J. Pandit

发表

Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.

V. L. Rath, M. Ammirati, P. Lemotte, 2000, Molecular cell.

Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand.

J. Pandit, S. Kim, Sung-Hou Kim, 1994, The Journal of biological chemistry.

Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography.

M. Mansour, D. Danley, G. Schulte, 2002, Journal of medicinal chemistry.

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases*

G Chelvanayagam, G. Chelvanayagam, D. Danley, 2000, The Journal of Biological Chemistry.

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.

M. Mansour, J. Pandit, BinQing Wei, 2012, Journal of medicinal chemistry.

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

Timothy L. Foley, K. Fennell, J. Pandit, 2017, Journal of medicinal chemistry.

The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene

M. Ammirati, P. Lemotte, D. Danley, 2007, Protein science : a publication of the Protein Society.

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

J. Pandit, E. Laird, D. Robertson, 2006, Bioorganic & medicinal chemistry letters.

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.

M. Mansour, D. Danley, G. Schulte, 2003, Bioorganic & medicinal chemistry letters.

The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).

J. Pandit, R. Hurst, M. Hajós, 2015, Journal of medicinal chemistry.

Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics

J. Pandit, R. Obach, Ji-Young Kim, 2013 .

PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, Bioorganic & medicinal chemistry letters.

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

J. Pandit, C. Whitehead, Cindy Spessard, 2013, Bioorganic & medicinal chemistry letters.

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.

J. Pandit, F. Menniti, M. Ahlijanian, 2009, Bioorganic & medicinal chemistry letters.

PDE4: New Structural Insights into the Regulatory Mechanism and Implications for the Design of Selective Inhibitors

J. Pandit, 2014 .

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

J. Pandit, J. Culp, K. Parris, 2017, Journal of medicinal chemistry.

Crystal Structure of Human Squalene Synthase

D. Danley, G. Schulte, J. Pandit, 2000, The Journal of Biological Chemistry.

Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.

J. Pandit, R. Klevit, C. C. Heikaus, 2009, Structure.

L-Tyrosyl-L-glutarnie Acid Monohydrate, C14H18N206.H20

J. Pandit, M. Viswamitra, T. Seshadri, 1984 .

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Timothy L. Foley, J. Pandit, J. Cianfrogna, 2018, Journal of medicinal chemistry.

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

D. Danley, J. Pandit, E. Laird, 2007, Bioorganic & medicinal chemistry letters.

Rational design, synthesis, and X-ray structure of renin inhibitors with extended P1 sidechains

M. Ammirati, D. Danley, G. Schulte, 1995 .

Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.

K. Fennell, J. Pandit, F. Menniti, 2011, Journal of medicinal chemistry.

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia.

Spiros Liras, Anne W. Schmidt, J. Pandit, 2009, Journal of medicinal chemistry.

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.

Dennis E Danley, P. Lemotte, M. Mansour, 2005, Journal of medicinal chemistry.

Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

M. Mansour, J. Pandit, F. Menniti, 2014 .

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.

Spiros Liras, Meihua Tu, J. Pandit, 2007, Journal of medicinal chemistry.

Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, ACS medicinal chemistry letters.

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.

Dennis E Danley, D. Danley, G. Schulte, 2002, Bioorganic & medicinal chemistry letters.

Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks.

J. Pandit, R. Volkmann, F. Menniti, 2013, Current topics in medicinal chemistry.

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

K. Fennell, J. Pandit, F. Menniti, 2009, Proceedings of the National Academy of Sciences.

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.

Howard Miller, J. Pandit, C. Whitehead, 2013, Bioorganic & medicinal chemistry letters.

Design of selective, ATP-competitive inhibitors of Akt.

Tracey Clark, Matthew Marx, Blaise Lippa, 2010, Journal of medicinal chemistry.

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4

J. Pandit, K. Geoghegan, A. Aulabaugh, 2015, Proceedings of the National Academy of Sciences.

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

J. Pandit, Ji-Young Kim, M. Hayward, 2012, ACS medicinal chemistry letters.

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Sai Chetan K. Sukuru, Frank Loganzo, Michael J. Shapiro, 2015 .

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Frank Loganzo, Carolyn A Leverett, Chakrapani Subramanyam, 2014, Journal of medicinal chemistry.

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Laura McDowell, Scot Mente, Mihaly Hajos, 2017, Journal of medicinal chemistry.

High-resolution structures of the ligand binding domain of the wild-type bacterial aspartate receptor.

Joanne I. Yeh, D. Koshland, J. Pandit, 1996, Journal of molecular biology.

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.

J. Pandit, S. Kim, Sung-Hou Kim, 1992, Science.

Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators.

J. Pandit, R. Hurst, M. Hajós, 2013, Journal of medicinal chemistry.

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

J. Pandit, F. Menniti, S. Liras, 2018, Journal of Medicinal Chemistry.

Synthesis and structure based optimization of novel Akt inhibitors.

Tracey Clark, Blaise Lippa, J. Pandit, 2008, Bioorganic & medicinal chemistry letters.

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

D. Buhl, J. Pandit, P. Chanda, 2016, Molecular Pharmacology.

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

Jerry R. Hobbs, J. Pandit, R. Horst, 2018, Structure.

6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.

Matthew D. Wessel, J. Pandit, M. Wessel, 2011, Bioorganic & medicinal chemistry letters.

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

J. Pandit, K. Parris, Eric F. Johnson, 2015, Journal of medicinal chemistry.

A proposal for a specific double-helical structure in which the polynucleotide strands intercalate instead of forming base-pairs.

J. Pandit, M. Viswamitra, 1983, Journal of biomolecular structure & dynamics.

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

J. Pandit, K. Parris, David A. Price, 2020, Journal of medicinal chemistry.

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.

J. Pandit, W. Hoffman, M. Hajós, 2018, Journal of medicinal chemistry.

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

D. Danley, J. Pandit, E. Laird, 2005, Bioorganic & medicinal chemistry letters.

The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding.

Joanne I. Yeh, D. Koshland, J. Pandit, 1994, The Journal of biological chemistry.

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.

J. Pandit, S. C. K. Sukuru, K. Parris, 2016, ACS medicinal chemistry letters.

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.

K. Fennell, J. Pandit, K. Parris, 2016, ACS chemical biology.

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.

Peter Cornelius, Eunsun Lee, Dennis E Danley, 2003, Bioorganic & medicinal chemistry letters.

Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.

J. Pandit, R. Klevit, C. C. Heikaus, 2009, Structure.

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

J. Pandit, E. Laird, D. Robertson, 2006, Bioorganic & Medicinal Chemistry Letters.