E. Neer

发表

G proteins: Critical control points for transmembrane signals

E. Neer, 1994, Protein science : a publication of the Protein Society.

Calmodulin activates the isolated catalytic unit of brain adenylate cyclase.

E. Neer, C. Klee, R. Salter, 1981, The Journal of biological chemistry.

The ancient regulatory-protein family of WD-repeat proteins

Temple F. Smith, E. Neer, C. J. Schmidt, 1994, Nature.

G PROTEIN BETA GAMMA SUBUNITS

D. Clapham, E. Neer, 1997 .

Heterotrimeric C proteins: Organizers of transmembrane signals

E. Neer, 1995, Cell.

The WD repeat: a common architecture for diverse functions.

Temple F. Smith, T. Smith, C. Gaitatzes, 1999, Trends in biochemical sciences.

The ancient regulatory-protein family of WD-repeat proteins

Raman Nambudripad, Temple F. Smith, E. Neer, 1994, Nature.

Studies of Solubilized Adenylate Cyclase

E. Neer, 1982 .

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

D. Clapham, E. Neer, Y. Kurachi, 1987, Nature.

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

E. Neer, R. Huff, J. Axton, 1985, The Journal of biological chemistry.

G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.

E. Neer, P. Huang, M. Fishman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.

S. Snyder, P. Worley, E. Neer, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and characterization of cDNA encoding the GTP-binding protein ai and identification of a related protein, (Xh

E. Neer, John A. Smith, T. Michel, 2022 .

Intracellular signalling: Turning down G-protein signals

E. Neer, E. J. Neer, 1997, Current Biology.

Desensitization of Chick Embryo Ventricle to the Physiological and Biochemical Effects of Isoproterenol: Evidence for Uncoupling of the β Receptor‐Adenylate Cyclase Complex

E. Neer, W. Barry, J. Marsh, 1980 .

Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy.

M. Pfeffer, E. Neer, C. Seidman, 1988, The Journal of clinical investigation.

Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q).

E. Neer, U. Mende, A. Kagen, 1999, Circulation research.

Evidence for uncoupling of the beta receptor-adenylate cyclase complex.

E. Neer, R. Alexander, W. Barry, 1980, Circulation research.

Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria

E. Neer, H. Wu, A. Lim, 1998, FEBS letters.

Subtype‐specific increase in G‐protein α‐subunit mRNA by interleukin 1β

Richard T. Lee, J. Seidman, E. Neer, 1989 .

Size and detergent binding of adenylate cyclase from bovine cerebral cortex.

E. Neer, 1978, The Journal of biological chemistry.

Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.

E. Neer, J. Galper, B. Liang, 1986, The Journal of biological chemistry.

The vasopressin-sensitive adenylate cyclase of the rat renal medulla.

E. Neer, 1973, Journal of Biological Chemistry.

Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h.

J. Seidman, E. Neer, J. Smith, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Subtype-specific increase in G-protein alpha-subunit mRNA by interleukin 1 beta.

J. Seidman, E. Neer, K. Bloch, 1989, FEBS letters.

The Gene for the ca Subunit of Human Guanine Nucleotide Binding Protein Maps near the Cystic Fibrosis Locus

J. Seidman, E. Neer, C. Morton, 2006 .

Genes for two homologous G-protein α subunits map to different human chromosomes

J. Seidman, E. Neer, R. Eddy, 1987, Human Genetics.

Reconstituted adenylate cyclase from bovine brain. Functions of the subunits.

E. Neer, R. Salter, 1981, The Journal of biological chemistry.

Localization of G alpha 0 to growth cones in PC12 cells: role of G alpha 0 association with receptors and G beta gamma.

E. Neer, O. Nüsse, 1996, Journal of cell science.

Localization of Gαo to growth cones in PC12 cells: role of Gαo association with receptors and Gβγ

E. Neer, O. Nüsse, 1996 .

Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13.

J. Seidman, E. Neer, C. Morton, 1992, Genomics.

Effect of Triton X-100 and Alamethicin on the susceptibility of brain adenylate cyclase to EGTA inhibition.

E. Neer, D. Echeverria, 1981, Biochemical pharmacology.

GO, a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse

U. Dräger, E. Neer, C. J. Schmidt, 1994, Journal of neuroscience research.

Reassembly of phospholipase C-beta2 from separated domains: analysis of basal and G protein-stimulated activities.

E. Neer, W. Zhang, 2001, The Journal of biological chemistry.

LIS is more

Temple F. Smith, E. Neer, C. J. Schmidt, 1993, Nature Genetics.

Physical and functional properties of adenylate cyclase from mature rat testis.

E. Neer, 1978, The Journal of biological chemistry.

GTPases in Biology II

Kj, Blumer, R. L. Johnson, 1993, Handbook of Experimental Pharmacology.

Analysis of G-protein alpha and beta gamma subunits by in vitro translation.

E. Neer, C. J. Schmidt, B. Denker, 1994, Methods in enzymology.

Conformations of the alpha 39, alpha 41, and beta.gamma components of brain guanine nucleotide-binding proteins. Analysis by limited proteolysis.

E. Neer, J. Winslow, J. V. Van Amsterdam, 1986, The Journal of biological chemistry.

G protein opening of K+ channels

D. Clapham, E. Neer, Y. Kurachi, 1987, Nature.

Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cells.

E. Neer, Y. Li, U. Mende, 1996, The Biochemical journal.

15 – Solubilization and Characterization of Adenylyl Cyclase: Approaches and Problems

E. Neer, 1977 .

New roles for G-protein (βγ-dimers in transmembrane signalling

David E. Clapham, D. Clapham, E. Neer, 1993, Nature.

New roles for G-protein beta gamma-dimers in transmembrane signalling.

D. Clapham, E. Neer, 1993, Nature.

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

D. Clapham, E. Neer, D. Bar-Sagi, 1989, Nature.

Properties of the adenylate cyclase catalytic unit from caudate nucleus.

E. Neer, J. L. Bender, 1983, The Journal of biological chemistry.

Properties of the separated catalytic and regulatory units of brain adenylate cyclase.

E. Neer, S. Strittmatter, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of soluble brain adenylate cyclase with manganese.

E. Neer, 1979, The Journal of biological chemistry.

Roles of G protein subunits in transmembrane signalling

David E. Clapham, D. Clapham, E. Neer, 1988, Nature.

The G protein alpha o subunit alters morphology, growth kinetics, and phospholipid metabolism of somatic cells

J. Seidman, E. Neer, D. Bloch, 1989 .

The G Protein αo Subunit Alters Morphology, Growth Kinetics, and Phospholipid Metabolism of Somatic Cells

J. Seidman, E. Neer, J. Bonventre, 1989, Molecular and cellular biology.

G PROTEIN BETA GAMMA SUBUNITS

David E. Clapham, D. Clapham, E. Neer, 1997 .

G0 is a major growth cone protein subject to regulation by GAP-43

E. Neer, M. Fishman, S. Strittmatter, 1990, Nature.

Reactive sulfhydryl groups of alpha 39, a guanine nucleotide-binding protein from brain. Location and function.

E. Neer, J. Smith, J. Winslow, 1987, The Journal of biological chemistry.

The size of adenylate cyclase.

E. Neer, 1974, The Journal of biological chemistry.

Specificity of G protein beta and gamma subunit interactions.

E. Neer, C. J. Schmidt, Michal A. Levine, 1992, The Journal of biological chemistry.

The Interactions between α and β Chains of Human Hemoglobin

E. Neer, W. Konigsberg, G. Guidotti, 1968 .

Vasopressin-responsive, soluble adenylate cyclase from the rat renal medulla.

E. Neer, 1973, The Journal of biological chemistry.

The Family of G Proteins

E. Neer, C. J. Schmidt, T. Michel, 1990 .

Guanylate cyclase from the rat renal medulla. Physical properties and comparison with adenylate cyclase.

E. Neer, E. A. Sukiennik, 1975, The Journal of biological chemistry.

Nerve growth factor changes G protein levels and localization in PC12 cells

E. Neer, M. Zubiaur, 1993, Journal of neuroscience research.

G protein beta gamma subunit: physical and chemical characterization.

T. Smith, E. Neer, T. Sladek, 1993, Biochemistry.

Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.

T. Smith, E. Neer, O. Reiner, 1996, Biochemistry.

G Protein Heterodimers: New Structures Propel New Questions

Temple F. Smith, E. Neer, 1996, Cell.

Identification of a retinal protein in Drosophila with antibody to the α subunit of bovine brain Go protein

E. Neer, C. J. Schmidt, S. Garen-Fazio, 1991 .

Neuronal expression of a newly identified Drosophila melanogaster G protein alpha 0 subunit.

E. Neer, C. J. Schmidt, Y. Chow, 1989, Cell regulation.

The stimulatory guanine-nucleotide regulatory unit of adenylate cyclase from bovine cerebral cortex. ADP-ribosylation and purification.

E. Neer, D. Gill, L. G. Wolf, 1987, The Biochemical journal.

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

J. Seidman, E. Neer, R. Mortensen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A groovy new structure.

T. Smith, E. Neer, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

E. Neer, L. G. Wolf, J. Lok, 1984, The Journal of biological chemistry.

CHAPTER 3 – Structure and Function of G-Protein βγ Subunit

E. Neer, 1990 .

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

D. Sibley, E. Neer, M. Caron, 1984, The Journal of biological chemistry.

Effect of deletion of the major brain G‐protein α subunit (αo) on coordination of G‐protein subunits and on adenylyl cyclase activity

E. Neer, M. Fishman, Ying-Lan Li, 1998 .

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

E. Neer, L. Birnbaumer, M. Bitensky, 1985, The Journal of biological chemistry.

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

D. Clapham, E. Neer, Y. Kurachi, 1987, Nature.

Increase in the size of soluble brain adenylate cyclase with activation by guanosine 5'-(beta, gamma-imino)triphosphate.

E. Neer, S. Knox, D. Echeverria, 1980, The Journal of biological chemistry.

Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex.

E. Neer, R. Huff, 1986, The Journal of biological chemistry.

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

E. Neer, F. Schoen, J. Aramburu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Gαo is necessary for muscarinic regulation of Ca2+ channels in mouse heart

E. Neer, M. Fishman, H. Mashimo, 1997 .

Signal transduction through G proteins in the cardiac myocyte.

D. Clapham, E. Neer, 1992, Trends in cardiovascular medicine.

Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: analysis of mutated G alpha o/G alpha i2 chimeras.

E. Neer, B. Denker, P. Boutin, 1995, Biochemistry.

G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity.

E. Neer, C. J. Schmidt, T. C. Thomas, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus.

E. Neer, C. J. Schmidt, B. Denker, 1992, The Journal of biological chemistry.

Analysis of the physical properties and molecular modeling of Sec13: A WD repeat protein involved in vesicular traffic.

T. Smith, C. Gaitatzes, E. Neer, 1996, Biochemistry.

Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o).

E. Neer, B. Bean, U. Mende, 2000, Journal of neurophysiology.

Subunit Interactions of Heterotrimeric G-Proteins

E. Neer, 1993 .

Expression of a G protein subunit, alpha i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation.

J. Seidman, E. Neer, T. Michel, 1991, The Journal of biological chemistry.

Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma.

E. Neer, T. C. Thomas, I. García-Higuera, 1996, The Journal of biological chemistry.

The G protein gamma subunit. Requirements for dimerization with beta subunits.

E. Neer, C. J. Schmidt, D. Spring, 1995, The Journal of biological chemistry.

The size of adenylate cyclase and guanylate cyclase from the rat renal medulla.

E. Neer, 1976, Journal of supramolecular structure.

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein βγ-subunits

E. Neer, P. Hammer, C. Berul, 2002 .

Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype.

E. Neer, F. Schoen, C. Semsarian, 2001, Journal of molecular and cellular cardiology.

Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure.

T. Smith, E. Neer, A. Gilman, 1998, The Journal of biological chemistry.

The G Protein γ Subunit

E. Neer, C. J. Schmidt, D. Spring, 1995, The Journal of Biological Chemistry.

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

D. Clapham, E. Neer, D. Logothetis, 1988, Proceedings of the National Academy of Sciences of the United States of America.

In vitro synthesis of G protein beta gamma dimers.

E. Neer, C. J. Schmidt, 1991, The Journal of biological chemistry.

Sites Important for PLCβ2 Activation by the G Protein βγ Subunit Map to the Sides of the β Propeller Structure*

Temple F. Smith, E. Neer, A. Gilman, 1998, The Journal of Biological Chemistry.

Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase*

Temple F. Smith, E. Neer, A. Gilman, 1998, The Journal of Biological Chemistry.

The amino terminus of G protein alpha subunits is required for interaction with beta gamma.

E. Neer, L. G. Wolf, L. Pulsifer, 1988, The Journal of biological chemistry.

Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

J. Seidman, E. Neer, S. Ang, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Modification of adenylate cyclase structure and function by ammonium sulfate.

E. Neer, R. Salter, 1981, The Journal of biological chemistry.

Differential degradation rates of the G protein alpha o in cultured cardiac and pituitary cells.

E. Neer, T. Michel, R. Lee, 1990, The Journal of biological chemistry.

Separation of soluble adenylate and guanylate cyclases from the mature rat testis.

E. Neer, F. Murad, 1979, Biochimica et biophysica acta.

Folding a WD Repeat Propeller

C. Gaitatzes, E. Neer, T F Smith, 1998, The Journal of Biological Chemistry.

Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.

E. Neer, C. J. Schmidt, B. Denker, 1992, The Journal of biological chemistry.

G PROTEIN SUBUNITS

D. Clapham, E. Neer, 1997 .

The Recombination of α and β Chains of Human Hemoglobin EFFECT OF SULFHYDRYL GROUP MODIFICATIONS

E. Neer, G. Guidotti, 1970 .

Regulation of alpha o expression by the 5'-flanking region of the alpha o gene.

E. Neer, Y. Li, R. Mortensen, 1994, The Journal of biological chemistry.

Two soluble forms of guanosine 5'-(beta,gamma-imino)triphosphate and fluoride-activated adenylate cyclase.

E. Neer, 1976, The Journal of biological chemistry.

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits.

E. Neer, P. Hammer, C. Berul, 2002, American journal of physiology. Heart and circulatory physiology.

Non-co-ordinate development of beta-adrenergic receptors and adenylate cyclase in chick heart.

E. Neer, R. Alexander, J. Galper, 1982, Biochemical Journal.

A 14-amino acid region of the G protein gamma subunit is sufficient to confer selectivity of gamma binding to the beta subunit.

E. Neer, D. Spring, 1994, The Journal of biological chemistry.