P. Lefevre

发表

An evaluation of 6 short-term tests for detecting organic chemical carcinogens.

I. Purchase, E. Longstaff, J. Ashby, 1978, British Journal of Cancer.

Comparison of prostate gene expression and tissue weight changes as monitors of antiandrogen activity in GNRH-inhibited rats.

J. Ashby, P. Lefevre, C. Nellemann, 2003, Birth defects research. Part B, Developmental and reproductive toxicology.

Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens.

J. Ashby, P. Lefevre, W. Owens, 2002, Regulatory toxicology and pharmacology : RTP.

Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay.

J. Ashby, P. Lefevre, R. Deghenghi, 2001, Regulatory toxicology and pharmacology : RTP.

The weanling male rat as an assay for endocrine disruption: preliminary observations.

J. Ashby, P. Lefevre, 1997, Regulatory toxicology and pharmacology : RTP.

The reported in vitro anti-estrogen pentachloronitrobenzene enhances the estrogenic activity of estradiol in vivo in the rat.

J. Ashby, P. Lefevre, J. Odum, 2005, Environmental toxicology and pharmacology.

Possible androgenic/anti‐androgenic activity of the insecticide fenitrothion

J. Ashby, P. Lefevre, P. Sohoni, 2001, Journal of applied toxicology : JAT.

Assessing the risks of adverse endocrine-mediated effects: where to from here?

J. Ashby, P. Lefevre, J. Odum, 1997, Regulatory toxicology and pharmacology : RTP.

Activity of 2-Acetylaminofluorene as a UDS inducting agent in B6C3F1 mouse hepatocytes in vitro

J. Ashby, P. Lefevre, 2004, Cell Biology and Toxicology.

Relative sensitivity of 32P-postlabelling of DNA and the autoradiographic UDS assay in the liver of rats exposed to 2-acetylaminofluorene (2AAF).

J. Lewtas, J. Ashby, P. Lefevre, 1991, Mutation research.

The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97.

J. Ashby, P. Lefevre, J. Haseman, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Non-genotoxicity of 2,4,6-Trinitrotoluene (TNT) to the mouse bone marrow and the rat liver: implications for its carcinogenicity

J. Ashby, P. Lefevre, B. Burlinson, 1985, Archives of Toxicology.

Hepatic gene mutations induced in Big Blue™ rats by both the potent rat liver Azo‐carcinogen 6BT and its reported noncarcinogenic analogue 5BT

J. Ashby, P. Lefevre, H. Tinwell, 1999, Environmental and molecular mutagenesis.

Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.

J. Ashby, P. Lefevre, H. Tinwell, 2001, Regulatory toxicology and pharmacology : RTP.

Replacement of surgical castration by GnRH inhibition for rat prostate androgen receptor preparations

J. Ashby, P. Lefevre, 2001, Journal of applied toxicology : JAT.

Evaluation of dichloromethane as an inducer of DNA synthesis in the B6C3F1 mouse liver.

J. Ashby, P. Lefevre, 1989, Carcinogenesis.

Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays.

J. Ashby, P. Lefevre, J. Sumpter, 2000, Toxicology letters.

Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of Muta™Mouse mice

J. Ashby, P. Lefevre, H. Tinwell, 1998, Environmental and molecular mutagenesis.

The possible role of azoreduction in the bacterial mutagenicity of 4-dimethylaminoazobenzene (DAB) and 2 of its analogues (6BT and 5I).

J. Ashby, P. Lefevre, R. Callander, 1983, Mutation research.

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.

J. Ashby, P. Lefevre, W. Pennie, 2000, Biochemical pharmacology.

Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.

J. Ashby, P. Lefevre, J. Sumpter, 1997, Regulatory toxicology and pharmacology : RTP.

Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.

J. Ashby, P. Lefevre, J. Odum, 2004, Environmental health perspectives.

The effects of pre-incubation period and norharman on the mutagenic potency of 4-dimethylaminoazobenzene and 3'-methyl-4-dimethylaminoazobenzene in S. typhimurium.

J. Ashby, P. Lefevre, 1981, Carcinogenesis.

The rat-liver carcinogen N-nitrosomorpholine initiates unscheduled DNA synthesis and induces micronuclei in the rat liver in vivo.

J. Ashby, P. Lefevre, 1989, Mutation research.

Investigations into the reported ability of cimetidine to initiate UDS in rat hepatocyte primary cultures.

J. Ashby, P. Lefevre, John Ashby, 1985, Environmental mutagenesis.

Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.

G. Orphanides, J. Ashby, P. Lefevre, 2002, Environmental health perspectives.

Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor

J. Ashby, P. Lefevre, L. Kier, 1996, Human & experimental toxicology.

Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A.

J. Ashby, P. Lefevre, J. Haseman, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning.

J. Ashby, P. Lefevre, R. Chapin, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Mitogenesis, micronuclei, and carcinogenesis in the rat liver: Some basic inconsistencies

J. Ashby, P. Lefevre, Dr. J . Ashby. ICl, 1992, Environmental and molecular mutagenesis.

Evaluation of the Genetic Toxicity of the Peroxisome Proliferator and Carcinogen Methyl Clofenapate, Including Assays Usin Muta TM Mouse and Big Blue™ Transgenic Mice

J. Ashby, P. Lefevre, S. Galloway, 1994, Human & experimental toxicology.

Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use

I. Purchase, E. Longstaff, J. Ashby, 1976, Nature.

An assessment of the in vivo rat hepatocyte DNA-repair assay.

J Ashby, J. Ashby, P. Lefevre, 1985, Mutation research.

Irreversible depression in the ratio of tetraploid:diploid liver nuclei in rats treated with 3'-methyl-4-dimethylaminoazobenzene (3'M).

J. Ashby, J. Styles, P. Lefevre, 1985, Carcinogenesis.

The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment.

J Ashby, J. Ashby, P. Lefevre, 1995, Mutagenesis.

Chloracetamide-N-metholol: an example of an in vitro and in vivo clastogen which is non-mutagenic to Salmonella.

J. Ashby, J. Styles, P. Lefevre, 1985, Mutation research.

Initiation/promotion versus complete carcinogenicity in the rodent liver

E. Longstaff, J. Ashby, J. Styles, 1983, Environmental health perspectives.

An overview of the chemical and biological reactivity of 4CMB and structurally related compounds: possible relevance to the overall findings of the UKEMS 1981 study.

J. Ashby, J. Styles, P. Lefevre, 1982, Mutation research.

Comparisons between carcinogenic potency and mutagenic potency to Salmonella in a series of derivatives of 4-dimethylaminoazobenzene (DAB).

J Ashby, J. Ashby, J. Styles, 1982, Mutation research.

Assay‐specific genotoxicity of N‐nitrosodibenzylamine to the rat liver in vivo

J. Ashby, P. Lefevre, B. Pool, 1990, Environmental and molecular mutagenesis.

Evaluation of the mutagenicity of acetochlor to male rat germ cells.

J. Ashby, P. Lefevre, L. Kier, 1997, Mutation research.

Methyl methanesulphonate (MMS) as a resource conserving and reliable positive control agent for male rat and male mouse dominant lethal assays.

J. Ashby, P. Lefevre, B. Elliott, 1996, Mutagenesis.

The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine.

J. Ashby, P. Lefevre, G. Brunborg, 1991, Mutation research.

Quinoline: Unscheduled DNA synthesis and mitogenesis data from the rat liver in vivo

J. Ashby, P. Lefevre, L. Bandara, 1989, Environmental and molecular mutagenesis.

Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: Empirical correlations with hepatic carcinogenicity

J. Ashby, P. Lefevre, 1992, Environmental and molecular mutagenesis.

Response of the MutaTMmouse lacZ/galE− transgenic mutation assay to DMN: comparisons with the corresponding Big BlueTM (lacI) responses

J. Ashby, P. Lefevre, H. Tinwell, 1994 .

Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.

J. Ashby, P. Lefevre, H. Tinwell, 1994, Mutation research.

The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.

J. Ashby, P. Lefevre, H. Tinwell, 1997, Mutation research.

Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning.

J. Ashby, P. Lefevre, D. Paton, 1997, Regulatory toxicology and pharmacology : RTP.

Mutagenicity to Salmonella of the mono methylamino and N-cyanoethyl analogues of 4-dimethylaminoazobenzene (DAB) and 6-dimethylaminophenylazobenzthiazole (6BT).

J. Ashby, P. Lefevre, D. Paton, 1984, Mutation research.

Potent mitogenic activity of 4-acetylaminofluorene to the rat liver.

J. Ashby, P. Lefevre, B. Burlinson, 1986, Mutation research.

Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF‐7 cells and its suggested cardiovascular protective effects

J. Ashby, P. Lefevre, W. Pennie, 1999, Journal of applied toxicology : JAT.

The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti‐androgens, oestrogens and metabolic modulators

J Ashby, J. Ashby, P. Lefevre, 2000, Journal of applied toxicology : JAT.

Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: consideration of a reduced mutation assay protocol.

J. Ashby, P. Lefevre, H. Tinwell, 1997, Mutagenesis.

Some properties of the organomercury‐degrading system in mammalian liver

P. Lefevre, J. W. Daniel, 1973, FEBS letters.

Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo.

J. Ashby, P. Lefevre, C. Elcombe, 1990, Mutagenesis.

Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay.

J Ashby, J. Ashby, P. Lefevre, 2004, Regulatory toxicology and pharmacology : RTP.

The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay.

J Ashby, J. Ashby, P. Lefevre, 1997, Regulatory toxicology and pharmacology : RTP.

Preliminary Evaluation of the Major Protocol Variables for the Hershberger Castrated Male Rat Assay for the Detection of Androgens, Antiandrogens, and Metabolic Modulators

J. Ashby, P. Lefevre, J. Ashby, 2000 .

Co-administration of mTor Inhibitors and Carbamazepine May Lead to Ineffectiveness of Therapy: A Case Report of a 24-year-old Man

P. Lefevre, J. Bergerat, V. Kemmel, 2022 .

The metabolism of phenylmercury by the rat.

P. Lefevre, J. Gage, J. W. Daniel, 1972, The Biochemical journal.

Synergy between synthetic oestrogens?

C. A. Harris, P. Lefevre, J. Sumpter, 1997, Nature.

The metabolism of methoxyethylmercury salts.

P. Lefevre, J. Gage, J. W. Daniel, 1971, The Biochemical journal.

Cyclic amines as less mutagenic replacements for dimethyl amino (--NMe2) substituents on aromatic organic compounds: implications for carcinogenicity and toxicity.

J. Ashby, P. Lefevre, D. Paton, 1983, Cancer letters.

Response of the Muta mouse lacZ/galE- transgenic mutation assay to DMN: comparisons with the corresponding Big Blue (lacI) responses.

J. Ashby, P. Lefevre, H. Tinwell, 1994, Mutation research.

Formaldehyde generators: relationship between stability, lipophilicity and carcinogenic potency.

J. Ashby, P. Lefevre, 1982, Carcinogenesis.

Comparison of Reproductive Tissue Weights in the Enhanced Hershberger Assay of 17α-Methyltestosterone between Peripubertal and Castrated Rats

J. Ashby, P. Lefevre, K. Yamasaki, 2000 .

Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.

J. Ashby, P. Lefevre, J. Short, 1994, Carcinogenesis.