D. Lacey

发表

Skeletal muscle adaptations to microgravity exposure in the mouse.

B. Harrison, D. Allen, B. Girten, 2003, Journal of applied physiology.

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.

D. Lacey, I. Sarosi, J. Delaney, 2000, Proceedings of the National Academy of Sciences of the United States of America.

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

S. Morony, D. Lacey, I. Sarosi, 1998, Genes & development.

Osteoclast differentiation and activation

David L. Lacey, D. Lacey, W. J. Boyle, 2003, Nature.

The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption

Sundeep Khosla, D. Lacey, B. Riggs, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis

Qing Chen, Tom Boone, Raj Haldankar, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice.

D. Lacey, K. Rex, S. Scully, 1999, International journal of radiation biology.

IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3.

D. Lacey, D. Villareal, R. Pacifici, 1993, The Journal of clinical investigation.

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

D. Lacey, A. Goldberg, T. Boone, 2010, Cell.

and platelets erythrocytes, C57BL/6 mouse. II. Activation, cytokines, the Contribution: Effects of spaceflight on immunity in Genetic Models in Applied Physiology: Selected

L. Stodieck, P. Kostenuik, S. Morony, 2006 .

Carbon dioxide angiography: effect of injection parameters on bolus configuration.

D L Lacey, D. Lacey, E. Lang, 1999, Journal of vascular and interventional radiology : JVIR.

Osteoprotegerin inhibits tumor‐induced osteoclastogenesis and bone tumor growth in osteopetrotic mice

D. Lacey, D. Clohisy, S. Scully, 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo.

D. Lacey, S. Knox, C. Shui, 1998, International journal of radiation oncology, biology, physics.

Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.

D. Lacey, T. Ulich, J. Tarpley, 1996, The American journal of pathology.

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

D. Lacey, Susan Y. Smith, M. Stolina, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice.

L. Stodieck, P. Kostenuik, T. Bateman, 2015, Bone.

Osteoprotegerin ameliorates sciatic nerve crush induced bone loss

T. Bateman, D. Lacey, V. Ferguson, 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Infrequent Delivery of a Long‐Acting PTH‐Fc Fusion Protein Has Potent Anabolic Effects on Cortical and Cancellous Bone

Steven W. Martin, P. Kostenuik, S. Morony, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats

P. Kostenuik, S. Morony, D. Lacey, 2001 .

Sall1 is essential for kidney development

D. Lacey, Kenji Nakamura, M. Katsuki, 2001 .

Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

D. Lacey, G. Rishton, W. H. Heaton, 2004, Journal of Pharmacology and Experimental Therapeutics.

CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin

P. Kostenuik, S. Morony, D. Lacey, 2004, Gut.

Interleukin 4 enhances osteoblast macrophage colony-stimulating factor, but not interleukin 6, production

D. Lacey, S. Perkins, J. Ohara, 1994, Calcified Tissue International.

Interleukin 4 increases type 5 acid phosphatase mrna expression in murine bone marrow macrophages

D. Lacey, H. Tan, J. Erdmann, 1994, Journal of cellular biochemistry.

1,25‐Dihydroxyvitamin D3 increases type 1 interleukin‐1 receptor expression in a murine T cell line

D. Lacey, H. Tan, J. Erdmann, 1993, Journal of cellular biochemistry.

Murine osteoblast interleukin 4 receptor expression: Upregulation by 1,25 dihydroxyvitamin D3

D. Lacey, H. Tan, J. Ohara, 1993, Journal of cellular biochemistry.

Ectopic overexpression of c-mpl by retroviral-mediated gene transfer suppressed megakaryopoiesis but enhanced erythropoiesis in mice.

D. Lacey, R. Hawley, C. Saris, 1999, Experimental hematology.

A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.

D. Lacey, R. Hawley, R. Hawley, 1996, Blood.

Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis.

P. Kostenuik, S. Morony, D. Lacey, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.

D. Lacey, D. Danilenko, K. Rex, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Cyclophosphamide prevents systemic keratinocyte growth factor-induced up-regulation of surfactant protein A after allogeneic transplant in mice.

D. Lacey, S. Matalon, I. Y. Haddad, 2000, American journal of respiratory and critical care medicine.

Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in mice.

D. Lacey, D. Cornfield, I. Y. Haddad, 1999, American Journal of Physiology.

Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in mice.

D. Lacey, D. Cornfield, I. Y. Haddad, 1999, American journal of physiology. Lung cellular and molecular physiology.

expressionof spaceflight on murine skeletal muscle gene

B. Harrison, L. Stodieck, P. Kostenuik, 2013 .

Keratinocyte growth factor causes proliferation of urothelium in vivo.

D. Lacey, D. Danilenko, A. Shabaik, 1995, The Journal of urology.

A murine osteoblast cell line (MC3T3) produces A soluble elastogenic compound

D. Lacey, L. Grosso, 1995, The Journal of pathology.

IL-1 and IL-4 modulate IL-1 receptor expression in a murine T cell line.

D. Lacey, J. Erdmann, 1990, Journal of immunology.

Characterization of osteoclast precursors in human blood

D. Lacey, N. Hawkins, M. Kelley, 2000, British journal of haematology.

Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice.

D. Lacey, T. Boone, T. Grasel, 1995, Blood.

Keratinocyte Growth Factor in the Nonhuman Primate Endometrium: Regulation and Action

D. Lacey, J. Rubin, R. Brenner, 1999 .

Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells.

D. Lacey, B. Riggs, S. Khosla, 1999, Bone.

Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.

D. Lacey, I. Y. Haddad, B. Blazar, 2003, American journal of physiology. Lung cellular and molecular physiology.

The Receptor Activator of Nuclear Factor-κB Ligand Inhibitor Osteoprotegerin Is a Bone-Protective Agent in a Rat Model of Chronic Renal Insufficiency and Hyperparathyroidism

P. Kostenuik, S. Morony, D. Lacey, 2005, Calcified Tissue International.

Laboratory Investigations The Receptor Activator of Nuclear Factor-jB Ligand Inhibitor Osteoprotegerin Is a Bone-Protective Agent in a Rat Model of Chronic Renal Insufficiency and Hyperparathyroidism

P. Kostenuik, S. Morony, D. Lacey, 2006 .

Calcification Inhibitors and Wnt Signaling Proteins Are Implicated in Bovine Artery Smooth Muscle Cell Calcification in the Presence of Phosphate and Vitamin D Sterols

D. Lacey, M. Boedigheimer, V. Shalhoub, 2006, Calcified Tissue International.

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation.

D. Lacey, D. Danilenko, D. Min, 2002, Blood.

Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism.

D. Lacey, C. Stehman-Breen, David A. Martin, 2005, Kidney international.

Sustained Antiresorptive Effects After a Single Treatment With Human Recombinant Osteoprotegerin (OPG): A Pharmacodynamic and Pharmacokinetic Analysis in Rats

Steven W. Martin, P. Kostenuik, S. Morony, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

IL-1 activates the Na+/H+ antiport in a murine T cell.

D. Lacey, K. Hruska, R. Civitelli, 1989, Journal of immunology.

Effects of keratinocyte growth factor in the endometrium of rhesus macaques during the luteal-follicular transition.

D. Lacey, J. Rubin, R. Brenner, 2000, The Journal of clinical endocrinology and metabolism.

Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors

D. Lacey, M. Kelley, W. J. Boyle, 1999, Journal of cellular biochemistry.

Characterization of osteoclast precursors in human blood.

D. Lacey, N. Hawkins, M. Kelley, 2000 .

Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways

D. Lacey, G. Pierce, J. Doukas, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats.

D. Lacey, J. Lakshmanan, S. Soltani, 1996, Gastroenterology.

1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism.

D. Lacey, D. Towler, David A. Martin, 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Interleukin 4, interferon-gamma, and prostaglandin E impact the osteoclastic cell-forming potential of murine bone marrow macrophages.

D. Lacey, S. Teitelbaum, H. Tan, 1995, Endocrinology.

Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization.

D. Lacey, S. Teitelbaum, S. Teitelbaum, 1993, The Biochemical journal.

Studies on the pathogenesis of avian rickets. I. Changes in epiphyseal and metaphyseal vessels in hypocalcemic and hypophosphatemic rickets.

D. Lacey, W. Huffer, 1982, The American journal of pathology.

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

S. Morony, D. Lacey, D. Goeddel, 1999, Genes & development.

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.

D. Lacey, D. Danilenko, K. Weinberg, 2002, Blood.

KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT.

D. Lacey, I. Y. Haddad, P. Bitterman, 2000, American journal of physiology. Lung cellular and molecular physiology.

A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3.

S. Morony, D. Lacey, T. Boone, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury.

D. Lacey, A. Üren, J. Rubin, 2000, Blood.

Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors

D. Lacey, V. Shalhoub, T. Burgess, 1999, Journal of cellular biochemistry.

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

D. Lacey, J. Fata, R. Khokha, 2000, Cell.

REGULATION OF GLUTATHIONE REDOX STATUS IN LUNG AND LIVER BY CONDITIONING REGIMENS AND KERATINOCYTE GROWTH FACTOR IN MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION1

Dean P. Jones, D. Lacey, T. Ziegler, 2001, Transplantation.

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

S. Morony, D. Lacey, T. Mak, 1999, Nature.

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

D. Lacey, I. Sarosi, J. Delaney, 1998, Cell.

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

G Shimamoto, D. Lacey, T. Boone, 1997, Cell.

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Josef M. Penninger, Brad Bolon, David L. Lacey, 1999, Nature.

A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL‐1β, TNF‐α, PTH, PTHrP, and 1,25(OH)2D3

S. Morony, D. Lacey, T. Boone, 1999 .

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

D. Lacey, B. Riggs, S. Khosla, 1999 .

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Josef M. Penninger, Brad Bolon, David L. Lacey, 1999, Nature.

D. Lacey, B. Riggs, S. Khosla, 2022 .

The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

D. Lacey, M. Kelley, W. J. Boyle, 1999, The Journal of cell biology.

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

S. Morony, D. Lacey, M. Bass, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo.

D L Lacey, D. Lacey, M. Kelley, 2000, The American journal of pathology.

Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

P. Kostenuik, S. Morony, D. Lacey, 2000, The Journal of experimental medicine.

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells.

D. Lacey, B. Riggs, B. L. Riggs, 1999, Endocrinology.

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

P. Kostenuik, S. Morony, D. Lacey, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1.

D. Lacey, B. L. Riggs, S. Khosla, 1999, Endocrinology.

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women.

D. Lacey, B. Riggs, B. L. Riggs, 2003, The Journal of clinical investigation.

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.

D. Lacey, K. Rex, C. Potten, 1998, Cancer research.

CHAPTER 7 – Osteoclast Biology

D. Lacey, M. Zaidi, H. Blair, 2008 .

Dickkopf-1 is a master regulator of joint remodeling

Georg Schett, D. Lacey, W. Richards, 2007, Nature Medicine.

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

P. Kostenuik, D. Lacey, W. Dougall, 2012, Nature Reviews Drug Discovery.

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.

D L Lacey, P. Kostenuik, S. Morony, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A Neu differentiation factor (NDF) domain essential for proliferation and alterations in morphology of colonic epithelial cells in vitro.

D. Lacey, J. Mayer, J. Tarpley, 1998, Growth factors.

microgravity conditions Plasticity of monkey triceps muscle fibers in

B. Harrison, D. Allen, B. Girten, 2015 .

Chronic expression of murine flt3 ligand in mice results in increased circulating white blood cell levels and abnormal cellular infiltrates associated with splenic fibrosis.

D. Lacey, Y. Sun, T. Juan, 1997, Blood.

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice.

D. Lacey, R. Hawley, M. Xia, 1995, Blood.

Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy.

P. Kostenuik, S. Morony, D. Lacey, 2000, Cancer research.

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

Daniel J Lightwood, D. Lacey, Susan Y. Smith, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

in Mice Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation Keratinocyte Growth Factor Administered Before Conditioning Ameliorates

D. Lacey, B. Blazar, D. Vallera, 2010 .

Keratinocyte Growth Factor Administered Before Conditioning Ameliorates Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Mice

D. Lacey, B. Blazar, D. Vallera, 1998 .

Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice.

D. Lacey, B. Blazar, D. Vallera, 1998, Blood.

Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation.

D. Lacey, R. Strieter, W. Murphy, 2000, Blood.

Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis.

D. Lacey, T. Ulich, J. Tarpley, 1997, Cancer research.

Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets.

L. Stodieck, P. Kostenuik, T. Bateman, 2003, Journal of applied physiology.

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.

P. Kostenuik, S. Morony, D. Lacey, 2006, Bone.

Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor–induced apoptosis in vivo and in vitro

D. Lacey, G. Senaldi, C. L. Shaklee, 1998, Hepatology.

Effects of spaceflight on murine skeletal muscle gene expression.

Louis S Stodieck, B. Harrison, D. Allen, 2009, Journal of applied physiology.

Interleukin 4 inhibits murine osteoclast formation in vitro

D. Lacey, S. Teitelbaum, F. Ross, 1991, Journal of cellular biochemistry.

Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis.

P. Kostenuik, S. Morony, D. Lacey, 2001, Cancer research.

Osteoprotegerin mitigates tail suspension-induced osteopenia.

T. Bateman, D. Lacey, V. Ferguson, 2000, Bone.

Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions.

Louis S Stodieck, L. Stodieck, P. Kostenuik, 2003, Journal of applied physiology.

Vascular and Interventional Radiology

David L. Lacey, D. Lacey, Benjamin Stradling, 2000 .

Dickkopf‐1 regulates bone formation in young growing rodents and upon traumatic injury

P. Kostenuik, D. Lacey, T. Horan, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Studies on the pathogenesis of avian rickets II. Necrosis of perforating epiphyseal vessels during recovery from rickets in chicks caused by vitamin D3 deficiency.

D. Lacey, W. Huffer, 1982, The American journal of pathology.

In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells.

D. Lacey, V. Shalhoub, David A. Martin, 2003, Critical reviews in eukaryotic gene expression.

Regulation of Protein Catabolism by Muscle-Specific and Cytokine-Inducible Ubiquitin Ligase E3α-II during Cancer Cachexia

D. Lacey, V. Baracos, W. J. Boyle, 2004, Cancer Research.

Interleukin 1 stimulates proliferation of a nontransformed T lymphocyte line in the absence of a co-mitogen.

D. Lacey, S. Teitelbaum, J. Chappel, 1987, Journal of immunology.

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

D. Lacey, B. Riggs, S. Khosla, 1999 .

Interleukin-4 inhibits bone resorption and acutely increases cytosolic Ca2+ in murine osteoclasts.

D. Lacey, R. Civitelli, S. Teitelbaum, 1994, The Journal of biological chemistry.