J. Klawitter

发表

Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.

T. Strom, T. Shokati, J. Klawitter, 2011, Journal of mass spectrometry : JMS.

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial

J. Klawitter, J. Klawitter, U. Christians, 2017, PLoS medicine.

Biomarkers in Transplantation—Proteomics and Metabolomics

J. Klawitter, J. Klawitter, U. Christians, 2016, Therapeutic drug monitoring.

Proteomics and metabolomics in renal transplantation‐quo vadis?

J. Klawitter, J. Klawitter, U. Christians, 2013, Transplant international : official journal of the European Society for Organ Transplantation.

The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools

J. Klawitter, J. Klawitter, U. Christians, 2011 .

A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine.

J. Klawitter, J. Klawitter, U. Christians, 2015, Clinica chimica acta; international journal of clinical chemistry.

Proteo‐Metabolomic Strategies in the Future of Drug Development

J. Klawitter, J. Klawitter, U. Christians, 2012 .

CYCLOPHILIN D KNOCKOUT PROTECTS THE MOUSE KIDNEY AGAINST CYCLOSPORIN A-INDUCED OXIDATIVE STRESS.

J. Klawitter, J. Klawitter, U. Christians, 2019, American journal of physiology. Renal physiology.

Mycophenolate Mofetil Enhances the Negative Effects of Sirolimus and Tacrolimus on Rat Kidney Cell Metabolism

T. Shokati, J. Klawitter, J. Klawitter, 2014, PloS one.

Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish.

J. Klawitter, U. Christians, C. Fæste, 2016, Journal of chromatography. A.

A proteomics–metabolomics approach indicates changes in hypothalamic glutamate–GABA metabolism of adult female rats submitted to intrauterine growth restriction

J. Klawitter, U. Christians, L. Oyama, 2018, European Journal of Nutrition.

Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data.

Uwe Christians, Jelena Klawitter, J. Klawitter, 2017, Journal of proteome research.

Single dose of 17β-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation

J. Klawitter, P. Herson, J. Orfila, 2019, Neurochemistry International.

Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.

J. Klawitter, J. Klawitter, U. Christians, 2013, Cardiovascular research.

Markers of Spontaneuous Preterm Delivery in Women living with HIV: Relationship with Protease Inhibitors and Vitamin D.

J. Klawitter, U. Christians, D. Wara, 2019, Journal of acquired immune deficiency syndromes.

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose.

Uwe Christians, Jost Klawitter, Jelena Klawitter, 2010, British journal of clinical pharmacology.

Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma.

J. Klawitter, J. Klawitter, U. Christians, 2021, Journal of analytical toxicology.

Everolimus and Sirolimus in Combination with Cyclosporine Have Different Effects on Renal Metabolism in the Rat

T. Shokati, J. Klawitter, J. Klawitter, 2012, PloS one.

Metabolic Profiles in Urine Reflect Nephrotoxicity of Sirolimus and Cyclosporine following Rat Kidney Transplantation

J. Klawitter, J. Klawitter, U. Christians, 2009, Nephron Experimental Nephrology.

Theophylline Dosing and Pharmacokinetics for Renal Protection in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

J. Klawitter, U. Christians, K. V. Van Meurs, 2020, Pediatric Research.

Exhaled Breath Condensate Nitrate Levels are Inversely Associated withthe Body Mass Index of Patients without Respiratory Disease

Alex, J. Klawitter, U. Christians, 2015 .

Surgical procedures suppress autophagic flux in the kidney

Daniel J. Atwood, J. Klawitter, A. Thorburn, 2021, Cell Death & Disease.

Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease.

J. Klawitter, M. Chonchol, Berenice Y. Gitomer, 2018, Clinical journal of the American Society of Nephrology : CJASN.

Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS.

J. Klawitter, J. Klawitter, U. Christians, 2007, Analytical biochemistry.

The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression

J. Klawitter, M. Chonchol, E. Kleczko, 2022, bioRxiv.

Endocannabinoid System in Polycystic Kidney Disease

J. Klawitter, J. Klawitter, U. Christians, 2022, American Journal of Nephrology.

Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study.

J. Klawitter, Weiqi Wang, M. Chonchol, 2021, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD

J. Klawitter, Weiqi Wang, M. Chonchol, 2021, Clinical journal of the American Society of Nephrology : CJASN.

Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial.

J. Klawitter, M. Chonchol, Berenice Y. Gitomer, 2019, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass

J. Klawitter, J. Jaggers, J. Davidson, 2020, Pediatric Research.

Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass

J. Klawitter, J. Jaggers, J. Davidson, 2022, Pediatric Research.

Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats

J. Klawitter, U. Christians, J. Repine, 2013, Inflammation.

Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease

J. Klawitter, J. Jaggers, Mark D Twite, 2020, Congenital heart disease.

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness

B. Golomb, J. Klawitter, J. Klawitter, 2019, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

Androgen and PARP-1 Regulation of TRPM2 Channels after Ischemic Injury

J. Klawitter, R. Traystman, A. Perraud, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study

J. Klawitter, Lori J Silveira, Mark D Twite, 2020, Metabolomics.

Proteomic Profiling Identifies Key Differences Between Inter-Stage Infants with Single Ventricle Heart Disease and Healthy Controls.

J. Klawitter, Lori J Silveira, Mark D Twite, 2020, Translational research : the journal of laboratory and clinical medicine.

Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared.

T. Shokati, J. Klawitter, J. Klawitter, 2011, Rapid communications in mass spectrometry : RCM.

Early Effect of Tidal Volume on Lung Injury Biomarkers in Surgical Patients with Healthy Lungs

Zung Vu Tran, Ana Fernandez-Bustamante, Uwe Christians, 2014, Anesthesiology.

Inhalation of two putative Gulf War toxins by mice

J. Klawitter, U. Christians, J. Repine, 2016, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

nephropathy in the eNOS-deficient mouse Nicorandil as a novel therapy for advanced diabetic

J. Klawitter, M. Miyazaki, M. Lanaspa, 2013 .

Correction

J. Klawitter, J. Jaggers, J. Davidson, 1885, Nature.

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart

J. Klawitter, J. Klawitter, U. Christians, 2017, Journal of cellular biochemistry.

Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

J. Klawitter, J. Klawitter, U. Christians, 2013, BMC Nephrology.

Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM

J. Klawitter, U. Christians, J. Thurman, 2018, European journal of immunology.

Bone marrow-derived cPLA2α contributes to renal fibrosis progression

J. Klawitter, J. Klawitter, Seth B. Furgeson, 2017, Journal of Lipid Research.

Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism.

J. Klawitter, J. Klawitter, U. Christians, 2012, Journal of proteome research.

Metabolic markers for differentiation between renal allograft rejection and immunosuppressant toxicity in rat urine

J. Klawitter, J. Klawitter, U. Christians, 2017, Metabolomics.

Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects

T. Shokati, J. Klawitter, J. Klawitter, 2014, Analytical and Bioanalytical Chemistry.

The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

J. Klawitter, U. Christians, C. Piantadosi, 2017, Canadian journal of physiology and pharmacology.

Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia

J. Klawitter, U. Christians, C. Piantadosi, 2017, Clinical pharmacology and therapeutics.

Inhibition of calcineurin combined with dasatinib has direct and indirect anti‐leukemia effects against BCR‐ABL1+ leukemia

J. Klawitter, U. Christians, J. DeGregori, 2014, American journal of hematology.

Kynurenines in polycystic kidney disease

J. Klawitter, J. Klawitter, U. Christians, 2022, Journal of Nephrology.

Cyclosporine induces endothelial cell release of complement-activating microparticles.

J. Klawitter, U. Christians, J. Thurman, 2013, Journal of the American Society of Nephrology : JASN.

Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury

J. Klawitter, J. Jaggers, J. Davidson, 2022, American journal of physiology. Renal physiology.

Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass

J. Klawitter, J. Jaggers, Mark D Twite, 2021, Pediatric Nephrology.

Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.

Yan Ling Zhang, J. Klawitter, J. Klawitter, 2009, Biomedical chromatography : BMC.

Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion1,2,3

J. Klawitter, P. Herson, H. Grewal, 2014, eNeuro.

Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma.

J. Klawitter, J. Klawitter, U. Christians, 2013, Clinica chimica acta; international journal of clinical chemistry.

Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography–mass spectrometry

L. C. Bidwell, J. Klawitter, J. Klawitter, 2021, Analytical and Bioanalytical Chemistry.

An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine

J. Klawitter, J. Klawitter, U. Christians, 2017, Therapeutic drug monitoring.

Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach

J. Klawitter, U. Christians, B. Soos, 2021, Frontiers in Medicine.

Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay

J. Klawitter, U. Christians, P. Mourani, 2018, Journal of the American Heart Association.

Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid.

J. Klawitter, V. Jevtovic-Todorovic, S. Todorovic, 2022, British journal of anaesthesia.

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells

J. Klawitter, S. Ficarro, J. Marto, 2017, Proceedings of the National Academy of Sciences.

Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass

J. Klawitter, P. Wischmeyer, Mark D Twite, 2016, PloS one.

HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma.

Yan Ling Zhang, J. Klawitter, U. Christians, 2007, Clinical chemistry.

Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney

J. Klawitter, J. Klawitter, U. Christians, 2017, Scientific Reports.

Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism.

J. Klawitter, U. Christians, D. Leibfritz, 2010, Chemical research in toxicology.

Experimental Pediatric Arterial Ischemic Stroke Model Reveals Sex-specific Estrogen Signaling

J. Klawitter, J. Klawitter, R. Traystman, 2013, Stroke.

Effects of lovastatin on breast cancer cells: a proteo-metabonomic study

T. Shokati, J. Klawitter, J. Klawitter, 2010, Breast Cancer Research.

Biomarkers of Acute Kidney Injury

J. Klawitter, C. Edelstein, Jeffrey C. Sirota, 2011, Journal of toxicology.

Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study.

Uwe Christians, Jost Klawitter, Jelena Klawitter, 2010, Journal of proteome research.

A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine.

T. Shokati, J. Klawitter, J. Klawitter, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Chapter Three – The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools

J. Klawitter, U. Christians, Jacek Klepacki, 2017 .

The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools

J. Klawitter, J. Klawitter, U. Christians, 2017 .

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

J. Klawitter, Jihye Kim, A. Tan, 2015, The Journal of clinical investigation.

Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.

Uwe Christians, Jost Klawitter, Jelena Klawitter, 2009, Chemical research in toxicology.

Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.

J. Klawitter, U. Christians, A. Marusyk, 2009, Cancer research.

Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways

J. Klawitter, U. Christians, G. Morgan, 2023, JACC. Advances.

Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions

Uwe Christians, Jost Klawitter, Jelena Klawitter, 2011, Expert opinion on drug metabolism & toxicology.

Bezielle (BZL101)‐induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: A combined proteomic and metabolomic study

J. Klawitter, J. Klawitter, U. Christians, 2011, International journal of cancer.

Endothelial dysfunction and oxidative stress in polycystic kidney disease.

Kaleab Z. Abebe, J. Klawitter, J. Klawitter, 2014, American journal of physiology. Renal physiology.

Abnormalities in Glucose Uptake and Metabolism in Imatinib-Resistant Human BCR-ABL–Positive Cells

J. Klawitter, L. Boros, J. Melo, 2009, Clinical Cancer Research.

Chapter Four – The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools

J. Klawitter, U. Christians, Jacek Klepacki, 2017 .

Effect of dietary sodium restriction on human urinary metabolomic profiles.

J. Klawitter, M. Chonchol, D. Seals, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Temsirolimus metabolic pathways revisited

T. Shokati, J. Klawitter, J. Klawitter, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease.

A. Halbower, J. Klawitter, R. Sokol, 2016, Journal of hepatology.

Toxicodynamic Therapeutic Drug Monitoring of Immunosuppressants: Promises, Reality, and Challenges

J. Klawitter, J. Klawitter, U. Christians, 2008, Therapeutic drug monitoring.

Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children

A. Halbower, J. Klawitter, R. Sokol, 2018, The Journal of pediatrics.

Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.

J. Klawitter, J. Klawitter, U. Christians, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress

J. Klawitter, K. Moreau, W. Kohrt, 2020, GeroScience.

A relative L‐arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition

J. Klawitter, U. Christians, K. Moreau, 2017, Physiological reports.

Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease.

J. Klawitter, J. Klawitter, U. Christians, 2022, American journal of physiology. Renal physiology.

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

J. Klawitter, U. Christians, J. Thurman, 2018, Journal of the American Heart Association.

Bioequivalence testing of immunosuppressants: concepts and misconceptions.

J. Klawitter, U. Christians, C. Clavijo, 2010, Kidney international. Supplement.

Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity

J. Klawitter, C. Baird, P. Wischmeyer, 2018, Pediatric Research.

Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

Uwe Christians, Jacek Klepacki, Jost Klawitter, 2016, Clinical biochemistry.

Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease

J. Klawitter, J. Klawitter, U. Christians, 2021, Scientific Reports.

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells

J. Klawitter, J. Klawitter, U. Christians, 2009, British journal of pharmacology.

Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest

J. Klawitter, J. Jaggers, J. Davidson, 2021, Metabolomics.

Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women.

J. Klawitter, U. Christians, K. Moreau, 2019, Journal of applied physiology.

Kynurenines in polycystic kidney disease

J. Klawitter, J. Klawitter, U. Christians, 2022, Journal of Nephrology.

Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse.

J. Klawitter, M. Miyazaki, M. Lanaspa, 2012, American journal of physiology. Renal physiology.

Fibronectin-Integrin Signaling Is Required for L-Glutamine’s Protection against Gut Injury

J. Klawitter, U. Christians, S. Niederlechner, 2012, PloS one.

How unbiased is non-targeted metabolomics and is targeted pathway screening the solution?

J. Klawitter, J. Klawitter, U. Christians, 2011, Current pharmaceutical biotechnology.

Bioactive lipid mediators in polycystic kidney disease

Kaleab Z. Abebe, J. Klawitter, J. Klawitter, 2014, Journal of Lipid Research.

Metabolic markers for differentiation between renal allograft rejection and immunosuppressant toxicity in rat urine

J. Klawitter, J. Klawitter, U. Christians, 2017, Metabolomics.

RESEARCH PAPER Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells

J. Klawitter, J. Klawitter, U. Christians, 2009 .

Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats

J. Klawitter, U. Christians, J. Repine, 2013, Inflammation.

15-Lipoxygenase Worsens Renal Fibrosis, Inflammation, and Metabolism in a Murine Model of Ureteral Obstruction.

J. Klawitter, Seth B. Furgeson, M. Weiser-Evans, 2021, American journal of physiology. Renal physiology.

Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.

William Checkley, Robert A Wise, Uwe Christians, 2016, Respiratory medicine.

Differentiating cross-reacting allergens in the immunological analysis of celery (Apium graveolens) by mass spectrometry.

Jelena Klawitter, J. Klawitter, K. E. Løvberg, 2010, Journal of AOAC International.

Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D

J. Klawitter, U. Christians, Y. Huo, 2022 .

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart

J. Klawitter, J. Klawitter, U. Christians, 2017, Journal of cellular biochemistry.

Bioactive lipid mediators in polycystic kidney disease

Kaleab Z. Abebe, J. Klawitter, J. Klawitter, 2014, Journal of Lipid Research.

Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns

T. Shokati, J. Klawitter, J. Klawitter, 2023, Metabolites.

Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much?

Uwe Christians, Jacek Klepacki, Touraj Shokati, 2012, Microchemical journal : devoted to the application of microtechniques in all branches of science.