmead, Herbert J Zeh, 2011, Clinical Cancer Research.

Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.

C. Langmead, J. Nithianantharajah, T. Pierce, 2020, ACS pharmacology & translational science.

Article pubs.acs.org/jmc Identification of Novel Adenosine A 2A Receptor Antagonists by Virtual Screening

Nathan Robertson, Jonathan S. Mason, Christopher J. Langmead, 2022 .

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Christopher J Langmead, Patrick M Sexton, C. Langmead, 2018, PloS one.

The von Mises Graphical Model: Expectation Propagation for Inference (CMU-CS-11-130/CMU-CB-11-102)

Hetunandan Kamisetty, Christopher J. Langmead, Narges Razavian, 2011 .

Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis‐associated neoplasia

C. Langmead, M. Bronner, R. Brand, 2011, Inflammatory bowel diseases.

Binding of SEP-363856 within TAAR1 and the 5HT1A receptor: implications for the design of novel antipsychotic drugs

Pramod C. Nair, C. Langmead, K. Gregory, 2021, Molecular Psychiatry.

Extracting structural information using time-frequency analysis of protein NMR data

Bruce Randall Donald, Christopher James Langmead, B. Donald, 2001, RECOMB.

Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics

C. Langmead, A. Fornito, Gregory D. Stewart, 2022, Translational Psychiatry.

Dynamic allostery governs cyclophilin A–HIV capsid interplay

K. Schulten, C. Langmead, A. Gronenborn, 2015, Proceedings of the National Academy of Sciences.

In the loop: extra-striatal regulation of spiny projection neurons by GPR52.

David M. Shackleford, C. Langmead, P. Sexton, 2020, ACS chemical neuroscience.

3D structural homology detection via NMR resonance assignment

Bruce Randall Donald, Christopher James Langmead, B. Donald, 2004, Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004..

An expectation/maximization nuclear vector replacement algorithm for automated NMR resonance assignments

Bruce Randall Donald, Christopher James Langmead, B. Donald, 2004, Journal of biomolecular NMR.

Large a polynomial-time nuclear vector replacement algorithm for automated NMR resonance assignments

Anthony K. Yan, Bruce Randall Donald, Ryan H. Lilien, 2003, RECOMB '03.

M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

C. Langmead, A. Lawrence, L. Walker, 2021, Pharmacology research & perspectives.

N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor

C. Langmead, C. Davies, J. Hagan, 2010, Neuropharmacology.

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

C. Langmead, P. White, P. Sexton, 2020, bioRxiv.

Structural and Molecular Determinants for Isoform Bias at Human Histamine H3 Receptor Isoforms.

C. Langmead, R. Leurs, A. Christopoulos, 2023, ACS chemical neuroscience.

Learning generative models of molecular dynamics

C. Langmead, N. Razavian, Hetunandan Kamisetty, 2012, BMC Genomics.

Learning generative models of molecular dynamics

Christopher James Langmead, Hetunandan Kamisetty, Narges Razavian, 2012, BMC Genomics.

Learning generative models for protein fold families

Sivaraman Balakrishnan, Su-In Lee, Christopher James Langmead, 2011, Proteins.

On-the-Fly Identification of Conformational Substates from Molecular Dynamics Simulations.

Arvind Ramanathan, Christopher J Langmead, Ji Oh Yoo, 2011, Journal of chemical theory and computation.

The von Mises Graphical Model: Regularized Structure and Parameter Learning (CMU-CS-11-129/CMU-CB-11-101)

Hetunandan Kamisetty, Christopher J. Langmead, Narges Razavian, 2011 .

A Bayesian Approach to Model Checking Biological Systems

Axel Legay, Sumit Kumar Jha, Edmund M. Clarke, 2009, CMSB.

Statistical Model Checking for Complex Stochastic Models in Systems Biology

Axel Legay, Sumit Kumar Jha, Edmund M. Clarke, 2009 .

Symbolic Approaches for Finding Control Strategies in Boolean Networks

Sumit Kumar Jha, Christopher James Langmead, C. Langmead, 2007, APBC.

Towards Inference and Learning in Dynamic Bayesian Networks using Generalized Evidence

Christopher J. Langmead, C. Langmead, 2008 .

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

C. Langmead, P. Sexton, A. Christopoulos, 2020, Molecular cell.

Muscarinic M5 receptors modulate ethanol seeking in rats

David M. Shackleford, Alice E. Berizzi, C. Langmead, 2018, Neuropsychopharmacology.

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

C. Langmead, J. Hagan, D. Middlemiss, 2005, European journal of pharmacology.

Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: facilitating research through infrastructure, workforce, resources and funding

C. Langmead, E. Neufeld, R. Lewis, 2023, Expert review of hematology.

Harvestman: a framework for hierarchical feature learning and selection from whole genome sequencing data

Christopher James Langmead, Guillaume Marçais, Carl Kingsford, 2020, bioRxiv.

Exploring behaviors of stochastic differential equation models of biological systems using change of measures

Sumit Kumar Jha, Christopher James Langmead, C. Langmead, 2012, BMC Bioinformatics.

A Bayesian approach to protein model quality assessment

Christopher James Langmead, Hetunandan Kamisetty, C. Langmead, 2009, ICML '09.

High throughput, quantitative analysis of human osteoclast differentiation and activity.

C. Langmead, P. Sexton, A. Christopoulos, 2017, Analytical biochemistry.

Structure-Based Chemical Shift Prediction Using Random Forests Non-Linear Regression

Christopher James Langmead, K. Arun, C. Langmead, 2005, APBC.

Structure-Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators.

Alice E. Berizzi, C. Langmead, P. Sexton, 2018, ACS chemical neuroscience.

Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

Alice E. Berizzi, C. Langmead, P. Sexton, 2016, Molecular Pharmacology.

Statistical Model Checking in BioLab: Applications to the Automated Analysis of T-Cell Receptor Signaling Pathway

Axel Legay, Sumit Kumar Jha, Edmund M. Clarke, 2008, CMSB.

A Probability-Based Similarity Measure for Saupe Alignment Tensors with Applications to Residual Dipolar Couplings in NMR Structural Biology

Anthony K. Yan, Bruce Randall Donald, Christopher James Langmead, 2005, Int. J. Robotics Res..

The use of GPCR structures in drug design.

Miles Congreve, Fiona H Marshall, Christopher Langmead, 2011, Advances in pharmacology.

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1

M. Whittington, C. Langmead, C. Davies, 2008, British journal of pharmacology.

Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist

C. Langmead, A. Christopoulos, I. Forbes, 2006, Molecular Pharmacology.

Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.

C. Langmead, P. Sexton, R. Danev, 2021, Biochemical and biophysical research communications.

Structure-Function Studies of Allosteric Agonism at M2 Muscarinic Acetylcholine Receptors

C. Langmead, P. Sexton, A. Christopoulos, 2007, Molecular Pharmacology.

Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms

C. Langmead, M. Febbraio, P. Sexton, 2021, BMJ Open Diabetes Research & Care.

Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands

C. Langmead, E. Hulme, B. Tehan, 2007, Molecular Pharmacology.

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.

Paul W Smith, C. Langmead, C. Davies, 2010, European journal of pharmacology.

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox.

C. Langmead, A. Christopoulos, 2006, Trends in pharmacological sciences.

Parameter Synthesis in Nonlinear Dynamical Systems: Application to Systems Biology

Gilles Clermont, Christopher James Langmead, Alexandre Donzé, 2009, RECOMB.

Supra‐physiological efficacy at GPCRs: superstition or super agonists?

C. Langmead, A. Christopoulos, 2013, British journal of pharmacology.

Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Pramod C. Nair, C. Langmead, K. Gregory, 2023, Molecular Psychiatry.

Crystal structure of the M5 muscarinic acetylcholine receptor

Alice E. Berizzi, C. Langmead, P. Sexton, 2019, Proceedings of the National Academy of Sciences.

The importance of sex differences in pharmacology research

C. Langmead, A. Lawrence, A. Gogos, 2019, British journal of pharmacology.

Fold Family-Regularized Bayesian Optimization for Directed Protein Evolution

Trevor S. Frisby, Christopher J. Langmead, C. Langmead, 2020, WABI.

Pharmacology and Structure of Isolated Conformations of the Adenosine A2A Receptor Define Ligand Efficacy

C. Langmead, F. Marshall, M. Weir, 2013, Molecular Pharmacology.

Crystal structure of the M5muscarinic acetylcholine receptor.

Alice E. Berizzi, C. Langmead, P. Sexton, 2019 .

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.

Alice E. Berizzi, C. Langmead, P. Sexton, 2018, ACS chemical neuroscience.

Automated parameter estimation for biological models using Bayesian statistical model checking

Sumit Kumar Jha, Faraz Hussain, Christopher J Langmead, 2015, BMC Bioinformatics.

From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Stephen R. Morairty, Robert T. Smith, G. Dawson, 2021, Cell.

Sex-dependent attentional impairments in a subchronic ketamine mouse model for schizophrenia

C. Langmead, J. Nithianantharajah, C. Nowell, 2023, Biological Psychiatry Global Open Science.

Phase-independent rhythmic analysis of genome-wide expression patterns

Anthony K. Yan, Bruce Randall Donald, Christopher James Langmead, 2002, RECOMB '02.

Screening for Positive Allosteric Modulators: Assessment of Modulator Concentration-Response Curves as a Screening Paradigm

C. Langmead, 2007, Journal of biomolecular screening.

Using Tensor Analysis to characterize Contact-map Dynamics of Proteins

Arvind Ramanathan, Christopher J. Langmead, Pratul K. Agarwal, 2008 .

Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.

C. Langmead, I. Forbes, R. Rivero, 2010, ACS medicinal chemistry letters.

3D structural homology detection via unassigned residual dipolar couplings

Bruce Randall Donald, Christopher James Langmead, B. Donald, 2003, Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003.

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gαo1 by the Ghrelin Receptor

C. Langmead, G. Milligan, A. Wise, 2009, Molecular Pharmacology.

Classifying Protein Structural Dynamics via Residual Dipolar Couplings

Ruben E. Valas, C. Langmead, 2004 .

Structure-Function Studies of Allosteric Agonism at M 2 Muscarinic Acetylcholine Receptors

C. Langmead, P. Sexton, A. Christopoulos, 2007 .

Efficient Modeling and Active Learning Discovery of Biological Responses

Robert F. Murphy, Armaghan W. Naik, Joshua D. Kangas, 2013, PloS one.

Hematocrit, Creatinine, and Blood Urea Nitrogen in the Assessment of Pancreatic Necrosis in Acute Pancreatitis: An International Study

Bechien U. Wu, C. Langmead, P. Banks, 2011 .

Admission Clinical Scores in Predicting Persistent Organ Failure in Acute Pancreatitis: A Head-to-Head Comparison and Design of Novel Step-up Classification Rules

C. Langmead, F. Bishehsari, D. Yadav, 2011 .

Serum biomarker profiles as diagnostic tools in lung cancer.

Christopher J Langmead, David O Wilson, C. Langmead, 2011, Cancer biomarkers : section A of Disease markers.

Angiopoietin-2, a Regulator of Vascular Permeability in Inflammation, Is Associated With Persistent Organ Failure in Patients With Acute Pancreatitis From the United States and Germany

G. Clermont, C. Langmead, V. Muddana, 2010, The American Journal of Gastroenterology.

ANGIOPOIETIN-2, A REGULATOR OF VASCULAR PERMEABILITY IN INFLAMMATION IS ELEVATED IN SEVERE ACUTE PANCREATITIS AND IS ASSOCIATED WITH SYSTEMIC ORGAN FAILURE

C. Langmead, M. Mullendore, G. Feldmann, 2008 .

High-Throughput 3D Homology Detection via NMR Resonance Assignment

C. Langmead, B. Donald, 2004 .

Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

Alice E. Berizzi, C. Langmead, P. Sexton, 2019 .

Asynchronous parallel Bayesian optimization for AI-driven cloud laboratories

Christopher James Langmead, Trevor S. Frisby, Trevor S Frisby, 2021, Bioinform..

Learning Sequence Determinants of Protein: Protein Interaction Specificity with Sparse Graphical Models

Chris Bailey-Kellogg, Christopher James Langmead, Bornika Ghosh, 2015, J. Comput. Biol..

Learning Sequence Determinants of Protein: Protein Interaction Specificity with Sparse Graphical Models

Chris Bailey-Kellogg, Christopher James Langmead, Bornika Ghosh, 2014, RECOMB.

Generalized Queries and Bayesian Statistical Model Checking in Dynamic Bayesian Networks: Application to Personalized Medicine

Christopher J. Langmead, C. Langmead, 2009 .

A Randomized Algorithm for Learning Mahalanobis Metrics: Application to Classification and Regression of Biological Data

Christopher James Langmead, C. Langmead, 2005, APBC.

Screening for Allosteric Modulators of G Protein‐Coupled Receptors

C. Langmead, 2010 .

Analogies between structural and systems biology and systems-of-systems engineering in dynamic environments

Judith Klein-Seetharaman, Oznur Tastan, Christopher James Langmead, 2010, 2010 5th International Conference on System of Systems Engineering.

The effect of SB‐269970, a 5‐HT7 receptor antagonist, on 5‐HT release from serotonergic terminals and cell bodies

C. Langmead, J. Hagan, D. Middlemiss, 2001, British journal of pharmacology.

An Online Approach for Mining Collective Behaviors from Molecular Dynamics Simulations

C. Langmead, A. Ramanathan, P. Agarwal, 2009, RECOMB.

Matching models to data: a receptor pharmacologist's guide

C. Langmead, David Hall, 2010, British journal of pharmacology.

Modeling Protein Structures with Conditional Random Fields: Final Report

Christopher Langmead, C. Langmead, 2008 .

Pharmacology and Structure of Isolated Conformations of the Adenosine A2A Receptor Define Ligand Efficacy

C. Langmead, F. Marshall, M. Weir, 2013, Molecular Pharmacology.

Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders.

C. Langmead, Natalie A. Diepenhorst, Maleesha Ubhayarathna, 2023, British journal of pharmacology.

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor

Alice E. Berizzi, C. Langmead, P. Sexton, 2021, ACS chemical neuroscience.

Determining allosteric modulator mechanism of action: integration of radioligand binding and functional assay data.

C. Langmead, 2011, Methods in molecular biology.

Synthesis and infeasibility analysis for stochastic models of biochemical systems using statistical model checking and abstraction refinement

Sumit Kumar Jha, Christopher James Langmead, C. Langmead, 2011, Theor. Comput. Sci..

N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor

C. Langmead, C. Davies, J. Hagan, 2010, Neuropharmacology.

Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists

C. Langmead, P. Sexton, A. Christopoulos, 2015, Molecular Pharmacology.

Label-free kinetics: exploiting functional hemi-equilibrium to derive rate constants for muscarinic receptor antagonists

C. Langmead, A. Christopoulos, W. Charman, 2015 .

Predicting Protein Folding Kinetics Via Temporal Logic Model Checking

Sumit Kumar Jha, Christopher James Langmead, C. Langmead, 2007, WABI.

Large scale testing of chemical shift prediction algorithms and improved machine learning-based approaches to shift prediction

Christopher James Langmead, K. Arun, C. Langmead, 2004, Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004..

International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

J. Changeux, R. Neubig, C. Langmead, 2014, Pharmacological Reviews.

Learning generative models for protein fold families

Su-In Lee, Sivaraman Balakrishnan, J. Carbonell, 2011, Proteins.

Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists

C. Langmead, P. Sexton, A. Christopoulos, 2017, Molecular Pharmacology.

A Polynomial-Time Nuclear Vector Replacement Algorithm for Automated NMR Resonance Assignments

C. Langmead, R. Lilien, B. Donald, 2004 .

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.

Christopher J Langmead, Jeannette Watson, C. Langmead, 2006, European journal of pharmacology.

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

C. Langmead, P. Sexton, A. Christopoulos, 2022, British journal of pharmacology.

Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M1 Muscarinic Acetylcholine Receptors

C. Langmead, E. Hulme, G. Lebon, 2009, Molecular Pharmacology.

Ligand properties and behaviours in an allosteric age.

C. Langmead, 2012, Trends in pharmacological sciences.

Multipathway In Vitro Pharmacological Characterization of Specialized Proresolving G Protein-Coupled Receptors

C. Langmead, S. Fabb, R. Summers, 2022, Molecular Pharmacology.

Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways.

C. Langmead, A. Christopoulos, C. Valant, 2023, Biochemical pharmacology.