Mark E. B. Smith

发表

Accurate Whole Human Genome Sequencing using Reversible Terminator Chemistry

Nancy F. Hansen, Lisa J. Murray, Phillip J. Black, 2008, Nature.

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all novel compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3cc45220d Click here for additio

Mark E. B. Smith, S. Caddick, K. Chester, 2013, Chemical communications.

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k Click he

James R. Baker, Gabriel Waksman, Finn Werner, 2011, Chemical communications.

An efficient route to all eight stereoisomers of a tri-functionalised cyclopentane scaffold for drug discovery

Mark E. B. Smith, R. Lloyd, Michael C. Lloyd, 2001 .

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

James R. Baker, Gabriel Waksman, Mark E. B. Smith, 2010, Journal of the American Chemical Society.

Bromopyridazinedione-mediated protein and peptide bioconjugationw

James R. Baker, Gabriel Waksman, Vijay Chudasama, 2011 .

Accelerating biocatalytic process design: Integrating new tools from biology, chemistry and engineering

John M. Woodley, John M. Woodley, Helen C. Hailes, 2007 .

One‐pot synthesis of amino‐alcohols using a de‐novo transketolase and β‐alanine: Pyruvate transaminase pathway in Escherichia coli

Helen C. Hailes, Paul A. Dalby, John M. Ward, 2007 .

Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate

Richard J. Fitzmaurice, Mark E. B. Smith, S. Caddick, 2012, Chembiochem : a European journal of chemical biology.

Bromomaleimides: new reagents for the selective and reversible modification of cysteine.

Mark E. B. Smith, J. Baker, L. Tedaldi, 2009, Chemical communications.

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'

James R. Baker, John M. Ward, Kerry A. Chester, 2013, Scientific Reports.

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

James R. Baker, Antoine Maruani, Kerry A. Chester, 2014, Organic & biomolecular chemistry.

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

James R. Baker, Andrew Tinker, Mark E. B. Smith, 2011, Bioconjugate chemistry.

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment.

Mark E. B. Smith, S. Caddick, R. Boyle, 2014, Bioconjugate chemistry.

Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis

Mark E. B. Smith, H. Hailes, J. Ward, 2007 .

Directed evolution of transketolase activity on non-phosphorylated substrates.

Tarik Senussi, Paul A Dalby, John M Ward, 2007, Journal of biotechnology.

α,α'-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes.

Mark E. B. Smith, P. Dalby, D. Steadman, 2010, Chemical communications.

Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single-Point Mutations

Mark E. B. Smith, P. Dalby, H. Hailes, 2008 .

Transketolase from Escherichia coli: A practical procedure for using the biocatalyst for asymmetric carbon-carbon bond synthesis

Mark E. B. Smith, M. Lilly, J. Woodley, 1996 .

Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one

Mark E. B. Smith, H. Hailes, J. Ward, 2009 .

A rapid, site-selective and efficient route to the dual modification of DARPins† †Electronic supplementary information (ESI) available: LC-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c4cc00053f Click here for additional data file.

Mark E. B. Smith, S. Caddick, Stephen R. Martin, 2014, Chemical communications.

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Mark E. B. Smith, S. Caddick, V. Chudasama, 2015, Organic & biomolecular chemistry.

Transgenic Cavendish bananas with resistance to Fusarium wilt tropical race 4

K. Mengersen, P. Waterhouse, Mark E. B. Smith, 2017, Nature Communications.

Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)

Mark E. B. Smith, S. Caddick, V. Chudasama, 2017 .

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

Mark E. B. Smith, S. Caddick, V. Chudasama, 2017 .

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine† †Electronic supplementary information (ESI) available: LC-MS, ES-MS and deconvoluted spectra for all reactions with proteins described herein, and 1H and 13C NMR spectra for all small molecule construc

Mark E. B. Smith, S. Caddick, J. Baker, 2015, Organic & biomolecular chemistry.

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

Mark E. B. Smith, S. Caddick, V. Chudasama, 2015, Chemical communications.

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.

Kersti Karu, Vijay Chudasama, James R Baker, 2017, Organic & biomolecular chemistry.

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones☆

Richard J. Fitzmaurice, Mark E. B. Smith, S. Caddick, 2013, Tetrahedron letters.

Homogeneous Bispecifics by Disulfide Bridging

Mark E. B. Smith, K. Chester, J. Baker, 2014, Bioconjugate chemistry.

Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file.

Mark E. B. Smith, G. Waksman, S. Caddick, 2011, Chemical communications.

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Mark E. B. Smith, S. Caddick, A. Tinker, 2014, Organic & biomolecular chemistry.