Hui Hong

发表

Rapamycin biosynthesis: Elucidation of gene product function.

Christine J. Martin, Lesley S. Sheehan, M. Gregory, 2006, Organic & biomolecular chemistry.

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

Frank Schulz, Hui Hong, P. Leadlay, 2008, Chemistry & biology.

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase

Hui Hong, D. Nietlispach, S. Vance, 2016, The Biochemical journal.

The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion‐trap mass spectrometry

Hui Hong, P. Leadlay, J. Staunton, 2009, The FEBS journal.

Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

Hui Hong, P. Leadlay, Simon R Williams, 2014, Chembiochem : a European journal of chemical biology.

Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum.

Hui Hong, Nicholas J. Tobias, T. Stinear, 2009, Microbiology.

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.

Hui Hong, P. Leadlay, T. Stinear, 2005, Chemical communications.

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Hui Hong, P. Leadlay, C. Demangel, 2008, Natural product reports.

An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain

Hui Hong, P. Leadlay, Z. Deng, 2017, Angewandte Chemie.

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea

Hui Hong, P. Leadlay, K. Weissman, 2004, Chembiochem : a European journal of chemical biology.

Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization.

Hui Hong, D. Spiteller, J. Spencer, 2008, Angewandte Chemie.

The fragmentation mechanism of five-membered lactones by electrospray ionisation tandem mass spectrometry

Hui Hong, J. Staunton, P. Gates, 2004 .

Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis

Hui Hong, P. Leadlay, Yuhui Sun, 2019, Nature Catalysis.

Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.

Hui Hong, P. Leadlay, Z. Deng, 2007, Chemistry & biology.

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Wolfgang Kroutil, James Staunton, Hui Hong, 2006, Chembiochem : a European journal of chemical biology.

Glyceryl‐S‐Acyl Carrier Protein as an Intermediate in the Biosynthesis of Tetronate Antibiotics

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

A Late‐Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

Hui Hong, P. Leadlay, Yuhui Sun, 2012, Chembiochem : a European journal of chemical biology.

C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A.

Hui Hong, P. Leadlay, M. Samborskyy, 2019, Cell chemical biology.

Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes

Hui Hong, P. Leadlay, M. Samborskyy, 2017, Beilstein journal of organic chemistry.

A common origin for guanidinobutanoate starter units in antifungal natural products.

Hui Hong, P. Leadlay, T. Fill, 2013, Angewandte Chemie.

Fragmentation studies on monensin A and B by accurate-mass electrospray tandem mass spectrometry.

Hui Hong, J. Staunton, P. Gates, 2002, Rapid communications in mass spectrometry : RCM.

A Study of the Effect of pH, Solvent System, Cone Potential and the Addition of Crown Ethers on the Formation of the Monensin Protonated Parent Ion in Electrospray Mass Spectrometry

Hui Hong, J. Staunton, P. Gates, 2001 .

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase

Hui Hong, P. Leadlay, Yuhui Sun, 2016, Beilstein journal of organic chemistry.

An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics

Hui Hong, P. Leadlay, M. Samborskyy, 2015, Angewandte Chemie.

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

Marion Leclerc, M. Leclerc, Hui Hong, 2008, PLoS neglected tropical diseases.

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

Hui Hong, P. Leadlay, Nicholas J. Tobias, 2013, PloS one.

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

Hui Hong, P. Leadlay, Peter J. Wilson, 2008, BMC Genomics.

Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans

Hui Hong, P. Leadlay, S. Cole, 2005, Journal of bacteriology.

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.

Marie-France Carlier, Fabrice Chrétien, Anne Danckaert, 2013, The Journal of clinical investigation.

A novel fluorinated erythromycin antibiotic.

Hui Hong, R. Goss, 2005, Chemical communications.

Engineered Biosynthesis of Phenyl‐Substituted Polyketides

Bradley S Moore, Hui Hong, P. Leadlay, 2004, Chembiochem : a European journal of chemical biology.

A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase

Hui Hong, P. Leadlay, T. Stinear, 2005, Chembiochem : a European journal of chemical biology.

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis

Hui Hong, P. Leadlay, M. Dias, 2015, Angewandte Chemie.

Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation.

Hui Hong, P. Leadlay, R. Broadhurst, 2016, Chemical communications.

An Additional Dehydratase‐Like Activity is Required for Lankacidin Antibiotic Biosynthesis

Hui Hong, P. Leadlay, Z. Deng, 2011, Chembiochem : a European journal of chemical biology.

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

Hui Hong, P. Leadlay, Luke Smith, 2008, Chembiochem : a European journal of chemical biology.

Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.

Markiyan Samborskyy, Hui Hong, P. Leadlay, 2006, Microbiology.

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.

Hui Hong, P. Leadlay, S. Cole, 2003, Chemical communications.

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Hui Hong, P. Leadlay, C. Demangel, 2007, Chembiochem : a European journal of chemical biology.

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

Hui Hong, L. Marsollier, E. Marion, 2009, PLoS neglected tropical diseases.

Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion‐trap mass spectrometry

Hui Hong, P. Leadlay, J. Staunton, 2005, The FEBS journal.

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea.

Hui Hong, P. Leadlay, K. Weissman, 2004 .

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.

M. Gregory, Hui Hong, R. Lill, 2004, Angewandte Chemie.

Evidence for a protein-protein interaction motif on an acyl carrier protein domain from a modular polyketide synthase.

Hui Hong, K. Weissman, F. Meersman, 2006, Chemistry & biology.

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chemistry & biology.

A Late‐Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

Hui Hong, P. Leadlay, Yuhui Sun, 2012, Chembiochem : a European journal of chemical biology.

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Hui Hong, P. Leadlay, C. Demangel, 2008, Natural product reports.

Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation.

Hui Hong, P. Leadlay, R. Broadhurst, 2016, Chemical communications.