C. Harris

发表

Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin‐43, an α‐helical protein with over 50% sequence identity to an all‐β protein

David T. Jones, David C. Jones, J. Thornton, 1996 .

Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein.

D. T. Jones, J. Thornton, C. Moody, 1996, Proteins.

Chemogenomics: structuring the drug discovery process to gene families.

C. Harris, A. Stevens, John Harris, 2006, Drug discovery today.

The Design and Application of Target-Focused Compound Libraries

C. Harris, P. Stouten, D. Sheppard, 2011, Combinatorial chemistry & high throughput screening.

Bringing kinases into focus: efficient drug design through the use of chemogenomic toolkits.

C. Harris, A. Stevens, V. Birault, 2006, Current medicinal chemistry.

How large does a compound screening collection need to be?

C. Harris, D. Livingstone, A. Stevens, 2008, Combinatorial chemistry & high throughput screening.

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.

C. Harris, K. Chibale, D. Warner, 2015, Bioorganic & medicinal chemistry.

Medium-ring diphosphines from diphosphabicyclo[k.l.0]alkanes: stereoselective syntheses, structure and properties

C. Harris, A. Orpen, R. Gleiter, 1998 .

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

G. Drewes, C. Harris, Markus Boesche, 2017, Journal of medicinal chemistry.

Human renin: a new class of inhibitors.

C. Harris, D. Stammers, J. Dann, 1986, Biochemical and biophysical research communications.

Novel renin inhibitors: synthesis of aminostatine and comparison with statine-containing analogues

John A. Robinson, David J. Williams, C. Harris, 1986 .

A rational approach to the design of antihypertensives: X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors

T. Blundell, C. Harris, J. Champness, 1991 .

Amino-alcohol dipeptide analogues: A simple synthesis of a versatile isostere for the development of proteinase inhibitors

C. Harris, D. E. Davies, R. J. Arrowsmith, 1987 .

Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.

C. Harris, Kei Imaizumi, J. Frearson, 2012, Journal of medicinal chemistry.

The synthesis and biological activities of some 12-Aza-prostaglandin analogues

C. Harris, N. Whittaker, J. Armstrong, 1978 .

Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties.

A. Robertson, C. Harris, P. Leff, 1996, Bioorganic & medicinal chemistry.

Synthesis and Inhibitory Activity on Platelet Aggregation of 13′‐Aza and Other ω‐Chain Modified BW245C Analogues

W. R. King, C. Harris, B. Whittle, 1994, Archiv der Pharmazie.

Bridgehead diphosphines in the bicyclo[3.3.3]undecane and bicyclo[4.4.4]tetradecane series: synthesis, structure and properties

C. Harris, A. Orpen, R. Gleiter, 1998 .

Synthesis of 1H-1,2,4-triazole 2-oxides and annelated derivatives

C. Harris, C. Moody, T. L. Gilchrist, 1976 .

s-Triazolo-N-oxides from sulphimides and nitrile oxides. Valence tautomerism of 5,7-dimethyl-2-p-tolyl-s-triazolo[1,5-α]pyrimidine 1-oxide

C. Harris, C. Moody, T. L. Gilchrist, 1974 .

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model

C. Harris, S. Knapp, M. Overduin, 2020, Journal of medicinal chemistry.

Synthesis and Reactivity of Cyclic (R3 P-PR3)++ Dications

C. Harris, R. Alder, 1992 .

Synthesis and reactions of 1,6-diphosphabicyclo[4.4.0]decane and related molecules

C. Harris, A. Orpen, R. Alder, 1992 .

Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides.

J M Thornton, P J Sadler, J. Thornton, 1996, European journal of biochemistry.

The preparation and reactions of 1,6-diphosphatricyclo[4.4.4.0]tetradecanediium ditrifluoromethanesulfonate

C. Harris, A. Orpen, R. Alder, 1992 .

Synthesis and Reactivity of Cyclic (R3P-PR3)++ Dications.

C. Harris, R. Alder, 1992 .

Synthesis and Platelet Aggregation Inhibiting Activity of Acid Side‐chain Modified Hydantoin Prostaglandin Analogues

R. Glen, C. Harris, N. Whittaker, 1993, Archiv der Pharmazie.

Prostaglandin synthesis

C. Harris, 1978, Nature.

Heterocyclic prostaglandin analogues. Part 2. Hydantoins and other imidazole analogues

C. Harris, N. Whittaker, R. Stepney, 1980 .

Conformational restraints revealing bioactive β‐bend structures for hα CGRP8–37 at the CGRP2 receptor of the rat prostatic vas deferens

P. M. Doyle, C. Harris, I. Marshall, 1999 .

Identification of a novel operon in Lactococcus lactis encoding three enzymes for lactic acid synthesis: phosphofructokinase, pyruvate kinase, and lactate dehydrogenase

B. E. Davidson, C. Harris, A. Hillier, 1993, Journal of bacteriology.

Comparison of angiotensinogen and tetradecapeptide as substrates for human renin. Substrate dependence of the mode of inhibition of renin by a statine-containing hexapeptide.

C. Harris, D. Stammers, J. Dann, 1987, Archives of biochemistry and biophysics.

Bridgehead Diphosphines in the Bicyclo[3.3.3]undecane and Bicyclo[4.4.4]tetradecane Series: Synthesis, Structure and Properties.

C. Harris, A. Orpen, R. Gleiter, 1998 .

Characterisation of the solution conformation of a cyclic RGD peptide analogue by NMR spectroscopy allied with a genetic algorithm approach and constrained molecular dynamics.

R C Glen, R. Glen, P. M. Doyle, 2009, International journal of peptide and protein research.

Designing multi-target drugs

J. Richard Morphy, C. Harris, C John Harris, 2012 .

Heterocyclic prostaglandin analogues. Part 4. Piperazine-2,5-diones, pyrazolidine-3,5-diones, 1,2,4-triazolidinediones, 1,3,4-oxadiazolidinediones and 1,3,4-thiadiazolidinediones

C. Harris, N. Whittaker, P. Barraclough, 1981 .

Design, synthesis and structure of a zinc finger with an artificial beta-turn.

J. Thornton, J. Uppenbrink, J. H. Viles, 1998, Journal of molecular biology.

Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation

C. Harris, N. Whittaker, R. Stepney, 1979 .

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.

C. Harris, K. Chibale, D. Warner, 2015, Bioorganic & medicinal chemistry.