D. Scudiero

发表

A gene expression database for the molecular pharmacology of cancer

D. Botstein, P. Brown, M. Eisen, 2000, Nature Genetics.

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.

D. Scudiero, M. Boyd, A. Monks, 1991, Journal of the National Cancer Institute.

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

G. S. Johnson, T. Myers, J. Weinstein, 1997, Science.

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

J N Weinstein, K W Kohn, D A Scudiero, 1997, Cancer research.

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

David Loegering, John C Reed, Y. Lazebnik, 2004, Clinical Cancer Research.

Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

D A Scudiero, K D Paull, D. Scudiero, 1989, Journal of the National Cancer Institute.

Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study

Jae K. Lee, William C. Reinhold, Uma T. Shankavaram, 2007, Molecular Cancer Therapeutics.

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

D. Scudiero, M. Boyd, A. Monks, 1988, Cancer research.

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

T. Myers, D. Scudiero, A. Fornace, 2000, Cancer research.

Karyotypic complexity of the NCI-60 drug-screening panel.

J. Weinstein, D. Scudiero, G. Tonon, 2003, Cancer research.

Development of human tumor cell line panels for use in disease-oriented drug screening.

D. Scudiero, M. Boyd, A. Monks, 1988, Progress in clinical and biological research.

New colorimetric cytotoxicity assay for anticancer-drug screening.

D. Scudiero, M. Boyd, A. Monks, 1990, Journal of the National Cancer Institute.

Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling.

William C Reinhold, Fuad G. Gwadry, John N Weinstein, 2003, Cancer research.

Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.

Kim-Anh Do, Wadih Arap, Renata Pasqualini, 2006, Cancer research.

Application of high-throughput, molecular-targeted screening to anticancer drug discovery.

D. Scudiero, E. Sausville, D. Covell, 2002, Current topics in medicinal chemistry.

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

Clemencia Pinilla, Kate Welsh, Adel Nefzi, 2004, Cancer cell.

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

D A Scudiero, D. Scudiero, M. Boyd, 1988, Cancer research.

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

D. Scudiero, E. Sausville, R. Shoemaker, 2002, Cancer research.

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

William C Reinhold, Fuad G. Gwadry, Wen-Lin Kuo, 2006, Molecular Cancer Therapeutics.

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen.

John N Weinstein, Mark Reimers, Michael L Bittner, 2008, Cancer research.

Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's drug discovery program for cancer and AIDS

M. Grever, T. Myers, J. Weinstein, 1994, Stem cells.

Nucleotide excision repair protein levels vis-à-vis anticancer drug resistance in 60 human tumor cell lines.

T. Myers, D. Scudiero, E. Sausville, 2002, Ai zheng = Aizheng = Chinese journal of cancer.

Dependence of mammalian DNA synthesis on DNA supercoiling. III. Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid.

D. Scudiero, M. Mattern, 1981, Biochimica et biophysica acta.

Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.

D. Scudiero, R. Shoemaker, M. Currens, 2012, Bioorganic & medicinal chemistry.

Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum.

D. Scudiero, R. Shoemaker, G. Melillo, 2008, Planta medica.

A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.

D. Scudiero, E. Sausville, R. Shoemaker, 2003, Analytical biochemistry.

Human tumor cell strains defective in the repair of alkylation damage.

D. Scudiero, R. Day, M. Mattern, 1980, Carcinogenesis.

Decreased DNA repair synthesis and defective colony-forming ability of ataxia telangiectasia fibroblast cell strains treated with N-methyl-N'-nitro-N-nitrosoguanidine.

D. Scudiero, 1980, Cancer research.

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from patients with Huntington disease, familial dysautonomia, and other primary neuronal degenerations.

D. Scudiero, R. Tarone, S. Meyer, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

D. Scudiero, A. Lubiniecki, S. Galloway, 1980, Nature.

Increased repair in DNA growing point regions after treatment of human lymphoma cells with N-methyl-N'-nitro-N-nitrosoguanidine.

D. Scudiero, B. Strauss, 1976, Mutation research.

The measurement of chemically-induced DNA repair synthesis in human cells by BND-cellulose chromatography.

D. Scudiero, B. Strauss, A. Norin, 1975, Mutation research.

Accumulation of single-stranded regions in DNA and the block to replication in a human cell line alkylated with methyl methane sulfonate.

D. Scudiero, B. Strauss, 1974, Journal of molecular biology.

The nature of the alkylation lesion in mammalian cells.

D. Scudiero, B. Strauss, E. Henderson, 1975, Basic life sciences.

Hypersensitivity to DNA-damaging agents in abiotrophies: a new explanation for degeneration of neurons, photoreceptors, and muscle in Alzheimer, Parkinson and Huntington diseases, retinitis pigmentosa, and Duchenne muscular dystrophy.

D. Scudiero, R. Tarone, F. Otsuka, 1985, Basic life sciences.

Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.

D. Scudiero, R. Shoemaker, M. Sehested, 2005, Cancer research.

Deficiency of Human Peripheral Blood Lymphocytes Treated with Chemical Carcinogens1

D. Scudiero, P. Karran, Bernard, 2006 .

Cell line designation change: multidrug-resistant cell line in the NCI anticancer screen.

D. Scudiero, E. Sausville, A. Monks, 1998, Journal of the National Cancer Institute.

Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.

L V Rubinstein, D A Scudiero, A D Koutsoukos, 1992, Cancer research.

The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets.

D A Scudiero, K D Paull, D. Scudiero, 1997, Anti-cancer drug design.

Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.

T. Myers, D. Scudiero, E. Sausville, 1998, The American journal of pathology.

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

D. Scudiero, R. Day, M. Mattern, 1984, Cancer research.

1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents.

D. Scudiero, C. Michejda, R. H. Smith, 1990, Journal of medicinal chemistry.

Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.

L V Rubinstein, D A Scudiero, K D Paull, 1990, Journal of the National Cancer Institute.

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.

D. Scudiero, R. Shoemaker, D. Lannigan, 2011, European journal of medicinal chemistry.

Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.

L. Staudt, R. Davis, D. Scudiero, 2009, Journal of natural products.

Bisimidazoacridones and related compounds: new antineoplastic agents with high selectivity against colon tumors.

D. Scudiero, C. Michejda, D. Djurickovic, 1995, Journal of medicinal chemistry.

Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production.

D. Scudiero, M. Boyd, A. Monks, 1991, Cancer research.

Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA.

D. Scudiero, R. Shoemaker, S. Almo, 2011, Biochemistry.

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen (Cancer Research (January 15, 2008) 68 (415-424))

Albert J. Fornace, Sally A. Amundson, Mark Reimers, 2008 .

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

J C Reed, D A Scudiero, D. Scudiero, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Lymphoblastoid lines and skin fibroblasts from patients with tuberous sclerosis are abnormally sensitive to ionizing radiation and to a radiomimetic chemical.

D. Scudiero, R. Tarone, S. Meyer, 1982, The Journal of investigative dermatology.

Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

D. Scudiero, R. Shoemaker, P. Schlag, 2011, Journal of the National Cancer Institute.

An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.

D A Scudiero, S. Friend, D. Scudiero, 1996, Cancer research.

Excision repair by human fibroblasts of DNA damaged by r-7, t-8-dihyroxy-t-9,10-oxy-7,8,9,10- tetrahydrobenzo(a)pyrene.

D. Scudiero, R. Day, M. Dimattina, 1978, Mutation research.

Physiological Modifications in the Production and Repair of Methyl Methane Sulfonate-Induced Breaks in the Deoxyribonucleic Acid of Escherichia coli K-12

D. Scudiero, B. Friesen, J. Baptist, 1973, Journal of bacteriology.

Hypersensitivity to DNA-damaging agents in cultured cells from patients with Usher's syndrome and Duchenne muscular dystrophy.

D. Scudiero, R. Tarone, F. Otsuka, 1984, Journal of neurology, neurosurgery, and psychiatry.

Statistical methods for in vitro cell survival assays.

D. Scudiero, R. Tarone, J. Robbins, 1983, Mutation research.

Non-genetic factors affecting the quantitative repair capability of cells

D. Scudiero, P. Karran, B. Strauss, 1976 .

DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens.

D. Scudiero, P. Karran, B. Strauss, 1976, Cancer research.

Glucose-induced resistance to methyl methanesulfonate in Escherichia coli

D. Scudiero, B. Friesen, J. Baptist, 2004, Molecular and General Genetics MGG.

Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical.

D. Scudiero, R. Tarone, R. Brumback, 1986, Mutation research.

Relationship of DNA repair phenotypes of human fibroblast and tumor strains to killing by N-methyl-N'-nitro-N-nitrosoguanidine.

D. Scudiero, R. Day, M. Mattern, 1984, Cancer research.

The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents.

D. Scudiero, J. Allalunis-Turner, R. Day, 1991, Mutation research.

P450 enzyme expression patterns in the NCI human tumor cell line panel.

D. Scudiero, E. Sausville, A. Monks, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Hybrids between human tumor cell strains differing in repair of MNNG-produced DNA damage.

D. Scudiero, J. Rhim, R. Day, 1984, Carcinogenesis.

Identification of a Bis-guanylhydrazone [4,4′-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase

D. Scudiero, Y. Pommier, R. Shoemaker, 2007, Molecular Pharmacology.

A Small Molecule (Pluripotin) as a Tool for Studying Cancer Stem Cell Biology: Proof of Concept

D. Scudiero, D. Covell, A. Monks, 2013, PloS one.

Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells

D. Scudiero, R. Shoemaker, R. Kotin, 2007, Gene Therapy.

Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells

D. Scudiero, R. Shoemaker, W. Walther, 2012, British Journal of Cancer.

Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma

K. Nagashima, D. Newton, D. Scudiero, 2012, PloS one.

Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.

D. Scudiero, A. Monks, T. Bauknecht, 2001, The American journal of pathology.

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

J C Reed, D A Scudiero, D. Scudiero, 1998, Cancer research.

Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

J C Reed, D. Scudiero, John Calvin Reed, 1998, Cancer research.

12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers.

D. Scudiero, R. Shoemaker, C. Vinson, 2010, Journal of structural biology.

Identification of PDGFR as a receptor for AAV-5 transduction

Giovanni Di Pasquale, D. Scudiero, A. Monks, 2003, Nature Medicine.

Identification of Small Molecule Inhibitors of Hypoxia-inducible Factor 1 Transcriptional Activation Pathway 1

D. Scudiero, E. Sausville, R. Shoemaker, 2002 .

Factor 1 Transcriptional Activation Pathway Identification of Small Molecule Inhibitors of Hypoxia-inducible Updated

D. Scudiero, E. Sausville, R. Shoemaker, 2002 .

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

D. Scudiero, R. Shoemaker, P. Schlag, 2011, Molecular biology of the cell.

The synthesis of XTT: a new tetrazolium reagent that is bioreducible to a water-soluble formazan

D. Scudiero, M. Boyd, A. Monks, 1988 .

A protein expression database for the molecular pharmacology of cancer

J N Weinstein, D A Scudiero, T G Myers, 1997, Electrophoresis.

The schweinfurthins: issues in the development of a plant-derived anticancer lead

Gordon M. Cragg, Maya S. Salnikova, John A. Beutler, 2006 .

Neural computing in cancer drug development: predicting mechanism of action.

J N Weinstein, K W Kohn, M R Grever, 1992, Science.

New carbon dioxide-independent basal growth medium for culture of diverse tumor and nontumor cells of human and nonhuman origin.

D. Scudiero, M. Boyd, A. Monks, 1990, Journal of the National Cancer Institute.

Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.

D. Scudiero, Y. Pommier, K. Paull, 1993, Biochemical pharmacology.

Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel

D. Scudiero, R. Shoemaker, C. Stuelten, 2010, Stem cells.

The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells.

D. Scudiero, R. Shoemaker, J. McNally, 2010, European journal of cell biology.

Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells

A. Feinberg, U. Scherf, J. Weinstein, 2007, Molecular Cancer Therapeutics.

A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors.

D. Scudiero, R. Shoemaker, C. Vinson, 2005, Analytical biochemistry.

A correlation between sensitization to gamma-rays by purine starvation and the rec genes in Escherichia coli K-12

D. Scudiero, B. Friesen, J. Baptist, 2004, Molecular and General Genetics MGG.

Correction: Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma

K. Nagashima, D. Newton, D. Scudiero, 2012, PLoS ONE.

Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitors.

John H Cardellina, D. Scudiero, R. Shoemaker, 2006, Planta medica.

Identification of a bis-guanylhydrazone ( NSC 109555 ) as a novel chemotype for inhibition of Chk 2 kinase

D. Scudiero, Y. Pommier, R. Shoemaker, 2007 .

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.

Rick Gussio, Tam Luong Nguyen, D. Scudiero, 2006, Bioorganic & medicinal chemistry.

The Mer Phenotype: Human Tumor Cell Strains Defective in Repair of Alkylation Damage

D. Scudiero, R. Day, M. Mattern, 1983 .

DNA repair protein levels vis-à-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program

T. Myers, D. Scudiero, E. Sausville, 2002, Anti-cancer drugs.

Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.

D. Scudiero, R. Shoemaker, G. Melillo, 2009, Journal of natural products.

Human tumor cell strains both unable to repair O6-methylguanine and hypersensitive to killing by human α and β interferons

D. Scudiero, R. Day, T. Yagi, 1985 .

The Synthesis of XTT: A New Tetrazolium Reagent (I) That is Bioreducible to a Water-Soluble Formazan (II).

D. Scudiero, M. Boyd, A. Monks, 1989 .

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

D. Scudiero, R. Day, M. Babich, 1987, Journal of Cell Science.

DecreasedDNARepairSynthesisand DefectiveColony-forming Ability of AtaxiaTelangiectasiaFibroblastCell StrainsTreatedwith N-Methyl- N'-nitro-N-nitrosoguanidine

D. Scudiero, 1980 .

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

D. Scudiero, R. Day, M. Mattern, 1984, Cancer research.

Karyotypic complexity of the NCI-60 drug-screening panel.

J. Weinstein, D. Scudiero, G. Tonon, 2003, Cancer research.

Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel

D. Scudiero, R. Shoemaker, C. Stuelten, 2010, Stem cells.

Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

D. Scudiero, R. Shoemaker, P. Schlag, 2011, Journal of the National Cancer Institute.

REPAIR DEFICIENCY IN N-METHYL-N′-NITRO-N-NITROSOGUANIDINE TREATED ATAXIA TELANGIECTASIA FIBROBLASTS

D. Scudiero, 1978 .

13 – Repair of Human DNA Damaged by Ultraviolet and Benzo[a]pyrene Diol Epoxide I

D. Scudiero, R. Day, M. Dimattina, 1978 .

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen (Cancer Research (January 15, 2008) 68 (415-424))

M. Bittner, P. Meltzer, J. Weinstein, 2008 .