K. Kinzler

K. Kinzler, B. Vogelstein, D. Chan, 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

An analysis of genetic heterogeneity in untreated cancers

Johannes G. Reiter, Jeffrey M. Gerold, M. Nowak, 2019, Nature Reviews Cancer.

The multistep nature of cancer.

K. Kinzler, B. Vogelstein, 1993, Trends in genetics : TIG.

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

K. Kinzler, B. Vogelstein, H. Clevers, 1997, Science.

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.

K. Kinzler, B. Vogelstein, T. Chan, 1999, Cell.

Utility of CT Radiomics Features in Differentiation of Pancreatic Ductal Adenocarcinoma From Normal Pancreatic Tissue.

A. Yuille, Seyoun Park, L. Chu, 2019, AJR. American journal of roentgenology.

A multimodality test to guide the management of patients with a pancreatic cyst

David L. Masica, Walter G. Park, M. Makary, 2019, Science Translational Medicine.

A simplified system for generating recombinant adenoviruses.

K. Kinzler, B. Vogelstein, J. Yu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

G. Parmigiani, J. Carpten, K. Kinzler, 2012, Science Translational Medicine.

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer.

R. Strausberg, K. Kinzler, B. Vogelstein, 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

R. Strausberg, K. Kinzler, B. Vogelstein, 2016, Science Translational Medicine.

Gene amplification in cancer: a molecular cytogenetic approach.

P. Meltzer, J. Trent, K. Kinzler, 1986, Cancer genetics and cytogenetics.

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

J. Ptak, K. Kinzler, B. Vogelstein, 2004, Science.

Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

G. Parmigiani, J. Ptak, K. Kinzler, 2003, Science.

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

R. Fleischmann, M. Adams, J. Venter, 1994, Nature.

Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.

K. Kinzler, B. Vogelstein, N. Nicolaides, 1995, Genomics.

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

G. Parmigiani, K. Kinzler, B. Vogelstein, 2008, Proceedings of the National Academy of Sciences.

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, Australian journal of chemistry.

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Ludmila V. Danilova, L. Cope, A. Zaheer, 2017, Science.

Altered Telomeres in Tumors with ATRX and DAXX Mutations

R. McLendon, K. Kinzler, C. Bettegowda, 2011, Science.

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

W. Hahn, B. Weir, K. Kinzler, 2012, PLoS genetics.

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

H. Ostrer, K. Kinzler, B. Vogelstein, 1997, Nature Genetics.

Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status

K. Kinzler, B. Vogelstein, V. Velculescu, 2002, Nature.

Circulating mutant DNA to assess tumor dynamics

S. Goodman, M. Choti, K. Kinzler, 2008, Nature Medicine.

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

Francisco M. De La Vega, K. McKernan, K. Kinzler, 2010, Science Translational Medicine.

Heteroplasmic mitochondrial DNA mutations in normal and tumor cells

D. Dressman, K. Kinzler, B. Vogelstein, 2010, Nature.

Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

K. Kinzler, B. Vogelstein, L. Su, 1992, Science.

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

R. Gibbs, J. Weinstein, D. Muzny, 2011, Science.

A multidimensional analysis of genes mutated in breast and colorectal cancers.

G. Parmigiani, L. Wood, K. Kinzler, 2007, Genome research.

Design and analysis issues in genome-wide somatic mutation studies of cancer.

G. Parmigiani, K. Kinzler, B. Vogelstein, 2009, Genomics.

The Genetic Landscape of the Childhood Cancer Medulloblastoma

Zev A. Binder, G. Parmigiani, M. Berger, 2011, Science.

Colorectal cancer: Mutations in a signalling pathway

J. Ptak, K. Kinzler, B. Vogelstein, 2005, Nature.

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

D. Dressman, K. Kinzler, B. Vogelstein, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Using the transcriptome to annotate the genome

A. Sparks, K. Kinzler, B. Vogelstein, 2002, Nature Biotechnology.

Scrambled exons

Kathleen R. Cho, K. Kinzler, B. Vogelstein, 1991, Cell.

Characterization of human FAST-1, a TGFβ and activin signal transducer

K. Kinzler, B. Vogelstein, Shibin Zhou, 1998 .

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

Johannes G. Reiter, M. Nowak, K. Kinzler, 2012, Nature.

Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience.

Yan Wang, Yingda Xia, Qihang Yu, 2019, Journal of the American College of Radiology : JACR.

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation.

A. Yuille, Seyoun Park, L. Chu, 2019, Diagnostic and interventional imaging.

Digital PCR.

K. Kinzler, B. Vogelstein, B Vogelstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Multicolor in vitro translation

K. Kinzler, B. Vogelstein, B. Levin, 2003, Nature Biotechnology.

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Johannes G. Reiter, M. Nowak, L. Wood, 2017, Nature Genetics.

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Gary L. Gallia, Arthur P. Grollman, Tian-Li Wang, 2013, Proceedings of the National Academy of Sciences.

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

Bert Vogelstein, Toby C. Cornish, Toby C Cornish, 2015, The New England journal of medicine.

Noninvasive imaging of infection after treatment with tumor‐homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI

Bert Vogelstein, Chetan Bettegowda, Guanshu Liu, 2013, Magnetic resonance in medicine.

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

Scott E. Kern, Bert Vogelstein, Stephan A. Hahn, 1996, Nature Genetics.

Mad-related genes in the human

Scott E. Kern, Bert Vogelstein, Kenneth W. Kinzler, 1996, Nature Genetics.

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

K. Kinzler, P. Gibbs, M. Christie, 2018, Gut.

Gene expression profiles in normal and cancer cells.

R H Hruban, K. Kinzler, B. Vogelstein, 1997, Science.

Cancer-susceptibility genes. Gatekeepers and caretakers.

K. Kinzler, B. Vogelstein, B Vogelstein, 1997, Nature.

Gatekeepers and caretakers

Bert Vogelstein, Kenneth W. Kinzler, K. Kinzler, 1997, Nature.

Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer

Bert Vogelstein, Kenneth W. Kinzler, A. Sparks, 1998 .

A Phosphatase Associated with Metastasis of Colorectal Cancer

Michael A. Choti, Carlo Rago, Victor E. Velculescu, 2001, Science.

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Robin J. Leach, Paul S. Meltzer, Jean Weissenbach, 1993, Cell.

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Bert Vogelstein, Kenneth W. Kinzler, Paul Modrich, 1993, Cell.

Addressing overdiagnosis and overtreatment in cancer: a prescription for change.

Sudhir Srivastava, Brian Reid, David F Ransohoff, 2014, The Lancet. Oncology.

DEC1 is a downstream target of TGF-β with sequence-specific transcriptional repressor activities

K. Kinzler, B. Vogelstein, Jian Yu, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

Alison P. Klein, James R. Eshleman, Giovanni Parmigiani, 2009, Science.

Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

K. Kinzler, B. Vogelstein, R. Hruban, 2013, Annals of Surgical Oncology.

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

A. Maitra, L. Wood, K. Kinzler, 2011, Science Translational Medicine.

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

A. Maitra, M. Choti, L. Wood, 2011, Proceedings of the National Academy of Sciences.

A Bacterial Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs

Xin Huang, Bert Vogelstein, Chetan Bettegowda, 2006, Science.

PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity

R. Cole, K. Kinzler, B. Vogelstein, 2015, Scientific Reports.

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

M. Choti, J. Cameron, L. Wood, 2014, Science Translational Medicine.

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer.

J. Ptak, K. Kinzler, B. Vogelstein, 2019, JAMA oncology.

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

J. Ptak, K. Kinzler, B. Vogelstein, 2018, Science Translational Medicine.

BEAMing up for detection and quantification of rare sequence variants

Frank Diehl, Bert Vogelstein, Meng Li, 2006, Nature Methods.

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

Yuchen Jiao, Bert Vogelstein, Chetan Bettegowda, 2011, Science.

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Bert Vogelstein, Christoph Lengauer, A. Feinberg, 2002, Nature.

Thiazolidinedione-Based PI3Kα Inhibitors: An Analysis of Biochemical and Virtual Screening Methods

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2011, ChemMedChem.

PAK1, a gene that can regulate p53 activity in yeast.

K. Kinzler, B. Vogelstein, S. Thiagalingam, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2008, The Biochemical journal.

Combination bacteriolytic therapy for the treatment of experimental tumors

K. Kinzler, C. Bettegowda, B. Vogelstein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors.

K. Kinzler, B. Vogelstein, L. Diaz, 2012, American journal of veterinary research.

Imaging of Musculoskeletal Bacterial Infections by [124I]FIAU-PET/CT

K. Kinzler, C. Bettegowda, B. Vogelstein, 2007, PloS one.

Discodermolide analogues as the chemical component of combination bacteriolytic therapy.

K. Kinzler, B. Vogelstein, M. LaMarche, 2005, Bioorganic & medicinal chemistry letters.

Pharmacologic and toxicologic evaluation of C. novyi-NT spores.

B. Peters, K. Kinzler, C. Bettegowda, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Carcinogens leave fingerprints

K. Kinzler, B. Vogelstein, 1992, Nature.

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Jin-Young Jang, Amanda Blackford, Mari Mino-Kenudson, 2015, Gastroenterology.

Detection of proximal colorectal cancers through analysis of faecal DNA

K. Kinzler, B. Vogelstein, B. Levin, 2002, The Lancet.

Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs)

K. Kinzler, B. Vogelstein, R. Hruban, 2018, Proceedings of the National Academy of Sciences.

Advances in Brief p 53 Mutation and MDM 2 Amplification in Human Soft Tissue Sarcomas 1

P. Meltzer, D. Hill, K. Kinzler, 2006 .

Selected reaction monitoring approach for validating peptide biomarkers

Tyler M. Tomita, J. Vogelstein, K. Kinzler, 2017, Proceedings of the National Academy of Sciences.

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.

K. Kinzler, B. Vogelstein, J. Cummins, 2004, Cancer research.

Phosphorylation of β-Catenin at S33, S37, or T41 Can Occur in the Absence of Phosphorylation at T45 in Colon Cancer Cells

K. Kinzler, B. Vogelstein, Zhenghe Wang, 2003 .

Phosphorylation of beta-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells.

K. Kinzler, B. Vogelstein, Zhenghe Wang, 2003, Cancer research.

APC gene mutations in the mutation cluster region are rare in esophageal cancers.

K. Kinzler, N. Papadopoulos, S. Powell, 1994, Gastroenterology.

Assignment of the Human p27Kipl Gene to 12pl3 and Its Analysis in Leukemias1

James M. Roberts, K. Kinzler, B. Vogelstein, 1995 .

Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomothearapy

G. Parmigiani, K. Kinzler, S. Gruber, 2009, Radiation oncology.

Direct Detection and Quantification of Neo-antigens

Bert, K. Kinzler, N. Papadopoulos, 2019 .

Direct Detection and Quantification of Neoantigens

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2019, Cancer Immunology Research.

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy.

K. Kinzler, B. Vogelstein, Shibin Zhou, 2015, ACS nano.

Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44].

A. Yuille, L. Chu, K. Kinzler, 2020, Diagnostic and interventional imaging.

Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study

K. Kinzler, B. Vogelstein, L. Diaz, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

catastrophe after DNA damage

K. Kinzler, B. Vogelstein, H. Hermeking, 1999 .

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.

K. Kinzler, B. Vogelstein, C. Rago, 2004, Nucleic acids research.

p2! Is Necessary for the p53-mediated G, Arrest in Human Cancer Cells'

K. Kinzler, B. Vogelstein, T. Waldman, 2006 .

Waf1 anti-tumoral

K. Kinzler, B. Vogelstein, 1994 .

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

K. Kinzler, B. Vogelstein, J. Taube, 2015, Journal of Immunotherapy for Cancer.

Identification of a chromosome 18q gene that is altered in colorectal cancers.

Kathleen R. Cho, K. Kinzler, B. Vogelstein, 1990, Science.

A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.

V. Chapman, M. Justice, K. Kinzler, 1992, Genomics.

The colorectal cancer gene hunt: current findings.

K. Kinzler, B. Vogelstein, 1992, Hospital practice.

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

K. Kinzler, B. Vogelstein, Jian Yu, 2001, Nature Medicine.

A gene for neurofibromatosis 2

K. Kinzler, B. Vogelstein, 1993, Nature.

Serial Analysis of Gene Expression

K. Kinzler, B. Vogelstein, V. Velculescu, 1995, Science.

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.

E. Lander, K. Kinzler, B. Vogelstein, 1993, Genomics.

Circulating tumor DNA (ctDNA) as a marker of recurrence risk in stage II colon cancer (CC).

R. Strausberg, K. Kinzler, B. Vogelstein, 2014 .

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.

J. Ptak, K. Kinzler, B. Vogelstein, 2022, The New England journal of medicine.

High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2016, Virchows Archiv.

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2017, Virchows Archiv.

Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2016, Human pathology.

Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2019, Virchows Archiv.

Winning the War: Science Parkour

K. Kinzler, B. Vogelstein, 2012, Science Translational Medicine.

EcoRI polymorphism within the GLI gene (chromosome 12q13.3-14.1).

K. Kinzler, B. Vogelstein, 1990, Nucleic acids research.

Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor.

K. Kinzler, P. Newberne, Y. Beazer-Barclay, 1996, Cancer research.

Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies

K. Kinzler, C. Bettegowda, B. Vogelstein, 2014 .

p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage

K. Kinzler, B. Vogelstein, T. Jacks, 2007 .

Somatic Mutations in the Chromatin Remodeling Gene ARID1A Occur in Several Tumor Types

Meng Li, Christine A Iacobuzio-Donahue, Bert Vogelstein, 2011, Human mutation.

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

K. Kinzler, B. Vogelstein, T. Chan, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Genomic organization of the human PMS2 gene family.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1995, Genomics.

PAK 1 , a gene that can regulate p 53 activity in yeast ( tumor suppressor / transactivation / posttranslational modification / phosphorylation )

K. Kinzler, B. Vogelstein, S. Thiagalingam, 2005 .

Mutation Screening of the TNFRSF11A Gene Encoding Receptor Activator of NFkB (RANK) in Familial and Sporadic Paget's Disease of Bone and Osteosarcoma

M. Adams, A. Sparks, J. Venter, 2001, Calcified Tissue International.

SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

Giovanni Parmigiani, Amanda Blackford, Christine A Iacobuzio-Donahue, 2009, Clinical Cancer Research.

Comparative lesion sequencing provides insights into tumor evolution

Martin A. Nowak, Arne Traulsen, Niko Beerenwinkel, 2008, Proceedings of the National Academy of Sciences.

Prevalence of somatic alterations in the colorectal cancer cell genome

Giovanni Parmigiani, Tian-Li Wang, Carlo Rago, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Predictive Capacity of Personal Genome Sequencing

Giovanni Parmigiani, Bert Vogelstein, Joshua T Vogelstein, 2012, Science Translational Medicine.

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers

Giovanni Parmigiani, Bert Vogelstein, Kishore Guda, 2009, Proceedings of the National Academy of Sciences.

Characterization of human FAST-1, a TGF beta and activin signal transducer.

K. Kinzler, B. Vogelstein, L. Zawel, 1998, Molecular cell.

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

K. Kinzler, B. Vogelstein, L. Diaz, 2014, Journal of Immunotherapy for Cancer.

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, The Biochemical journal.

Conversion of diploidy to haploidy - Individuals susceptible to multigene disorders may now be spotted more easily.

A. Chapelle, K. Kinzler, B. Vogelstein, 2000 .

Classification of pancreatic cystic neoplasms using radiomic feature analysis is equivalent to an experienced academic radiologist: a step toward computer-augmented diagnostics for radiologists

Seyoun Park, L. Chu, K. Kinzler, 2022, Abdominal Radiology.

Erratum: Genetic determinants of p53-induced apoptosis and growth arrest ((Genes and Development (1996) 10 (1945-1952))

K. Kinzler, B. Vogelstein, K. Polyak, 1996 .

Advances in Brief X-Linked Inhibitor of Apoptosis Protein ( XIAP ) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand ( TRAIL )-Mediated Apoptosis in Human Cancer Cells

K. Kinzler, B. Vogelstein, J. Cummins, 2004 .

Detection of APC mutations in fecal DNA from patients with colorectal tumors.

K. Kinzler, B. Vogelstein, B. Levin, 2002, The New England journal of medicine.

Insertion/Deletion Polymorphism and Other Restriction Fragment Length Polymorphisms in the MCC Gene

Yusuke Nakamura, K. Kinzler, B. Vogelstein, 1992, Japanese journal of cancer research : Gann.

Families Evaluable by Linkage

K. Kinzler, B. Vogelstein, L. Aaltonen, 2007 .

The potential of circulating tumor DNA (ctDNA) to guide adjuvant chemotherapy decision making in locally advanced rectal cancer (LARC).

K. Kinzler, B. Vogelstein, P. Gibbs, 2017 .

The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19

S. Athey, J. Vogelstein, L. Rose, 2021, Frontiers in Medicine.

Relationship between gene amplification and chromosomal deviations in malignant human gliomas.

K. Kinzler, B. Vogelstein, D. Bigner, 1987, Cancer genetics and cytogenetics.

Bacteriolytic therapy can generate a potent immune response against experimental tumors.

Bert Vogelstein, Mitsuaki Tatsumi, Richard L Wahl, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Role of BAX in the apoptotic response to anticancer agents.

K. Kinzler, B. Vogelstein, Jian Yu, 2000, Science.

Cancer therapy meets p53.

K. Kinzler, B. Vogelstein, 1994, The New England journal of medicine.

Less death in the dying

K. Kinzler, B. Vogelstein, K. Polyak, 1997, Cell Death and Differentiation.

Classification of pancreatic cystic neoplasms using radiomic feature analysis is equivalent to an experienced academic radiologist: a step toward computer-augmented diagnostics for radiologists

Seyoun Park, L. Chu, K. Kinzler, 2022, Abdominal Radiology.

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

Robert S. Benjamin, Ravi Murthy, Bert Vogelstein, 2014, Science Translational Medicine.

Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

David R. Jones, K. Schuebel, M. Brock, 2021, Nature.

Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Yuchen Jiao, Yuxuan Wang, Bert Vogelstein, 2012, Cancer discovery.

Sensitive digital quantification of DNA methylation in clinical samples

S. Goodman, K. Kinzler, B. Vogelstein, 2009, Nature Biotechnology.

Targeted deletion of Smad 4 shows it is required for transforming growth factor b and activin signaling in colorectal cancer cells

K. Kinzler, B. Vogelstein, G. Riggins, 1998 .

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2016, Modern Pathology.

Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine–resistant cancer cells

K. Kinzler, B. Vogelstein, A. Bardelli, 2005, Molecular Cancer Therapeutics.

Familial and sporadic pancreatic cancer share the same molecular pathogenesis

K. Kinzler, B. Vogelstein, Siân Jones, 2015, Familial Cancer.

Characterization of the Yeast Transcriptome

Wei Zhou, Bert Vogelstein, Jacob V. Vogelstein, 1997, Cell.

Design, synthesis and evaluation of new RDP inhibitors

K. Kinzler, B. Vogelstein, P. Buckhaults, 2003 .

Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase.

K. Kinzler, B. Vogelstein, Saeed R. Khan, 2004, Bioorganic & medicinal chemistry letters.

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

K. Kinzler, B. Vogelstein, J. Taube, 2015, Journal of Immunotherapy for Cancer.

Inactivation of hCDC4 can cause chromosomal instability

Carlo Rago, Victor E. Velculescu, Bert Vogelstein, 2004, Nature.

Remote loading of preencapsulated drugs into stealth liposomes

Bert Vogelstein, Kenneth W. Kinzler, K. Kinzler, 2014, Proceedings of the National Academy of Sciences.

SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.

K. Kinzler, B. Vogelstein, Jian Yu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT

G. Parmigiani, K. Kinzler, C. Bettegowda, 2006, Nature Biotechnology.

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

T. Pawlik, L. Wood, K. Kinzler, 2013, Nature Genetics.

A protocol for rapid generation of recombinant adenoviruses using the AdEasy system

K. Kinzler, B. Vogelstein, T. He, 2007, Nature Protocols.

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis.

K. Kinzler, B. Vogelstein, T. Chan, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Targeting public neoantigens for cancer immunotherapy

K. Kinzler, C. Bettegowda, B. Vogelstein, 2021, Nature Cancer.

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

K. Kinzler, B. Vogelstein, G. Riggins, 2018, Nature.

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Bert Vogelstein, Sandra B Gabelli, Diana Mandelker, 2007, Science.

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

K. Kinzler, B. Vogelstein, L. Diaz, 2014, Journal of Immunotherapy for Cancer.

Epitope landscape in breast and colorectal cancer.

K. Kinzler, B. Vogelstein, V. Velculescu, 2008, Cancer research.

Assessing tumors in living animals through measurement of urinary β-human chorionic gonadotropin

K. Kinzler, B. Vogelstein, D. Chan, 2000, Nature Medicine.

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A

K. Kinzler, B. Vogelstein, J. Ruppert, 1991, Molecular and cellular biology.

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity

K. Kinzler, B. Vogelstein, J. Ruppert, 1990, Molecular and cellular biology.

The GLI-Kruppel family of human genes

S. O’Brien, K. Kinzler, B. Vogelstein, 1988, Molecular and cellular biology.

The GLI gene is a member of the Kruppel family of zinc finger proteins

Bert Vogelstein, Kenneth W. Kinzler, K. Kinzler, 1988, Nature.

Whole‐exome sequencing of pancreatic neoplasms with acinar differentiation

J. Herman, L. Wood, K. Kinzler, 2014, The Journal of pathology.

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

K. Kinzler, B. Vogelstein, E. Stanbridge, 1992, Molecular and cellular biology.

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

K. Kinzler, B. Vogelstein, T. Jacks, 1995, Genes & development.

Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

K. Kinzler, C. Bettegowda, B. Vogelstein, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells

Bert Vogelstein, Kenneth W. Kinzler, K. Kinzler, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.

K. Kinzler, B. Vogelstein, B. Park, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Effective expression of small interfering RNA in human cells

A. Sparks, K. Kinzler, B. Vogelstein, 2022 .

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

R. McLendon, A. Friedman, K. Kinzler, 2012, Oncotarget.

Mutations of mitotic checkpoint genes in human cancers

Bert Vogelstein, Kenneth W. Kinzler, Christoph Lengauer, 1998, Nature.

PUMA induces the rapid apoptosis of colorectal cancer cells.

K. Kinzler, B. Vogelstein, Jian Yu, 2001, Molecular cell.

Top-down morphogenesis of colorectal tumors

K. Kinzler, B. Vogelstein, I. Shih, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

J. Ptak, K. Kinzler, C. Bettegowda, 2015, Proceedings of the National Academy of Sciences.

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

K. Kinzler, B. Vogelstein, Jian Yu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Gene expression analysis goes digital

K. Kinzler, V. Velculescu, Victor E Velculescu, 2007, Nature Biotechnology.

Genetic Progression and the Waiting Time to Cancer

Martin A. Nowak, Arne Traulsen, Niko Beerenwinkel, 2007, PLoS Comput. Biol..

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

K. Kinzler, B. Vogelstein, V. Velculescu, 2007, Proceedings of the National Academy of Sciences.

Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers

Giovanni Parmigiani, Tian-Li Wang, Brock A. Peters, 2004, Science.

Three classes of genes mutated in colorectal cancers with chromosomal instability.

J. Ptak, K. Kinzler, B. Vogelstein, 2004, Cancer research.

Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

Giovanni Parmigiani, Bert Vogelstein, Sanford Markowitz, 2003, Nature Reviews Cancer.

Targeting loss of heterozygosity for cancer-specific immunotherapy

K. Kinzler, C. Bettegowda, B. Vogelstein, 2021, Proceedings of the National Academy of Sciences.

BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions

Frank Diehl, Bert Vogelstein, Yiping He, 2006, Nature Methods.

Landscaping the Cancer Terrain

K. Kinzler, B. Vogelstein, 1998, Science.

Patient-oriented gene set analysis for cancer mutation data

Giovanni Parmigiani, Bert Vogelstein, Simina M Boca, 2010, Genome Biology.

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

Akhilesh Pandey, Christine A Iacobuzio-Donahue, Anthony Gacita, 2015, Genome research.

Identification of microbial DNA in human cancer

Tian-Li Wang, Bert Vogelstein, C. Schaefer, 2009, BMC Medical Genomics.

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

David R. Jones, K. Schuebel, M. Brock, 2021, Nature.

PI3Kα Inhibitors That Inhibit Metastasis

K. Kinzler, B. Vogelstein, Shibin Zhou, 2010, Oncotarget.

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

Michael A. Choti, Yuchen Jiao, Victor E. Velculescu, 2011, Science.

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

Tian-Li Wang, Kentaro Nakayama, Bert Vogelstein, 2010, Science.

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas

Yuchen Jiao, Jinyong Luo, Tong-Chuan He, 2014, Genes, chromosomes & cancer.

Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma

L. Wood, K. Kinzler, B. Vogelstein, 2016, Cancer Prevention Research.

Has the breast cancer gene been found?

K. Kinzler, B. Vogelstein, 1994, Cell.

Somatic mutations of the mitochondrial genome in human colorectal tumours

Bert Vogelstein, Kenneth W. Kinzler, Kornelia Polyak, 1998, Nature Genetics.

The Path to Cancer --Three Strikes and You're Out.

Bert Vogelstein, K. Kinzler, B. Vogelstein, 2015, The New England journal of medicine.

APC mutations occur early during colorectal tumorigenesis

Bert Vogelstein, Kenneth W. Kinzler, Stanley R. Hamilton, 1992, Nature.

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.

K. Kinzler, B. Vogelstein, H. Hermeking, 1999, Nature.

MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

K. Kinzler, B. Vogelstein, R. Ward, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

K. Kinzler, N. Papadopoulos, J. Jass, 1996, Nature Medicine.

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

D. Ledbetter, K. Kinzler, C. Bettegowda, 2020, Science.

Founding mutations and Alu-mediated recombination in hereditary colon cancer

K. Kinzler, B. Vogelstein, L. Aaltonen, 1995, Nature Medicine.

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

K. Kinzler, B. Vogelstein, R. Karchin, 2013, Science Translational Medicine.

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

Bert Vogelstein, Kenneth W. Kinzler, Christoph Lengauer, 1996, Nature.

Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

Alexander V. Favorov, L. Cope, K. Kinzler, 2021, eLife.

Precancerous neoplastic cells can move through the pancreatic ductal system

Johannes G. Reiter, Jeffrey M. Gerold, M. Nowak, 2018, Nature.

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Ludmila V. Danilova, L. Cope, K. Kinzler, 2019, Journal of Immunotherapy for Cancer.

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

J. Herman, S. Baylin, K. Kinzler, 2003, Cancer cell.

CpG methylation is maintained in human cancer cells lacking DNMT1

J. Herman, K. Schuebel, S. Baylin, 2000, Nature.

Tumor DNA as a Cancer Biomarker through the Lens of Colorectal Neoplasia

K. Kinzler, N. Papadopoulos, J. Cohen, 2020, Cancer Epidemiology, Biomarkers & Prevention.

Revisiting the tumorigenesis timeline with a data-driven generative model

D. Geman, L. Younes, K. Kinzler, 2019, Proceedings of the National Academy of Sciences.

An analysis of genetic heterogeneity in untreated cancers

Johannes G. Reiter, Jeffrey M. Gerold, K. Kinzler, 2019, Nature Reviews Cancer.

Minimal functional driver gene heterogeneity among untreated metastases

Johannes G. Reiter, Jeffrey M. Gerold, M. Nowak, 2018, Science.

Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2017, Proceedings of the National Academy of Sciences.

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

K. Kinzler, B. Vogelstein, L. Diaz, 2015, Proceedings of the National Academy of Sciences.

Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis

Yusuke Nakamura, K. Kinzler, G. Petersen, 1993, Human Genetics.

Mechanisms underlying losses of heterozygosity in human colorectal cancers

K. Kinzler, B. Vogelstein, J. Willson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

K. Kinzler, B. Vogelstein, V. Velculescu, 2016, Nature Communications.

The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene

K. Kinzler, B. Vogelstein, A. Levine, 2006 .

NORF5/HUG1 Is a Component of theMEC1-Mediated Checkpoint Response to DNA Damage and Replication Arrest in Saccharomyces cerevisiae

K. Kinzler, V. Velculescu, P. Hieter, 1999, Molecular and Cellular Biology.

Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.

K. Kinzler, B. Vogelstein, V. Velculescu, 2007, Cancer research.

Analysis of Circulating DNA Serial Assessment of Human Tumor Burdens in Mice by the

K. Kinzler, B. Vogelstein, V. Velculescu, 2007 .

Massively Parallel Sequencing of Esophageal Brushings Enables an Aneuploidy-Based Classification of Patients with Barrett's Esophagus.

K. Kinzler, C. Bettegowda, B. Vogelstein, 2021, Gastroenterology.

Exome sequencing identifies frequent inactivating mutations in BAP 1 , ARID 1 A and PBRM 1 in intrahepatic cholangiocarcinomas

Aldo, Nickolas, Scarpa, 2014 .

Exomic Sequencing of Four Rare Central Nervous System Tumor Types

Gary L. Gallia, Yuchen Jiao, Yuxuan Wang, 2013, Oncotarget.

DNA methylation and genetic instability in colorectal cancer cells.

K. Kinzler, B. Vogelstein, C. Lengauer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

ATM mutations in patients with hereditary pancreatic cancer.

Yuchen Jiao, Michele L Cote, Bert Vogelstein, 2012, Cancer discovery.

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer.

J. Potash, P. Zandi, L. Wood, 2016, Cancer discovery.

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

Giovanni Parmigiani, Amanda Blackford, Victor E. Velculescu, 2012, Nature Genetics.

Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

Klaus Pantel, K. Kinzler, E. Diamandis, 2016, Clinical chemistry.

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

K. Kinzler, B. Vogelstein, D. Mandelker, 2009, Proceedings of the National Academy of Sciences.

Genetic instability and darwinian selection in tumours.

K. Kinzler, B. Vogelstein, D. Cahill, 1999, Trends in cell biology.

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

K. Kinzler, C. Bettegowda, B. Vogelstein, 2015, Science Translational Medicine.

STATISTICAL METHODS FOR THE ANALYSIS OF CANCER GENOME SEQUENCING DATA

Giovanni Parmigiani, Bert Vogelstein, Kenneth W. Kinzler, 2007 .

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

M. Pittman, K. Kinzler, B. Vogelstein, 2016, Gastroenterology.

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

K. Kinzler, B. Vogelstein, T. Chan, 1999, Cell.

Association between wild type and mutant APC gene products.

K. Kinzler, B. Vogelstein, L. Su, 1993, Cancer research.

In vivo cloning of PCR products in E. coli.

K. Kinzler, B. Vogelstein, J. Oliner, 1993, Nucleic acids research.

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

K. Kinzler, B. Vogelstein, Jian Yu, 2001, Nature Medicine.

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.

G. Parmigiani, M. Choti, K. Kinzler, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Securin Is Required for Chromosomal Stability in Human Cells

Michael R. Speicher, Bert Vogelstein, Kenneth W. Kinzler, 2001, Cell.

Identification and classification of p 53-regulated genes

K. Kinzler, B. Vogelstein, Jian Yu, 1999 .

Leary Patients with Whole-Genome Sequencing Detection of Chromosomal Alterations in the Circulation of Cancer

Shaughnessy, G. Parmigiani, J. Carpten, 2012 .

Low‐grade serous carcinomas of the ovary contain very few point mutations

K. Kinzler, B. Vogelstein, V. Velculescu, 2012, The Journal of pathology.

Counting alleles to predict recurrence of early-stage colorectal cancers

S. Goodman, M. Choti, E. Montgomery, 2002, The Lancet.

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

K. Kinzler, B. Vogelstein, V. Velculescu, 2010, Proceedings of the National Academy of Sciences.

Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients.

S. Goodman, K. Kinzler, B. Vogelstein, 2008, Gastroenterology.

Carcinogen-specific induction of genetic instability

K. Kinzler, B. Vogelstein, D. Cahill, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

K. Kinzler, B. Vogelstein, G. Riggins, 2015, Oncotarget.

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria

Bert Vogelstein, Kenneth W. Kinzler, Chetan Bettegowda, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The Structure of a Human p110a/p85a Complex Elucidates the Effects of Oncogenic PI3Ka Mutations

K. Kinzler, B. Vogelstein, V. Velculescu, 2007 .

IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients

K. Kinzler, B. Vogelstein, L. Diaz, 2011, Oncotarget.

The role of companion diagnostics in the development and use of mutation-targeted cancer therapies

Bert Vogelstein, K. Kinzler, B. Vogelstein, 2006, Nature Biotechnology.

Detection and quantification of mutations in the plasma of patients with colorectal tumors.

Frank Diehl, Bert Vogelstein, Steven N Goodman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

M. Makary, S. Hanash, Song-Cheol Kim, 2017, Proceedings of the National Academy of Sciences.

Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

Yuchen Jiao, Ami A. Shah, Bert Vogelstein, 2014, Science.

Human Smad3 and Smad4 are sequence-specific transcription activators.

K. Kinzler, B. Vogelstein, S. Kern, 1998, Molecular cell.

Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation

K. Kinzler, B. Vogelstein, T. Chan, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Lessons from Hereditary Review Colorectal Cancer

K. Kinzler, B. Vogelstein, 1996 .

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Michelle S. Miller, K. Kinzler, C. Bettegowda, 2021, Nature Communications.

Frequency of Smad gene mutations in human cancers.

K. Kinzler, B. Vogelstein, G. Riggins, 1997, Cancer research.

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

Arthur P. Grollman, Bert Vogelstein, Kenneth W. Kinzler, 2016, Proceedings of the National Academy of Sciences.

Small changes in expression affect predisposition to tumorigenesis

K. Kinzler, B. Vogelstein, S. Gruber, 2002, Nature Genetics.

In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3–14.1

K. Kinzler, B. Vogelstein, F. Mitelman, 1989, Human Genetics.

Molecular genetic profiles of colitis-associated neoplasms.

K. Kinzler, C. Caldas, S. Kern, 1994, Gastroenterology.

Breast and Colorectal Cancers The Consensus Coding Sequences of Human

G. Parmigiani, J. Ptak, L. Wood, 2007 .

PRL-3 expression in metastatic cancers.

K. Kinzler, B. Vogelstein, V. Velculescu, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine.

K. Kinzler, B. Vogelstein, R. Hruban, 2013, Cancer research.

PPAR d Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

K. Kinzler, B. Vogelstein, T. Chan, 1999 .

Somatic mutations of EGFR in colorectal cancers and glioblastomas.

K. Kinzler, B. Vogelstein, V. Velculescu, 2004, The New England journal of medicine.

Applications of liquid biopsies for cancer

K. Kinzler, C. Bettegowda, B. Vogelstein, 2019, Science Translational Medicine.

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer.

J. Ptak, K. Kinzler, B. Vogelstein, 2019, JAMA oncology.

Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

K. Kinzler, B. Vogelstein, L. Su, 1992, Science.

Oncogenic forms of p53 inhibit p53-regulated gene expression.

K. Kinzler, B. Vogelstein, S. Kern, 1992, Science.

Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.

K. Kinzler, B. Vogelstein, S. Thibodeau, 2012, Gastroenterology.

Targeted inactivation of p53 in human cells does not result in aneuploidy.

K. Kinzler, B. Vogelstein, C. Fauth, 2002, Cancer research.

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

L. Wood, E. Montgomery, K. Kinzler, 2014, Nature Genetics.

Conversion of diploidy to haploidy

James R. Eshleman, Bert Vogelstein, Kenneth W. Kinzler, 2000, Nature.

p53 tagged sites from human genomic DNA.

K. Kinzler, B. Vogelstein, T. Tokino, 1994, Human molecular genetics.

Genetic determinants of p53-induced apoptosis and growth arrest.

K. Kinzler, B. Vogelstein, K. Polyak, 1996, Genes & development.

Aristolochic Acid in the Etiology of Renal Cell Carcinoma

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2016, Cancer Epidemiology, Biomarkers & Prevention.

Targeting a neoantigen derived from a common TP53 mutation

Michelle S. Miller, K. Kinzler, C. Bettegowda, 2021, Science.

Combinatorial chemoprevention of intestinal neoplasia

Bert Vogelstein, Kenneth W. Kinzler, Allan Wissner, 2000, Nature Medicine.

Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity

K. Kinzler, B. Vogelstein, R. Hruban, 2012, Clinical Cancer Research.

Cancer‐Associated Mutations in Endometriosis without Cancer

L. Wood, K. Kinzler, B. Vogelstein, 2017, The New England journal of medicine.

Somatic Mutations in CCK2R Alter Receptor Activity that Promote Oncogenic Phenotypes

K. Kinzler, B. Vogelstein, V. Velculescu, 2012, Molecular Cancer Research.

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

K. Kinzler, B. Vogelstein, G. Riggins, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis of nSH2 regulation and lipid binding in PI3Kα

L. Mario Amzel, Philip E. Thompson, Bert Vogelstein, 2014, Oncotarget.

Structural basis of nSH 2 regulation and lipid binding in PI 3 Kα

Michelle S. Miller, K. Kinzler, B. Vogelstein, 2014 .

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

K. Kinzler, B. Vogelstein, D. Chan, 2004, Clinical Cancer Research.

TEM8 Interacts with the Cleaved C5 Domain of Collagen α3(VI)

K. Kinzler, B. Vogelstein, S. Seaman, 2004, Cancer Research.

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.

M. Kanda, K. Kinzler, B. Vogelstein, 2012, Gastroenterology.

Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers

A. Venkatesan, K. Kinzler, C. Bettegowda, 2021, Journal for ImmunoTherapy of Cancer.

Contribution of bone marrow–derived endothelial cells to human tumor vasculature

B. Peters, K. Kinzler, B. Vogelstein, 2005, Nature Medicine.

FAST-SeqS: A Simple and Efficient Method for the Detection of Aneuploidy by Massively Parallel Sequencing

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2012, PloS one.

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Bert Vogelstein, Sandra B Gabelli, Michelle S. Miller, 2017, Bioorganic & medicinal chemistry.

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

K. Kinzler, B. Vogelstein, L. Diaz, 2009, Proceedings of the National Academy of Sciences.

Oncogenic forms of p53 inhibit p53-regulated gene expression

K. Kinzler, B. Vogelstein, S. Kern, 1992 .

Characterization of MAD2B and other mitotic spindle checkpoint genes.

K. Kinzler, B. Vogelstein, D. Cahill, 1999, Genomics.

Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.

K. Kinzler, B. Vogelstein, D. Huso, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche.

K. Kinzler, B. Vogelstein, E. Fishman, 2014, Cancer research.

Mononucleotide Repeat Sequence Variability in Mismatch Repair-deficient Cancers 1

K. Kinzler, B. Vogelstein, Jian Yu, 2001 .

CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling

Tong-Chuan He, Bert Vogelstein, Kornelia Polyak, 1999, Oncogene.

Apoptosis and APC in colorectal tumorigenesis.

K. Kinzler, B. Vogelstein, P. Morin, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Polymerase δ variants in RER colorectal tumours

A. Chapelle, K. Kinzler, B. Vogelstein, 1995, Nature Genetics.

The potential of circulating tumor DNA (ctDNA) to reshape the design of clinical trials testing adjuvant therapy in patients with early stage cancers.

R. Strausberg, K. Kinzler, B. Vogelstein, 2016 .

X-rays strike p53 again

Bert Vogelstein, Kenneth W. Kinzler, K. Kinzler, 1994, Nature.

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

Michael A Choti, Bert Vogelstein, Timothy M Pawlik, 2011, Nature Genetics.

Incidence and Distribution of UroSEEK Gene Panel in a Multi-institutional Cohort of Bladder Urothelial Carcinoma

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2019, Modern Pathology.

Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2019, Human pathology.

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Ludmila V. Danilova, J. Ptak, K. Kinzler, 2018, eLife.

Asef , a Link Between the Tumor Suppressor APC and G-Protein Signaling

K. Kinzler, B. Vogelstein, V. Velculescu, 2022 .

Counting alleles reveals a connection between chromosome 18q loss and vascular invasion

Michael A. Choti, Steven N. Goodman, Wei Zhou, 2001, Nature Biotechnology.

Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2007, Journal of the National Cancer Institute.

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions

K. Kinzler, I. Shih, Tian-Li Wang, 2019, The Journal of pathology.

University of Southern Denmark Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

J. Ptak, K. Kinzler, B. Vogelstein, 2018 .

Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2013, Journal of Neuro-Oncology.

Genetic mutations associated with cigarette smoking in pancreatic cancer.

G. Parmigiani, J. Cameron, K. Kinzler, 2009, Cancer research.

A nanoparticle formulation that selectively transfects metastatic tumors in mice

K. Kinzler, B. Vogelstein, Shibin Zhou, 2013, Proceedings of the National Academy of Sciences.

What's mice got to do with it?

K. Kinzler, B. Vogelstein, 1996, Nature.

Alpha-1 adrenergic receptor antagonists for preventing acute respiratory distress syndrome and death from cytokine storm syndrome.

E. Stuart, S. Athey, J. Vogelstein, 2020, ArXiv.

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Zev A. Binder, K. Kinzler, C. Bettegowda, 2018, Nature Communications.

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

E. Stuart, S. Athey, J. Vogelstein, 2020, eLife.

Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists.

S. Athey, J. Vogelstein, B. Mensh, 2020, The Journal of clinical investigation.

Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.

K. Kinzler, B. Vogelstein, Hai Yan, 2002, Cancer research.

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.

K. Kinzler, B. Vogelstein, R. Hruban, 2012, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Life (and death) in a malignant tumour

K. Kinzler, B. Vogelstein, 1996, Nature.

Cooperative effects of genes controlling the G(2)/M checkpoint.

K. Kinzler, B. Vogelstein, H. Hermeking, 2000, Genes & development.

Expression of the APC tumor suppressor protein in oligodendroglia

K. Kinzler, J. Baraban, R. Bhat, 1996, Glia.

Achilles' heel of cancer?

K. Kinzler, B. Vogelstein, 2001, Nature.

Bispecific antibodies targeting mutant RAS neoantigens

Michelle S. Miller, K. Kinzler, C. Bettegowda, 2021, Science Immunology.

GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as “Incipient IPMNs”

G. Kristiansen, K. Kinzler, B. Vogelstein, 2014, The American journal of surgical pathology.

Cell surface tumor endothelial markers are conserved in mice and humans.

K. Kinzler, B. Vogelstein, D. N. Watkins, 2001, Cancer research.

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Young Joon Ahn, Elliot K. Fishman, Yuxuan Wang, 2017, J. Am. Medical Informatics Assoc..

Through the Glass Lightly

K. Kinzler, B. Vogelstein, 1995, Science.

Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2011, Blood.

Mutant proteins as cancer-specific biomarkers

K. Kinzler, B. Vogelstein, R. Hruban, 2011, Proceedings of the National Academy of Sciences.

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.

L. Wood, K. Kinzler, C. Bettegowda, 2013, The Journal of clinical endocrinology and metabolism.

Use of isogenic human cancer cells for high-throughput screening and drug discovery

K. Kinzler, B. Vogelstein, C. Torrance, 2001, Nature Biotechnology.

Large-scale identification of novel transcripts in the human genome.

B. Peters, J. Ptak, K. Kinzler, 2007, Genome research.

Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia

K. Kinzler, B. Vogelstein, V. Velculescu, 2011, Leukemia.

A diaCEST MRI approach for monitoring liposomal accumulation in tumors.

K. Kinzler, B. Vogelstein, J. Bulte, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis

M. Choti, K. Kinzler, B. Vogelstein, 2011, Clinical Cancer Research.

Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies

J. Ptak, K. Kinzler, B. Vogelstein, 2020, International journal of cancer.

Tumour suppression: Disruption of HAUSP gene stabilizes p53

Carlo Rago, Bert Vogelstein, Kenneth W. Kinzler, 2004, Nature.

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Michelle S. Miller, K. Kinzler, B. Vogelstein, 2019, The Journal of Biological Chemistry.

Three dinucleotide repeat polymorphisms proximal to the D2S123 locus.

K. Kinzler, B. Vogelstein, J. Yu, 1994, Human molecular genetics.

TCR β chain–directed bispecific antibodies for the treatment of T cell cancers

K. Kinzler, C. Bettegowda, B. Vogelstein, 2021, Science Translational Medicine.

Allelotype of pancreatic adenocarcinoma.

C Caldas, R H Hruban, K. Kinzler, 1994, Cancer research.

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

K. Kinzler, B. Vogelstein, G. Riggins, 2018, Nature.

An isogenic cell line panel for sequence-based screening of targeted anticancer drugs

K. Kinzler, C. Bettegowda, B. Vogelstein, 2021, bioRxiv.

Diagnostic potential of tumor DNA from ovarian cyst fluid

K. Kinzler, B. Vogelstein, L. Diaz, 2016, eLife.

The rapid and highly parallel identification of antibodies with defined biological activities by SLISY

K. Kinzler, C. Bettegowda, B. Vogelstein, 2023, Nature Communications.

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke

M. Meyerson, J. Derisi, L. Wood, 2015, Head & neck.

Response to Comments on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"

Giovanni Parmigiani, Victor E. Velculescu, Bert Vogelstein, 2007, Science.

Cancer in Predisposing to Colorectal hPMS 2 and hPMS 1 The Role of Updated Version

K. Kinzler, B. Vogelstein, Hai Yan, 2001 .

The Role of hPMS 1 and hPMS 2 in Predisposing to Colorectal Cancer 1

K. Kinzler, B. Vogelstein, Hai Yan, 2001 .

Spore Coat Architecture of Clostridium novyi NT Spores

K. Kinzler, C. Bettegowda, B. Vogelstein, 2007, Journal of bacteriology.

A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype

K. Kinzler, B. Vogelstein, P. Modrich, 1998, Molecular and Cellular Biology.

Non-invasive detection of bladder cancer through the analysis of driver gene 1 mutations and aneuploidy 2 3

Nickolas, Natalie, J. Ptak, 2017 .

Hyper-recombination and genetic instability in BLM-deficient epithelial cells.

K. Kinzler, C. Bettegowda, B. Vogelstein, 2003, Cancer research.

Monoallelic mutation analysis (MAMA) for identifying germline mutations

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1995, Nature Genetics.

Familial and sporadic pancreatic cancer share the same molecular pathogenesis

K. Kinzler, B. Vogelstein, Siân Jones, 2014, Familial Cancer.

The DCC gene product in cellular differentiation and colorectal tumorigenesis.

Kathleen R. Cho, K. Kinzler, B. Vogelstein, 1994, Genes & development.

Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation.

K. Kinzler, B. Vogelstein, R. Hruban, 2015, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis

L. Wood, K. Kinzler, B. Vogelstein, 2015, Clinical Cancer Research.

Assessing aneuploidy with repetitive element sequencing

Tian-Li Wang, Rachel Karchin, Robert E. Schoen, 2019, Proceedings of the National Academy of Sciences.

Genotyping by mass spectrometric analysis of short DNA fragments

K. Kinzler, B. Vogelstein, J. Groopman, 1998, Nature Biotechnology.

GNAS Codon 201 mutations are uncommon in Intraductal Papillary Neoplasms of the Bile Duct

K. Kinzler, B. Vogelstein, R. Hruban, 2012 .

A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles

K. Kinzler, B. Vogelstein, G. Riggins, 2011, Oncotarget.

Polymerase delta variants in RER colorectal tumours.

K. Kinzler, B. Vogelstein, A. de la Chapelle, 1995, Nature genetics.

Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study

J. Ptak, K. Kinzler, B. Vogelstein, 2021, PLoS medicine.

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.

K. Kinzler, N. Papadopoulos, C. Caldas, 1995, Gastroenterology.

Non-invasive detection of upper tract urothelial carcinomas through the analysis of driver gene mutations and aneuploidy in urine

Ludmila V. Danilova, J. Ptak, K. Kinzler, 2017, bioRxiv.

Targeted Inactivation of p 53 in Human Cells Does Not Result in Aneuploidy 1

K. Kinzler, B. Vogelstein, C. Fauth, 2002 .

Detection of Somatic TP53 Mutations in Tampons of Patients With High-Grade Serous Ovarian Cancer

K. Kinzler, B. Vogelstein, L. Diaz, 2014, Obstetrics and gynecology.

Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

K. Kinzler, C. Bettegowda, B. Vogelstein, 2013, Science Translational Medicine.

Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules.

J. Ptak, K. Kinzler, C. Bettegowda, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers

J. Ptak, L. Wood, K. Kinzler, 2006, Human mutation.

Cancer, crash sites, and the new genetics of neoplasia.

K. Kinzler, B. Vogelstein, S. Gruber, 1999, Gastroenterology.

Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands

J. Ptak, K. Kinzler, B. Vogelstein, 2021, Nature Biotechnology.

β-Catenin Mutations: Insights into the APC Pathway and the Power of Genetics.

A. Sparks, K. Kinzler, P. Morin, 2016, Cancer Research.

Advances in Brief Cell Surface Tumor Endothelial Markers Are Conserved in Mice and Humans 1

K. Kinzler, B. Vogelstein, D. N. Watkins, 2001 .

Targeting the catecholamine-cytokine axis to prevent SARS-CoV-2 cytokine storm syndrome

S. Athey, J. Vogelstein, B. Mensh, 2020, medRxiv.

TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).

K. Kinzler, B. Vogelstein, S. Seaman, 2004, Cancer research.

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Zev A. Binder, K. Kinzler, C. Bettegowda, 2018, Nature Communications.

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

K. Kinzler, B. Vogelstein, P. Gibbs, 2019, International journal of cancer.

Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

J. Ptak, K. Kinzler, B. Vogelstein, 2018, eLife.

Serial circulating tumor DNA (ctDNA) analysis as a prognostic marker and a real-time indicator of adjuvant chemotherapy (CT) efficacy in stage III colon cancer (CC).

K. Kinzler, B. Vogelstein, P. Gibbs, 2018 .

Converting cancer genes into killer genes.

K. Kinzler, B. Vogelstein, J. Jen, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R

K. Kinzler, B. Vogelstein, S. Seaman, 2004, Cancer Research.

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.

J. Herman, S. Baylin, K. Kinzler, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Circulating tumor DNA as a prognostic biomarker in early stage pancreatic cancer.

K. Kinzler, B. Vogelstein, P. Gibbs, 2018 .

Serial circulating tumor DNA (ctDNA) and recurrence risk in patients (pts) with resectable colorectal liver metastasis (CLM).

R. Strausberg, K. Kinzler, B. Vogelstein, 2016 .

Research Corrigenda

S. Goodman, M. Choti, E. Montgomery, 2001, Nature Biotechnology.

Mutation of a mutL homolog in hereditary colon cancer.

R. Fleischmann, M. Adams, J. Venter, 1994, Science.

Genes expressed in human tumor endothelium.

K. Kinzler, B. Vogelstein, V. Velculescu, 2000, Science.

Alpha-1 adrenergic receptor antagonists prevent acute respiratory distress syndrome and death: implications for Coronavirus disease 2019

S. Athey, J. Vogelstein, B. Mensh, 2020 .

The molecular basis of Turcot's syndrome.

K. Kinzler, B. Vogelstein, Z. Cohen, 1995, The New England journal of medicine.

Identification of p53 as a sequence-specific DNA-binding protein

K. Kinzler, B. Vogelstein, S. Kern, 1991, Science.

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

K. Kinzler, B. Vogelstein, Y. Nakamura, 1991, Science.

APC binds to the novel protein EB1.

R. Brent, J. Trent, K. Kinzler, 1995, Cancer research.

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

T. Pollard, K. Kinzler, B. Vogelstein, 1994, Cancer research.

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

K. Kinzler, B. Vogelstein, D. Bigner, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies.

J. Trent, K. Kinzler, B. Vogelstein, 1995, Cytogenetics and cell genetics.

Identification of FAP locus genes from chromosome 5q21.

S. Altschul, M. Boguski, K. Kinzler, 1991, Science.

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

P. Meltzer, K. Kinzler, B. Vogelstein, 1993, Cancer research.

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

K. Kinzler, B. Vogelstein, Y. Miki, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Molecular diagnosis of familial adenomatous polyposis.

K. Kinzler, B. Vogelstein, J. Jen, 1993, The New England journal of medicine.

Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.

K. Kinzler, B. Vogelstein, B. Levin, 1992, Science.

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.

K. Kinzler, B. Vogelstein, L. Myeroff, 1995, Science.

The Structure of a Human p 110 a / p 85 a Complex Elucidates the Effects of Oncogenic PI 3 K a Mutations

L. Mario Amzel, Victor E. Velculescu, Bert Vogelstein, 2007 .

Identification of an amplified, highly expressed gene in a human glioma.

J. Trent, S. O’Brien, D. Bigner, 1987, Science.

Clues to the pathogenesis of familial colorectal cancer.

K. Kinzler, B. Vogelstein, L. Aaltonen, 1993, Science.

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

K. Kinzler, B. Vogelstein, Y. Nakamura, 1992, Cancer research.

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

K. Kinzler, B. Vogelstein, L. Myeroff, 1995, Cancer research.

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

K. Kinzler, B. Vogelstein, A. de la Chapelle, 1994, Cancer research.

Allelic loss of chromosome 18q and prognosis in colorectal cancer.

Z. F. Liu, K. Kinzler, B. Vogelstein, 1994, The New England journal of medicine.

The Genetic Basis of Human Cancer

K. Kinzler, B. Vogelstein, 1997 .

Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia.

K. Kinzler, B. Vogelstein, K. Polyak, 1996, The American journal of pathology.

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.

S. Goodman, K. Kinzler, B. Vogelstein, 2001, Cancer research.

APC mutations in colorectal tumors with mismatch repair deficiency.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Cancer risk associated with germline DNA mismatch repair gene mutations.

A D Carothers, K. Kinzler, B. Vogelstein, 1997, Human molecular genetics.

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

K. Kinzler, B. Vogelstein, V. Velculescu, 1995, Cancer research.

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

Kathleen R. Cho, K. Kinzler, B. Vogelstein, 1995, Cancer research.

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

K. Kinzler, B. Vogelstein, S. Hamilton, 1991, Science.

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

James M. Roberts, B. Trask, K. Kinzler, 1995, Cancer research.

Inactivation of both APC alleles in human and mouse tumors.

K. Kinzler, B. Vogelstein, K. Kinzler, 1994, Cancer research.

Molecular determinants of dysplasia in colorectal lesions.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1994, Cancer research.

Amplification of cyclin genes in colorectal carcinomas.

S. Elledge, K. Kinzler, B. Vogelstein, 1993, Cancer research.

Hereditary Nonpolyposis Colorectal Cancer Patients Replication Errors in Benign and Malignant Tumors from

H T Lynch, K. Kinzler, B. Vogelstein, 2006 .

TCR-mimic bispecific antibodies to target the HIV-1 reservoir

R. Siliciano, K. Kinzler, B. Vogelstein, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

K. Kinzler, B. Vogelstein, L. Myeroff, 1999, Cancer research.

APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis.

K. Kinzler, B. Vogelstein, S. Gruber, 1997, Gut.

Mutations of GTBP in genetically unstable cells.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1995, Science.

Mismatch repair deficiency in phenotypically normal human cells

K. Kinzler, B. Vogelstein, R. Parsons, 1995, Science.

The APC gene product in normal and tumor cells.

K. Kinzler, B. Vogelstein, J. Willson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Sulindac suppresses tumorigenesis in the Min mouse.

K. Kinzler, B. Vogelstein, S. Hamilton, 1996, Carcinogenesis.

Secreted and cell surface genes expressed in benign and malignant colorectal tumors.

K. Kinzler, B. Vogelstein, P. Buckhaults, 2001, Cancer research.

Paradoxical inhibition of solid tumor cell growth by bcl2.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 1994, Cancer research.

Advances in Brief HMSH 2 Mutations in Hereditary Nonpolyposis Colorectal Cancer Kindreds 1

A. Chapelle, K. Kinzler, B. Vogelstein, 2006 .

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.

K. Kinzler, B. Vogelstein, C. Rago, 2004, Cancer research.

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.

A. Sparks, K. Kinzler, B. Vogelstein, 1999, Oncogene.

A public database for gene expression in human cancers.

S. Altschul, R. Strausberg, R. McLendon, 1999, Cancer research.

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, Australian journal of chemistry.

The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.

K. Kinzler, B. Vogelstein, I. Shih, 2000, Cancer research.

Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model.

K. Kinzler, B. Vogelstein, J. Geschwind, 2016, Biochemical and biophysical research communications.

Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

Christopher M. Jackson, J. Ptak, K. Kinzler, 2022, medRxiv.

Detecting colorectal cancer in stool with the use of multiple genetic targets.

S. Goodman, K. Kinzler, B. Vogelstein, 2001, Journal of the National Cancer Institute.

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

K. Kinzler, B. Vogelstein, L. Myeroff, 1995, Cancer research.

Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen

K. Kinzler, C. Bettegowda, B. Vogelstein, 2023, Nature communications.

1213 Hydrophobic interactions underlie recognition of a KRAS G12V neoantigen by a TCR-mimic antibody

K. Kinzler, B. Vogelstein, Shibin Zhou, 2022, Regular and Young Investigator Award Abstracts.

A retrospective clinical study supporting the rationale for trials of Alpha-1 Adrenoreceptor Antagonists to prevent cytokine storm and severe COVID-19

S. Athey, J. Vogelstein, B. Mensh, 2020 .

Deletion of p16 and p15 genes in brain tumors.

K. Kinzler, B. Vogelstein, D. Bigner, 1994, Cancer research.

Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers.

K. Kinzler, B. Vogelstein, Jian Yu, 2001, Cancer research.

Human Cancer Biology Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis

M. Choti, K. Kinzler, B. Vogelstein, 2011 .

Molecular cloning of the N-terminus of GTBP.

K. Kinzler, B. Vogelstein, J. Jiricny, 1996, Genomics.

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.

A. Chapelle, K. Kinzler, B. Vogelstein, 1994, American journal of human genetics.

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

K. Kinzler, C. Bettegowda, B. Vogelstein, 2023, bioRxiv.

References and Notes Supporting Online Material Predictive Codes for Forthcoming Perception in the Frontal Cortex

Jennifer A. Mangels, C. Summerfield, T. Egner, 2022 .

Colorectal cancer and the intersection between basic and clinical research.

K. Kinzler, B. Vogelstein, 1994, Cold Spring Harbor symposia on quantitative biology.

Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.

K. Kinzler, B. Vogelstein, S. Thibodeau, 2012, Gastroenterology.

Altered Telomeres in Tumors with ATRX and DAXX Mutations

R. McLendon, K. Kinzler, C. Bettegowda, 2011, Science.

Microbiota organization is a distinct feature of proximal colorectal cancers

K. Kinzler, B. Vogelstein, S. Peterson, 2014, Proceedings of the National Academy of Sciences.

Addressing overdiagnosis and overtreatment in cancer: a prescription for change.

L. Esserman, K. Kinzler, D. Ransohoff, 2014, The Lancet. Oncology.

Correction for Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

G M Anantharamaiah, K. Kinzler, V. Velculescu, 2010 .

Genetic Testing-- Present and Future

K. Kinzler, B. Vogelstein, Hai-Yan Yan, 2000, Science.

Evaluation of the FHIT gene in colorectal cancers.

M. Wigler, K. Kinzler, B. Vogelstein, 1996, Cancer research.

The Antisense Transcriptomes of Human Cells

K. Kinzler, B. Vogelstein, V. Velculescu, 2008, Science.

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2014, Proceedings of the National Academy of Sciences.

Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder.

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2016, Human pathology.

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

K. Kinzler, B. Vogelstein, N. Papadopoulos, 2014, Proceedings of the National Academy of Sciences.

Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations.

Leyla Isik, K. Kinzler, B. Vogelstein, 2009, Cancer research.

Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs ( NSAIDs ) in colon cancer cells

K. Kinzler, B. Vogelstein, Jian Yu, 2004 .

Whole‐exome sequencing of pancreatic neoplasms with acinar differentiation

J. Herman, L. Wood, K. Kinzler, 2014, The Journal of pathology.

The Genetic Landscape of the Childhood Cancer Medulloblastoma

Zev A. Binder, G. Parmigiani, M. Berger, 2011, Science.

The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.

K. Kinzler, B. Vogelstein, A. Lindblom, 2001, Cancer research.

Digital PCR.

K. Kinzler, B. Vogelstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Precancerous neoplastic cells can move through the pancreatic ductal system

Johannes G. Reiter, Jeffrey M. Gerold, M. Nowak, 2018, Nature.

Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features.

A. Yuille, Seyoun Park, E. Fishman, 2020, Diagnostic and interventional imaging.

Molecular genetic alterations in gastrointestinal polyposis syndromes : with emphasis on the Peutz-Jeghers syndrome

K. Kinzler, U. Mujumdar, F. Giardiello, 2009 .

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

M. Pittman, K. Kinzler, B. Vogelstein, 2016, Gastroenterology.

Progression ofColorectal CancerIsAssociated withMultiple Tumor Suppressor GeneDefects butInhibition ofTumorigenicity IsAccomplished byCorrection ofAnySingle Defect viaChromosome Transfer

Kathleen R. Cho, K. Kinzler, 1992 .

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

M. Choti, L. Wood, K. Kinzler, 2011, Proceedings of the National Academy of Sciences.

Heteroplasmic mitochondrial DNA mutations in normal and tumor cells

D. Dressman, K. Kinzler, B. Vogelstein, 2010, Nature.

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

K. Kinzler, B. Vogelstein, D. Mandelker, 2009, Proceedings of the National Academy of Sciences.

Dissecting Isoform Selectivity of PI3 Kinase Inhibitors. The Role of Non-conserved Residues in the Catalytic Pocket

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2010 .

Analysis of masked mutations in familial adenomatous polyposis.

K. Kinzler, B. Vogelstein, S. Gruber, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Absence of secretory phospholipase A2 gene alterations in human colorectal cancer.

K. Kinzler, B. Vogelstein, G. Riggins, 1995, Cancer research.

Exomic Sequencing of Four Rare Central Nervous System Tumor Types

Zev A. Binder, R. McLendon, L. Wood, 2013, OncoTarget.

Genetic landscape of extreme responders with anaplastic oligodendroglioma

M. Mehta, K. Kinzler, C. Bettegowda, 2017, Oncotarget.