I. Pastan

I. Pastan, M. Brechbiel, J. Carrasquillo, 1997, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid-Biotin

William C Eckelman, Ira Pastan, Chang H Paik, 2004, Clinical Cancer Research.

Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.

T. Waldmann, I. Pastan, M. Brechbiel, 2002, Cancer research.

Imaging of Convection Enhanced Delivery of Toxins in Humans

A. Friedman, I. Pastan, D. Bigner, 2011, Toxins.

Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1

D. Bigner, I. Pastan, R. Raghavan, 2010, Journal of Neuro-Oncology.

Immunotoxins and Endocytosis

I. Pastan, M. Willingham, R. Pirker, 1987 .

Involvement of Na+ and HCO 3− in receptor‐mediated endocytosis of α2‐macroglobulin, epidermal growth factor, and vesicular stomatitis virus

I. Pastan, M. Willingham, R. Dickson, 1982, Journal of cellular physiology.

Stabilization of a recombinant Fv fragment by base-loop interconnection and V(H)-V(L) permutation.

I. Pastan, U. Brinkmann, G. Vasmatzis, 1997, Journal of molecular biology.

Immunotoxins: From Design to Clinical Application

I. Pastan, R. Kreitman, 2021, Biomolecules.

Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells.

I. Pastan, M. Willingham, M. Gallo, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients

I. Pastan, S. Nagata, M. Binder, 2017, Leukemia.

Growth Hormone and Prolactin

I. Pastan, M. Willingham, P. Kelly, 1990 .

PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach

I. Pastan, P. Duray, B. Sathyanarayana, 2002, Proceedings of the National Academy of Sciences of the United States of America.

POTE paralogs are induced and differentially expressed in many cancers.

I. Pastan, Byungkook Lee, Y. Hahn, 2006, Cancer research.

Cloning, molecular characterization, and expression analysis of Copine 8.

I. Pastan, D. Grigoryev, Byungkook Lee, 2003, Biochemical and biophysical research communications.

A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.

I. Pastan, U. Brinkmann, J. Buchner, 1992, Analytical biochemistry.

Keap1 inhibition attenuates glomerulosclerosis.

I. Pastan, Takafumi Suzuki, Masayuki Yamamoto, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis

I. Pastan, Qi Zhou, M. Prunotto, 2016, Proceedings of the National Academy of Sciences.

Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts.

G. S. Johnson, I. Pastan, J. Otten, 1972, The Journal of biological chemistry.

Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.

I. Pastan, D. Werth, 1984, The Journal of biological chemistry.

Expression of Lewis carbohydrate antigens in metastatic lesions from human prostatic carcinoma

H. Klocker, I. Pastan, G. Bartsch, 1998, The Prostate.

New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.

I. Pastan, M. Gottesman, G. Merlino, 1991, The Journal of urology.

MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants.

I. Pastan, M. Gottesman, O. Yoshida, 1989, Journal of the National Cancer Institute.

Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.

I. Pastan, M. Gottesman, T. Tsuruo, 1997, Cancer gene therapy.

An episomally maintained MDR1 gene for gene therapy.

I. Pastan, M. Gottesman, C. G. Lee, 2001, Human gene therapy.

A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells.

I. Pastan, M. Gottesman, S. Kane, 1989, Gene.

Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.

I. Pastan, R. Kreitman, Gilad Kaplan, 2017, Cellular immunology.

Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein.

I. Pastan, R. Puri, W. Debinski, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

I. Pastan, R. Puri, D. Hoon, 1996, Cancer research.

Cyclic AMP and the transformation of fibroblasts.

G. S. Johnson, I. Pastan, Ira Pastan, 1974, Advances in cancer research.

Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ).

G. S. Johnson, I. Pastan, M. D'armiento, 1972, Proceedings of the National Academy of Sciences of the United States of America.

A phospholipase specific for sphingomyelin from Clostridium perfringens.

I. Pastan, V. Macchia, R. Katzen, 1968, The Journal of biological chemistry.

Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models

I. Pastan, Y. Leshem, 2019, Toxins.

Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits.

I. Pastan, M. Willingham, F. Maxfield, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

I. Pastan, S. Keir, D. Bigner, 2019, PloS one.

Combination Treatments with the PKC Inhibitor, Enzastaurin, Enhance the Cytotoxicity of the Anti-Mesothelin Immunotoxin, SS1P

I. Pastan, D. FitzGerald, Abid R Mattoo, 2013, PloS one.

An scFv phage clone that binds to human β2-microglobulin

I. Pastan, J. Engberg, R. Kreitman, 1999 .

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

I. Pastan, Gilad Kaplan, D. Crown, 2015, Cellular and Molecular Immunology.

Evidence for participation of transglutaminase in receptor-mediated endocytosis.

I. Pastan, M. Willingham, A. Levitzki, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones

I. Pastan, J. Fagan, G. Jay, 1980, Journal of virology.

Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability.

I. Pastan, T. Bera, 1998, Bioconjugate chemistry.

Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase.

I. Pastan, M. Gottesman, A. LeCam, 1981, Biochimica et biophysica acta.

Transforming Growth Factor-α—Pseudomonas Exotoxin Fusion Protein (TGF-α-PE38) Treatment of Subcutaneous and Intracranial Human Glioma and Medulloblastoma Xenografts in Athymic Mice

I. Pastan, H. Brem, O. Colvin, 1994 .

Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells

Leonard A. Smith, I. Pastan, M. Gottesman, 1992 .

Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

I. Pastan, M. Gottesman, S. Currier, 1992, The Journal of biological chemistry.

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.

I. Pastan, M. Gottesman, L. Goldstein, 1992, Blood.

Retroviral transfer of a chimeric multidrug resistance‐adenosine deaminase gene

I. Pastan, M. Gottesman, U. Germann, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.

I. Pastan, R. Kreitman, K. Webber, 1995, Cancer research.

Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.

I. Pastan, R. Kreitman, 1993, Bioconjugate chemistry.

Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.

I. Pastan, D. Fitzgerald, S. Seetharam, 1993, Bioconjugate chemistry.

Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.

I. Pastan, D. Fitzgerald, L. Pai, 1990, Cancer research.

Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

I. Pastan, O. Colvin, H. Brem, 1994, Cancer research.

Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA

I. Pastan, N. Shimizu, G. Merlino, 1985, Somatic cell and molecular genetics.

Selective elimination in vitro of alloresponsive T cells to human transplantation antigens by toxin or radionuclide conjugated anti-IL-2 receptor (Tac) monoclonal antibody.

T. Waldmann, I. Pastan, C. Goldman, 1990, Journal of immunology.

Synergistic AntitumorActivity ofTaxol and Immunotoxin SS1P inTumor-BearingMice

Mitchell Ho, I. Pastan, J. Carrasquillo, 2006 .

Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry

I. Pastan, M. Willingham, G. Jay, 1979, Cell.

Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.

T. Waldmann, I. Pastan, J. Carrasquillo, 1999, Cytokine.

Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

I. Pastan, S. Batra, C. Wikstrand, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts

I. Pastan, N. Richert, G. Jay, 1979, Journal of virology.

Systemic immune changes accompany combination treatment with immunotoxin LMB‐100 and nab‐paclitaxel

S. Steinberg, I. Pastan, D. Venzon, 2022, Cancer medicine.

Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.

I. Pastan, M. Gottesman, G. Merlino, 1991, Cancer research.

KB Carcinoma Cell Lines Reduced Drug Accumulation in Multiply Drug-resistant Human

I. Pastan, M. Gottesman, A. Fojo, 2006 .

In situ Localization of the Human Multidrug‐resistance Gene mRNA Using Thymine‐Thymine Dimerized Single‐stranded cDNA

I. Pastan, M. Gottesman, S. Mori, 1990, Japanese journal of cancer research : Gann.

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

I. Pastan, M. Gottesman, A. Fojo, 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

I. Pastan, M. Willingham, M. Gottesman, 1986, Cancer research.

Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity.

I. Pastan, D. Fitzgerald, C. Theuer, 1993, Cancer research.

Pseudomonas exotoxin--immunotoxins.

I. Pastan, M. Willingham, D. Fitzgerald, 1988, Cancer treatment and research.

Use of Pseudomonas aeruginosa toxin A in the construction of conjugate vaccines and immunotoxins.

I. Pastan, M. Willingham, D. Fitzgerald, 1987, Reviews of infectious diseases.

Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.

I. Pastan, M. Willingham, R. Ozols, 1987, Cancer research.

Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.

I. Pastan, M. Willingham, D. Fitzgerald, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses.

I. Pastan, R. Kreitman, 1998, Cancer research.

Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells.

I. Pastan, R. Kreitman, 1997, Blood.

LL2-Fab' Induce Regression of Subcutaneous Human B-Cell Lymphoma in Mice1

I. Pastan, R. Kreitman, David, 2006 .

Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha.

I. Pastan, A. Kihara, 1994, Bioconjugate chemistry.

A proper amino terminus of diphtheria toxin is important for cytotoxicity.

I. Pastan, D. Fitzgerald, V. Chaudhary, 1991, Biochemical and biophysical research communications.

Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin

I. Pastan, D. Fitzgerald, W. Debinski, 1991, Molecular and cellular biology.

Domain II mutants of Pseudomonas exotoxin deficient in translocation.

I. Pastan, M. Willingham, S. Adhya, 1989, The Journal of biological chemistry.

Generation of a Transgenic BALB/c Mouse Line With Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin-targeted Immunotherapy

I. Pastan, S. Kozlov, T. Bera, 2019, Journal of immunotherapy.

Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis

I. Pastan, R. McCarron, J. Rose, 1991, Journal of Neuroimmunology.

Pseudomonas Exotoxin and Recombinant Immunotoxins Derived from It

I. Pastan, D. FitzGerald, 1993, Annals of the New York Academy of Sciences.

Humoral Immune Response toMesothelin inMesothelioma and Ovarian Cancer Patients

Mitchell Ho, I. Pastan, Jingli Zhang, 2005 .

Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice.

I. Pastan, M. Willingham, D. Fitzgerald, 1989, Cancer research.

Recombinant single-chain immunotoxins against T and B cell leukemias.

I. Pastan, R. Kreitman, 1994, Leukemia & lymphoma.

Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes

I. Pastan, D. Fitzgerald, M. Ogata, 1991, Infection and immunity.

12 making fusion toxins to target leukemia and lymphoma.

I. Pastan, R. Kreitman, 2000, Methods in molecular medicine.

Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.

I. Pastan, D. Davies, F. Dyda, 1996, Proceedings of the National Academy of Sciences of the United States of America.

from patients with chronic lymphocytic leukemia monoclonal antibody to the interleukin-2 receptor kill malignant cells Recombinant toxins containing the variable domains of the anti-Tac

I. Pastan, D. Fitzgerald, V. Chaudhary, 2011 .

Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.

I. Pastan, U. Brinkmann, H. Blum, 2008, World journal of gastroenterology.

Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma.

I. Pastan, B. Barlogie, D. Fitzgerald, 1992, Blood.

Inhibition of TNF-α Produced by Kupffer Cells Protects Against the Nonspecific Liver Toxicity of Immunotoxin Anti-Tac(Fv)-PE38, LMB-2

I. Pastan, M. Willingham, Y. Tsutsumi, 2000, The Journal of Immunology.

Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies

I. Pastan, R. Kreitman, A. Keppler-Hafkemeyer, 2000, International journal of cancer.

LMB-2 Toxicity of Immunotoxin Anti-Tac ( Fv )-PE 38 , Cells Protects Against the Nonspecific Liver Produced by Kupffer α Inhibition of TNF-Pastan

I. Pastan, M. Willingham, Y. Tsutsumi, 2000 .

Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.

I. Pastan, D. Fitzgerald, V. Chaudhary, 1992, Blood.

Low pH-induced changes in Pseudomonas exotoxin and its domains: increased binding of Triton X-114

I. Pastan, D. Fitzgerald, T. Idziorek, 1990, Infection and immunity.

An epidermal growth factor‐ricin a chain (EGF‐RTA)‐resistant mutant and an epidermal growth factor‐Pseudomonas endotoxin (EGF‐PE)‐resistant mutant have distinct phenotypes

I. Pastan, M. Gottesman, D. Banker, 1989, Journal of cellular physiology.

Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with pseudomonas exotoxin

I. Pastan, M. Willingham, M. Gottesman, 1984, Journal of Cellular Physiology.

Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.

I. Pastan, N. Richert, S. Ito, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Vinculin phosphorylation by the src kinase: inhibition by chlorpromazine, imipramine and local anesthetics.

I. Pastan, N. Richert, S. Ito, 1982, Biochemical and biophysical research communications.

Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

I. Pastan, Qi Zhou, B. Molitoris, 2020, Proceedings of the National Academy of Sciences.

Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.

T. Waldmann, I. Pastan, J. Carrasquillo, 1997, Cancer research.

Gene expression profile analysis of pituitary adenomas developed by HMGA transgenic mice ”

J. Herman, I. Pastan, M. Gottesman, 2007 .

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.

I. Pastan, U. Brinkmann, Y. Reiter, 1994, Cancer research.

Monoclonal antibody 101 that precipitates the glycoprotein receptor for epidermal growth factor is directed against the Y antigen, not the H type 1 antigen.

I. Pastan, M. Willingham, J. Le Pendu, 1985, Carbohydrate research.

Effect of ABC transporters on HIV‐1 infection: inhibition of virus production by the MDR1 transporter

I. Pastan, M. Gottesman, K. Jeang, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A primate-specific POTE-actin fusion protein plays a role in apoptosis

I. Pastan, T. Bera, Xiu-fen Liu, 2009, Apoptosis.

Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver.

I. Pastan, G. Merlino, S. Garfield, 1988, Biochemical and biophysical research communications.

Initial steps in receptor-mediated endocytosis. The influence of temperature on the shape and distribution of plasma membrane clathrin-coated pits in cultured mammalian cells.

I. Pastan, M. Willingham, K. Goldenthal, 1984, Experimental cell research.

Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.

I. Pastan, T. Miyata, M. Nagata, 2015, American journal of physiology. Renal physiology.

Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma

W. Wilson, I. Pastan, T. Kipps, 2007, Leukemia.

Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms.

U. Scherf, I. Pastan, U. Brinkmann, 1997, The American journal of pathology.

Cyclic AMP and the malignant transformation of cells.

I. Pastan, 1975, Advances in metabolic disorders.

Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.

I. Pastan, M. Gottesman, K. Ueda, 1990, Biochemical and biophysical research communications.

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.

I. Pastan, L. Silverman, J. Whitlock, 2017, Blood.

Phase I Study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.

I. Pastan, L. Silverman, J. Whitlock, 2017, Blood.

Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.

I. Pastan, O. Chertov, Laiman Xiang, 2013, Leukemia research.

Role of caspases in immunotoxin-induced apoptosis of cancer cells.

I. Pastan, U. Brinkmann, A. Keppler-Hafkemeyer, 1998, Biochemistry.

TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells

I. Pastan, S. Srivastava, S. Wright, 2014, Oncology letters.

Multidrug resistant transgenic mice as a novel pharmacologic tool

I. Pastan, M. Gottesman, G. Mickisch, 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.

I. Pastan, M. Gottesman, S. S. Chauhan, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA.

B. Roe, I. Pastan, S. Ishii, 1986, Biochimica et biophysica acta.

Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.

I. Pastan, R. Kageyama, G. Merlino, 1988, The Journal of biological chemistry.

Recombinant immunotoxins in the treatment of cancer.

I. Pastan, R. Beers, T. Bera, 2004, Methods in molecular biology.

ACTH stimulation of adenyl cyclase in adrenal homogenates.

I. Pastan, O. D. Taunton, J. Roth, 1967, Biochemical and biophysical research communications.

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.

I. Pastan, M. Gottesman, M. Ramachandra, 1998, Biochemistry.

Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2).

I. Pastan, M. Gottesman, Y. Zhou, 1999, Molecular pharmacology.

Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.

I. Pastan, N. Richert, S. Taylor, 1985, Science.

Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src

I. Pastan, C. Kahn, M. White, 1984, Journal of cellular biochemistry.

In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer

I. Pastan, G. Niederfellner, K. Hollevoet, 2014, Molecular Cancer Therapeutics.

Large Molecule Therapeutics In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG 7787 in Pancreatic Cancer

I. Pastan, G. Niederfellner, K. Hollevoet, 2014 .

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.

I. Pastan, R. Puri, N. Behari, 1998, Cancer research.

Multidrug resistance.

I. Pastan, M. Gottesman, M. Gottesman, 1991, Annual review of medicine.

Ultrastructural immunocytochemical localization of myosin in cultured fibroblastic cells.

I. Pastan, M. Willingham, P. Bechtel, 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Characterization of a major fibroblast cell surface glycoprotein.

I. Pastan, K. Yamada, D. Schlesinger, 1977, Biochemistry.

Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells

Kenneth M. Yamada, I. Pastan, K. Yamada, 1976, Cell.

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

Mitchell Ho, I. Pastan, T. Ise, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.

I. Pastan, M. Willingham, D. Fitzgerald, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Filamin-actin interaction. Dissociation of binding from gelation by Ca2+-activated proteolysis.

I. Pastan, M. Willingham, P. Davies, 1978, The Journal of biological chemistry.

Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells.

I. Pastan, M. Willingham, R. Dickson, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Transfer and expression of the human multiple drug resistance gene into live mice.

I. Pastan, M. Gottesman, A. Bank, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells.

I. Pastan, M. Willingham, 1985, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein.

I. Pastan, R. Bird, J. Batra, 1994, Advances in enzyme regulation.

A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.

I. Pastan, U. Brinkmann, M. Onda, 1998, Journal of molecular biology.

Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations.

I. Pastan, P. Chowdhury, Ira Pastan, 1999, Journal of immunological methods.

Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury.

I. Pastan, R. Harris, T. Matsusaka, 2017, Kidney international.

A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs.

I. Pastan, V. Rajagopal, R. Kreitman, 1997, Protein engineering.

Structure of the promoter for chicken a 2 i type I collagen gene

I. Pastan, Yoshihiko Yamada, B. Crombrugghe, 2022 .

Stimulation of guanylate cyclase of fibroblasts by free fatty acids.

I. Pastan, D. Wallach, 1976, The Journal of biological chemistry.

Studies on the mechanism of action of thyroid stimulating hormone on glucose oxidation.

I. Pastan, J. Field, B. Herring, 1961, Biochimica et Biophysica Acta.

Characterization of the 3,3',5-triiodo-L-thyronine-binding site on plasma membranes from human placenta.

I. Pastan, S. Cheng, R. Alderson, 1985, Endocrinology.

Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.

I. Pastan, J. Carrasquillo, C. Choi, 1995, Cancer research.

Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts.

I. Pastan, B. de Crombrugghe, T. Yamamoto, 1981, Biochemistry.

Cyclic AMP increases the concentration of insulin receptors in cultured fibroblasts and lymphocytes.

I. Pastan, P. Thomopoulos, F. C. Kosmakos, 1977, Biochemical and biophysical research communications.

Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor.

I. Pastan, N. Richert, D. Blithe, 1982, The Journal of biological chemistry.

Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity.

I. Pastan, M. Willingham, M. Gottesman, 1982, National Cancer Institute monograph.

new approach to specific cytocidal therapy. Binding of a growth factor to its cell surface receptor induces the initiation of a signal transduc

I. Pastan, A. Kihara, 2006 .

Antibody–Toxin and Growth Factor–Toxin Fusion Proteins

I. Pastan, R. Kreitman, D. FitzGerald, 2002 .

PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

I. Pastan, U. Brinkmann, L. Pai, 2001 .

INTERLEUKIN-13 RECEPTORS ON HUMAN PROSTATE CARCINOMA CELL LINES REPRESENT A NOVEL TARGET FOR A CHIMERIC PSEUDOMONAS EXOTOXIN PROTEIN COMPOSED OF IL-13 AND A MUTATED FORM OF

I. Pastan, G. Haas, R. Puri, 1997 .

Recombinant immunotoxins for the treatment of cancer

I. Pastan, D. FitzGerald, 1996 .

Small chimeric toxins containing only transforming growth factor alpha and domain III of Pseudomonas exotoxin with good antitumor activity in mice.

I. Pastan, A. Kihara, 1994, Cancer research.

Immunotoxins and recombinant toxins in the treatment of solid carcinomas.

I. Pastan, C. Theuer, 1993, American journal of surgery.

Monovalent immunotoxin containing truncated form of Pseudomonas exotoxin as potent antitumor agent.

I. Pastan, W. Debinski, 1992, Cancer research.

A Lewisy epitope mimicking peptide induces anti-Lewisy immune responses in rabbits and mice

I. Pastan, Q. Lou, 1999 .

Phage display of disulfide-stabilized Fv fragments.

I. Pastan, U. Brinkmann, P. Chowdhury, 1995, Journal of immunological methods.

Nature and function of the structural phospholipids of an arbovirus.

I. Pastan, R. Friedman, 1969, Journal of molecular biology.

Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.

I. Pastan, M. Willingham, D. Fitzgerald, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines.

I. Pastan, M. Gottesman, S. Johnson, 1996, Experimental cell research.

Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.

I. Pastan, M. Gottesman, Y. Lu, 1991, Journal of cell science.

The purification and quantitation of myosin from cultured cells.

I. Pastan, R. Ostlund, 1976, Biochimica et biophysica acta.

Cell surface myosin in cultured fibroblasts

I. Pastan, M. Willingham, K. Olden, 1976, Cell.

Efficient ablation by immunotoxin‐mediated cell targeting of the cell types that express human interleukin‐2 receptor depending on the internal ribosome entry site

T. Kaneko, I. Pastan, Kazuto Kobayashi, 2001, The journal of gene medicine.

A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting.

I. Pastan, T. Nagatsu, K. Kobayashi, 1996, Nucleic acids research.

Change in growth and morphology of fibroblasts by prostaglandins.

G. S. Johnson, I. Pastan, Ira Pastan, 1971, Journal of the National Cancer Institute.

Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase.

I. Pastan, M. Gottesman, J. Hochman, 1985, The Journal of biological chemistry.

Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.

I. Pastan, M. Gottesman, C. Roth, 1981, The Journal of biological chemistry.

Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach.

I. Pastan, M. Gottesman, A. LeCam, 1980, The Journal of biological chemistry.

Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP

I. Pastan, M. Gottesman, M. Bukowski, 1980, Somatic cell genetics.

A mutation affecting the catalytic subunit of cyclic AMP-dependent protein kinase in CHO cells.

I. Pastan, M. Gottesman, W. Anderson, 1979, The Journal of biological chemistry.

CYCLIC AMP MEDIATES THE CONCANAVALIN A AGGLUTINABILITY OF MOUSE FIBROBLASTS

I. Pastan, M. Willingham, Mark C. Willingham, 1974, The Journal of cell biology.

Role of 3',5'-adenosine monophosphate in regulation of morphology and growth of transformed and normal fibroblasts.

G. S. Johnson, I. Pastan, 1972, Journal of the National Cancer Institute.

Isolation of human KB cell lines resistant to epidermal growth factor-Pseudomonas exotoxin conjugates.

I. Pastan, M. Gottesman, J. Hwang, 1987, Cancer research.

INTERACTION BETWEEN THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR AND PDK 1 AS POTENTIAL THERAPEUTIC TARGET IN NEOPLASTIC CELLS ”

J. Herman, I. Pastan, M. Gottesman, 2007 .

Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene.

I. Pastan, B. de Crombrugghe, G. Merlino, 1981, The Journal of biological chemistry.

Structure of the promoter for chicken alpha 2 type I collagen gene.

I. Pastan, B. de Crombrugghe, Y. Yamada, 1981, Proceedings of the National Academy of Sciences of the United States of America.

GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines.

I. Pastan, H. Yamazaki, H. Yokozaki, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Roleofa Low-pHEnvironment inAdenovirus Enhancement ofthe Toxicity ofa Pseudomonas Exotoxin-Epidermal GrowthFactor

I. Pastan, P. Seth, 1984 .

Inhibition of the nuclear entry of 3,3',5'-triiodo-L-thyronine by monodansylcadaverine in GH3 cells.

I. Pastan, M. Willingham, S. Cheng, 1982, The Journal of biological chemistry.

Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin.

I. Pastan, M. Willingham, F. Maxfield, 1981, Biochemistry.

Epidermal growth factor receptor. Characterization of a monoclonal antibody specific for the receptor of A431 cells.

I. Pastan, M. Willingham, N. Richert, 1983, The Journal of biological chemistry.

PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells.

I. Pastan, M. Willingham, D. Peehl, 1993, Journal of the National Cancer Institute.

Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells.

I. Pastan, S. Hirohashi, Y. Shimosato, 1987, Cancer research.

THE USE OF TRANSFORMED FIBROBLASTIC CELLS AS A MODEL FOR DIFFERENTIATION

Kenneth M. Yamada, I. Pastan, M. Willingham, 1978 .

Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia

I. Pastan, R. Faggioni, Y. Chia, 2020, British journal of clinical pharmacology.

Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40.

I. Pastan, R. Nussenblatt, D. Fitzgerald, 1991, Cellular immunology.

Localization of rat thyroid alkaline protease to mast cells.

I. Pastan, S. Almqvist, 1966, Endocrinology.

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

I. Pastan, M. Kawano, M. Yamagishi, 2019, Scientific Reports.

Chromosomal localization of the gene for a human thyroid hormone-binding protein.

I. Pastan, S. Cheng, N. Popescu, 1988, American journal of human genetics.

Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy

I. Pastan, Michael Dieffenbach, 2020, Biomolecules.

Recombinant toxins.

I. Pastan, R. Kreitman, 1994, Advances in pharmacology.

Clinical trials with Pseudomonas exotoxin immunotoxins.

I. Pastan, L. Pai, 1998, Current topics in microbiology and immunology.

Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells.

I. Pastan, S. Epstein, R. Kreitman, 1993, The Journal of biological chemistry.

Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes

I. Pastan, D. Lowy, A. Levitzki, 1986, FEBS letters.

The use of immunotoxins for cancer therapy.

I. Pastan, L. Pai, 1993, European journal of cancer.

Anticorps anti-mesotheline

Mitchell Ho, I. Pastan, 2010 .

Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin.

I. Pastan, R. Puri, W. Debinski, 1994, Cellular immunology.

Purification and Partial Characterization of an Interleukin 2-Pseudomonas Exotoxin Fusion Protein

I. Pastan, M. Gately, H. Lorberboum-Galski, 1988, Bio/Technology.

Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box.

I. Pastan, R. Kageyama, G. Merlino, 1989, The Journal of biological chemistry.

Ultrastructural immunocytochemical localization of calmodulin in cultured cells.

I. Pastan, M. Willingham, C. Klee, 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Lipoprotein Modulation of Proteinuric Renal Injury

I. Pastan, T. Ikizler, M. Linton, 2019, Laboratory Investigation.

The Multichain Interleukin-2 Receptor: A Target for Immunotherapy

T. Waldmann, I. Pastan, O. Gansow, 1988, Annals of Internal Medicine.

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

I. Pastan, D. Fitzgerald, V. Chaudhary, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Properties and purification of a glucose-regulated protein from chick embryo fibroblasts.

I. Pastan, R. Shiu, 1979, Biochimica et biophysica acta.

Expression Profile of Saccharide Epitope CaMBr1 in Normal and Neoplastic Tissue from Dogs, Cats, and Rats: Implication for the Development of Human-derived Cancer Vaccines

I. Pastan, G. Rasi, P. Kuppen, 1999, The Histochemical Journal.

Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers

I. Pastan, U. Brinkmann, P. Chowdhury, 1997, International journal of cancer.

Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies.

I. Pastan, M. Willingham, S. Cheng, 1986, Biochemistry.

An Atlas of Immunofluorescence in Cultured Cells

I. Pastan, M. Willingham, 1985 .

Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides.

I. Pastan, C. Peschel, T. Decker, 2002, Blood.

Anti‐Tac(Fab)‐PE40, a recombinant double‐chain immunotoxin which kills interleukin‐2‐receptor‐bearing cells and induces complete remission in an in vivo tumor model

I. Pastan, R. Kreitman, C. Queen, 1994, International journal of cancer.

Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.

I. Pastan, M. Willingham, N. Richert, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Fluorescent rhodamine‐labeled thyroid hormone derivatives

I. Pastan, N. Eberhardt, J. Baxter, 1979, FEBS letters.

Ultrastructural localization of tubulin in cultured fibroblasts.

I. Pastan, M. Willingham, S. Yamada, 1980, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors

I. Pastan, Jingli Zhang, R. Hassan, 2015, Molecular Cancer Therapeutics.

An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity.

I. Pastan, R. Puri, J. Mulé, 1996, Cellular immunology.

Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.

I. Pastan, R. Bird, J. Batra, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein.

I. Pastan, M. Gottesman, J. Aran, 1998, Cancer gene therapy.

IL-4 receptors on human tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein.

I. Pastan, J. Silber, B. Joshi, 2002 .

Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury.

I. Pastan, T. Matsusaka, I. Ichikawa, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase

I. Pastan, S. Adhya, V. Macchia, 1981, Journal of bacteriology.

Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A

I. Pastan, Y. Tsutsumi, Ø. Bruland, 2001, Journal of immunotherapy.

Binding of adenovirus and its external proteins to Triton X-114. Dependence on pH.

I. Pastan, M. Willingham, P. Seth, 1985, The Journal of biological chemistry.

Adenovirus-dependent release of 51Cr from KB cells at an acidic pH.

I. Pastan, M. Willingham, P. Seth, 1984, The Journal of biological chemistry.

High Response Rate of Moxetumomab Pasudotox in Relapsed/Refractory Hairy Cell Leukemia Includes Eradication of Minimal Residual Disease: Potential Importance for Outcome

W. Wilson, I. Pastan, M. Tallman, 2015 .

An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies.

I. Pastan, R. Kreitman, M. Onda, 2014, Leukemia research.

Pharmacokinetic Analysis Of Response In Hairy Cell Leukemia Treated By Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

W. Wilson, I. Pastan, M. Stetler-Stevenson, 2013 .

Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy

T. Waldmann, I. Pastan, M. Stetler-Stevenson, 2011 .

Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins.

I. Pastan, C. Peschel, T. Decker, 2004, Blood.

Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells.

I. Pastan, M. Chiron, E. Mansfield, 1997, Biochemical Society transactions.

Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.

I. Pastan, E. Padlan, S. Jung, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia.

T. Waldmann, I. Pastan, V. Chaudhary, 1993, Leukemia.

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

I. Pastan, M. Gottesman, S. Akiyama, 1988, Molecular pharmacology.

Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent

I. Pastan, A. Shintani, T. Matsusaka, 2010, Hypertension.

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

J. Weinstein, I. Pastan, B. Moss, 1990, Proceedings of the National Academy of Sciences of the United States of America.

CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.

I. Pastan, B. Moss, S. Chakrabarti, 1989, Proceedings of the National Academy of Sciences of the United States of America.

A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.

I. Pastan, U. Brinkmann, E. Brinkmann, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Transfer and expression of the human multiple drug resistance gene into live mice.

I. Pastan, M. Gottesman, C. Richardson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

After Breast Cancer Chemotherapy Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells

I. Pastan, M. Gottesman, D. Venzon, 2013 .

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.

W. Wilson, S. Steinberg, I. Pastan, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin.

I. Pastan, M. Gottesman, A. Rahman, 1992, Journal of the National Cancer Institute.

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

I. Pastan, M. Gottesman, G. Merlino, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Generation of high titer antisera in rabbits by DNA immunization.

I. Pastan, P. Chowdhury, M. Gallo, 2001, Journal of immunological methods.

B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.

I. Pastan, K. Webber, M. Choe, 1994, Cancer research.

A Recombinant Immunotoxin in Which a Mutant Form of Pseudomonas Exotoxin Is Fused to the Fab Fragment of Monoclonal Antibody B 3

I. Pastan, K. Webber, M. Choe, 2022 .

Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity.

I. Pastan, S. Adhya, D. Fitzgerald, 1988, The Journal of biological chemistry.

Deletion and insertion mutants of the multidrug transporter.

I. Pastan, M. Willingham, M. Gottesman, 1989, The Journal of biological chemistry.

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

I. Pastan, M. Gottesman, W. Hait, 1990, Cancer research.

Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells

I. Pastan, M. Gottesman, C. Roth, 1984, Molecular and cellular biology.

N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells.

G. S. Johnson, I. Pastan, 1972, Nature: New biology.

Cyclic AMP increases the Adhesion of Fibroblasts to Substratum

G. S. Johnson, I. Pastan, 1972 .

CURRENT DIRECTIONS IN RESEARCH ON CYCLIC AMP

I. Pastan, 1972 .

CYCLIC AMP‐TREATED SARCOMA CELLS ACQUIRE SEVERAL MORPHOLOGICAL CHARACTERISTICS OF NORMAL FIBROBLASTS

G. S. Johnson, I. Pastan, R. Friedman, 1971, Annals of the New York Academy of Sciences.

Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor‐targeted therapy

I. Pastan, M. Korc, T. Ishiwata, 1997, International journal of cancer.

Cancer Immunity (19 December 2007) Vol. 7, p. 20

I. Pastan, C. Iacobuzio-Donahue, E. Jaffee, 2005 .

Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.

I. Pastan, M. Gottesman, N. Richert, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Activation of thyroid adenyl cyclase by long-acting thyroid stimulator.

I. Pastan, G. Levey, 1970, Life sciences. Pt. 1: Physiology and pharmacology.

Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.

I. Pastan, J. Roth, O. D. Taunton, 1969, The Journal of biological chemistry.

Mechanism of thyroid-stimulating hormone action. Studies with dibutyl 3',5'-adenosine monophosphate and lecithinase C.

I. Pastan, V. Macchia, 1967, The Journal of biological chemistry.

Mammalian cell display for antibody engineering.

Mitchell Ho, I. Pastan, 2009, Methods in molecular biology.

A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen.

I. Pastan, M. Willingham, N. Richert, 1983, The Journal of biological chemistry.

Serial section analysis of clathrin-coated pits in rat liver sinusoidal endothelial cells.

I. Pastan, M. Willingham, K. Goldenthal, 1985, Experimental cell research.

Receptosomes, endosomes, CURL: different terms for the same organelle system

I. Pastan, M. Willingham, 1985 .

Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs

I. Pastan, E. Berger, 2010, PLoS pathogens.

Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.

I. Pastan, U. Brinkmann, I. Benhar, 1994, Bioconjugate chemistry.

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

P. Kantoff, I. Pastan, M. Gottesman, 1990, Journal of the National Cancer Institute.

On the mechanism of action of lac repressor.

I. Pastan, M. Gottesman, W. Anderson, 1971, Nature: New biology.

Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter.

I. Pastan, M. Essand, V. Giandomenico, 2003, Endocrinology.

Identification of a transformation-specific protein induced by a rous sarcoma virus

I. Pastan, G. Jay, A. Levine, 1978, Cell.

The binding of cyclic adenosine monophosphate receptor to deoxyribonucleic acid.

I. Pastan, W. Anderson, R. Perlman, 1972, The Journal of biological chemistry.

Magnetic-affinity cell sorting of human multidrug-resistant cells.

I. Pastan, M. Willingham, M. Gottesman, 1991, Journal of the National Cancer Institute.

Lines Reversal of Multidrug Resistance in Human and Murine Cell Cellular and Biochemical Characterization of Thioxanthenes for Updated

I. Pastan, M. Gottesman, W. Hait, 2006 .

Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.

I. Pastan, M. Gottesman, R. Pirker, 1989, Cancer communications.

Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin

Mitchell Ho, I. Pastan, P. Azadi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Immunogenicity of therapeutic recombinant immunotoxins

I. Pastan, M. Onda, R. Mazor, 2016, Immunological reviews.

Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes.

I. Pastan, R. Perlman, I Pastan, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli.

I. Pastan, R. Perlman, 1969, Biochemical and biophysical research communications.

The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3',5'-adenosine monophosphate.

I. Pastan, R. Perlman, 1968, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic 3'5-AMP: stimulation of beta-galactosidase and tryptophanase induction in E. coli.

I. Pastan, R. Perlman, I Pastan, 1968, Biochemical and biophysical research communications.

Genetic analysis of the multidrug transporter.

I. Pastan, M. Gottesman, U. Germann, 1995, Annual review of genetics.

Effect of propranolol and phentolamine on canine and bovine responses to TSH.

I. Pastan, J. Roth, G. Levey, 1969, Endocrinology.

Stimulation in vitro of pathways of glucose oxidation in thyroid by thyroid-stimulating hormone.

I. Pastan, J. Field, B. Herring, 1960, The Journal of biological chemistry.

Segregation and Coactivation of Developing Neocortical Layer 1 Neurons

D. Watanabe, I. Pastan, S. Nakanishi, 2003, The Journal of Neuroscience.

Distinct Roles of Segregated Transmission of the Septo-Habenular Pathway in Anxiety and Fear

Takashi Yamaguchi, Ira Pastan, Takatoshi Hikida, 2013, Neuron.

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice

I. Pastan, É. Mezey, B. Mayer, 2014, Brain Structure and Function.

P-glycoprotein and multidrug resistance.

I. Pastan, M. Gottesman, S. Ambudkar, 1996, Current opinion in genetics & development.

Immunotoxin Therapy for Brain Tumors

I. Pastan, D. Bigner, J. Sampson, 2017 .

Toxin-Based Targeted Therapy for Malignant Brain Tumors

I. Pastan, D. Bigner, J. Sampson, 2012, Clinical & developmental immunology.

Multiple-drug resistance in human cancer.

I. Pastan, M. Gottesman, I Pastan, 1987, The New England journal of medicine.

Purification of and Properties of the Cyclic Adenosine 3',5'-Monophosphate Receptor Protein which Mediates Cyclic Adenosine 3',5'-Monophosphate-dependent Gene Transcription in Escherichia coli

Robert L. Perlman, Ira Pastan, I. Pastan, 1971 .

Regulation of beta-galactosidase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate.

I. Pastan, R. Perlman, 1968, The Journal of biological chemistry.

TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates.

I. Pastan, Byungkook Lee, Y. Hahn, 2003, Biochemical and biophysical research communications.

Monensin blocks endocytosis of vesicular stomatitis virus.

I. Pastan, M. Willingham, R. Schlegel, 1981, Biochemical and biophysical research communications.

Interrelationship between adenylate cyclase activity, adenosine 3':5' cyclic monophosphate phosphodiesterase activity, adenosine 3':5' cyclic monophosphate levels, and growth of cells in culture.

I. Pastan, R. Carchman, W. Anderson, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic AMP and growth of fibroblasts: effect of environmental pH.

G. S. Johnson, I. Pastan, M. D'armiento, 1973, Nature: New biology.

Regulation of Cell Motility by Cyclic AMP

G. S. Johnson, I. Pastan, W. Morgan, 1972, Nature.

Nucleotide sequence of a collagen cDNA-fragment coding for the carboxyl end of pro alpha 1(I)-chains.

I. Pastan, B. Olsen, E. Eikenberry, 1980, FEBS letters.

Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.

G. S. Johnson, I. Pastan, J. Otten, 1971, Biochemical and biophysical research communications.

PYRIDINE NUCLEOTIDES IN THE THYROID. II. THE EFFECT OF THYROID-STIMULATING HORMONE, EPINEPHRINE, SEROTONIN, ACETYLCHOLINE, MENADIONE, AND GLUCOSE CONCENTRATION ON THE LEVELS OT TPN AND TPNH.

I. Pastan, J. Field, P. Johnson, 1963, The Journal of biological chemistry.

PYRIDINE NUCLEOTIDES IN THE THYROID. I. A METHOD FOR THE MEASUREMENT OF OXIDIZED AND REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDES WITH THE USE OF 6-PHOSPHOGLUCONATE-1-C14.

I. Pastan, J. Field, B. Herring, 1963, The Journal of biological chemistry.

Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury.

I. Pastan, A. Nishiyama, T. Yokoo, 2015, American journal of physiology. Renal physiology.

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

Raghu Raghavan, Christoph Pedain, Allan H Friedman, 2007, Neuro-oncology.

Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.

R. Coleman, I. Pastan, R. Puri, 2007, AJR. American journal of roentgenology.

INTRACEREBRAL INFUSATE DISTRIBUTION BY CONVECTION‐ENHANCED DELIVERY IN HUMANS WITH MALIGNANT GLIOMAS: DESCRIPTIVE EFFECTS OF TARGET ANATOMY AND CATHETER POSITIONING

Christoph Pedain, Allan H Friedman, Raj K Puri, 2007, Neurosurgery.

Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination

K. Toyama, D. Watanabe, I. Pastan, 1998, Cell.

Altered adenylate cyclase activity: its role in growth regulation and malignant transformation of fibroblasts.

I. Pastan, W. Anderson, 1975, Advances in cyclic nucleotide research.

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

M C Willingham, I. Pastan, M. Willingham, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic Adenosine Monophosphate in Bacteria

I. Pastan, R. Perlman, I Pastan, 1970, Science.

Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10−15 M

I. Pastan, C. Vinson, S. Ruvinov, 2001, Protein science : a publication of the Protein Society.

A mutant fibroblast cell line defective in glycoprotein synthesis due to a deficiency of glucosamine phosphate acetyltransferase.

I. Pastan, E. Neufeld, 1978, Archives of biochemistry and biophysics.

The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin.

I. Pastan, K. Yamada, S. Yamada, 1975, Proceedings of the National Academy of Sciences of the United States of America.

HYDROLYSIS OF THYROGLOBULIN CATALYZED BY RAT THYROID PARTICLES.

I. Pastan, S. Almqvist, 1965, Biochemical and biophysical research communications.

Unusual methylation pattern of the α2(I) collagen gene

I. Pastan, B. Crombrugghe, H. Ohkubo, 1982, Cell.

Expression of a multidrug-resistance gene in human tumors and tissues.

I. Pastan, M. Gottesman, A. Fojo, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.

I. Pastan, M. Willingham, J. Schlessinger, 1978, Proceedings of the National Academy of Sciences of the United States of America.

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

I. Pastan, M. Willingham, G. Merlino, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus

I. Pastan, B. Crombrugghe, T-A M Yamamoto, 1980, Cell.

ENERGY‐DEPENDENT CALCIUM UPTAKE BY FIBROBLAST MICROSOMES

I. Pastan, I Pastan, L Moore, 1978, Annals of the New York Academy of Sciences.

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

I. Pastan, M. Gottesman, B. Sarkadi, 1993, The Journal of biological chemistry.

Treatment of corneal allograft rejection with the cytotoxin IL-2-PE40.

I. Pastan, D. Fitzgerald, F. Roberge, 1991, Transplantation.

Recombinant anti‐podoplanin (NZ‐1) immunotoxin for the treatment of malignant brain tumors

I. Pastan, S. Keir, D. Bigner, 2013, International journal of cancer.

Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes

I. Pastan, U. Brinkmann, E. Brinkmann, 2000, Cancer Gene Therapy.

Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments

I. Pastan, U. Brinkmann, Byungkook Lee, 1996, Nature Biotechnology.

Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation.

I. Pastan, U. Brinkmann, Byungkook Lee, 1995, Protein engineering.

Adenovirus-dependent increase in cell membrane permeability.

I. Pastan, M. Willingham, P. Seth, 1985, The Journal of biological chemistry.

Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.

I. Pastan, M. Willingham, J. Hanover, 1985, The Journal of biological chemistry.

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

S. Thorgeirsson, I. Pastan, M. Gottesman, 1987, Science.

Cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities are under separate genetic control.

I. Pastan, T. Russell, 1974, Journal of Biological Chemistry.

Interferon and cyclic-3'5'-adenosine monophosphate: potentiation of antiviral activity.

I. Pastan, R. Friedman, 1969, Biochemical and biophysical research communications.

Studies on the mechanism by which epinephrine stimulates glucose oxidation in the thyroid.

I. Pastan, J. Field, B. Herring, 1962, The Journal of biological chemistry.

Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets

I. Pastan, M. Willingham, J. Keen, 1979, Cell.

Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

I. Pastan, M. Willingham, J. Schlessinger, 1978, Cell.

Clostridium barkeri sp. n

T C Stadtman, I. Pastan, E. Stadtman, 1972, Journal of bacteriology.

NICOTINIC ACID METABOLISM. I. DISTRIBUTION OF ISOTOPE IN FERMENTATION PRODUCTS OF LABELLED NICOTINIC ACID.

I. Pastan, E. Stadtman, L. Tsai, 1964, The Journal of biological chemistry.

Regulation of galactokinase synthesis by cyclic adenosine 3',5'-monophosphate in cell-free extracts of Escherichia coli.

I. Pastan, M. Gottesman, J. Parks, 1971, The Journal of biological chemistry.

Cyclic adenosine 5'-monophosphate in Escherichia coli

I. Pastan, S. Adhya, 1976 .

Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription.

I. Pastan, M. Gottesman, W. Anderson, 1971, Nature: New biology.

Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose.

H. Varmus, I. Pastan, R. Perlman, 1970, The Journal of biological chemistry.

Further studies on effects of thyroid-stimulating hormone on thyroid glucose oxidation.

I. Pastan, J. Field, P. Johnson, 1963, The Journal of biological chemistry.

A circularly permuted recombinant interleukin 4 toxin with increased activity.

I. Pastan, R. Puri, R. Kreitman, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic AMP-dependent phosphorylation in intact cells and in cell-free extracts from Chinese hamster ovary cells. Studies with wild type and cyclic AMP-resistant mutants.

I. Pastan, M. Gottesman, J. Nicolas, 1981, The Journal of biological chemistry.

The effect of dibutyryl cyclic 3',5'-AMP on the thyroid.

I. Pastan, Ira Pastan, 1966, Biochemical and biophysical research communications.

Inhibitors of 125I-epidermal growth factor internalization.

I. Pastan, M. Willingham, H. Haigler, 1980, Biochemical and biophysical research communications.

The effect of dibutyryl cyclic adenosine monophosphate on synthesis of sulfated acid mucopolysaccharides by transformed fibroblasts.

G. S. Johnson, I. Pastan, J. F. Goggins, 1972, The Journal of biological chemistry.

Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant.

I. Pastan, M. Willingham, J. Pouysségur, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines

I. Pastan, M. Gottesman, M. Slovak, 1995, Somatic cell and molecular genetics.

Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression

S. Steinberg, I. Pastan, M. Miettinen, 2013, Science Translational Medicine.

Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin

I. Pastan, R. Wittes, M. Willingham, 1996, Nature Medicine.

Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts

I. Pastan, M. Willingham, J. Pouysségur, 1977, Cell.

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1&agr;-secreting Glioblastoma

I. Pastan, G. Schackert, A. Temme, 2015, Journal of immunotherapy.

The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines.

M. Polymeropoulos, I. Pastan, U. Brinkmann, 1996, Genome research.

Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.

I. Pastan, U. Brinkmann, E. Brinkmann, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins

I. Pastan, U. Brinkmann, E. Brinkmann, 1995, Molecular medicine.

A mutation in a rous sarcoma virus gene that controls adenosine 3',5'-monophosphate levels and transformation.

G. S. Johnson, I. Pastan, J. Bader, 1972, The Journal of biological chemistry.

Plasma membrane cyclic adenosine 3':5'-monophosphate phosphodiesterase of cultured cells and its modification after trypsin treatment of intact cells.

I. Pastan, T. Russell, 1973, The Journal of biological chemistry.

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

I. Pastan, D. Heitjan, C. June, 2009, Proceedings of the National Academy of Sciences.

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors.

I. Pastan, J. I. Izpisúa Belmonte, Mo Li, 2016, Cell stem cell.

Phase I Clinical Trial of the Anti-CD22 Immunotoxin CAT-8015 (HA22) for Pediatric Acute Lymphoblastic Leukemia (ALL).

C. Pui, I. Pastan, M. Stetler-Stevenson, 2009 .

Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity.

I. Pastan, S. Cheng, B. Rossi, 1984, Biochemical and biophysical research communications.

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

I. Pastan, M. Gottesman, S. Ishii, 1986, The Journal of biological chemistry.

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Y H Xu, I. Pastan, G. Merlino, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Actinomycin D: Inhibition of Phospholipid Synthesis in Chick Embryo Cells

I. Pastan, R. M. Friedman, 1968, Science.

Action of phospholipase C on the thyroid. Abolition of the response to thyroid-stimulating hormone.

I. Pastan, V. Macchia, 1967, The Journal of biological chemistry.

Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate.

I. Pastan, J. Pouysségur, 1977, The Journal of biological chemistry.

Adenylate cyclase activity in fibroblasts transformed by Kirsten or Moloney sarcoma viruses. Decreased activity and loss of response to prostaglandin E1.

I. Pastan, W. Anderson, M. Gallo, 1974, The Journal of biological chemistry.

Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus.

I. Pastan, W. Anderson, E. Lovelace, 1973, Biochemical and biophysical research communications.

Simian virus 40 rapidly lowers cAMP levels in mouse cells.

G. S. Johnson, I. Pastan, R. Carchman, 1973, Biochemical and biophysical research communications.

Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor.

I. Pastan, M. Kasuga, N. Richert, 1984, Biochemical and biophysical research communications.

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

I. Pastan, R. Nordan, D. Fitzgerald, 1990, Cancer research.

Activation of adenyl cyclase in thyroid homogenates by thyroid-stimulating hormone.

I. Pastan, R. Katzen, 1967, Biochemical and biophysical research communications.

Guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities and cyclic guanosine 3':5'-monophosphate levels in normal and transformed fibroblasts in culture.

I. Pastan, W. Anderson, T. Russell, 1976, The Journal of biological chemistry.

Conditional Ablation of Striatal Neuronal Types Containing Dopamine D2 Receptor Disturbs Coordination of Basal Ganglia Function

I. Pastan, Kazuto Kobayashi, Y. Yasoshima, 2003, The Journal of Neuroscience.

16 – Expression, Amplification, and Transfer of DNA Sequences Associated with Multidrug Resistance

I. Pastan, M. Willingham, M. Gottesman, 1988 .

Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.

I. Pastan, D. Kaufman, Byungkook Lee, 2008, Stem cells and development.

Expression of POTE protein in human testis detected by novel monoclonal antibodies.

I. Pastan, T. Ise, M. Anver, 2008, Biochemical and biophysical research communications.

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

I. Pastan, Byungkook Lee, Y. Hahn, 2006, Gene.

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

I. Pastan, Byungkook Lee, B. Sathyanarayana, 2004, Gene.

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer

I. Pastan, Byungkook Lee, B. Sathyanarayana, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal Antibody K1 Reacts With Epithelial Mesothelioma but not With Lung Adenocarcinoma

I. Pastan, M. Willingham, H. Pass, 1992, The American journal of surgical pathology.

Molecular properties of a major cell surface protein from chick embryo fibroblasts.

I. Pastan, H. Edelhoch, K. Yamada, 1978, The Journal of biological chemistry.

Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts.

M C Willingham, I. Pastan, M. Willingham, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Alpha 2-macroglobulin binding to cultured fibroblasts: identification by affinity chromatography of high-affinity binding sites.

I. Pastan, M. Willingham, J. Hanover, 1983, Archives of biochemistry and biophysics.

Cell surface protein and neoplastic transformation

Kenneth M. Yamada, I. Pastan, K. Yamada, 1976 .

The purification and properties of a thyroid-stimulating factor isolated from Clostridium perfringens.

I. Pastan, V. Macchia, R. Bates, 1967, The Journal of biological chemistry.

Clinical trials of agents that reverse multidrug-resistance.

I. Pastan, M. Gottesman, M. Gottesman, 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

I. Pastan, M. Gottesman, A. Fojo, 1986, Science.

Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.

Byungkook Lee, Yoonsoo Hahn, Ira Pastan, 2008, Cancer research.

alpha-Galactosidase A deficient mice: a model of Fabry disease.

I. Pastan, M. Gottesman, A. Kulkarni, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway

I. Pastan, Qi Zhou, R. Hassan, 2017, Oncotarget.

The multidrug transporter, a double-edged sword.

I. Pastan, M. Gottesman, 1988, The Journal of biological chemistry.

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

R. McLendon, I. Pastan, D. Bigner, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy.

I. Pastan, M. Gottesman, J. Aran, 1999, Advances in pharmacology.

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.

I. Pastan, D. Dimitrov, R. Morgan, 2013, Blood.

Absorption and secretion of iodide by the intestine of the rat.

I. Pastan, Ira Pastan, 1957, Endocrinology.

Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

R. McLendon, I. Pastan, S. Keir, 2013, Clinical Cancer Research.

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.

R. Coleman, R. McLendon, A. Friedman, 2005, Neuro-oncology.

Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin Termed PE-38 (TP-38) for the Treatment of Malignant Brain Tumors

M. Berger, R. McLendon, A. Friedman, 2003, Journal of Neuro-Oncology.

125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.

I. Pastan, M. Zalutsky, C. Foulon, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

125 I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts 1

I. Pastan, D. Bigner, M. Zalutsky, 1999 .

Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease.

I. Pastan, M. Gottesman, R. Brady, 1995, Human gene therapy.

Guanylate cyclase in Escherichia coli. Purification and properties.

I. Pastan, H. Weissbach, V. Macchia, 1975, The Journal of biological chemistry.

Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity

I. Pastan, Qi Zhou, Hisataka Kobayashi, 2019, Molecular Cancer Therapeutics.

Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma

S. Steinberg, I. Pastan, J. Trepel, 2019, Clinical Cancer Research.

Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity

Mitchell Ho, I. Pastan, Qi Zhou, 2018, Proceedings of the National Academy of Sciences.

Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

I. Pastan, U. Brinkmann, F. Bauss, 2016, Molecular oncology.

The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin.

I. Pastan, D. FitzGerald, Xiufen Liu, 2013, Cancer research.

A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

I. Pastan, J. Weldon, John E. Weldon, 2011, The FEBS journal.

Immunotoxin therapy of cancer.

Ira Pastan, I. Pastan, R. Kreitman, 1993, Nature reviews. Cancer.

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

B. Roe, I. Pastan, S. Ishii, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA.

I. Pastan, J. Fagan, K. Yamada, 1981, The Journal of biological chemistry.

Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts.

I. Pastan, J. Alwine, S. Adams, 1979, The Journal of biological chemistry.

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

K Ueda, I. Pastan, M. Gottesman, 1990, The Journal of biological chemistry.

Immunotoxins in cancer therapy.

Ira Pastan, I. Pastan, R. Kreitman, 1999, Current opinion in investigational drugs.

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

I. Pastan, M. Willingham, M. Gottesman, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Adenyl cyclase in normal and transformed fibroblasts in tissue culture. Activation by prostaglandins.

G. S. Johnson, I. Pastan, C. V. Peery, 1971, The Journal of biological chemistry.

Stimulation of membranous guanylate cyclase by concentrations of calcium that are in the physiological range.

I. Pastan, D. Wallach, 1976, Biochemical and biophysical research communications.

P-glycoproteins: mediators of multidrug resistance.

I. Pastan, M. Gottesman, U. Germann, 1993, Seminars in cell biology.

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

I. Pastan, D. Bigner, J. Sampson, 2012, Proceedings of the National Academy of Sciences.

Nicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid.

I. Pastan, E. Stadtman, L. Tsai, 1966, Journal of Biological Chemistry.

Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.

Byungkook Lee, Yoonsoo Hahn, I. Pastan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic guanosine monophosphate and cellular growth

I. Pastan, M. Gallo, E. Lovelace, 1975, Science.

Evolution and expression of chimeric POTE–actin genes in the human genome

Byungkook Lee, Yoonsoo Hahn, Ira Pastan, 2006, Proceedings of the National Academy of Sciences.

High expression of a cytokeratin-associated protein in many cancers.

R. Strausberg, I. Pastan, Byungkook Lee, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.

Ira Pastan, Ulrich Brinkmann, I. Pastan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins

Byungkook Lee, James J. Vincent, Robert Strausberg, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.

I. Pastan, U. Brinkmann, Byungkook Lee, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.

I. Pastan, R. Puri, N. Patronas, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Doctorate Program in Molecular Oncology and Endocrinology

J. Herman, I. Pastan, M. Gottesman, 2006 .

Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin

Mitchell Ho, I. Pastan, J. Schlom, 2005, Clinical Cancer Research.

Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components.

I. Pastan, W. Webb, E. Elson, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and characterization of a human DNA binding factor that represses transcription

I. Pastan, R. Kageyama, 1989, Cell.

A transcription factor active on the epidermal growth factor receptor gene.

I. Pastan, R. Kageyama, G. Merlino, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins

I. Pastan, U. Brinkmann, E. Mansfield, 2004, Apoptosis.

Epidermal growth factor regulates the expression of its own receptor.

I. Pastan, S. Ishii, G. Merlino, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic Antitumor Activity of Taxol and Immunotoxin SS1P in Tumor-Bearing Mice

Mitchell Ho, I. Pastan, J. Carrasquillo, 2006, Clinical Cancer Research.

Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma

I. Pastan, L. Bazhenova, H. Kindler, 2014, Clinical Cancer Research.

Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.

I. Pastan, C. Iacobuzio-Donahue, E. Jaffee, 2007, Cancer immunity.

Anti-Tumor Activity of K1-LysPE38QQR, an Immunotoxin Targeting Mesothelin, a Cell-Surface Antigen Overexpressed in Ovarian Cancer and Malignant Mesothelioma

I. Pastan, R. Kreitman, R. Hassan, 2000, Journal of immunotherapy.

Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

I. Pastan, I Pastan, K. Chang, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Activity of a Chick Collagen Gene in Heterologous and Homologous Cell-Free Extracts

I. Pastan, G. Merlino, J. Tyagi, 1984 .

Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.

Y H Xu, I. Pastan, S. Ishii, 1984, Science.

Selectable Markers for Gene Therapy

I. Pastan, M. Gottesman, C. Kimchi-Sarfaty, 2008 .

Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA.

I. Pastan, G. Jay, T. Yamamoto, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Immunotoxin treatment of cancer.

I. Pastan, R. Kreitman, R. Hassan, 2007, Annual review of medicine.

Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia.

W. Wilson, I. Pastan, M. Stetler-Stevenson, 2001, The New England journal of medicine.

Anti‐prostate immunotoxins: Cytotoxicity of E4 antibody–pseudomonas exotoxin constructs

I. Pastan, Magnus Essand, 1998, International journal of cancer.

Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.

I. Pastan, Kazuto Kobayashi, A. Akatsuka, 2005, Journal of the American Society of Nephrology : JASN.

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

I. Pastan, M. Willingham, M. Gottesman, 1989, Molecular and cellular biology.

Effects of phosphorylation of P-glycoprotein on multidrug resistance

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Journey to the center of the cell: role of the receptosome.

I. Pastan, M. Willingham, 1981, Science.

THE COLLAGEN GENE

I. Pastan, G. Merlino, E. Avvedimento, 1981 .

Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA

Ira Pastan, Yoshihiko Yamada, J. Maizel, 1980, Cell.

Expression of mesothelin in thymic carcinoma and its potential therapeutic significance.

G. Giaccone, S. Steinberg, I. Pastan, 2016, Lung cancer.

In Vivo Drug‐Selectable Genes: A New Concept in Gene Therapy

I. Pastan, F. Herrmann, T. Licht, 1997, Stem cells.

The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders

I. Pastan, M. Gottesman, F. Herrmann, 1996, Annals of Hematology.

Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein.

I. Pastan, M. Gottesman, T. Licht, 1999, Human gene therapy.

Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.

I. Pastan, M. Gottesman, T. Licht, 1996, Human gene therapy.

Efficient Expression of Drug-selectable Genes in Retroviral Vectors Under Control of an Internal Ribosome Entry Site

I. Pastan, M. Gottesman, Y. Sugimoto, 1994, Bio/Technology.

Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.

I. Pastan, M. Gottesman, A. Bank, 1992, Blood.

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics.

I. Pastan, S. Nagata, 2009, Advanced drug delivery reviews.

Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli.

H. Varmus, I. Pastan, R. Perlman, 1970, Biochemical and biophysical research communications.

Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate.

H. Varmus, I. Pastan, R. Perlman, 1969, The Journal of biological chemistry.

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells

B. Roe, R. Wilson, I. Pastan, 1984, Nature.

Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Rajarshi Guha, Eugen C. Buehler, Ira Pastan, 2015, Proceedings of the National Academy of Sciences.

MDR1 gene expression in lung cancer.

I. Pastan, M. Gottesman, A. Gazdar, 1989, Journal of the National Cancer Institute.

NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.

Byungkook Lee, Yoonsoo Hahn, Ira Pastan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer

Alan T. Remaley, Ira Pastan, Masanori Onda, 2006, Clinical Cancer Research.

Retroviral transfer of human MDR1 gene into human T lymphocytes.

I. Pastan, C. G. Lee, M. Gottesman, 1998, Methods in enzymology.

Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene.

I. Pastan, K. Jeang, M. Martin, 1997, Antisense & nucleic acid drug development.

Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study

I. Pastan, S. Sukumar, Alok Kumar, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin.

I. Pastan, M. Kawai, H. Shinohara, 2002, The Journal of surgical research.

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.

I. Pastan, M. Ramachandra, S. Ambudkar, 1996, Molecular biology of the cell.

Multidrug Resistance Transporter

I. Pastan, M. Gottesman, S. Ambudkar, 1996 .

Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.

I. Pastan, M. Gottesman, C. Cardarelli, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Rous sarcoma virus transformed cells are resistant to cyclic AMP

I. Pastan, M. Gottesman, C. Roth, 1982, Journal of cellular physiology.

Permanent Genetic Tagging of Podocytes: Fate of Injured Podocytes in a Mouse Model of Glomerular Sclerosis Materials and Methods Animal Experiments

I. Pastan, T. Matsusaka, A. Fogo, 2022 .

Regulation of intracellular calcium in chick embryo fibroblast: Calcium uptake by the microsomal fraction

I. Pastan, L. Moore, 1977, Journal of cellular physiology.

Myosin is a component of the cell surface of cultured cells.

I. Pastan, M. Willingham, R. Ostlund, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

I. Pastan, Byungkook Lee, R. Kreitman, 2011, Proceedings of the National Academy of Sciences.

A tri-specific killer engager against mesothelin targets NK cells towards lung cancer

I. Pastan, R. Kratzke, D. Vallera, 2023, Frontiers in Immunology.

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

I. Pastan, D. Schrump, P. Czapiewski, 2017, Oncotarget.

Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

I. Pastan, O. Chertov, T. Bera, 2016, Molecular Cancer Therapeutics.

Loss of mesothelin expression by mesothelioma cells grown in vitro determines sensitivity to anti-mesothelin immunotoxin SS1P.

I. Pastan, M. Merino, Jingli Zhang, 2012, Anticancer research.

Mesothelin Expression in Human Lung Cancer

Mitchell Ho, I. Pastan, M. Willingham, 2007, Clinical Cancer Research.

Identification of Novel Human CTL Epitopes and TheirAgonist Epitopes ofMesothelin

Mitchell Ho, I. Pastan, J. Schlom, 2005 .

Mesothelin Is Not Required for Normal Mouse Development or Reproduction

I. Pastan, T. Bera, 2000, Molecular and Cellular Biology.

Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity.

I. Pastan, P. Chowdhury, R. Beers, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Expression of a human multidrug resistance gene in ovarian carcinomas.

I. Pastan, M. Gottesman, J. Bourhis, 1989, Cancer research.

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

N. Nomura, I. Pastan, T. Yamamoto, 1986, Cancer research.

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

I. Pastan, M. Gottesman, K. Ueda, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of lac mRNA synthesis in a soluble cell-free system.

H. Varmus, I. Pastan, M. Gottesman, 1971, Nature: New biology.

Effect of Rho on transcription of bacterial operons.

I. Pastan, S. Adhya, M. Gottesman, 1973, Nature: New biology.

Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis.

W. V. Shaw, I. Pastan, J. Rosner, 1973, Nature: New biology.

Regulation of Gal Messenger Ribonucleic Acid Syuthesis in

I. Pastan, J. Parks, R. Perlman, 2011 .

Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus

G. S. Johnson, I. Pastan, E. Scolnick, 1974 .

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells

Y H Xu, B. Roe, I. Pastan, 1985, Molecular and cellular biology.

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

M C Willingham, I. Pastan, M. Willingham, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Expression of the multidrug resistance gene in myeloid leukemias.

I. Pastan, M. Gottesman, H. Sato, 1990, Leukemia research.

Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein.

I. Pastan, M. Gottesman, V. Chaudhary, 1991, BioTechniques.

Genetic basis of multidrug resistance of tumor cells

I. Pastan, M. Gottesman, S. Kane, 1990, Journal of bioenergetics and biomembranes.

Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease

I. Pastan, M. Gottesman, S. Kane, 1988, Molecular and cellular biology.

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

M C Willingham, I H Pastan, I. Pastan, 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts.

I. Pastan, G. Merlino, J. Tyagi, 1982, The Journal of biological chemistry.

Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency

I. Pastan, M. Gottesman, J. Puck, 1998, Gene Therapy.

Gene Transfer of Drug Resistance Genes Implications for Cancer Therapy

I. Pastan, M. Gottesman, Y. Sugimoto, 1994, Annals of the New York Academy of Sciences.

Selectable Markers for Gene Therapy 2

I. Pastan, M. Gottesman, C. Kimchi-Sarfaty, 2003 .

MDR 1 Gene Transfer to Hematopoietic Cells

I. Pastan, M. Gottesman, T. Licht, 1999 .

Retroviral transfer of multidrug transporter to murine hematopoietic stem cells.

I. Pastan, M. Gottesman, T. Licht, 1998, Methods in enzymology.

Transfer of the MDR1 gene into haematopoietic cells.

I. Pastan, M. Gottesman, M. Baudard, 1996, European journal of cancer.

Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells.

I. Pastan, M. Gottesman, T. Licht, 1995, Blood.

P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells

I. Pastan, M. Gottesman, F. Herrmann, 1994, Annals of Hematology.

In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells.

I. Pastan, M. Gottesman, R. Gallo, 1996, Human gene therapy.

Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.

I. Pastan, M. Gottesman, J. Aran, 1994, Proceedings of the National Academy of Sciences of the United States of America.

XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.

I. Pastan, L. Helman, B. Lee, 2000, Cancer research.

High-density functional display of proteins on bacteriophage lambda.

I. Pastan, S. Adhya, V. Chaudhary, 2003, Journal of molecular biology.

Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins

I. Pastan, L. Pai, D. M. Roscoe, 1997, European journal of immunology.

Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin

I. Pastan, S. Jung, B. Lee, 1994, Infection and immunity.

Complete Remissions of Adult T-cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity

W. Wilson, S. Steinberg, T. Waldmann, 2015, Clinical Cancer Research.

Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter.

I. Pastan, S. Ishii, G. Merlino, 1985, Science.

Inhibition of the transformation-specific kinase in ASV-transformed cells by N-α-tosyl-L-lysyl chloromethyl ketone

I. Pastan, N. Richert, G. Jay, 1979, Cell.

Putative “MDR enhancer” is located on human chromosome 20 and not linked to the MDRI gene on chromosome 7

I. Pastan, M. Gottesman, D. Zimonjic, 1994 .

Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis

I. Pastan, Y. Koyama, K. Iwaisako, 2021, Proceedings of the National Academy of Sciences.

Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.

I. Pastan, M. Gottesman, D. Shen, 1998, Cancer research.

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.

I. Pastan, M. Gottesman, M. Ramachandra, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

I. Pastan, M. Gottesman, K. Ueda, 1992, Science.

Analysis of the Fusion of XC Cells Induced by Homogenates of Murine Leukemia Virus-Infected Cells and by Purified Murine Leukemia Virus

G. S. Johnson, I. Pastan, R. Friedman, 1971, Journal of Virology.

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

I. Pastan, M. Gottesman, A. Fojo, 1985, Cancer research.

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

I. Pastan, M. Gottesman, K. Ueda, 1987, The Journal of biological chemistry.

Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models

R. McLendon, I. Pastan, D. Bigner, 2023, Science Translational Medicine.

Reduction of EGF receptor synthesis by antisense RNA vectors

I. Pastan, G. Merlino, Nobuyoshi Shimizu, 1986, FEBS letters.

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (*)

I. Pastan, M. Gottesman, S. Ambudkar, 1996, The Journal of Biological Chemistry.

Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines

I. Pastan, M. Gottesman, B. Schimmer, 1992, Journal of cellular physiology.

The cyclic AMP receptor of Escherichia coli: immunological studies in extracts of Escherichia coli and other organisms.

I. Pastan, W. Anderson, 1973, Biochimica et biophysica acta.

Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo.

I. Pastan, M. Gottesman, T. Licht, 1995, Cytokines and molecular therapy.

Function and regulation of the human multidrug resistance gene.

I. Pastan, M. Gottesman, K. Chin, 1993, Advances in cancer research.

Regulation of cellular growth.

I. Pastan, 1975, Advances in metabolic disorders.

Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance.

I. Pastan, S. Nakanishi, M. Gottesman, 1988, The Journal of urology.

Affinity‐matured anti‐glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

I. Pastan, S. Keir, D. Bigner, 2011, International journal of cancer.

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

I. Pastan, M. Gottesman, U. Germann, 1989, The Journal of biological chemistry.

Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells.

I. Pastan, M. Gottesman, Y. Sugimoto, 1994, The Journal of urology.

Studies of pathways of glucose metabolism of endocrine tissues.

I. Pastan, J. Field, B. Herring, 1960, Endocrinology.

pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein.

I. Pastan, T. Shoshani, Y. Sugimoto, 1998, Methods in enzymology.

Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention

Mitchell Ho, I. Pastan, D. Urban, 2020, Hepatology.

Construction of an immunotoxin, HN3-mPE24, targeting glypican-3 for liver cancer therapy

Mitchell Ho, I. Pastan, Wei Gao, 2016, Oncotarget.

BL22: A Milestone in Targeting CD22

I. Pastan, R. Kreitman, D. FitzGerald, 2017 .

ANTIBODY DERIVATIVES AS NEW THERAPEUTICS FOR HEMATOLOGIC MALIGNANCIES Immunotoxins for leukemia

I. Pastan, R. Kreitman, A. Wayne, 2014 .

BL22 and lymphoid malignancies.

I. Pastan, R. Kreitman, 2006, Best practice & research. Clinical haematology.

Filamin inhibits actin activation of heavy meromyosin ATPase

I. Pastan, P. Bechtel, P. Davies, 1977, FEBS letters.

Purification and properties of filamin, and actin binding protein from chicken gizzard.

I. Pastan, Y. Shizuta, P. Davies, 1976, The Journal of biological chemistry.

Hydrolysis of thyroglobulin by a mast cell enzyme present in rat thyroid homogenates.

I. Pastan, S. Almqvist, 1966, Endocrinology.

Receptor-mediated endocytosis of hormones in cultured cells.

M C Willingham, I H Pastan, I. Pastan, 1981, Annual review of physiology.

The role of cyclic AMP in malignant transformation.

I. Pastan, 1975, American journal of clinical pathology.

Purification and properties of a mast cell protease.

I. Pastan, S. Almqvist, 1966, The Journal of biological chemistry.

TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus.

James J. Vincent, I. Pastan, Byungkook Lee, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A calcium requirement for movement of cultured cells

I. Pastan, L. Moore, 1979, Journal of cellular physiology.

RECEPTOR‐MEDIATED ENDOCYTOSIS OF α2‐MACROGLOBULIN: INHIBITION BY IONOPHORES AND STIMULATION BY Na+ AND HCO3‐

I. Pastan, M. Willingham, R. Dickson, 1982, Annals of the New York Academy of Sciences.

Phosphorylation of filamin and other proteins in cultured fibroblasts.

I. Pastan, K. Olden, Y. Shizuta, 1977, Biochemical and biophysical research communications.

Purification and properties of avian and mammalian filamins.

I. Pastan, Y. Shizuta, P. Davies, 1982, Methods in Enzymology.

Self-association of chicken gizzard filamin and heavy merofilamin.

I. Pastan, M. Willingham, P. Davies, 1980, Biochemistry.

A high molecular weight phosphoprotein in cultured fibroblasts that associates with polymerized tubulin.

I. Pastan, M. Willingham, I. Klein, 1978, Experimental cell research.

Diminished content of plasma membrane-associated myosin in transformed fibroblasts

I. Pastan, K. Olden, Y. Shizuta, 1976, Nature.

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery

I. Pastan, D. Bigner, Vidyalakshmi Chandramohan, 2016, Receptors & clinical investigation.

Thyroglobulin: Evidence for Crystallization and Association

I. Pastan, H. Edelhoch, J. E. Rall, 1966, Science.

GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells.

I. Pastan, M. Gottesman, I. Lelong, 1994, Biochemistry.

The visualization of fluorescent proteins in living cells by video intensification microscopy (VIM)

Ira Pastan, I. Pastan, M. Willingham, 1978, Cell.

Cyclic AMP-dependent phosphorylation of filamin in mammalian smooth muscle.

I. Pastan, P. Davies, D. Wallach, 1978, The Journal of biological chemistry.

Purification of mammalian filamin. Similarity to high molecular weight actin-binding protein in macrophages, platelets, fibroblasts, and other tissues.

I. Pastan, P. Davies, D. Wallach, 1978, The Journal of biological chemistry.

Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts.

I. Pastan, L. Zech, R. Chabay, 1980, Biochimica et biophysica acta.

Myosin in cultured fibroblasts.

I. Pastan, R. Adelstein, R. Ostlund, 1974, The Journal of biological chemistry.

Isolation and characterization of myosin from cloned mouse fibroblasts.

G. S. Johnson, T. Pollard, I. Pastan, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

I. Pastan, M. Gottesman, S. Ambudkar, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

I. Pastan, M. Gottesman, H. Pollard, 1990, The Journal of biological chemistry.

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

I. Pastan, M. Gottesman, I Pastan, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

I. Pastan, M. Kawano, M. Yamagishi, 2019, Scientific Reports.

Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.

I. Pastan, C. Siegall, J. Madri, 1992, Cancer research.

Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase

I. Pastan, M. Gottesman, Y. Zhou, 1999, Molecular and Cellular Biology.

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

I. Pastan, M. Willingham, M. Gottesman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

ANKRD26 and Its Interacting Partners TRIO, GPS2, HMMR and DIPA Regulate Adipogenesis in 3T3-L1 Cells

I. Pastan, Thelma M. Escobar, T. Bera, 2012, PloS one.

Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice

I. Pastan, O. Gavrilova, T. Bera, 2011, Diabetologia.

Phase 1 study of the immunotoxin LMB‐100 in patients with mesothelioma and other solid tumors expressing mesothelin

S. Steinberg, I. Pastan, A. Italiano, 2020, Cancer.

Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti–PD-1 antibody in patients with mesothelioma and mouse tumor models

S. Steinberg, I. Pastan, A. Ghafoor, 2020, Science Translational Medicine.

The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2.

I. Pastan, M. Gottesman, Y. Zhou, 1999, Archives of biochemistry and biophysics.

Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.

I. Pastan, T. Shoshani, S. Dey, 1998, Molecular pharmacology.

Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis.

I. Pastan, A. Fukamizu, M. Nagata, 2015, The American journal of pathology.

Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase

I. Pastan, M. Willingham, P. Seth, 1987, Journal of Virology.

Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor

I. Pastan, C. Lyons, D. Sakiestewa, 1999, Bone Marrow Transplantation.

Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.

I. Pastan, A. Barrett, N. Hensel, 1996, Bone marrow transplantation.

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

W. Wilson, I. Pastan, J. Delgado, 2018, Leukemia.

Mesothelin-Targeted Agents in Clinical Trials and in Preclinical Development

Ira Pastan, I. Pastan, R. Kelly, 2012, Molecular Cancer Therapeutics.

Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats

Byungkook Lee, Yoonsoo Hahn, Ira Pastan, 2009, BMC Structural Biology.

Improving antibody affinity by mimicking somatic hypermutation in vitro

I. Pastan, P. Chowdhury, 1999, Nature Biotechnology.

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

M. Hudgens, I. Pastan, A. Haase, 2014, PLoS pathogens.

CD21−/low Marginal Zone B Cells Highly Express Fc Receptor–like 5 Protein and Are Killed by Anti–Fc Receptor–like 5 Immunotoxins in Hepatitis C Virus–Associated Mixed Cryoglobulinemia Vasculitis

I. Pastan, D. Klatzmann, T. Ise, 2014, Arthritis & rheumatology.

PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity*

I. Pastan, R. Papke, R. Matusik, 2008, Journal of Biological Chemistry.

T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin.

I. Pastan, M. Essand, C. Wolfgang, 2001, Cancer research.

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface

I. Pastan, M. Willingham, F. Maxfield, 1979, Nature.

Delivery systems for the MDR 1 gene

I. Pastan, M. Gottesman, W. Vieira, 2013 .

Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers.

I. Pastan, M. Gottesman, P. Hafkemeyer, 2000, Human gene therapy.

Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice

I. Pastan, M. Gottesman, T. Licht, 2000, Gene Therapy.

Mechanism of Action of Human P-glycoprotein ATPase Activity

I. Pastan, M. Gottesman, P. Pedersen, 1998, The Journal of Biological Chemistry.

Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.

I. Pastan, M. Ramachandra, S. Ambudkar, 1998, Methods in enzymology.

Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes.

T. Flotte, I. Pastan, M. Gottesman, 1996, Human gene therapy.

Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.

I. Pastan, M. Gottesman, S. Akiyama, 1995, British Journal of Cancer.

Chapter 1 The Multidrug Transporter: Mechanistic Considerations

I. Pastan, M. Gottesman, W. Stein, 1994 .

In vivo models of P-glycoprotein-mediated multidrug resistance.

I. Pastan, M. Gottesman, G. Mickisch, 1994, Cancer treatment and research.

MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia

R. Day, I. Pastan, R. Larson, 1990, British journal of haematology.

Regulation of the multidrug resistance gene in regenerating rat liver.

I. Pastan, M. Gottesman, P. A. Marino, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

K Ueda, I. Pastan, M. Gottesman, 1989, Biochemical and biophysical research communications.

A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system

I. Pastan, D. Bigner, J. Sampson, 2013, Oncoimmunology.

Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner.

I. Pastan, A. Nishiyama, T. Matsusaka, 2019, Hypertension.

Recombinant Immunotoxins: From Basic Research to Cancer Therapy

I. Pastan, U. Brinkmann, 1995 .

Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.

I. Pastan, I. Benhar, 1994, Protein engineering.

Factors that Determine Sensitivity and Resistances of Tumor Cells Towards Antibody-Targeted Protein Toxins

I. Pastan, U. Brinkmann, S. Stahl, 2015 .

Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein.

I. Pastan, R. Weichselbaum, D. Kufe, 1998, Cancer research.

P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.

I. Pastan, J. Yewdell, J. Bennink, 1998, Cancer research.

PRAC2: A new gene expressed in human prostate and prostate cancer

Byungkook Lee, Ira Pastan, I. Pastan, 2003, The Prostate.

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

I. Pastan, Jingli Zhang, M. Onda, 2016, Oncotarget.

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

Ronit Mazor, Ira Pastan, I. Pastan, 2012, Proceedings of the National Academy of Sciences.

MRP8, A New Member of ABC Transporter Superfamily, Identified by EST Database Mining and Gene Prediction Program, Is Highly Expressed in Breast Cancer

I. Pastan, Sanghyuk Lee, Byungkook Lee, 2001, Molecular medicine.

Cytotoxicity of TGFα-PE40 and correlation to expression of epidermal growth factor receptor

I. Pastan, R. Mertelsmann, H. Fiebig, 1995 .

Sequence rearrangement and duplication of double stranded fibronectin cDNA probably occurring during cDNA synthesis by AMV reverse transcriptase and Escherichia coli DNA polymerase I

Ira Pastan, J. B. Fagan, B. de Crombrugghe, 1980, Nucleic Acids Res..

Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome

I. Pastan, D. Venzon, S. Adams, 2014, British journal of haematology.

A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.

I. Pastan, M. Gottesman, P. Hafkemeyer, 1999, Biochemistry.

Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma.

I. Pastan, N. Kneteman, D. Douglas, 2013, Biomaterials.

Anti-CD 30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma

I. Pastan, N. Kneteman, D. Douglas, 2013 .

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point.

I. Pastan, G. Vasmatzis, R. Kreitman, 1999, Journal of immunology.

Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

R. Pieters, K. Sikora, W. Siegert, 1991, Journal of Cancer Research and Clinical Oncology.

Studies on the mechanism of action of the gal repressor.

I. Pastan, S. Adhya, M. Gottesman, 1973, The Journal of biological chemistry.

MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

I. Pastan, Sanghyuk Lee, Byungkook Lee, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl‐2 expression

I. Pastan, C. Peschel, T. Decker, 2010, British journal of haematology.

Selective effects of MgCl2 and temperature on the initiation of transcription at lac, gal, and lambda promoters.

I. Pastan, S. Adhya, M. Gottesman, 1975, The Journal of biological chemistry.

Unusual methylation pattern of the alpha 2 (l) collagen gene.

I. Pastan, H. Ohkubo, C. McKeon, 1982, Cell.

Megakaryocytic Potentiating Factor and Mature Mesothelin Stimulate the Growth of a Lung Cancer Cell Line in the Peritoneal Cavity of Mice

I. Pastan, Jingli Zhang, R. Hassan, 2014, PloS one.

Immunotoxins in the treatment of hematologic malignancies.

I. Pastan, R. Kreitman, 2006, Current drug targets.

Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts.

I. Pastan, E. Avvedimento, Y. Yamada, 1981, Nucleic acids research.

Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.

I. Pastan, M. Mudryj, V. Avvedimento, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and characterization of genomic DNA coding for α2 Type I collagen

J. Maizel, I. Pastan, E. Avvedimento, 1980 .

Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts.

I. Pastan, B. Howard, M. Sobel, 1978, The Journal of biological chemistry.

In vitro repression of the transcription of gas operon by purified gal repressor.

I. Pastan, S. Adhya, M. Gottesman, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

I. Pastan, M. Gottesman, W. Stein, 1994, Molecular pharmacology.

Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition.

H. Varmus, I. Pastan, R. Perlman, 1970, The Journal of biological chemistry.

Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin.

I. Pastan, G. Haas, R. Puri, 1997, The Journal of urology.

Human CTLs to Wild-Type and Enhanced Epitopes of a Novel Prostate and Breast Tumor-Associated Protein, TARP, Lyse Human Breast Cancer Cells

I. Pastan, W. M. Linehan, J. Berzofsky, 2004, Cancer Research.

Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy

S. Steinberg, I. Pastan, M. Raffeld, 2006, Cancer Immunology, Immunotherapy.

Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies.

J. D. White, W. Wilson, T. Waldmann, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Multidrug resistance in human cancer.

I. Pastan, M. Gottesman, L. Goldstein, 1992, Critical reviews in oncology/hematology.

Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure.

I. Pastan, U. Brinkmann, D. Segal, 1995, Immunity.

5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox

I. Pastan, M. Cam, Chin-Hsien Tai, 2018, Proceedings of the National Academy of Sciences.

Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice.

I. Pastan, M. Gottesman, J. Campain, 1993, The Journal of urology.

Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.

I. Pastan, M. Gottesman, G. Mickisch, 1992, Cancer research.

Vinculin, a cytoskeletal substrate of protein kinase C.

I. Pastan, J. Niedel, D. Werth, 1983, The Journal of biological chemistry.

Vinculin phosphorylation by the src kinase. Interaction of vinculin with phospholipid vesicles.

I. Pastan, N. Richert, S. Ito, 1983, The Journal of biological chemistry.

The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness.

I. Pastan, J. Pouysségur, 1979, Experimental Cell Research.

Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin

I. Pastan, Chin-Hsien Tai, F. Hakim, 2016, The AAPS Journal.

Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.

Chin-Hsien Tai, Byungkook Lee, Ronit Mazor, 2015, Journal of immunological methods.

A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.

I. Pastan, M. Gottesman, J. Campain, 1994, Biochemistry.

Targeting malignant B cells with an immunotoxin against ROR1

W. Wilson, I. Pastan, A. Wiestner, 2012, mAbs.

Identification of cytotoxic T‐lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4)

I. Pastan, J. Schlom, J. Gulley, 2007, International journal of cancer.

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

D. Baker, I. Pastan, Byungkook Lee, 2014, Proceedings of the National Academy of Sciences.

Methylation-Associated Partial Down-Regulation of Mesothelin Causes Resistance to Anti-Mesothelin Immunotoxins in a Pancreatic Cancer Cell Line

I. Pastan, K. Hollevoet, Emily Mason-Osann, 2015, PloS one.

Modulating Mesothelin Shedding to Improve Therapy

I. Pastan, Yujian Zhang, 2012, Oncotarget.

Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding.

I. Pastan, Jingli Zhang, O. Chertov, 2011, Cancer research.

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

I. Pastan, Y. Reiter, Y. Leshem, 2018, Toxins.

The improvement of an anti-CD22 immunotoxin

Mitchell Ho, I. Pastan, R. Kreitman, 2011, mAbs.

A novel high‐affinity human monoclonal antibody to mesothelin

Mitchell Ho, I. Pastan, R. Fisher, 2011, International journal of cancer.

Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins.

I. Pastan, Y. Reiter, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

I. Pastan, G. Salvatore, R. Kreitman, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Removing T-cell epitopes with computational protein design

David Baker, Chris King, Marion Pepper, 2014, Proceedings of the National Academy of Sciences.

Regulatory T Cells IL-2 Nonresponsive Subset of Human Fc Receptor-Like 3 Protein Expressed on

I. Pastan, S. Nagata, 2009 .

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Mitchel S Berger, Allan H Friedman, James M Provenzale, 2008, Neuro-oncology.

Molecular biology of multidrug resistance in human cells.

I. Pastan, M. Gottesman, 1988, Important advances in oncology.

Rapid grouping of monoclonal antibodies based on their topographical epitopes by a label-free competitive immunoassay.

I. Pastan, Byungkook Lee, Y. Hahn, 2004, Journal of immunological methods.

DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins.

Ira Pastan, Giuliana Salvatore, I. Pastan, 2003, Journal of immunological methods.

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments.

I. Pastan, R. Kreitman, S. Nagata, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Biochemical characterization of human GCF transcription factor in tumor cells.

I. Pastan, H. Yamazaki, L. Beguinot, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein.

I. Pastan, C. King, P. Fischer, 1996, Seminars in cancer biology.

Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide‐stabilized anti‐TAC Fv fragment and truncated pseudomonas exotoxin

I. Pastan, U. Brinkmann, Y. Reiter, 1994, International journal of cancer.

Multiple proteases are involved in mesothelin shedding by cancer cells

I. Pastan, Chin-Hsien Tai, A. Chan, 2020, Communications biology.

Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.

I. Pastan, B. Olsen, T. Yamamoto, 1980, The Journal of biological chemistry.

Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor.

I. Pastan, M. Willingham, N. Richert, 1986, The Journal of biological chemistry.

Sensitivity of human acute myeloid leukaemia to diphtheria toxin‐GM‐CSF fusion protein

A. Hagenbeek, I. Pastan, I. Touw, 1997, British journal of haematology.

C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes

I. Pastan, T. Matsusaka, M. Koizumi, 2022, Scientific Reports.

High Shed Antigen Levels within Tumors: An Additional Barrier to Immunoconjugate Therapy

I. Pastan, Yujian Zhang, 2008, Clinical Cancer Research.

Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Transgenic Mice Carrying the Human MDR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance

I. Pastan, M. Gottesman, G. Mickisch, 1992 .

Effect of fluoride on the metabolic activity of thyroid slices.

I. Pastan, V. Macchia, R. Katzen, 1968, Endocrinology.

Liver angiotensinogen is the primary source of renal angiotensin II.

I. Pastan, H. Kobori, A. Nishiyama, 2012, Journal of the American Society of Nephrology : JASN.

In vitrom stimulation of the hexose monophosphate pathway in thyroid by thyroid stimulating hormone

I. Pastan, J. Field, B. Herring, 1959 .

Changes in diphosphopyridine nucleotide and triphosphopyridine nucleotide levels produced by thyroid-stimulating hormone in thyroid slices in vitro.

I. Pastan, J. Field, B. Herring, 1961, The Journal of biological chemistry.

Immunoconjugates in the management of hairy cell leukemia.

I. Pastan, R. Kreitman, 2015, Best practice & research. Clinical haematology.

ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues.

I. Pastan, P. Duray, G. Vasmatzis, 2001, Gene.

Anti‐HIV‐1 immunotoxin 3B3(Fv)‐PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques

I. Pastan, M. Gallo, Qing-cheng Wang, 2006, Journal of leukocyte biology.

Isolation of new anti‐CD30 scFvs from DNA‐immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin

I. Pastan, P. Chowdhury, R. Kreitman, 2001, International journal of cancer.

Improved stability and yield of a Fv-toxin fusion protein by computer design and protein engineering of the Fv.

I. Pastan, G. Vasmatzis, P. Chowdhury, 1998, Journal of molecular biology.

A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

Mitchell Ho, I. Pastan, D. Dimitrov, 2009, Molecular Cancer Therapeutics.

Megakaryocyte Potentiation Factor Cleaved from Mesothelin Precursor Is a Useful Tumor Marker in the Serum of Patients with Mesothelioma

Mitchell Ho, I. Pastan, S. Nagata, 2006, Clinical Cancer Research.

Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.

James J. Vincent, I. Pastan, Y. Tsutsumi, 2001, Cancer research.

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

I. Pastan, Kazuto Kobayashi, M. Onda, 2019, Proceedings of the National Academy of Sciences.

Effect of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors from a Mathematical Model

I. Pastan, Youngshang Pak, Byungkook Lee, 2014, PloS one.

Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts

I. Pastan, J. O’Shea, K. Ghoreschi, 2014, The Journal of Immunology.

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.

I. Pastan, M. Stetler-Stevenson, R. Kreitman, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.

I. Pastan, C. Kuan, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Immunotoxins and recombinant toxins for cancer treatment.

I. Pastan, L. Pai, 1994, Important advances in oncology.

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

I. Pastan, Byungkook Lee, R. Kreitman, 2012, Proceedings of the National Academy of Sciences.

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

I. Pastan, Byungkook Lee, M. Onda, 2012, Protein engineering, design & selection : PEDS.

The improvement of an anti-CD 22 immunotoxin

Mitchell Ho, I. Pastan, R. Kreitman, 2011 .

Increased Affinity and Stability of an Anti-HIV-1 Envelope Immunotoxin by Structure-based Mutagenesis*

Ira Pastan, I. Pastan, D. Hamer, 2002, The Journal of Biological Chemistry.

Treatment of acute myelocytic leukemia with interleukin-6 Pseudomonas exotoxin fusion protein in a rat leukemia model.

A. Hagenbeek, I. Pastan, I. Touw, 1996, Leukemia.

Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes.

I. Pastan, S. Kasturi, C. Theuer, 1994, Biochemistry.

Multiple proteases are involved in mesothelin shedding by cancer cells

I. Pastan, Chin-Hsien Tai, T. Andresson, 2020, Communications Biology.

Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front‐line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125

S. Steinberg, I. Pastan, Jingli Zhang, 2014, Cancer.

Recognition of Mesothelin by the Therapeutic Antibody MORAb-009

I. Pastan, L. Esser, D. Xia, 2012, The Journal of Biological Chemistry.

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake.

Mitchell Ho, I. Pastan, M. Onda, 2010, Cancer research.

Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

I. Pastan, R. Hassan, Laiman Xiang, 2007, Proceedings of the National Academy of Sciences.

Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.

I. Pastan, M. Willingham, M. Brechbiel, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Specific Killing of HIV-infected Lymphocytes by a Recombinant Immunotoxin Directed against the HIV-1 Envelope Glycoprotein

C. Barbas, I. Pastan, E. Berger, 1998, Molecular medicine.

Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system

I. Pastan, Kazuto Kobayashi, K. Nishii, 1998, Journal of neuroscience research.

Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice.

I. Pastan, E. Berger, H. Goldstein, 2000, The Journal of infectious diseases.

Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer.

I. Pastan, T. Bera, Junxia Wei, 2019, Clinical colorectal cancer.

Anti-Mesothelin Immunotoxin and Immune Suppression Major Cancer Regressions in Mesothelioma After Treatment with an

S. Steinberg, I. Pastan, M. Miettinen, 2013 .

PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.

I. Pastan, U. Brinkmann, Byungkook Lee, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.

C R King, I. Pastan, U. Brinkmann, 1994, The Journal of biological chemistry.

Fluorescence In Situ Hybridization

G. Giaccone, S. Steinberg, I. Pastan, 2020, Definitions.

Effect of liposomes containing cholesterol on adenylate cyclase activity of cultured mammalian fibroblasts.

I. Pastan, L. Moore, I. Klein, 1978, Biochimica et biophysica acta.

Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity.

G. S. Johnson, I. Pastan, W. Anderson, 1973, Proceedings of the National Academy of Sciences of the United States of America.

vascular smooth muscle cells Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating

I. Pastan, S. Epstein, D. Fitzgerald, 2011 .

Receptor-mediated endocytosis in cultured fibroblasts: cryptic coated pits and the formation of receptosomes.

I. Pastan, M. Willingham, J. Wehland, 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.

I. Pastan, I. Fidler, S. Yano, 2000, International journal of oncology.

Epidermal growth factor‐dependent growth of human KB cells in a defined medium and altered growth factor requirements of KB mutants resistant to EGF‐Pseudomonas exotoxin conjugates

I. Pastan, M. Gottesman, F. Amano, 1988, Journal of cellular physiology.

Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts.

I. Pastan, M. Willingham, R. Dickson, 1982, Experimental cell research.

Internalization of alpha 2 macroglobulin in receptosomes. Studies with monovalent electron microscopic markers.

I. Pastan, M. Willingham, R. Dickson, 1981, Experimental cell research.

Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine.

I. Pastan, M. Willingham, S. Cheng, 1981, Science.

Activation of transcription at specific promoters by glycerol.

I. Pastan, S. Adhya, M. Gottesman, 1974, The Journal of biological chemistry.

Studies with cyclic adenosine monophosphate receptor and stimulation of in vitro transcription of the Gal operon.

I. Pastan, M. Gottesman, W. Anderson, 1974, The Journal of biological chemistry.

Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.

W. P. Schneider, T. Waldmann, I. Pastan, 1992, Journal of immunology.

A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing.

I. Pastan, D. Fitzgerald, C. Theuer, 1992, The Journal of biological chemistry.

A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer.

I. Pastan, D. Fitzgerald, C. Theuer, 1993, The Journal of urology.

Compensation of Depleted Neuronal Subsets by New Neurons in a Local Area of the Adult Olfactory Bulb

D. Watanabe, I. Pastan, S. Nakanishi, 2011, The Journal of Neuroscience.

Crystal structure of the disulfide‐stabilized Fv fragment of anticancer antibody B1: Conformational influence of an engineered disulfide bond

I. Pastan, G. Gilliland, Byungkook Lee, 1998, Proteins: Structure, Function, and Bioinformatics.

Biochemical Basis for Multidrug Resistance in Cancer

I. Pastan, M. Gottesman, P. Schoenlein, 1991 .

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

I. Pastan, M. Willingham, N. Richert, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Activation of adenylate cyclase in cultured fibroblasts by trypsin.

I. Pastan, W. Anderson, D. Wallach, 1978, The Journal of biological chemistry.

Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice.

D. Watanabe, I. Pastan, S. Nakanishi, 2002, Brain research. Molecular brain research.

Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3

I. Pastan, Byungkook Lee, S. Jung, 1994, Proteins.

Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.

I. Pastan, M. Willingham, G. Sahagian, 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Ultrastructural Localization ofTubulin in Cultured Fibroblasts

I. Pastan, M. Willingham, S. Yamada, 1980 .

Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts.

I. Pastan, M. Willingham, F. Maxfield, 1980, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Roles of Inhibitory Interneurons in the Cerebellar Cortex

D. Watanabe, I. Pastan, S. Nakanishi, 2002, Annals of the New York Academy of Sciences.

RECEPTOR-MEDIATED ENDOCYTOSIS OF HORMONES IN CULTURED FIBROBLASTS

I. Pastan, M. Willingham, 1981 .

Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts.

I. Pastan, M. Willingham, J. Hanover, 1985, Experimental cell research.

Random recombination of antibody single chain Fv sequences after fragmentation with DNaseI in the presence of Mn2+.

I. Pastan, I. Lorimer, 1995, Nucleic acids research.

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.

I. Pastan, M. Gottesman, L. Greenberger, 1994, Molecular pharmacology.

Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab.

I. Pastan, M. Dreher, B. Jang, 2012, Nuclear medicine and biology.

Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes

I. Pastan, M. Gottesman, I. Roninson, 1991 .

Analysis of glycoproteins in cancers and normal tissues reactive with monoclonal antibodies B3 and B1.

I. Pastan, A. Mariano, V. Macchia, 2000, International journal of oncology.

Recombinant immunotoxins

I. Pastan, U. Brinkmann, L. Pai, 2005, Breast Cancer Research and Treatment.

Recombinant single‐chain and disulfide‐stabilized Fv‐immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice

I. Pastan, Y. Reiter, D. Tonge, 1996, International journal of cancer.

Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease.

I. Pastan, A. Tomasselli, R. Heinrikson, 1990, The Journal of biological chemistry.

Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine

I. Pastan, S. Nakanishi, T. Hikida, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Activation of transcription by guanosine 5'-diphosphate,3'-diphosphate, transfer ribonucleic acid, and novel protein from Escherichia coli.

I. Pastan, M. Aboud, 1975, The Journal of biological chemistry.

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

M. Ferrer, I. Pastan, R. Guha, 2016, PloS one.

A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors.

I. Pastan, C. Wellbrock, W. Sebald, 1999, Analytical biochemistry.

Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.

I. Pastan, U. Brinkmann, Byungkook Lee, 1999, Cancer research.

Anti-drug antibodies to LMB-100 are enhanced by mAbs targeting OX40 and CTLA4 but not by mAbs targeting PD1 or PDL-1.

I. Pastan, E. King, R. Mazor, 2018, Cellular immunology.

Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo.

I. Pastan, S. Adhya, M. Gottesman, 1974, Cell.

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

I. Pastan, T. Pippucci, G. Martinelli, 2017, Journal of Hematology & Oncology.

Thyroid hormone down-regulates p55, a thyroid hormone-binding protein that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase.

I. Pastan, S. Cheng, Q. Gong, 1988, The Journal of biological chemistry.

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

I. Pastan, D. Bigner, A. Desjardins, 2019, Journal of Immunotherapy for Cancer.

Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line.

I. Pastan, M. Willingham, S. Cheng, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.

T Nagatsu, D. Watanabe, I. Pastan, 2000, Science.

Impairment of reward-related learning by cholinergic cell ablation in the striatum

D. Watanabe, I. Pastan, S. Nakanishi, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Expression of the MDR1 gene in human cancers.

I. Pastan, M. Gottesman, L. Goldstein, 1991, Cancer treatment and research.

Studies on the regulation of insulin receptors in cultured BALB/3T3 fibroblasts.

I. Pastan, M. Willingham, P. Thomopoulos, 1978, Experimental cell research.

Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts.

I. Pastan, M. Brechbiel, J. Carrasquillo, 1993, Nuclear medicine and biology.

Podocyte injury damages other podocytes.

I. Pastan, A. Shintani, T. Matsusaka, 2011, Journal of the American Society of Nephrology : JASN.

Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation.

I. Pastan, A. Nishiyama, A. Shintani, 2014, Kidney international.

In vitro transcription of the gal operon requires cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein.

I. Pastan, M. Gottesman, W. Anderson, 1971, The Journal of biological chemistry.

Effect of adenosine 3',5'-monophosphate analogues on the activity of the cyclic adenosine 3',5'-monophosphate receptor in Escherichia coli.

I. Pastan, W. Anderson, R. Perlman, 1972, The Journal of biological chemistry.

The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli.

I. Pastan, S. Weissman, J. Sklar, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Purification of calf thymus RNA polymerase II for in vitro transcription studies.

I. Pastan, J. Tyagi, 1990, Journal of Biochemical and Biophysical Methods.

Nature and intracellular location of the product of the src gene of avian sarcoma virus.

I. Pastan, M. Willingham, N. Richert, 1980, Cold Spring Harbor symposia on quantitative biology.

Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules.

I. Pastan, D. Fitzgerald, C. Siegall, 1990, Seminars in cancer biology.

Isolation of the gal repressor.

I. Pastan, R. Weisberg, M. Gottesman, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.

I. Pastan, G. Merlino, J. Tyagi, 1982, The Journal of biological chemistry.

Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity

I. Pastan, J. Berzofsky, Chin-Hsien Tai, 2017, Cancer Immunology Research.

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice

I. Pastan, É. Mezey, B. Mayer, 2014, Brain Structure and Function.

Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.

W C Eckelman, E Jagoda, I. Pastan, 1997, Bioconjugate chemistry.

Moxetumomab pasudotox as re-treatment for heavily-pretreated relapsed hairy cell leukemia

I. Pastan, S. Coutre, R. Kreitman, 2021, Leukemia & lymphoma.

Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

I. Pastan, Qi Zhou, S. Nagata, 2019, Proceedings of the National Academy of Sciences.

Preclinical development of anti-BCMA immunotoxins targeting multiple myeloma.

I. Pastan, T. Ise, S. Nagata, 2018, Antibody therapeutics.

Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin

I. Pastan, E. King, R. Mazor, 2018, The Journal of Immunology.

A novel effect of EGF on mRNA stability.

I. Pastan, G. Merlino, Y. Jinno, 1988, Nucleic acids research.

Biochemistry of the Nitrogen-Containing Hormones

I. Pastan, 1966 .

Selective immunosuppression of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis.

I. Pastan, D. Fitzgerald, C. Chan, 1989, Journal of immunology.

Energy-dependent calcium uptake activity in cultured mouse fibroblast microsomes. Regulation of the uptake system by cell density.

I. Pastan, L. Moore, 1977, The Journal of biological chemistry.

Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin.

I. Pastan, D. Fitzgerald, V. Chaudhary, 1992, Bioconjugate chemistry.

Composition pharmaceutique pour le traitement de la pharmacodependance

I. Pastan, S. Nakanishi, T. Hikida, 2004 .

Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

The relationship between cell surface protein and glucose and α‐aminoisobutyrate transport in transformed chick and mouse cells

Kenneth M. Yamada, I. Pastan, K. Yamada, 1976, Journal of cellular physiology.

Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors

Mitchell Ho, I. Pastan, Q. Jiang, 2022, Molecular cancer therapeutics.

Effect of cell density on energy‐dependent calcium uptake by Balb/c 3T3 membranes is independent of protein synthesis and attachment to substratum

I. Pastan, L. Moore, 1979, Journal of cellular physiology.

Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens

D. Watanabe, I. Pastan, S. Nakanishi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.

I. Pastan, M. Brechbiel, J. Carrasquillo, 2001, Nuclear medicine and biology.

Interactions Between Immunotoxins and the Plasma Membrane

C. P. Winlove, I. Pastan, R. Titball, 2018 .

Repression of beta-galactosidase synthesis by glucose in phosphotransferase mutants of Escherichia coli. Repression in the absence of glucose phosphorylation.

I. Pastan, R. Perlman, 1969, The Journal of biological chemistry.

Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.

I. Pastan, M. Essand, G. Vasmatzis, 1999, Biochemical and biophysical research communications.

Advances in Brief XAGE-1 , A New Gene That Is Frequently Expressed in Ewing ’ s Sarcoma 1

I. Pastan, Byungkook Lee, L. Helman, 2000 .

Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.

I. Pastan, R. Friedman, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Both ATP sites of human P-glycoprotein are essential but not symmetric.

I. Pastan, M. Ramachandra, P. Cheng, 1999, Biochemistry.

Epidermal growth factor (EGF) receptor gene transcription

I. Pastan, R. Kageyama, G. Merlino, 1988 .

Display and selection of scFv antibodies on HEK-293T cells.

Mitchell Ho, I. Pastan, 2009, Methods in molecular biology.

A Lewis(y) epitope mimicking peptide induces anti-Lewis(y) immune responses in rabbits and mice.

I. Pastan, Q. Lou, 1999, The journal of peptide research : official journal of the American Peptide Society.

Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results

I. Pastan, G. Niederfellner, K. Hollevoet, 2015, Scientific Reports.

The effect of growth conditions on NAD+ and NADH concentrations and the NAD+:NADH ratio in normal and transformed fibroblasts.

G. S. Johnson, I. Pastan, J. P. Schwartz, 1974, The Journal of biological chemistry.

The Regulation of lac Operon Transcription by Cyclic Adenosine 3′, 5′-Monophosphate

H. Varmus, I. Pastan, M. Gottesman, 1970 .

Anoctamin and transmembrane channel-like proteins are evolutionarily related.

Dong Seon Kim, I. Pastan, Byungkook Lee, 2009, International journal of molecular medicine.

Docetaxel in adjuvant therapy of breast cancer : results of the TAXIT 216 multicenter phase III trial ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Selection and maintenance of multidrug-resistant cells.

I. Pastan, M. Gottesman, T. Licht, 1998, Methods in enzymology.

Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.

I. Pastan, M. Gottesman, L. Pulaski, 2000, Biochemistry.

Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis

I. Pastan, K. Becker, Yonqing Zhang, 2011, Oncogene.

Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.

I. Pastan, M. Ramachandra, C. Hrycyna, 1998, Methods in enzymology.

Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.

I. Pastan, R. Kreitman, T. Nagatsu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

280 Updated results of the phase I study of SS1(dsFv)PE38 for targeted therapy of mesothelin expressing cancers

I. Pastan, H. Kindler, R. Hassan, 2004 .

The stability of cell surface protein to surfactants and denaturants.

I. Pastan, H. Edelhoch, K. Yamada, 1978, The Journal of biological chemistry.

Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.

I. Pastan, M. Gottesman, J. Handler, 1990, Biochimica et biophysica acta.

Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types

I. Pastan, T. Hla, R. Forough, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand.

I. Pastan, D. Fitzgerald, V. Chaudhary, 1992, Bioconjugate chemistry.

The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene.

I. Pastan, B. Olsen, E. Eikenberry, 1981, The Journal of biological chemistry.

In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.

I. Pastan, M. Gottesman, D. Shen, 1988, Cancer research.

High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.

I. Pastan, U. Brinkmann, P. Duray, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox (HA22, CAT-8015): Activity in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia (ALL) After Allogeneic Hematopoietic Stem Cell Transplantation (SCT)

I. Pastan, L. Silverman, J. Whitlock, 2012 .

Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection.

I. Pastan, Kazuto Kobayashi, T. Matsusaka, 2011, American journal of physiology. Renal physiology.

Nucleotide sequence of a collagen cDNA‐fragment coding for the carboxyl end of proα1(I)‐chains

I. Pastan, B. Olsen, E. Eikenberry, 1980 .

A phase I study of MORab-009, a monoclonal antibody against mesothelin, in mesothelioma, pancreatic and ovarian cancer

I. Pastan, E. Jaffee, D. Laheru, 2008 .

The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin.

I. Pastan, D. Davies, F. Dyda, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Erratum to: Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1

D. Bigner, I. Pastan, R. Raghavan, 2010, Journal of Neuro-Oncology.

Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.

I. Pastan, R. Kageyama, A. Johnson, 1992, Journal of Biological Chemistry.

Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates

I. Pastan, A. Tomasselli, I. Reardon, 1990, Journal of virology.

Identification of Residues That Stabilize the Single-chain Fv of Monoclonal Antibodies B3 (*)

I. Pastan, I. Benhar, 1995, The Journal of Biological Chemistry.

Ankrd26 Gene Disruption Enhances Adipogenesis of Mouse Embryonic Fibroblasts*

I. Pastan, Laiman Xiang, T. Bera, 2011, The Journal of Biological Chemistry.

Role of lecithin in the mechanism of TSH action.

I. Pastan, O. Tamburrini, V. Macchia, 1970, Endocrinology.

Moxetumomab pasudotox in heavily pretreated patients with relapsed/refractory hairy cell leukemia: Results of a pivotal international study.

W. Wilson, I. Pastan, J. Delgado, 2018 .

Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.

T. Waldmann, I. Pastan, J. Carrasquillo, 1999, Journal of Nuclear Medicine.

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.

I. Pastan, S. Ambudkar, T. Chambers, 1995, Biochemistry.

Resolution of Hairy Cell Leukemia Minimal Residual Disease by Both BRAF and Clone-Specific Real-Time Quantitative PCR (RQ-PCR) After Treatment with Moxetumomab Pasudotox.

W. Wilson, I. Pastan, M. Raffeld, 2012 .

IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.

T. Waldmann, I. Pastan, M. Willingham, 1990, Journal of immunology.

Redirecting Pseudomonas exotoxin.

I. Pastan, D. Fitzgerald, 1991, Seminars in cell biology.

Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

I. Pastan, U. Brinkmann, H. Kettenberger, 2018, Redox biology.

Microinjection of anticlathrin antibodies into cultured fibroblasts: clathrin-coated structures in receptor-mediated endocytosis and in exocytosis.

I. Pastan, M. Willingham, J. Wehland, 1982, Cold Spring Harbor symposia on quantitative biology.

alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites.

I. Pastan, M. Willingham, J. Hanover, 1983, The Journal of biological chemistry.

Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.

I. Pastan, G. Merlino, J. Tyagi, 1983, Journal of Biological Chemistry.

Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cancer

I. Pastan, U. Langsenlehner, W. Renner, 2004, Clinical Cancer Research.

Construction of MDR1 vectors for gene therapy.

I. Pastan, M. Gottesman, T. Tsuruo, 1998, Methods in Enzymology.

Control of expression of genetic information in E. coli by cyclic AMP.

I. Pastan, B. De Crombrugghe, 1972, Acta endocrinologica. Supplementum.

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

I. Pastan, C. Kuan, Q. Wang, 1994, The Journal of biological chemistry.

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

I. Pastan, M. Willingham, M. Gottesman, 1992, The Journal of biological chemistry.

Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats

I. Pastan, Byungkook Lee, B. Sathyanarayana, 2009, BMC Structural Biology.

Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens

D. Watanabe, I. Pastan, S. Nakanishi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A repetitive structure in the chick alpha 2-collagen gene.

I. Pastan, M. Mudryj, Y. Yamada, 1981, Cold Spring Harbor Symposia on Quantitative Biology.

Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development.

I. Pastan, G. Merlino, B. Crombrugghe, 1983, The Journal of biological chemistry.

In vitro stimulation of glucose oxidation in thyroid by serotonin.

I. Pastan, J. Field, 1962, Endocrinology.

Certain functions of isolated thyroid cells.

I. Pastan, Ira Pastan, 1961, Endocrinology.

Structure and regulation of a collagen gene

I. Pastan, B. Crombrugghe, 1982 .

Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.

I. Pastan, U. Brinkmann, Y. Reiter, 1994, Protein engineering.

Phase II trial of CAT-3888 (BL22) in chemo-resistant hairy cell leukemia

W. Wilson, I. Pastan, M. Stetler-Stevenson, 2007 .

Expression of Multidrug Resistance Gene in Human Cancers

I. Pastan, M. Willingham, M. Gottesman, 1989 .

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A

I. Pastan, G. Bhardwaj, David Baker, 2016, Toxins.

Abstract CT230: Pediatric phase 1 trial of moxetumomab pasudotox: Activity in chemotherapy refractory acute lymphoblastic leukemia (ALL)

I. Pastan, L. Silverman, J. Whitlock, 2014 .

Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent

I. Pastan, A. Shintani, T. Matsusaka, 2010, Hypertension.

Partial purification and characterization of the messenger RNA for cell fibronectin.

I. Pastan, J. Fagan, K. Yamada, 1979, Nucleic Acids Research.

Modulation of fibronectin gene activity in chick embryo fibroblasts transformed by a temperature-sensitive strain (ts68) of Rous sarcoma virus.

I. Pastan, J. Tyagi, H. Hirano, 1985, Nucleic acids research.

Effects of anterior pituitary hormones on glucose metabolism by rat mammary gland in vitro.

I. Pastan, A. Weinberg, J. Field, 1961, The Journal of biological chemistry.

Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2

I. Pastan, U. Brinkmann, S. Dengl, 2018, Biological chemistry.

Specific inhibition of virus growth in cells treated with phospholipase C.

I. Pastan, B. Robert, M. Friedman, 1968, Proceedings of the National Academy of Sciences of the United States of America.

Exploiting multidrug resistance to treat cancer.

I. Pastan, M. Gottesman, S. Ambudkar, 1994, Cold Spring Harbor Symposia on Quantitative Biology.

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer.

W. Wilson, I. Pastan, M. Gottesman, 1994, Human gene therapy.

Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.

I. Pastan, M. Gottesman, N. Richert, 1983, The Journal of biological chemistry.

The Internalization of Insulin and Other Hormones by Fibroblastic Cells

I. Pastan, M. Willingham, 1981, Diabetes Care.

Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate.

H. Varmus, I. Pastan, J. Parks, 1971, The Journal of biological chemistry.

Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P

I. Pastan, R. Kreitman, R. Hassan, 2009, Clinical Cancer Research.

NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.

I. Pastan, M. Willingham, Byungkook Lee, 2007, Cancer research.

Effect of sphingomyelinase from Clostridium perfringens on the metabolic activity and phospholipid composition of thyroid slices.

I. Pastan, V. Macchia, 1968, Biochimica et biophysica acta.

Mesothelin-Targeted Agents in Clinical Trials and in Preclinical Development

I. Pastan, R. Kelly, R. Hassan, 2012, Molecular Cancer Therapeutics.

Discovery of mesothelin and exploiting it as a target for immunotherapy.

I. Pastan, R. Hassan, 2014, Cancer research.

Antitumor activity of SS1P with pemetrexed and cisplatin for front-line treatment of pleural mesothelioma and utility of serum mesothelin as a marker of tumor response.

I. Pastan, E. Sharon, A. Ling, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts

I. Pastan, M. Onda, Justin Taylor, 2011, Clinical Cancer Research.

Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy.

I. Pastan, A. Remaley, R. Hassan, 2010, Lung cancer.

Mesothelin

I. Pastan, R. Hassan, T. Bera, 2004, Clinical Cancer Research.

Amatuximab, a chimeric monoclonal antibody to mesothelin, in combination with pemetrexed and cisplatin in patients with unresectable pleural mesothelioma: Results of a multicenter phase II clinical trial.

I. Pastan, L. Bazhenova, H. Kindler, 2012 .

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers

S. Steinberg, I. Pastan, T. Ried, 2012, Clinical chemistry and laboratory medicine.

Immunogenicity of therapeutic recombinant immunotoxins

I. Pastan, M. Onda, R. Mazor, 2016, Immunological reviews.

Role of domain II of Pseudomonas exotoxin in the secretion of proteins into the periplasm and medium by Escherichia coli.

Y H Xu, I. Pastan, S. Adhya, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

I. Pastan, Kai Chang, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit alpha 2-macroglobulin binding and uptake.

I. Pastan, M. Willingham, J. Hanover, 1986, The Journal of biological chemistry.

Liver angiotensinogen is the primary source of renal angiotensin II.

I. Pastan, H. Kobori, A. Nishiyama, 2012, Journal of the American Society of Nephrology : JASN.

Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury.

I. Pastan, T. Matsusaka, I. Ichikawa, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Charles J. Vaske, Joe Y. Chang, Scott R. Presnell, 2016, Journal for ImmunoTherapy of Cancer.

Combining the Antimesothelin Immunotoxin SS1P With the BH3-mimetic ABT-737 Induces Cell Death in SS1P-resistant Pancreatic Cancer Cells

I. Pastan, A. Antignani, K. Hollevoet, 2014, Journal of immunotherapy.

PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity*

I. Pastan, R. Papke, R. Matusik, 2008, Journal of Biological Chemistry.

Recombinant anti‐podoplanin (NZ‐1) immunotoxin for the treatment of malignant brain tumors

I. Pastan, S. Keir, D. Bigner, 2013, International journal of cancer.

Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis.

I. Pastan, T. Matsusaka, A. Fogo, 2005, Journal of the American Society of Nephrology : JASN.

Role of cell surface carbohydrates and proteins in cell behavior: Studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant (cell surface glycoproteins/membrane mutant/growth control/phenotypic transformation/3T3 Balb cells)

I. Pastan, M. Willingham, J. Pouysségur, 2016 .