G. Varani

发表

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

D. Baker, B. Stoddard, B. Kuhlman, 2003, Science.

High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design

D. Baker, B. Kuhlman, G. Dantas, 2007, Journal of molecular biology.

A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys.

D. Baker, G. Varani, T. Kortemme, 2004, Nucleic acids research.

Engineering RNA‐binding proteins for biology

Gabriele Varani, Yu Chen, G. Varani, 2013, The FEBS journal.

The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection

D. Baker, G. Varani, T. Sosnick, 2007, Cell.

RNA recognition by RNP proteins during RNA processing.

G. Varani, K. Nagai, 1998, Annual review of biophysics and biomolecular structure.

The G x U wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems.

G. Varani, W. McClain, 2000, EMBO reports.

Exceptionally stable nucleic acid hairpins.

G. Varani, 1995, Annual review of biophysics and biomolecular structure.

RNA structure and NMR spectroscopy

G. Varani, I. Tinoco, Gabriele Varani, 1991, Quarterly Reviews of Biophysics.

Simple yet functional phosphate-loop proteins

Dan S. Tawfik, D. Baker, G. Varani, 2018, Proceedings of the National Academy of Sciences.

The Seattle Structural Genomics Center for Infectious Disease (SSGCID).

G. Varani, P. Myler, W. V. Voorhis, 2009, Infectious disorders drug targets.

Structure based approaches for targeting non-coding RNAs with small molecules.

Gabriele Varani, G. Varani, M. Shortridge, 2015, Current opinion in structural biology.

Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements.

John A. Robinson, G. Varani, K. Moehle, 2004, Journal of the American Chemical Society.

TAR RNA recognition by a cyclic peptidomimetic of Tat protein.

John A. Robinson, G. Varani, R. A. Dias, 2005, Biochemistry.

Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus.

John A. Robinson, G. Varani, K. Moehle, 2007, Biochemistry.

Swelling and drug release from oral thin films (OTFs)

G. Varani, A. Adrover, P. Paolicelli, 2016 .

A knowledge‐based potential function predicts the specificity and relative binding energy of RNA‐binding proteins

Gabriele Varani, Suxin Zheng, Timothy A Robertson, 2007, The FEBS journal.

NMR studies of protein-nucleic acid interactions.

G. Varani, Yu Chen, T. Leeper, 2004, Methods in molecular biology.

Decrypting noncoding RNA interactions, structures, and functional networks

G. Varani, M. Fabbri, G. Calin, 2019, Genome research.

Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification

G. Varani, T. Magnuson, J. M. Calabrese, 2019, Genetics.

A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments.

Gabriele Varani, Amy Davidson, G. Varani, 2011, Journal of molecular biology.

Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".

Gabriele Varani, Mohammad Afshar, Ben Davis, 2004, Journal of molecular biology.

Nuclear magnetic resonance methods to study structure and dynamics of RNA-protein complexes.

G. Varani, L. Varani, M. Allen, 2001, Methods in enzymology.

How accurately and precisely can RNA structure be determined by NMR?

G. Varani, F. Allain, G Varani, 1997, Journal of molecular biology.

NMR investigation of RNA structure

Gabriele Varani, Frédéric H.-T. Allain, G. Varani, 1996 .

Current topics in RNA-protein recognition: control of specificity and biological function through induced fit and conformational capture.

G. Varani, N. Leulliot, G Varani, 2001, Biochemistry.

Structure-based and combinatorial search for new RNA-binding drugs.

M Afshar, G. Varani, M. Afshar, 1999, Current opinion in biotechnology.

Multivalent Drug Design and Inhibition of Cholera Toxin by Specific and Transient Protein–Ligand Interactions

G. Varani, C. Verlinde, D. W. Begley, 2008, Chemical biology & drug design.

Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.

M G Spillantini, G. Varani, M. Goedert, 2000, Nucleic acids research.

An evolutionarily conserved RNA structure in the functional core of the lincRNA Cyrano

G. Varani, Giuseppina Pisignano, T. Pavelitz, 2020, RNA.

Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3′-end processing signals

G. Varani, Fan Yang, Wen Yang, 2017, Nucleic acids research.

3D fluid-dynamic ovarian cancer model resembling systemic drug administration for efficacy assay.

G. Varani, S. Scaglione, A. Marrella, 2020, ALTEX.

13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein.

G. Varani, Z. Shajani, 2005, Journal of molecular biology.

miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

G. Varani, H. Ruohola-Baker, Yu Chen, 2014, RNA.

The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae.

G. Varani, Gerald O. Hunter, A. Mosley, 2014, Molecular bioSystems.

Correlation of deformability at a tRNA recognition site and aminoacylation specificity.

G. Varani, W. McClain, S. Bhattacharya, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Splicing factor 1 in the pocket.

G. Varani, A. Ramos, 2003, Structure.

Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution.

D. Baker, B. Stoddard, B. Kuhlman, 2006, Journal of molecular biology.

RNA Structure and RNA-Protein Recognition During Regulation of Eukaryotic Gene Expression

G. Varani, A. Ramos, L. Varani, 1999 .

5 – RNA—Protein Recognition during RNA Processing and Maturation*

G. Varani, 1998 .

Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films

G. Varani, A. Adrover, P. Paolicelli, 2018, Pharmaceutics.

Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.

J. Karn, G. Varani, F. Aboul-Ela, 1996, Nucleic acids research.

Counterion Redistribution upon Binding of a Tat-Protein Mimic to HIV-1 TAR RNA.

Trang N. Do, G. Varani, M. Parrinello, 2012, Journal of chemical theory and computation.

13C/15N-19F intermolecular REDOR NMR study of the interaction of TAR RNA with Tat peptides.

G. Varani, G. Drobny, Wei Huang, 2010, Journal of the American Chemical Society.

The HIV Tat-TAR interaction, a novel target for drug discovery

J. Karn, G. Varani, E. Felder, 1998 .

Drug-like small molecules that inhibit expression of the oncogenic microRNA-21

G. Varani, G. Calin, T. Pavelitz, 2022, bioRxiv.

High-Tech and Nature-Made Nanocomposites and Their Applications in the Field of Sensors and Biosensors for Gas Detection

G. Varani, M. Giardi, Amina Antonacci, 2020, Biosensors.

Recognition of HIV-1 TAR RNA by Tat protein and Tat-derived peptides

G. Varani, F. Aboul-Ela, F. Aboul-ela, 1998 .

Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.

G. Varani, S. L. Le Grice, Joanna Sztuba-Solinska, 2016, Journal of medicinal chemistry.

Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD.

G. Varani, A. Mosley, Fan Yang, 2014, Journal of molecular biology.

High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device

G. Varani, S. Scaglione, N. Aceto, 2021, PloS one.

Design of a tunable nanocomposite double network hydrogel based on gellan gum for drug delivery applications

G. Varani, S. Pacelli, J. Tirillò, 2018, European Polymer Journal.

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

G. Varani, Abhishek Mitra, S. Di Marco, 2017, Nature Communications.

Determination of the structure of the RNA complex of a double‐stranded RNA‐binding domain from Drosophila Staufen protein

G. Varani, A. Ramos, P. Bayer, 1999, Biopolymers.

Investigating the Role of Polydopamine to Modulate Stem Cell Adhesion and Proliferation on Gellan Gum-Based Hydrogels.

G. Varani, S. Pacelli, A. Paul, 2020, ACS applied bio materials.

Targeting Influenza A Virus RNA Promoter

G. Varani, M. Pellecchia, A. Bottini, 2015, Chemical biology & drug design.

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD‐Kumamoto)

G. Schellenberg, G. Varani, T. Iwatsubo, 2000, Annals of neurology.

Slow exchange model of nonrigid rotational motion in RNA for combined solid-state and solution NMR studies.

Prashant S. Emani, G. Varani, G. Drobny, 2010, The journal of physical chemistry. B.

Behind Every Good Metabolite there is a Great Enzyme (and perhaps a

G. Varani, P. Myler, W. V. Voorhis, 2012 .

Locking out viral replication.

G. Varani, D. W. Begley, 2009, Nature chemical biology.

Comparative structure, dynamics and evolution of acyl-carrier proteins from Borrelia burgdorferi, Brucella melitensis and Rickettsia prowazekii.

G. Varani, M. Kaur, A. Heckert, 2020, The Biochemical journal.

Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.

G. Varani, T. Magnuson, J. M. Calabrese, 2019, Genetics.

Structure-Based Design of RNA-Binding Peptides

G. Varani, M. Walker, 2019 .

Nuclear magnetic resonance methods to study RNA-protein complexes.

G. Varani, L. Varani, P. Bayer, 2000, Methods in enzymology.

A Model for C74 Addition by CCA-adding Enzymes

A. Weiner, G. Varani, Yu Chen, 2006, Journal of Biological Chemistry.

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.

G. Varani, Byong-Seok Choi, M. Pellecchia, 2014, Chemical communications.

Applications of NMR to structure determination of RNAs large and small.

G. Varani, Fan Yang, R. Barnwal, 2017, Archives of biochemistry and biophysics.

NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.

G. Varani, Shrikant Sharma, 2020, Biochemical and biophysical research communications.

NMR structure of an acyl-carrier protein from Borrelia burgdorferi

G. Varani, W. V. Van Voorhis, R. Barnwal, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Finding the missing code of RNA recognition by PUF proteins.

G. Varani, Yu Chen, 2011, Chemistry & biology.

A microbial sensor platform based on bacterial bioluminescence (luxAB) and green fluorescent protein (gfp) reporters for in situ monitoring of toxicity of wastewater nitrification process dynamics.

G. Varani, M. Giardi, M. Turemis, 2021, Talanta.

Mitochondrial cytochromes c: a comparative analysis

G. Varani, A. Rosato, I. Bertini, 1999, JBIC Journal of Biological Inorganic Chemistry.

The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein.

G. Varani, S. Hassard, A. Lever, 2000, Journal of molecular biology.

A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.

M. Ares, G. Varani, M. Graille, 2004, The EMBO journal.

Structure, Function, and Biogenesis of Small Nucleolar Ribonucleoprotein Particles

G. Varani, K. Godin, 2013 .

DNA melting induced by alcohols: Role of the solvent properties

G. Varani, G. Baldini, L. Cordone, 1985 .

RNA is rarely at a loss for companions; as soon as RNA

Gabriele Varani, Bradley M. Lunde, G. Varani, 2008 .

Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.

G. Varani, G Varani, J Gallego, 2001, Accounts of chemical research.

Comprehensive computational design of ordered peptide macrocycles

David Baker, Joshua N. Adkins, Gabriele Varani, 2017, Science.

γ-AApeptides bind to RNA by mimicking RNA-binding proteins.

G. Varani, Y. Niu, Haifan Wu, 2011, Organic & biomolecular chemistry.

Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein

Gabriele Varani, John A. Robinson, John A. Robinson, 2010, Nucleic Acids Res..

Solvation thermodynamics of ethidium bromide in mixed solvents

G. Varani, G. Baldini, G. Chirico, 1988 .

Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.

G. Varani, Suxin Zheng, M. Wolfe, 2009, Journal of medicinal chemistry.

Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study

Gabriele Varani, Paolo Carloni, Fan Yang, 2018, PLoS Comput. Biol..

Examining the relationship between RNA function and motion using nuclear magnetic resonance

G. Varani, Michael F. Bardaro, 2012, Wiley interdisciplinary reviews. RNA.

Unifying Solution and Solid-State NMR Studies of Nucleic Acid Dynamics

G. Varani, G. Drobny, Z. Shajani, 2010 .

High-Sensitivity Metal Oxide Sensors Duplex for On-the-Field Detection of Acetic Acid Arising from the Degradation of Cellulose Acetate-Based Cinematographic and Photographic Films

G. Varani, I. Iatsunskyi, M. Giardi, 2022, Chemosensors.

Effect of glycerol on the physical and mechanical properties of thin gellan gum films for oral drug delivery

Gabriele Varani, Settimio Pacelli, Alessandra Adrover, 2018, International journal of pharmaceutics.

The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.

G. Varani, H. van Tilbeurgh, N. Leulliot, 2011, Genes & development.

The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.

G. Varani, H. van Tilbeurgh, N. Leulliot, 2009, Journal of molecular biology.

The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.

G. Varani, H. van Tilbeurgh, N. Leulliot, 2007, Journal of molecular biology.

Innovative Eco-Friendly Conductive Ink Based on Carbonized Lignin for the Production of Flexible and Stretchable Bio-Sensors.

G. Varani, I. Iatsunskyi, M. Giardi, 2021, Nanomaterials.

Carbon-Proton Scalar Couplings in RNA: 3D Heteronuclear and 2D Isotope-Edited NMR of a 13C-Labeled Extra-stable Hairpin

G. Varani, I. Tinoco, J. Hines, 1994 .

The stereospecific assignment of H5' and H5'' in RNA using the sign of two-bond carbon-proton scalar couplings

G. Varani, I. Tinoco, J. Hines, 1993 .

Fluorescence of ethidium bromide in alcohol–water solutions

G. Varani, G. Baldini, M. Manfredi, 1987 .

GFT projection NMR for efficient 1H/13C sugar spin system identification in nucleic acids

G. Varani, T. Szyperski, H. Atreya, 2012, Journal of Biomolecular NMR.

Role of solvation on dye fluorescence

G. Varani, G. Baldini, G. Chirico, 1988 .

Structure of the P1 helix from group I self-splicing introns.

G. Varani, F. Allain, Gabriele Varani, 1995, Journal of molecular biology.

Novel techniques in nuclear magnetic resonance for nucleic acids.

G. Varani, F. Aboul-ela, 1995, Current opinion in biotechnology.

Novel three-dimensional 1H−13C−31P triple resonance experiments for sequential backbone correlations in nucleic acids

G. Varani, F. Allain, F. Aboul-ela, 1995, Journal of Biomolecular NMR.

NMR studies of dynamics in RNA and DNA by 13C relaxation.

G. Varani, Z. Shajani, 2007, Biopolymers.

Validation of automated docking programs for docking and database screening against RNA drug targets.

Gabriele Varani, Carsten Detering, G. Varani, 2004, Journal of medicinal chemistry.

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication.

J. Karn, G. Varani, E. Felder, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA

John A. Robinson, J. Karn, G. Varani, 2011, PLoS pathogens.

Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion

Dan S. Tawfik, G. Varani, L. Longo, 2020, Proceedings of the National Academy of Sciences.

Primordial emergence of a nucleic acid binding protein via phase separation and statistical ornithine to arginine conversion

Dan S. Tawfik, G. Varani, L. Longo, 2020, bioRxiv.

Preparation of RNA samples with narrow line widths for solid state NMR investigations.

G. Varani, G. Drobny, Wei Huang, 2012, Journal of magnetic resonance.

Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy.

G. Varani, G. Drobny, Gregory L. Olsen, 2010, Journal of the American Chemical Society.

Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site.

G. Varani, G. Drobny, Z. Shajani, 2008, Journal of the American Chemical Society.

Monitoring tat peptide binding to TAR RNA by solid-state 31P–19F REDOR NMR

Gabriele Varani, Thomas E. Edwards, G. Varani, 2005, Nucleic acids research.

Hydration dependent dynamics in RNA

Gabriele Varani, G. Varani, G. Drobny, 2009, Journal of biomolecular NMR.

Carbon assignments and heteronuclear coupling constants for an RNA oligonucleotide from natural abundance carbon-13-proton correlated experiments

G. Varani, I. Tinoco, 1991 .

The structure of an enzyme-activating fragment of human telomerase RNA.

G. Varani, T. Leeper, 2005, RNA.

The solution structure of an essential stem-loop of human telomerase RNA.

Gabriele Varani, Thomas Leeper, Nicolas Leulliot, 2003, Nucleic acids research.

The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.

J. Karn, G. Varani, J Karn, 1995, Journal of molecular biology.

Structure of an unusually stable RNA hairpin.

G. Varani, I. Tinoco, C. Cheong, 1991, Biochemistry.

A slow dynamic RNA switch regulates processing of microRNA-21

G. Varani, M. Walker, Wen Yang, 2021, bioRxiv.

Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer

G. Varani, Yu Chen, Fan Yang, 2016, Nucleic acids research.

A new α‐helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III

M. Ares, G. Varani, M. Graille, 2004 .

An Allosteric Switch Primes Sequence-Specific DNA Recognition

G. Varani, M. Walker, 2019, Cell.

Identification of the optimal third generation antifolate against P. falciparum and P. vivax.

Gabriele Varani, Carsten Detering, Carol Hopkins Sibley, 2005, Molecular and biochemical parasitology.

A Small Cyclic β‐Hairpin Peptide Mimics the Rbfox2 RNA Recognition Motif and Binds to the Precursor miRNA 20b

G. Varani, M. Shortridge, Yi-Ting Sun, 2019, Chembiochem : a European journal of chemical biology.

Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins

G. Varani, Suxin Zheng, Yu Chen, 2016, Nature chemical biology.

Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1.

G. Varani, C. Moore, T. Leeper, 2010, Journal of molecular biology.

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.

G. Varani, A. Klug, B. Ghetti, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis

Daniel J. Wilson, G. Varani, D. Wilson, 2021, PLoS pathogens.

Polymorphisms affecting expression of the vaccine antigen factor H binding protein influence invasiveness of Neisseria meningitidis

G. Varani, S. Earle, C. Tang, 2021, medRxiv.

Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein.

L. Kay, G. Varani, A. Mittermaier, 1999, Journal of molecular biology.

Structural basis of the RNA‐binding specificity of human U1A protein

G. Varani, D. Neuhaus, F. Allain, 1997, The EMBO journal.

Protein families and RNA recognition

Gabriele Varani, Yu Chen, G. Varani, 2005, The FEBS journal.

Drug-like small molecules that inhibit expression of the oncogenic microRNA-21

G. Varani, G. Calin, T. Pavelitz, 2022, bioRxiv.

Efficient NMR Screening Approach to Discover Small Molecule Fragments Binding Structured RNA.

G. Varani, M. Shortridge, 2021, ACS medicinal chemistry letters.

An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb

John A. Robinson, J. Karn, G. Varani, 2018, Nucleic acids research.

A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.

G. Varani, Yu Chen, M. Walker, 2017, ACS chemical biology.

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein

Gabriele Varani, John A. Robinson, Thomas C. Leeper, 2009, Proceedings of the National Academy of Sciences.

Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).

G. Varani, Suxin Zheng, M. Wolfe, 2009, Chemistry & biology.

Preparation of RNA:protein complexes for X-ray crystallography and NMR

G. Varani, C. Oubridge, K. Nagai, 1998 .

Solution structure of an unusually stable RNA hairpin, 5GGAC(UUCG)GUCC

G. Varani, I. Tinoco, C. Cheong, 1990, Nature.

Faculty Opinions recommendation of Systematic discovery of structural elements governing stability of mammalian messenger RNAs.

Gabriele Varani, Yu Chen, G. Varani, 2012 .

Design of RNA-targeting macrocyclic peptides.

G. Varani, M. Walker, 2019, Methods in enzymology.

The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling.

Lucas C. Reineke, S. Hanash, G. Varani, 2020, Gastroenterology.

The Cbf5–Nop10 complex is a molecular bracket that organizes box H/ACA RNPs

Gabriele Varani, G. Varani, A. Ferré-D’Amaré, 2005, Nature Structural &Molecular Biology.

Structure of the dengue virus RNA promoter

G. Varani, Yi-Ting Sun, 2022, bioRxiv.

The structure and function of small nucleolar ribonucleoproteins

Gabriele Varani, G. Varani, A. Ferré-D’Amaré, 2007, Nucleic acids research.

Delivering messages from the 3′ end

G. Varani, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the RNA specialized translation initiation element that recruits eIF3 to the 5'-UTR of c-Jun.

G. Varani, M. Walker, M. Shortridge, 2020, Journal of Molecular Biology.

The C-terminal Domains of Vertebrate CstF-64 and Its Yeast Orthologue Rna15 Form a New Structure Critical for mRNA 3′-End Processing*

G. Varani, S. Agrawal, C. Moore, 2007, Journal of Biological Chemistry.

The G·U wobble base pair

Gabriele Varani, G. Varani, W. McClain, 2000 .

The conformation of loop E of eukaryotic 5S ribosomal RNA.

G. Varani, I. Tinoco, B. Wimberly, 1993, Biochemistry.

Nop10 is a conserved H/ACA snoRNP molecular adaptor.

G. Varani, S. Reichow, 2008, Biochemistry.

Eukaryotic translation initiation: there are (at least) two sides to every story

G. Varani, A. Sachs, 2000, Nature Structural Biology.

The H / ACA RNP assembly factor SHQ 1 functions as an RNA mimic Material Supplemental

G. Varani, H. Tilbeurgh, N. Leulliot, 2011 .

Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain

Fan Yang, Gabriele Varani, Minkyu Kim, 2010, Nature Structural &Molecular Biology.

Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner

A. Gasch, G. Varani, M. Washburn, 2017, Proceedings of the National Academy of Sciences.

Structure of a low-population binding intermediate in protein-RNA recognition

Carlo Camilloni, Michele Vendruscolo, Gabriele Varani, 2016, Proceedings of the National Academy of Sciences.

RNA-Protein Intermolecular Recognition

Gabriele Varani, G. Varani, 1997 .

Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.

Gabriele Varani, G. Varani, C. Moore, 2008, Journal of molecular biology.

RNA - Protein Intermolecular Recognition

G. Varani, 1997 .

How Arginine-Rich Domains Coordinate mRNA Maturation Events

G. Varani, K. Godin, 2007, RNA biology.

Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary sequence specificity

G. Varani, Fan Yang, Xuan Ye, 2021, bioRxiv.

The NMR structure of the 38 kDa U1A protein – PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein

L. Kay, G. Varani, L. Varani, 2000, Nature Structural Biology.

The kinase inhibitor Palbociclib is a potent and specific RNA-binding molecule

G. Varani, M. Shortridge, Venkata Vidalala, 2022, bioRxiv.

Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation

G. Varani, K. Nagai, F. Allain, 1996, Nature.

Structure of stem‐loop IV of Tetrahymena telomerase RNA

G. Varani, Yu Chen, T. Bryan, 2006, The EMBO journal.

Faculty Opinions recommendation of Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

G. Varani, Yu Chen, 2010 .

The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3′-end processing

G. Varani, Susan D. Lee, C. Moore, 2017, RNA.

Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3′ end processing complex CF I

G. Varani, Susan D. Lee, C. Moore, 2012, Proceedings of the National Academy of Sciences of the United States of America.

Recognition of GU‐rich polyadenylation regulatory elements by human CstF‐64 protein

Gabriele Varani, G. Varani, José Manuel Pérez Cañadillas, 2003, The EMBO journal.

Cell-free selection of RNA-binding proteins using in vitro compartmentalization

G. Varani, Yu Chen, Jana Mandic, 2008, Nucleic acids research.

Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein.

G. Varani, P. K. Rajan, Pritilekha Deka, 2005, Journal of molecular biology.

Recent advances in RNA-protein recognition.

G. Varani, G Varani, J M Pérez-Cañadillas, 2001, Current opinion in structural biology.

A cap for all occasions.

G. Varani, 1997, Structure.

Determination of the NMR structure of the complex between U1A protein and its RNA polyadenylation inhibition element

G. Varani, D. Neuhaus, F. Allain, 1998, Journal of biomolecular NMR.

Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.

G. Varani, K. Nagai, F. Allain, 1996, Journal of molecular biology.

How a rotavirus hijacks the human protein synthesis machinery

G. Varani, F. Allain, 2002, Nature Structural Biology.

Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis

G. Varani, H. Lavender, E. Loh, 2016, Nucleic acids research.

Decoding RNA motional codes.

G. Varani, Pritilekha Deka, Z. Shajani, 2006, Trends in biochemical sciences.

RNA/Peptide Binding Driven by Electrostatics-Insight from Bidirectional Pulling Simulations.

Giovanni Bussi, Gabriele Varani, Paolo Carloni, 2013, Journal of chemical theory and computation.

How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape

Gabriele Varani, John A. Robinson, G. Varani, 2009, Nucleic acids research.

High-resolution structural validation of the computational redesign of human U1A protein.

David Baker, Gabriele Varani, Neil Dobson, 2006, Structure.

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

G. Varani, V. Daggett, C. Link, 2019, Proceedings of the National Academy of Sciences.

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

G. Varani, V. Daggett, B. Caughey, 2014, eLife.

Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal.

G. Varani, A. Lever, J. Gallego, 2002, Journal of molecular biology.

A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript

G. Varani, Giuseppina Pisignano, C. Catapano, 2021, bioRxiv.

Fragment‐based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping

G. Varani, Suxin Zheng, D. W. Begley, 2010, Chemical biology & drug design.

Elucidating Molecular Motion through Structural and Dynamic Filters of Energy-Minimized Conformer Ensembles

G. Varani, G. Drobny, Wei Huang, 2014, The journal of physical chemistry. B.

RNA recognition by a Staufen double‐stranded RNA‐binding domain

Gabriele Varani, Andres Ramos, Stefan Freund, 2000, The EMBO journal.

Faculty Opinions recommendation of Kemp elimination catalysts by computational enzyme design.

Gabriele Varani, G. Varani, 2008 .

3D Perfusable Hydrogel Recapitulating the Cancer Dynamic Environment to in Vitro Investigate Metastatic Colonization

G. Varani, S. Scaglione, M. Fato, 2020, Polymers.

Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration.

G. Varani, G. Chillemi, T. Castrignanò, 2002, Biophysical journal.

An all‐atom, distance‐dependent scoring function for the prediction of protein–DNA interactions from structure

Gabriele Varani, Timothy A Robertson, G. Varani, 2006, Proteins.

Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.

G. Varani, Chin-Ju Park, Byong-Seok Choi, 2012, Molecular bioSystems.

Independent alignment of RNA for dynamic studies using residual dipolar couplings

G. Varani, Michael F. Bardaro, 2012, Journal of Biomolecular NMR.

Independent alignment of RNA for dynamic studies using residual dipolar couplings

G. Varani, Michael F. Bardaro, M. F. Bardaro, 2012, Journal of biomolecular NMR.

Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase.

G. Varani, S. Bae, Chin-Ju Park, 2003, Nucleic acids research.

Conformation and dynamics of an RNA internal loop.

G. Varani, I. Tinoco, B. Wimberly, 1989, Biochemistry.

Solution structure of the inﬂuenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase

G. Varani, S. Bae, Chin-Ju Park, 2022 .

The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.

G. Varani, Suxin Zheng, N. Harmer, 2011, The Biochemical journal.

Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.

G. Varani, T. Magnuson, J. M. Calabrese, 2019, Genetics.

The TFIIIA recognition fragment d(GGATGGGAG).d(CTCCCATCC) is B-form in solution.

G. Varani, I. Tinoco, G. Walker, 1988, Nucleic acids research.

Real-time multidimensional NMR follows RNA folding with second resolution

Lucio Frydman, Gabriele Varani, G. Varani, 2010, Proceedings of the National Academy of Sciences.

Structural biology: RNA switches function

G. Varani, S. Reichow, 2006, Nature.

A conserved RNA structure within the HCV IRES eIF3-binding site

Gabriele Varani, G. Varani, P. Cole, 2002, Nature Structural Biology.

Structural genomics of infectious disease drug targets: the SSGCID

Gabriele Varani, Garry W. Buchko, Peter J. Myler, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Design of β-Hairpin Peptidomimetics That Inhibit Binding of α-Helical HIV-1 Rev Protein to the Rev Response Element RNA†

John A. Robinson, G. Varani, K. Moehle, 2007 .

DESIGN AND CHARACTERIZATION OF A BIOCOMPATIBLE PHYSICAL HYDROGEL BASED ON SCLEROGLUCAN FOR TOPICAL DRUG DELIVERY.

G. Varani, S. Pacelli, A. Adrover, 2017, Carbohydrate polymers.

Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA.

Gabriele Varani, Costin M. Gherghe, K. Weeks, 2008, Journal of the American Chemical Society.

Decision making based on hybrid modeling approach applied to cellulose acetate based historical films conservation

G. Varani, M. Pinto, A. Ramos, 2021, Scientific Reports.

Nucleic acids structure and recognition.

G. Varani, G Varani, K Y Chang, 1997, Nature structural biology.

Determination of sugar conformation in large RNA oligonucleotides from analysis of dipole–dipole cross correlated relaxation by solution NMR spectroscopy

H. Schwalbe, G. Varani, C. Richter, 1999, Journal of Biomolecular NMR.

Recent solution structures of RNA and its complexes with drugs, peptides and proteins.

G. Varani, A. Ramos, C. Gubser, 1997, Current opinion in structural biology.

Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase.

G. Varani, P. Rathod, F. Buckner, 2005, Molecular and biochemical parasitology.

Quantum dots functionalised artificial peptides bioinspired to the D1 protein from the Photosystem II of Chlamydomonas reinhardtii for endocrine disruptor optosensing.

G. Varani, M. Giardi, Amina Antonacci, 2020, Talanta.

The hepatitis C virus internal ribosome-entry site: a new target for antiviral research.

G. Varani, J. Gallego, 2001, Biochemical Society transactions.

Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR.

Prashant S. Emani, G. Varani, G. Drobny, 2017, The journal of physical chemistry. B.

Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens

G. Varani, P. Myler, W. V. Van Voorhis, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Theory of nonrigid rotational motion applied to NMR relaxation in RNA.

Prashant S. Emani, G. Varani, G. Drobny, 2011, The journal of physical chemistry. A.

RNA-binding proteins: modular design for efficient function

G. Varani, C. Moore, B. M. Lunde, 2007, Nature Reviews Molecular Cell Biology.

1H, 13C and 15N Resonance Assignments of URNdesign, a Computationally Redesigned RRM Protein

G. Dantas, G. Varani, Neil Dobson, 2005, Journal of biomolecular NMR.

A New Method To Detect Long-Range Protein−RNA Contacts: NMR Detection of Electron−Proton Relaxation Induced by Nitroxide Spin-Labeled RNA

Gabriele Varani, Andres Ramos, G. Varani, 1998 .

Structure of the acceptor stem of Escherichia coli tRNA Ala: role of the G3.U70 base pair in synthetase recognition.

G. Varani, A. Ramos, 1997, Nucleic acids research.

Divalent metal ion binding to a conserved wobble pair defining the upstream site of cleavage of group I self-splicing introns.

G. Varani, F. Allain, G Varani, 1995, Nucleic acids research.

NMR studies of U1 snRNA recognition by the N‐terminal RNP domain of the human U1A protein.

G. Varani, K. Nagai, D. Neuhaus, 1994, The EMBO journal.

Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site.

G. Varani, G. Drobny, Z. Shajani, 2008, Journal of the American Chemical Society.

Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA.

Gabriele Varani, Paolo Carloni, Giulia Rossetti, 2014, Journal of the American Chemical Society.

Refinement of the structure of protein–RNA complexes by residual dipolar coupling analysis

G. Varani, L. Varani, P. Bayer, 1999, Journal of biomolecular NMR.

The role of the solvent on the binding of ethidium bromide to DNA in alcohol–water mixtures

G. Varani, G. Baldini, 1986, Biopolymers.

Pseudoelectrostatic effects in the thermodynamics of dye binding to DNA

G. Varani, G. Baldini, M. Fornoni, 1985 .

Nonspecific interactions in dye binding to DNA. Influence of alcohols and amides.

G. Varani, G. Baldini, L. Della Torre, 1987, Biophysical Chemistry.

Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA.

G. Varani, C. Micheletti, P. Carloni, 2014, Journal of the American Chemical Society.

Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA.

K. Weeks, G. Varani, K. Wilkinson, 2008, Journal of the American Chemical Society.

Faculty Opinions recommendation of Substrate-specific structural rearrangements of human Dicer.

G. Varani, Yu Chen, 2013 .

Structural Biology and Crystallization Communications Comparative Analysis of Glutaredoxin Domains from Bacterial Opportunistic Pathogens

G. Varani, P. Myler, W. V. Van Voorhis, 2022 .

Structure of the polyadenylation regulatory element of the human U1A pre-mRNA 3'-untranslated region and interaction with the U1A protein.

G. Varani, C. Gubser, 1996, Biochemistry.

Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies.

G. Varani, G. Drobny, Z. Shajani, 2007, Biochemistry.

Real-time multidimensional NMR follows RNA folding with second resolution

G. Varani, L. Frydman, Mi-Kyung Lee, 2010, Proceedings of the National Academy of Sciences.