D. Engelman

发表

Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.

T. Steitz, D. Engelman, A. Goldman, 1986, Annual review of biophysics and biophysical chemistry.

Probe for the measurement of cell surface pH in vivo and ex vivo

D. Engelman, Michael Anderson, A. Moshnikova, 2016, Proceedings of the National Academy of Sciences.

Annual review of biophysics and biomolecular structure

T. Pollard, C. Cantor, D. Engelman, 1992 .

Annual review of biophysics and biophysical chemistry

T. Pollard, C. Cantor, D. Engelman, 1985 .

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

M. Gerstein, D. Engelman, A. Senes, 2000, Journal of molecular biology.

The effect of point mutations on the free energy of transmembrane alpha-helix dimerization.

D. Engelman, K. G. Fleming, A. Ackerman, 1997, Journal of molecular biology.

Normal modes for predicting protein motions: A comprehensive database assessment and associated Web tool

Mark Gerstein, Nathaniel Echols, Ursula Lehnert, 2005, Protein science : a publication of the Protein Society.

Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions.

D. Engelman, D. Schneider, Donald M Engelman, 2004, Journal of molecular biology.

Helical membrane protein folding, stability, and evolution.

D. Engelman, J. Popot, D M Engelman, 2000, Annual review of biochemistry.

Membrane protein folding and oligomerization: the two-stage model.

D. Engelman, J. Popot, D M Engelman, 1990, Biochemistry.

A Transmembrane Helix Dimer: Structure and Implications

James H. Prestegard, Donald M. Engelman, D. Engelman, 1997, Science.

Family of pH (low) insertion peptides for tumor targeting

Yana K Reshetnyak, D. Engelman, A. Moshnikova, 2013, Proceedings of the National Academy of Sciences.

Polar residues drive association of polyleucine transmembrane helices

D. Engelman, A. Brunger, F. Zhou, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Sequence motifs, polar interactions and conformational changes in helical membrane proteins.

D. Engelman, A. Curran, Donald M Engelman, 2003, Current opinion in structural biology.

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol

Graham Warren, Donald M. Engelman, D. Engelman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic Helix Interactions in Transmembrane Signaling

Donald M. Engelman, D. Engelman, M. Zoonens, 2006, Cell.

The GxxxG motif: a framework for transmembrane helix-helix association.

D. Engelman, W. P. Russ, W P Russ, 2000, Journal of molecular biology.

The Cα—H⋅⋅⋅O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions

Alessandro Senes, Donald M. Engelman, D. Engelman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

D. Engelman, B. Bormann, J. Hunt, 1992, The Journal of biological chemistry.

Sequence specificity in the dimerization of transmembrane alpha-helices.

D. Engelman, J. Zhang, M. Lemmon, 1992, Biochemistry.

Helical membrane proteins: diversity of functions in the context of simple architecture.

D. Engelman, I. Ubarretxena-Belandia, D M Engelman, 2001, Current opinion in structural biology.

Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.

M. Gerstein, D. Engelman, Yang Liu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Genomic analysis of membrane protein families: abundance and conserved motifs

M. Gerstein, D. Engelman, Yang Liu, 2002, Genome Biology.

Sequence context strongly modulates association of polar residues in transmembrane helices.

D. Engelman, C. Deber, R. Melnyk, 2003, Journal of molecular biology.

MicroRNA silencing for cancer therapy targeted to the tumor microenvironment

Christopher J. Cheng, F. Slack, D. Engelman, 2014, Nature.

Membranes are more mosaic than fluid

D. Engelman, 2005, Nature.

Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2020, Frontiers in Bioengineering and Biotechnology.

Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families.

Kevin Y. Yip, M. Gerstein, D. Engelman, 2010, Genome research.

The planar organization of lecithin-cholesterol bilayers.

J. Rothman, D. Engelman, D M Engelman, 1972, The Journal of biological chemistry.

Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles.

D. Engelman, D M Engelman, B. A. Lewis, 1983, Journal of molecular biology.

Structural organization of the pentameric transmembrane alpha‐helices of phospholamban, a cardiac ion channel.

D. Engelman, P. Adams, A. Brünger, 1994, The EMBO journal.

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

T. Steitz, D. Engelman, D. M. Engelman, 1981, Cell.

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein

D. Engelman, N. Kondo, Yufei Long, 2010, Retrovirology.

Conversion of phospholamban into a soluble pentameric helical bundle.

T. Steitz, D. Engelman, H. Li, 2001, Biochemistry.

Helix-helix interactions inside membranes

D. Engelman, A. Brunger, J. Hunt, 1995 .

MEMBRANE PROTEIN MODELS: POSSIBILITIES AND PROBABILITIES

D. Engelman, J. Popot, 1990 .

On the Folding of Bacteriorhodopsin

D. Engelman, 1986 .

[11] The identification of helical segments in the polypeptide chain of bacteriorhodopsin

Donald M. Engelman, Thomas A. Steitz, T. Steitz, 1982 .

An Implication of the Structure of Bacteriorhodopsin: Globular Membrane Proteins are Stabilized by Polar Interactions.

D. Engelman, 1982, Biophysical journal.

Neutron diffraction analysis of cytochrome b5 reconstituted in deuterated lipid multilayers.

D. Engelman, G. Zaccai, E. Gogol, 1983, Biophysical journal.

Conformation of liquid N-alkanes.

D. Engelman, F. Goodsaid-Zalduondo, 1981, Biophysical journal.

Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors.

D. Engelman, Y. Reshetnyak, M. Zoonens, 2008, Biophysical journal.

The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion.

J. Rothman, D. Engelman, T. Weber, 1999, Molecular cell.

The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices.

D. Engelman, A. Brünger, A. Brunger, 1992, Biochemistry.

A method for determining transmembrane helix association and orientation in detergent micelles using small angle x-ray scattering.

D. Engelman, Z. Bu, Donald M Engelman, 1999, Biophysical journal.

Leucine side-chain rotamers in a glycophorin A transmembrane peptide as revealed by three-bond carbon—carbon couplings and 13C chemical shifts

D. Engelman, J. Prestegard, K. MacKenzie, 1996, Journal of biomolecular NMR.

pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Proceedings of the National Academy of Sciences.

Computationalanalysisofmembraneproteins: genomicoccurrence,structurepredictionand helixinteractions

M. Gerstein, Haiyuan Yu, D. Engelman, 2004 .

Computational analysis of membrane proteins: the largest class of drug targets.

Mark B Gerstein, Ekta Khurana, M. Gerstein, 2009, Drug discovery today.

Characterization of the plasma membrane of Mycoplasma laidlawii. I. Sodium dodecyl sulfate solubilization.

D. Engelman, H. Morowitz, T. M. Terry, 1967, Biochimica et biophysica acta.

Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.

D. Engelman, D. DiMaio, K. Yates, 2005, Journal of molecular biology.

Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation

D. Engelman, D. Tobias, D. DiMaio, 2017, Proceedings of the National Academy of Sciences.

Novel ex vivo endoscopic near infrared fluorescence imaging method using pHLIP®/ICG in patients undergoing radical cystectomy for urothelial carcinoma of the bladder

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2017 .

Artiﬁcial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redeﬁne Sequence Requirements for Activation of the Platelet-Derived Growth Factor (cid:2) Receptor (cid:1) †

M. Gerstein, Ekta Khurana, D. Engelman, 2009 .

MicroRNA function can be reversed by altering target gene expression levels

D. Engelman, S. Campbell, Alexander A. Svoronos, 2021, iScience.

Targeting bladder urothelial carcinoma with pHLIP-ICG and inhibition of urothelial cancer cell proliferation by pHLIP-amanitin

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2022, Frontiers in Urology.

Amphipols: polymeric surfactants for membrane biology research

D. Engelman, E. Berry, Y. Gohon, 2003, Cellular and Molecular Life Sciences CMLS.

Glycophorin A helical transmembrane domains dimerize in phospholipid bilayers: a resonance energy transfer study.

D. Engelman, B. Adair, 1994, Biochemistry.

pHLIP Peptides Target Acidity in Activated Macrophages

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2022, Molecular Imaging and Biology.

Interhelical hydrogen bonding drives strong interactions in membrane proteins

D. Engelman, W. P. Russ, A. Brunger, 2000, Nature Structural Biology.

Biologically active LIL proteins built with minimal chemical diversity

D. Engelman, D. DiMaio, L. Petti, 2015, Proceedings of the National Academy of Sciences.

A Small-Angle X-ray Scattering Apparatus for Studying Biological Macromolecules in Solution

D. Engelman, H. Wyckoff, Z. Bu, 1998 .

The lac Repressor Protein: Molecular Sha Model for Operator Interaction Based on (electron microscopy/x-ray diffraction/protein-DNA intern

T. Steitz, D. Engelman, T. Richmond, 2016 .

Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity

D. Engelman, Y. Reshetnyak, O. Andreev, 2021, NAR cancer.

Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2022, Frontiers in Oncology.

Structural comparisons of native and reaggregated membranes from Mycoplasma laidlawii and erythrocytes by x-ray diffraction and nuclear magnetic resonance techniques.

D. Engelman, S. Metcalfe, J. Metcalfe, 1971, Biochimica et biophysica acta.

Characterization of the plasma membrane of Mycoplasma laidlawii. 3. The formation and aggregation of small lipoprotein structures derived from sodium dodecyl sulfate-solubilized membrane components.

D. Engelman, H. Morowitz, 1968, Biochimica et biophysica acta.

Characterization of the plasma membrane of Mycoplasma laidlawii. IV. Structure and composition of membrane and aggregated components.

D. Engelman, H. Morowitz, 1968, Biochimica et biophysica acta.

Characterization of the plasma membrane of Mycoplasma laidlawii. II. Modes of aggregation of solubilized membrane components.

D. Engelman, H. Morowitz, T. M. Terry, 1967, Biochimica et biophysica acta.

On the feasibility and interpretation of intersubunit distance measurements using neutron scattering.

D. Engelman, P. Moore, 1979, Methods in enzymology.

Asymmetry in the 50S ribosomal subunit of Escherichia coli.

B. Schoenborn, D. Engelman, P. Moore, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Neutron scattering shows that cytochrome b5 penetrates deeply into the lipid bilayer.

D. Engelman, E. Gogol, 1984, Biophysical journal.

Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions

Mark Gerstein, Yang Liu, Yu Xia, 2004, Quarterly Reviews of Biophysics.

Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor

D. Engelman, D. DiMaio, F. Barrera, 2010, Proceedings of the National Academy of Sciences.

Small angle X-ray scattering of dimeric yeast hexokinase in solution.

T. Steitz, D. Engelman, R. Mcdonald, 1979, The Journal of biological chemistry.

Quaternary Organization of the 30S Ribosomal Subunit of Escherichia Coli.

D. Engelman, M. Capel, P. Moore, 1986, Biophysical journal.

Uses of X-Ray and Neutron Solution Scattering in Membrane Structural Studies

D. Engelman, 1985 .

A neutron scattering study of the distribution of protein and RNA in the 30 S ribosomal subunit of Escherichia coli.

B. Schoenborn, D. Engelman, P. Moore, 1975, Journal of molecular biology.

A view of dynamics changes in the molten globule-native folding step by quasielastic neutron scattering.

D. Engelman, D. Neumann, C. Brown, 2000, Journal of molecular biology.

CURRENT MODELS FOR THE STRUCTURE OF BIOLOGICAL MEMBRANES

D. Engelman, W. Stoeckenius, 1969, The Journal of cell biology.

Bilayer structure in membranes.

D. Engelman, A. Blaurock, M. Wilkins, 1971, Nature: New biology.

Bacteriorhodopsin/amphipol complexes: structural and functional properties.

D. Engelman, R. Ruigrok, Y. Gohon, 2008, Biophysical journal.

Tertiary structure of bacteriorhodopsin. Positions and orientations of helices A and B in the structural map determined by neutron diffraction.

D. Engelman, O. Gurel, J. Popot, 1989, Journal of molecular biology.

Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose 6-phosphate.

T. Steitz, D. Engelman, R. Mcdonald, 1979, Biochemistry.

High-Yield Synthesis and Purification of an α-Helical Transmembrane Domain

D. Engelman, L. Fisher, 2001 .

Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor.

M. Gerstein, D. Engelman, Yu Xia, 2004, Journal of molecular biology.

Selection and Characterization of Small Random Transmembrane Proteins That Bind and Activate the Platelet-derived Growth Factor B Receptor

M. Gerstein, D. Engelman, Yu Xia, 2022 .

A dimerization motif for transmembrane α–helices

D. Engelman, P. Adams, A. Brünger, 1994, Nature Structural Biology.

X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawii.

D. Engelman, Donald M. Engelman, 1970, Journal of molecular biology.

Mapping the Homodimer Interface of an Optimized, Artificial, Transmembrane Protein Activator of the Human Erythropoietin Receptor

D. Engelman, D. DiMaio, F. Barrera, 2014, PloS one.

Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor

M. Gerstein, Ekta Khurana, D. Engelman, 2009, Journal of Virology.

Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix.

D. Engelman, Y. Reshetnyak, O. Andreev, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins*

H. Lodish, D. Engelman, W. P. Russ, 2003, Journal of Biological Chemistry.

Tumor treatment by pHLIP-targeted antigen delivery

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2023, Frontiers in Bioengineering and Biotechnology.

Lipid bilayer structure in the membrane of Mycoplasma laidlawii.

D. Engelman, Donald M. Engelman, 1971, Journal of molecular biology.

A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli.

J A Langer, B P Schoenborn, M Kjeldgaard, 1987, Science.

Design of single-layer β-sheets without a hydrophobic core

D. Engelman, A. Koide, S. Koide, 2000, Nature.

Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase.

T. Steitz, D. Engelman, D. Mckay, 1979, The Journal of biological chemistry.

BACTERIORHODOPSIN RECONSTITUTED FROM TWO INDIVIDUAL HELICES AND THE COMPLEMENTARY FIVE‐HELIX FRAGMENT IS PHOTOACTIVE

D. Engelman, M. Kataoka, F. Tokunaga, 1992, Photochemistry and photobiology.

Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin.

J M Sturtevant, D. Engelman, J. Sturtevant, 1992, Biochemistry.

Small angle x-ray scattering studies of magnetically oriented lipid bilayers.

D. Engelman, J. Prestegard, B. Hare, 1995, Biophysical journal.

Neutron diffraction analysis of the structure of rod photoreceptor membranes in intact retinas.

B. Schoenborn, D. Engelman, L. Stryer, 1980, Journal of molecular biology.

Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban.

S. O. Smith, D. Engelman, I. Arkin, 1996, Biophysical journal.

Two EGF molecules contribute additively to stabilization of the EGFR dimer

D. Engelman, I. Lax, J. Schlessinger, 1997, The EMBO journal.

Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process.

D. Engelman, J. Popot, D M Engelman, 1987, Journal of molecular biology.

Melittin binding causes a large calcium-dependent conformational change in calmodulin.

D. Engelman, B. Seaton, M. Kataoka, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo

D. Engelman, Y. Reshetnyak, O. Andreev, 2007, Proceedings of the National Academy of Sciences.

Bacteriorhodopsin in and out of Shape: Experimental Evidence in Favor of a Two-Stage Mechanism for Integral Membrane Protein Folding

D. Engelman, J. Popot, 1988 .

Pair distribution functions of bacteriorhodopsin and rhodopsin in model bilayers.

D. Engelman, S. Chan, L. T. Pearson, 1983, Biophysical journal.

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

D. Engelman, J. Rogers, L. Gotow, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP.

D. Engelman, F. Barrera, J. Deacon, 2015, Archives of biochemistry and biophysics.

Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library.

D. Engelman, J. Beckwith, D. Boyd, 2001, Journal of molecular biology.

TOXCAT: a measure of transmembrane helix association in a biological membrane.

D. Engelman, W. P. Russ, W P Russ, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Compositional mapping of cholesteryl ester droplets in the fatty streaks of human aorta.

D. Engelman, G. M. Hillman, 1976, The Journal of clinical investigation.

Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose

D. Engelman, A. Dianoux, B. Jacrot, 1982, Nature.

Bacteriorhodopsin can be refolded from two independently stable transmembrane helices and the complementary five-helix fragment.

D. Engelman, T. W. Kahn, 1992, Biochemistry.

Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching

D. Engelman, P. Adams, A. Brünger, 1996, Proteins.

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

Paul D. Adams, Isaiah T. Arkin, Axel T. Brünger, 1995, Nature Structural Biology.

GALLEX, a Measurement of Heterologous Association of Transmembrane Helices in a Biological Membrane*

Donald M. Engelman, D. Engelman, D. Schneider, 2003, The Journal of Biological Chemistry.

Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain.

D. Engelman, J. Sturgis, L. Fisher, 1999, Journal of molecular biology.

Are there dominant membrane protein families with a given number of helices?

A T Brünger, D. Engelman, A. Brünger, 1997, Proteins.

Quantitative application of the helical hairpin hypothesis to membrane proteins.

T. Steitz, D. Engelman, A. Goldman, 1982, Biophysical journal.

An integrated system for studying residue coevolution in proteins

Mark Gerstein, Drew McDermott, Kevin Y. Yip, 2008, Bioinform..

Invariant chain transmembrane domain trimerization: a step in MHC class II assembly.

D. Engelman, Erin E. Matthews, Jessica P. Dawson, 2006, Biochemistry.

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

D. Engelman, D. Stern, M. Lemmon, 1997, Oncogene.

Thermostability of membrane protein helix–helix interaction elucidated by statistical analysis

M. Gerstein, D. Engelman, Yang Liu, 2002, FEBS letters.

Specificity in transmembrane helix–helix interactions can define a hierarchy of stability for sequence variants

D. Engelman, D M Engelman, K G Fleming, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Image analysis of soft-tissue in-growth and attachment into highly porous alumina ceramic foam metals.

D. Engelman, I. Dickey, M. Hawkins, 2009, Medical engineering & physics.

Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2016, Proceedings of the National Academy of Sciences.

Specificity and promiscuity in membrane helix interactions

D. Engelman, M. Lemmon, D M Engelman, 1994, Quarterly Reviews of Biophysics.

Positions of proteins S10, S11 and S12 in the 30 S ribosomal subunit of Escherichia coli.

D. Engelman, P. Moore, D. Schindler, 1979, Journal of molecular biology.

Hepatitis C Virus RNA Replication and Virus Particle Assembly Require Specific Dimerization of the NS4A Protein Transmembrane Domain

Andrew S. Kohlway, D. Engelman, B. Lindenbach, 2013, Journal of Virology.

A zinc-binding domain involved in the dimerization of RAG1.

D. Schatz, D. Engelman, D M Engelman, 1996, Journal of molecular biology.

pHLIP peptide targets nanogold particles to tumors

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2012, Proceedings of the National Academy of Sciences.

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Molecular membrane biology.

Membranes Do Not Tell Proteins How To Fold.

D. Engelman, J. Popot, 2016, Biochemistry.

pHLIP and Acidity as a Universal Biomarker for Cancer

D. Engelman, Justin Fendos, 2012, The Yale journal of biology and medicine.

Specificity and promiscuity in membrane helix interactions

D. Engelman, M. Lemmon, 1994, FEBS letters.

Positions of proteins S6, S11 and S15 in the 30 S ribosomal subunit of Escherichia coli.

D. Engelman, V. Ramakrishnan, P. Moore, 1981, Journal of molecular biology.

Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy

O. Tillement, D. Engelman, F. Hyder, 2020, Translational oncology.

The lac repressor protein: molecular shape, subunit structure, and proposed model for operator interaction based on structural studies of microcrystals.

T. Steitz, D. Engelman, T. Richmond, 1974, Proceedings of the National Academy of Sciences of the United States of America.

A dimerization motif for transmembrane alpha-helices.

A T Brünger, P D Adams, D. Engelman, 1994, Nature structural biology.

The Affinity of GXXXG Motifs in Transmembrane Helix-Helix Interactions Is Modulated by Long-range Communication*

D. Engelman, J. Bowie, Sanguk Kim, 2004, Journal of Biological Chemistry.

Transmembrane homodimerization of receptor‐like protein tyrosine phosphatases

D. Engelman, J. Sachs, C. Chin, 2005, FEBS letters.

Bacteriorhodopsin is an inside-out protein.

D. Engelman, G. Zaccai, D M Engelman, 1980, Proceedings of the National Academy of Sciences of the United States of America.

On the interpretation and prediction of X‐ray scattering profiles of biomolecules in solution

D. Engelman, C. A. Pickover, D. M. Engelman, 1982 .

Path of the polypeptide in bacteriorhodopsin.

D. Engelman, R. Henderson, B. Wallace, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Surface Area per Lipid Molecule in the Intact Membrane of the Human Red Cell

D. Engelman, 1969, Nature.

Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP).

D. Engelman, Y. Reshetnyak, O. Andreev, 2009, Chimica oggi.

Molecular mechanism for the interaction of phospholipid with cholesterol.

J. Rothman, D. Engelman, 1972, Nature: New biology.

Inelastic neutron scattering studies of hexokinase in solution.

D. Engelman, A. Dianoux, B. Jacrot, 1984, Basic life sciences.

Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle X-ray scattering.

F M Richards, F. Richards, D. Engelman, 1985, Biochemistry.

Small-angle X-ray scattering studies of calmodulin mutants with deletions in the linker region of the central helix indicate that the linker region retains a predominantly alpha-helical conformation.

D. Engelman, A. Persechini, R. Kretsinger, 1991, Biochemistry.

Mutations can cause large changes in the conformation of a denatured protein.

D. Engelman, M. Kataoka, T. Fujisawa, 1993, Biochemistry.

Surface point mutations that significantly alter the structure and stability of a protein's denatured state

L. Regan, D. Engelman, K. Anderson, 1996, Protein science : a publication of the Protein Society.

Protein area occupancy at the center of the red blood cell membrane

D. Engelman, Donald M Engelman, Allison D Dupuy, 2008, Proceedings of the National Academy of Sciences.

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.

F. Slack, D. Engelman, Alexander A. Svoronos, 2016, Cancer research.

Helix-helix interactions inside lipid bilayers

D. Engelman, M. Lemmon, 1992, Current Opinion in Structural Biology.

Ku80-Targeted pH-Sensitive Peptide–PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation

D. Engelman, P. Glazer, R. Bahal, 2020, Molecular Cancer Research.

Motifs of serine and threonine can drive association of transmembrane helices.

D. Engelman, J. S. Weinger, Jessica P. Dawson, 2002, Journal of molecular biology.

Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.

D. Engelman, P. Glazer, D. DiMaio, 2019, Molecular pharmaceutics.

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions

D. Engelman, A. Harris, A. Moshnikova, 2015, Proceedings of the National Academy of Sciences.

X-ray and neutron small-angle scattering studies of the complex between protein S1 and the 30-S ribosomal subunit.

D. Engelman, P. Moore, M. Laughrea, 1978, European Journal of Biochemistry.

Assessment of the aggregation state of integral membrane proteins in reconstituted phospholipid vesicles using small angle neutron scattering.

D. Engelman, P. McCrea, J. Hunt, 1997, Journal of Molecular Biology.

Ion Channels

D. Engelman, G. Heijne, Stephen H. White, 2004, Cell Boundaries.

Model calculations of protein pair interference functions.

D. Engelman, P. Moore, 1977, Journal of molecular biology.

Determination of quaternary structure by small angle neutron scattering.

D. Engelman, P. Moore, 1975, Annual review of biophysics and bioengineering.

Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1.

D. Engelman, A. Curran, Jong Hwa Kim, 2009, Biochimica et biophysica acta.

Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations.

D. Engelman, T. Woolf, H. Petrache, 2000, Journal of molecular biology.

Bacteriorhodopsin remains dispersed in fluid phospholipid bilayers over a wide range of bilayer thicknesses.

D. Engelman, B. Lewis, B. A. Lewis, 1983, Journal of molecular biology.

Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix.

D. Engelman, J. Hunt, K. Rothschild, 1997, Biochemistry.

Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer

D. Engelman, Michael Anderson, Y. Reshetnyak, 2014, Proceedings of the National Academy of Sciences.

Targeting diseased tissues by pHLIP insertion at low cell surface pH

D. Engelman, Y. Reshetnyak, O. Andreev, 2013, Front. Physiol..

Modulation of the pHLIP transmembrane helix insertion pathway.

D. Engelman, Y. Reshetnyak, O. Andreev, 2012, Biophysical journal.

Roles of carboxyl groups in the transmembrane insertion of peptides.

D. Engelman, Michael Anderson, Y. Reshetnyak, 2011, Journal of molecular biology.

Tuning the insertion properties of pHLIP.

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Biochimica et biophysica acta.

Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane

D. Engelman, Y. Reshetnyak, O. Andreev, 2008, Proceedings of the National Academy of Sciences.

A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers.

D. Engelman, Y. Reshetnyak, O. Andreev, 2007, Biophysical journal.

Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7.

B. Schoenborn, D. Engelman, P. Moore, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Positions of S2, S13, S16, S17, S19 and S21 in the 30 S ribosomal subunit of Escherichia coli.

M Kjeldgaard, D. Engelman, M. Capel, 1988, Journal of molecular biology.

Positions of proteins S14, S18 and S20 in the 30 S ribosomal subunit of Escherichia coli.

D. Engelman, M. Capel, V. Ramakrishnan, 1984, Journal of molecular biology.

Membrane physical properties influence transmembrane helix formation

D. Engelman, F. Barrera, Justin Fendos, 2012, Proceedings of the National Academy of Sciences.

Truncated staphylococcal nuclease is compact but disordered.

D. Engelman, D. Shortle, M. Kataoka, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Applications of pHLIP Technology for Cancer Imaging and Therapy.

D. Engelman, Y. Reshetnyak, O. Andreev, 2017, Trends in Biotechnology.

Structural perspectives of phospholamban, a helical transmembrane pentamer.

S. O. Smith, D. Engelman, P. Adams, 1997, Annual review of biophysics and biomolecular structure.

PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

Valerie A Longo, D. Engelman, Y. Reshetnyak, 2016, Bioconjugate chemistry.

Pharmacokinetic modeling reveals parameters that govern tumor targeting and delivery by a pH-Low Insertion Peptide (pHLIP)

D. Engelman, Alexander A. Svoronos, 2020, Proceedings of the National Academy of Sciences.

pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2020, Scientific Reports.

Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2018, Proceedings of the National Academy of Sciences.

Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

D. Engelman, Jianzhu Chen, B. Engelward, 2013, Future microbiology.

pH (low) insertion peptide (pHLIP) targets ischemic myocardium

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2012, Proceedings of the National Academy of Sciences.

In Vivo pH Imaging with 99mTc-pHLIP

D. Engelman, Y. Reshetnyak, O. Andreev, 2012, Molecular Imaging and Biology.

Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.

D. Engelman, Y. Reshetnyak, O. Andreev, 2011, Biochemistry.

Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP

D. Engelman, Y. Reshetnyak, O. Andreev, 2011, Molecular Imaging and Biology.

Accurate Analysis of Tumor Margins Using a Fluorescent pH Low Insertion Peptide (pHLIP)

D. Engelman, Y. Reshetnyak, O. Andreev, 2009, International journal of molecular sciences.

A novel technology for the imaging of acidic prostate tumors by positron emission tomography.

Yana K Reshetnyak, D. Engelman, Y. Reshetnyak, 2009, Cancer research.

Neutron scattering and the 30 S ribosomal subunit of E. coli.

B. Schoenborn, D. Engelman, V. Ramakrishnan, 1984, Basic life sciences.

Structural model of the phospholamban ion channel complex in phospholipid membranes.

S. O. Smith, D. Engelman, I. Arkin, 1995, Journal of molecular biology.

Membrane protein folding: beyond the two stage model

Alessandro Senes, Ursula Lehnert, Yana K Reshetnyak, 2003, FEBS letters.

Intramembrane helix-helix association in oligomerization and transmembrane signaling.

D. Engelman, B. Bormann, D M Engelman, 1992, Annual review of biophysics and biomolecular structure.

pHLIP-mediated translocation of membrane-impermeable molecules into cells.

D. Engelman, M. An, Damien Thévenin, 2009, Chemistry & biology.

pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Proceedings of the National Academy of Sciences.

Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions.

D. Engelman, Z. Matsuda, Kosuke Miyauchi, 2006, Japanese journal of infectious diseases.

Involvement of Transmembrane Domain Interactions in Signal Transduction by α/β Integrins*

Donald M. Engelman, D. Engelman, D. Schneider, 2004, Journal of Biological Chemistry.

Effect of detergents on the association of the glycophorin a transmembrane helix.

D. Engelman, J. Sturgis, L. Fisher, 2003, Biophysical journal.

Cholesteryl myristate conformation in liquid crystalline mesophases determined by neutron scattering.

D. Engelman, C. Burks, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Molecular organization of the cholesteryl ester droplets in the fatty streaks of human aorta.

D. Engelman, G. M. Hillman, 1976, The Journal of clinical investigation.

Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.

D. Engelman, Y. Reshetnyak, O. Andreev, 2018, Biophysical journal.

A 19 Protein Map of the 30S Ribosomal Subunit of Escherichia coli

D. Engelman, M. Capel, P. Moore, 1986 .

A complete mapping of the positions of the proteins in the small ribosomal subunit of escherichia coli

B. Schoenborn, D. Engelman, M. Capel, 1988 .

Neutron-scattering measurement of protein pair scattering functions from ribosomes containing deuterated proteins.

D. Engelman, 1979, Methods in enzymology.

Transmembrane topography of the nicotinic acetylcholine receptor delta subunit.

D. Engelman, P. McCrea, J. Popot, 1987, The EMBO journal.

The stability of transmembrane helix interactions measured in a biological membrane.

D. Engelman, D. Otzen, D. Schneider, 2006, Journal of molecular biology.

The "microassembly" of integral membrane proteins: applications & implications.

D. Engelman, J. Popot, G. Zaccai, 1990, Progress in clinical and biological research.

Kinetics of pHLIP peptide insertion into and exit from a membrane

D. Engelman, Y. Reshetnyak, O. Andreev, 2020, Proceedings of the National Academy of Sciences.

Spontaneous , pH-Dependent Membrane Insertion of a Transbilayer R-Helix †

D. Engelman, J. Hunt, K. Rothschild, 1997 .

Structure of the Transmembrane Cysteine Residues in Phospholamban

S. O. Smith, D. Engelman, P. Adams, 1997, The Journal of Membrane Biology.

Topography of integral membrane proteins: hydrophobicity analysis vs. immunolocalization.

D. Engelman, P. McCrea, J. Popot, 1988, Trends in biochemical sciences.

Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function.

D. Engelman, J. Sachs, Jonathan N. Sachs, 2006, Annual review of biochemistry.

Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices.

K. Schulten, D. Engelman, Rosemary Braun, 2004, Biophysical journal.

Neutron-scattering studies of the ribosome.

D. Engelman, P. Moore, 1976, Scientific American.

Assignment of segments of the bacteriorhodopsin sequence to positions in the structural map.

D. Engelman, J. Trewhella, S. Khan, 1983, Biophysical journal.

Crossing the Hydrophobic Barrier--Insertion of Membrane Proteins

D. Engelman, D M Engelman, 1996, Science.

Computation and mutagenesis suggest a right‐handed structure for the synaptobrevin transmembrane dimer

D. Engelman, D M Engelman, K G Fleming, 2001, Proteins.

Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization.

D. Engelman, D M Engelman, K R MacKenzie, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A new method for the determination of biological quarternary structure by neutron scattering.

D. Engelman, P. Moore, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Aspartate embedding depth affects pHLIP's insertion pKa.

D. Engelman, F. Barrera, Justin Fendos, 2013, Biochemistry.

Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling.

D. Engelman, A. Brünger, J. Hunt, 1993, Society of General Physiologists series.

RESEARCH ARTICLE In Vivo pH Imaging with 99m Tc-pHLIP

D. Engelman, Y. Reshetnyak, O. Andreev, 2012 .

Structural comparisons of native and reaggregated membranes from Mycoplasma laidawii and erythrocytes using a fluorescence probe.

D. Engelman, S. Metcalfe, J. Metcalfe, 1971, Biochimica et biophysica acta.

Structure-function studies of bacteriorhodopsin XV. Effects of deletions in loops B-C and E-F on bacteriorhodopsin chromophore and structure.

H. Khorana, D. Engelman, M. Gilles‐Gonzalez, 1991, The Journal of biological chemistry.

pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2014, ACS chemical biology.

The planar distributions of surface proteins and intramembrane particles in Acholeplasma laidlawii are differentially affected by the physical state of membrane lipids.

D. Engelman, B. Wallace, Donald M Engelman, 1978, Biochimica et biophysica acta.

The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii.

F. Richards, D. Engelman, B. Wallace, 1976, Journal of molecular biology.

Mapping the lipid-exposed surfaces of membrane proteins

D. Engelman, I. Arkin, Steven O. Smith, 1996, Nature Structural Biology.

Rotational orientation of transmembrane alpha-helices in bacteriorhodopsin. A neutron diffraction study.

D. Engelman, C. Etchebest, J. Popot, 1994, Journal of molecular biology.

Reformation of crystalline purple membrane from purified bacteriorhodopsin fragments.

D. Engelman, J. Trewhella, J. Popot, 1986, The EMBO journal.

Localization of two chymotryptic fragments in the structure of renatured bacteriorhodopsin by neutron diffraction.

D. Engelman, J. Trewhella, J. Popot, 1986, EMBO Journal.

Neutron-scattering studies of the ribosome of Escherichia coli: a provisional map of the locations of proteins S3, S4, S5, S7, S8 and S9 in the 30 S subunit.

D. Engelman, P. Moore, J. Langer, 1978, Journal of molecular biology.

Limitations of the lipid state hypothesis for atherosclerosis are revealed by X-ray diffraction measurements.

D. Engelman, C. Burks, S. Hong, 1989, Atherosclerosis.

The measurement of the locations and radii of gyration of proteins in the 30S ribosomal subunit of E. coli by neutron scattering

D. Engelman, P. Moore, J. Langer, 1978 .

Mapping pH at Cancer Cell Surfaces

D. Engelman, Y. Reshetnyak, O. Andreev, 2019, Molecular Imaging and Biology.

Computational analysis ofmembraneproteins: genomicoccurrence,structurepredictionand helix interactions

M. Gerstein, Haiyuan Yu, D. Engelman, 2005 .

A biophysical study of integral membrane protein folding.

T. Earnest, D. Engelman, J. Hunt, 1997, Biochemistry.

Electrostatic fasteners hold the T cell receptor-CD3 complex together.

D. Engelman, 2003, Molecular cell.

Injection of Molecules into Cells using a pH-Triggered Molecular Nanosyringe

D. Engelman, Y. Reshetnyak, O. Andreev, 2006 .

Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor.

M. Gerstein, D. Engelman, Yu Xia, 2004, Journal of molecular biology.

Rational design of 'water-soluble' bacteriorhodopsin variants.

T. Steitz, D. Engelman, K. Mitra, 2002, Protein engineering.

Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins.

D. Engelman, D. Schneider, Donald M Engelman, 2004, The Journal of biological chemistry.

Forces involved in the assembly and stabilization of membrane proteins 1

D C Rees, D. Engelman, G. Heijne, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Visual Arrestin Activity May Be Regulated by Self-association*

D. Engelman, P. Sigler, C. Schubert, 1999, The Journal of Biological Chemistry.

Chapter 6 Bacteriorhodopsin Folding in Membranes: A Two-Stage Process

D. Engelman, J. Hunt, J. Popot, 1990 .

Mutational analysis of synaptobrevin transmembrane domain oligomerization.

D. Engelman, A. Brunger, M. Bowen, 2002, Biochemistry.

pH (low) insertion peptide (pHLIP) targets ischemic myocardium

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2012, Proceedings of the National Academy of Sciences.

A Transmembrane Helix Dimer: Structure and Implications

D. Engelman, J. Prestegard, K. MacKenzie, 1997, Science.

Computation and mutagenesis suggest a right‐handed structure for the synaptobrevin transmembrane dimer

D. Engelman, K. Fleming, 2001, Proteins.

Probe for the measurement of cell surface pH in vivo and ex vivo

D. Engelman, Michael Anderson, A. Moshnikova, 2016, Proceedings of the National Academy of Sciences.

Genomic analysis of membrane protein families: abundance and conserved motifs

M. Gerstein, D. Engelman, Yang Liu, 2002, Genome Biology.

Stability of transmembrane regions in bacteriorhodopsin studied by progressive proteolysis

F. Richards, D. Engelman, J. Trewhella, 2005, The Journal of Membrane Biology.

Neutron Diffraction Studies of Bacteriorhodopsin Structure

D. Engelman, J. Trewhella, G. Zaccai, 1984 .

A NewMethodfortheDetermination ofBiological Quarternary Structure

D. Engelman, P. Moore, 1999 .

pHLIP-mediated translocation of membrane-impermeable molecules into cells.

D. Engelman, M. An, Damien Thévenin, 2009, Chemistry & biology.

High-Yield Synthesis and Purification of an a-Helical ransmembrane Domain

D. Engelman, L. Fisher, 2000 .

Novel Concept of Delivery of Diagnostic and Therapeutic Agents to Cells in Acidic Diseased Tissue using Energy of Membrane-Associated Folding

D. Engelman, Y. Reshetnyak, O. Andreev, 2013 .

Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides

D. Engelman, Y. Reshetnyak, O. Andreev, 2024, Frontiers in pharmacology.

pHLIP peptide targets nanogold particles to tumors

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2012, Proceedings of the National Academy of Sciences.

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Molecular membrane biology.

Annual Review of Biophysics and Bioengineering

Charles R. Cantor, Thomas D. Pollard, Manuel F. Morales, 1972 .

Mapping pH at Cancer Cell Surfaces

D. Engelman, Y. Reshetnyak, O. Andreev, 2019, Molecular Imaging and Biology.

Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2016, Proceedings of the National Academy of Sciences.

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions

D. Engelman, A. Harris, A. Moshnikova, 2015, Proceedings of the National Academy of Sciences.

Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer

D. Engelman, Michael Anderson, Y. Reshetnyak, 2014, Proceedings of the National Academy of Sciences.

Aspartate embedding depth affects pHLIP's insertion pKa.

D. Engelman, F. Barrera, Justin Fendos, 2013, Biochemistry.

Modulation of the pHLIP transmembrane helix insertion pathway.

D. Engelman, Y. Reshetnyak, O. Andreev, 2012, Biophysical journal.

Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.

D. Engelman, Y. Reshetnyak, O. Andreev, 2011, Biochemistry.

Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors.

D. Engelman, Y. Reshetnyak, M. Zoonens, 2008, Biophysical journal.

Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.

D. Engelman, Y. Reshetnyak, O. Andreev, 2018, Biophysical Journal.

Bilayer thickness and curvature influence binding and insertion of Bilayer thickness and curvature influence binding and insertion of a pHLIP a pHLIP ®® peptide peptide

D. Engelman, Y. Reshetnyak, O. Andreev, 2022 .

pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path

D. Engelman, Y. Reshetnyak, O. Andreev, 2010, Proceedings of the National Academy of Sciences.

Kinetics of pHLIP peptide insertion into and exit from a Kinetics of pHLIP peptide insertion into and exit from a membrane membrane

D. Engelman, Y. Reshetnyak, O. Andreev, 2023 .

pHLIP targeted intracellular delivery of calicheamicin.

D. Engelman, A. Moshnikova, Y. Reshetnyak, 2024, International journal of pharmaceutics.