Dudley Lamming

Deyang Yu, Jacqueline A. Brinkman, D. Sherman, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of TOR Signaling in Mammals

Dudley Lamming, D. Sabatini, 2010 .

Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin

Dudley Lamming, 2016 .

High fat diet enhances stemness and tumorigenicity of intestinal progenitors

Dudley Lamming, D. Sabatini, S. Orkin, 2016, Nature.

Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome

Dudley Lamming, 2014, F1000Research.

The TSC-mTOR pathway regulates macrophage polarization

Dudley Lamming, D. Sabatini, I. Ben-Sahra, 2013, Nature Communications.

Regulation of metabolic health by dietary histidine in mice

Deyang Yu, Shany E. Yang, Dudley Lamming, 2022, bioRxiv.

We are more than what we eat

Dudley Lamming, Cara L. Green, 2021, Nature Metabolism.

mTORC2 Puts Its Shoulder to Krebs' Wheel.

S. A. Arriola Apelo, Dudley Lamming, 2016, Molecular cell.

FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice

Dudley Lamming, R. Babygirija, M. Sonsalla, 2022, bioRxiv.

mTORC2 takes the longevity stAGE

Dudley Lamming, 2014, OncoTarget.

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017, The Journal of clinical investigation.

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017, The Journal of clinical investigation.

Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice

S. A. Arriola Apelo, Emma L. Baar, Dudley Lamming, 2017, Nutrition and healthy aging.

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

Dudley Lamming, I. Ong, K. Matkowskyj, 2022, bioRxiv.

Is rapamycin a rapalog?

Dudley Lamming, D. Glass, 2019, Nutrition and Healthy Aging.

FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice

Dudley Lamming, R. Babygirija, M. Sonsalla, 2022, bioRxiv.

Resistance exercise protects mice from protein-induced metabolic dysfunction

Dudley Lamming, T. Hornberger, C. Elliehausen, 2022, bioRxiv.

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Dudley Lamming, D. Guertin, D. Sabatini, 2012, Science.

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

Dudley Lamming, D. Sabatini, T. Peng, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Dudley Lamming, T. Prolla, J. Denu, 2022, Aging cell.

The regulation of lifespan by sirtuins in Saccharomyces cerevisiae

Dudley Lamming, 2008 .

Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction.

Deyang Yu, Dudley Lamming, J. Rabinowitz, 2022, Cell metabolism.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Phuong Chung, Siva Lavu, Dudley Lamming, 2003, Nature.

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

Dudley Lamming, D. Sabatini, M. Mino‐Kenudson, 2012, Nature.

Rapamycin and Rapalogs

Dudley Lamming, 2021 .

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

S. A. Arriola Apelo, Dudley Lamming, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice

Deyang Yu, D. Sherman, Dudley Lamming, 2020, Nature Aging.

SYK kinase mediates brown fat differentiation and activation

Dudley Lamming, H. Lodish, J. Hansen, 2017, Nature Communications.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

Deyang Yu, Shany E. Yang, Dudley Lamming, 2019, bioRxiv.

The central moTOR of metabolism.

Dudley Lamming, J. Simcox, 2022, Developmental cell.

Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association

Dudley Lamming, J. Denu, Hua Bai, 2021, GeroScience.

HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction

Dudley Lamming, D. Sinclair, Magda Latorre-Esteves, 2005, Science.

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

Molecular mechanisms of dietary restriction promoting health and longevity

Dudley Lamming, L. Fontana, Cara L. Green, 2021, Nature Reviews Molecular Cell Biology.

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Dudley Lamming, D. Sabatini, J. de Magalhães, 2016, Aging cell.

Lysosome: The metabolic signaling hub

Dudley Lamming, L. Bar-Peled, 2018, Traffic.

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

B. Kennedy, Dudley Lamming, 2016, Cell metabolism.

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

Dudley Lamming, D. Sabatini, J. Baur, 2013, Aging cell.

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.

Deyang Yu, Jacqueline A. Brinkman, Shany E. Yang, 2021, Cell metabolism.

Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

S. A. Arriola Apelo, Jacqueline A. Brinkman, Emma L. Baar, 2020, eLife.

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension.

Deyang Yu, Jacqueline A. Brinkman, Faizan A. Syed, 2019, Cell reports.

Hypothalamic mTORC2 is essential for metabolic health and longevity

S. A. Arriola Apelo, Jacqueline A. Brinkman, Kathryn A Carbajal, 2019, Aging cell.

Restoration of metabolic health by decreased consumption of branched‐chain amino acids

S. A. Arriola Apelo, Deyang Yu, D. Sherman, 2017, The Journal of physiology.

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.

S. A. Arriola Apelo, Emma L. Baar, Dudley Lamming, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

S. A. Arriola Apelo, Faizan A. Syed, Emma L. Baar, 2015, Aging cell.

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Emma L. Baar, Dudley Lamming, D. Sabatini, 2014, Aging cell.

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

Dudley Lamming, D. Sabatini, J. Baur, 2012, Front. Gene..

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

T. Pawson, Dudley Lamming, J. Dennis, 2014, Science Signaling.

Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"

Dudley Lamming, D. Sinclair, Magda Latorre-Esteves, 2006, Science.

The regulation of healthspan and lifespan by dietary amino acids.

Dudley Lamming, R. Babygirija, 2021, Translational medicine of aging.

Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism.

Sushma Kaul, Jacqueline A. Brinkman, Dudley Lamming, 2020, Cell metabolism.

Next generation strategies for geroprotection via mTORC1 inhibition.

Dudley Lamming, S. Dumas, 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.

The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome

Deyang Yu, Jacqueline A. Brinkman, Shany E. Yang, 2019, Scientific Reports.

Pharmacologic Means of Extending Lifespan

Dudley Lamming, D. Sabatini, J. Baur, 2012, Journal of clinical & experimental pathology.

Molecular mechanisms of dietary restriction promoting health and longevity

Dudley Lamming, L. Fontana, Cara L. Green, 2021, Nature reviews. Molecular cell biology.

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

B. Ueberheide, D. Green, Dudley Lamming, 2017, Cell.

A toolbox for the longitudinal assessment of healthspan in aging mice

R. de Cabo, Dudley Lamming, I. Bellantuono, 2020, Nature Protocols.

MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis

Dudley Lamming, D. Sinclair, Jason G. Wood, 2004, Molecular microbiology.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity

Emma L. Baar, Dudley Lamming, J. Denu, 2016, Diabetes.

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

Dudley Lamming, P. Seale, J. Baur, 2016, Diabetes.

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

Jacqueline A. Brinkman, D. Sherman, Dudley Lamming, 2018, Scientific Reports.

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Dudley Lamming, D. Sinclair, J. Baur, 2007, Cell.

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Dudley Lamming, I. Ben-Sahra, B. Manning, 2016, eLife.

Aging

Deyang Yu, Dudley Lamming, L. Fontana, 2020, Principles of Nutrigenetics and Nutrigenomics.

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways

Dudley Lamming, Nicole E. Cummings, 2017, Molecular and Cellular Endocrinology.

Erratum: Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages (The Journal of clinical investigation (2017) 127 7 (2842-2854) PII: 95841)

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017 .

The role of protein arginine methylation in the formation of silent chromatin.

Pamela A Silver, David A Sinclair, P. Silver, 2006, Genes & development.

A Central role for mTOR in lipid homeostasis.

Dudley Lamming, D. Sabatini, 2013, Cell metabolism.

Contrasting recruitment of skin‐associated adipose depots during cold challenge of mouse and human

H. Völzke, Dudley Lamming, O. MacDougald, 2021, The Journal of physiology.

Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human

H. Völzke, Dudley Lamming, O. MacDougald, 2020 .

Metabolic Effects of Caloric Restriction

Dudley Lamming, Rozalyn M. Anderson, Rozalyn M. Anderson, 2014 .

Aging and drug discovery

Martijn S. Luijsterburg, Polina Mamoshina, Vadim N. Gladyshev, 2018, Aging.

Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.

W. K. Roberts, Dudley Lamming, P. Roepe, 1997, Biochemistry.

Restricting dietary protein or dietary isoleucine improves metabolic health in aged mice

Dudley Lamming, T. Hacker, R. Babygirija, 2023, bioRxiv.

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

Dudley Lamming, Heidi M Umhoefer, J. Han, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

Kathryn A Carbajal, Dudley Lamming, M. Kimple, 2020, The Journal of biological chemistry.

Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease

Dudley Lamming, M. Sonsalla, 2023, GeroScience.

TORwards a victory over aging.

Dudley Lamming, A. Salmon, 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.

Sex‐ and tissue‐specific changes in mTOR signaling with age in C57BL/6J mice

Emma L. Baar, Kathryn A Carbajal, Dudley Lamming, 2015, Aging cell.

Targeting the biology of aging with mTOR inhibitors

Dudley Lamming, J. Mannick, 2023, Nature Aging.

Metabolism The Adaptor Protein p 66 Shc Inhibits mTOR-Dependent Anabolic `

T. Pawson, Dudley Lamming, J. Dennis, 2014 .