I. Kozone

发表

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Junko Hashimoto, Haruo Ikeda, Mamoru Komatsu, 2020, Nature Communications.

Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb.

T. Hashimoto, J. Hashimoto, I. Kozone, 2018, Organic letters.

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.

I. Kozone, K. Shin‐ya, Y. Ohya, 2012, FEMS yeast research.

An unusual extender unit is incorporated into the modular polyketide synthase of scopranones biosynthesis.

J. Hashimoto, I. Kozone, M. Komatsu, 2019, Biochemistry.

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

J. Hashimoto, I. Kozone, H. Ikeda, 2018, Nature Communications.

Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.

J. Hashimoto, I. Kozone, K. Shin‐ya, 2014, Chemistry & biology.

MBJ-0110, a novel cyclopeptide isolated from the fungus Penicillium sp. f25267

I. Kozone, K. Shin‐ya, Teppei Kawahara, 2015, The Journal of Antibiotics.

New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.

M. Nishiyama, I. Kozone, K. Shin‐ya, 2009, Organic & biomolecular chemistry.

Novel β‐1,3‐, 1,6‐oligoglucan elicitor from Alternaria alternata 102 for defense responses in tobacco

I. Kozone, H. Matsuoka, K. Matsuoka, 2006, The FEBS journal.

Novel 24-membered macrolides, JBIR-19 and -20 isolated from Metarhizium sp. fE61

I. Kozone, K. Shin‐ya, Y. Ohya, 2009, The Journal of Antibiotics.

De-N-methylpamamycin-593A and B, new pamamycin derivatives isolated from Streptomyces alboniger.

I. Kozone, H. Abé, M. Natsume, 1999, The Journal of antibiotics.

C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium

J. Hashimoto, I. Kozone, K. Shin‐ya, 2020, Biomolecules.

Viable Cell Detection by the Combined Use of Fluorescent Glucose and Fluorescent Glycine

I. Kozone, H. Matsuoka, S. Igimi, 2003, Bioscience, biotechnology, and biochemistry.

MIDDAS-M: Motif-Independent De Novo Detection of Secondary Metabolite Gene Clusters through the Integration of Genome Sequencing and Transcriptome Data

Kiyoshi Asai, Katsuhisa Horimoto, Nozomi Nagano, 2013, PloS one.

Structure-activity Relationship of Pamamycins: Effect of Side Chain Length on Aerial Mycelium-inducing Activity

I. Kozone, H. Kawaide, H. Abé, 2008, The Journal of Antibiotics.

Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.

I. Kozone, K. Shin‐ya, T. Doi, 2015, Chemistry.

Rapid evaluation of the efficacy of microbial cell removal from fabrics

I. Kozone, H. Matsuoka, M. Saito, 2006, Journal of Industrial Microbiology and Biotechnology.

New hydroxamate metabolite, MBJ-0003, from Micromonospora sp. 29867

I. Kozone, K. Shin‐ya, Teppei Kawahara, 2013, The Journal of Antibiotics.

Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity.

I. Kozone, K. Shin‐ya, S. Kumazawa, 2012, Journal of agricultural and food chemistry.

Mechanism of S-Adenosyl-l-methionine C-Methylation by Cobalamin-dependent Radical S-Adenosyl-l-methionine Methylase in 1-Amino-2-methylcyclopropanecarboxylic Acid Biosynthesis.

J. Hashimoto, I. Kozone, K. Shin‐ya, 2022, Organic letters.

Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin

T. Hashimoto, J. Hashimoto, I. Kozone, 2020, The Journal of Antibiotics.

Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

Junko Hashimoto, Satoshi Omura, Yuuki Yamada, 2013, ACS synthetic biology.

JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55

I. Kozone, K. Shin‐ya, M. Takagi, 2009, The Journal of Antibiotics.

JBIR-52, a New Antimycin-Like Compound, from Streptomyces sp. ML55.

I. Kozone, K. Shin‐ya, M. Takagi, 2010 .

A phenylacetylated peptide, JBIR-96, isolated from Streptomyces sp. RI051-SDHV6.

I. Kozone, K. Shin‐ya, M. Takagi, 2011, Journal of natural products.

Isolation of New Hexapeptides-JBIR-39 and JBIR-40-from a Marine Sponge-Derived Streptomyces sp. Sp080513SC-24

I. Kozone, K. Shin‐ya, T. Doi, 2011 .

Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.

I. Kozone, K. Shin‐ya, M. Takagi, 2011, Environmental microbiology.

Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster.

J. Hashimoto, I. Kozone, N. Kagaya, 2018, Journal of natural products.

A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900.

K. Kudo, T. Hashimoto, J. Hashimoto, 2020, Bioscience, biotechnology, and biochemistry.

Novel thioviridamide derivative—JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis

J. Hashimoto, I. Kozone, N. Kagaya, 2015, The Journal of Antibiotics.

Relationship between Response to and Production of the Aerial Mycelium-inducing Substances Pamamycin-607 and A-factor

I. Kozone, H. Kawaide, H. Abé, 2003, Bioscience, biotechnology, and biochemistry.

Effect of Antibiotics on Formation of Aerial Mycelium and Production of Phytotoxins in Streptomyces spp.

I. Kozone, H. Abé, M. Hashimoto, 2003 .

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.

Junko Hashimoto, Shunji Takahashi, Hiroyuki Osada, 2017, Angewandte Chemie.

Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571

I. Kozone, K. Shin‐ya, M. Takagi, 2009, The Journal of Antibiotics.

Ammocidins B, C and D, New Cytotoxic 20-Membered Macrolides from Saccharothrix sp. AJ9571.

I. Kozone, K. Shin‐ya, M. Takagi, 2009 .

Identification of functional cytochrome P450 and ferredoxin from Streptomyces sp. EAS-AB2608 by transcriptional analysis and their heterologous expression

J. Hashimoto, I. Kozone, H. Ikeda, 2021, Applied Microbiology and Biotechnology.

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

J. Hashimoto, I. Kozone, H. Ikeda, 2017, Scientific Reports.

New acylated anthocyanins from purple yam and their antioxidant activity

I. Kozone, K. Shin‐ya, N. Terahara, 2015, Bioscience, biotechnology, and biochemistry.

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.

I. Kozone, K. Shin‐ya, Y. Ohya, 2012, FEMS yeast research.

Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

K. Kudo, J. Hashimoto, I. Kozone, 2021, Scientific Reports.

Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds.

K. Kudo, J. Hashimoto, I. Kozone, 2024, The Journal of antibiotics.