N. Osheroff

N. Osheroff, J. Deweese, M. Osheroff, 2008, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

N. Osheroff, C. Turnbough, R. Kerns, 2017, Biochemistry.

Mechanism of Quinolone Action and Resistance

N. Osheroff, R. Kerns, Katie J. Aldred, 2014, Biochemistry.

Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde.

N. Osheroff, V. Anderson, 2001, Current pharmaceutical design.

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

Michelle R. Arkin, Andrew Conroy, Robert S. McDowell, 2010, PloS one.

Preferred sites on cytochrome c for electron transfer with two positively charged blue copper proteins, Anabaena variabilis plastocyanin and stellacyanin.

E. Margoliash, N. Osheroff, A. Aitken, 1986, Biochemistry.

Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes.

E. Margoliash, N. Osheroff, S. Chapman, 1983, The Journal of biological chemistry.

Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids

N. Osheroff, N. Schley, Scott M Chapp, 2021, ACS central science.

Bimodal actions of a naphthyridone/aminopiperidine-based antibacterial that targets gyrase and topoisomerase IV.

N. Osheroff, K. Neuman, M. Cacho, 2019, Biochemistry.

Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance

N. Osheroff, R. Kerns, E. Gibson, 2018 .

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

N. Osheroff, J. Berger, T. R. Blower, 2016, Proceedings of the National Academy of Sciences.

Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.

N. Osheroff, C. Turnbough, R. Kerns, 2015, Biochemistry.

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

N. Osheroff, C. Turnbough, R. Kerns, 2013, ACS chemical biology.

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

N. Osheroff, C. Turnbough, R. Kerns, 2013, Nucleic acids research.

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

N. Osheroff, A. Minarini, R. Bertorelli, 2020, Journal of medicinal chemistry.

Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.

N. Osheroff, C. Turnbough, R. Kerns, 2012, Biochemistry.

First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA.

N. Osheroff, I. Turel, F. Perdih, 2010, Inorganic chemistry.

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

N. Osheroff, T. Gootz, S. Elsea, 1993, Antimicrobial Agents and Chemotherapy.

Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

N. Osheroff, C. Anklin, R. Bender, 2008, Biochemistry.

Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics.

E. Margoliash, N. Osheroff, W. Koppenol, 1981, The Journal of biological chemistry.

Topoisomerase IV Catalysis and the Mechanism of Quinolone Action*

N. Osheroff, T. Gootz, V. Anderson, 1998, The Journal of Biological Chemistry.

Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.

N. Osheroff, A. Corbett, R. Devore, 1992, Cancer research.

Quinolones and Eukaryotic Topoisomerases

N. Osheroff, T. Gootz, 2003 .

DNA topoisomerase II, genotoxicity, and cancer.

N. Osheroff, A. McClendon, A. Mcclendon, 2007, Mutation research.

Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.

N. Osheroff, Amy M. Wilstermann, 2003, Current topics in medicinal chemistry.

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

N. Osheroff, D. Brutlag, E. Shelton, 1983, The Journal of biological chemistry.

Eukaryotic topoisomerase II. Characterization of enzyme turnover.

N. Osheroff, 1986, The Journal of biological chemistry.

DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.

N. Osheroff, D. Brutlag, E. Shelton, 1983, The Journal of biological chemistry.

Quinolones Inhibit DNA Religation Mediated by Staphylococcus aureus Topoisomerase IV

N. Osheroff, T. Gootz, F. Kaczmarek, 1999, The Journal of Biological Chemistry.

Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.

N. Osheroff, J. P. Lomenick, M. Westergaard, 1997, Biochemistry.

Increased Drug Affinity as the Mechanistic Basis for Drug Hypersensitivity of a Mutant Type II Topoisomerase (*)

N. Osheroff, D. Burden, S. Elsea, 1995, The Journal of Biological Chemistry.

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism (*)

N. Osheroff, S. J. Froelich-Ammon, 1995, The Journal of Biological Chemistry.

Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.

N. Osheroff, R. Thompson, N Osheroff, 1995, The Journal of Biological Chemistry.

Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers.

N. Osheroff, E. L. Zechiedrich, E. Zechiedrich, 1990, The EMBO journal.

Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate.

N. Osheroff, K. Gale, 1990, Biochemistry.

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

N. Osheroff, M. Robinson, 1990, Biochemistry.

Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction.

N. Osheroff, E. L. Zechiedrich, P. S. Jensen, 1989, Biochemistry.

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

N. Osheroff, N Osheroff, 1989, Biochemistry.

Role of the divalent cation in topoisomerase II mediated reactions.

N. Osheroff, 1987, Biochemistry.

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

N. Osheroff, E. L. Zechiedrich, E. Zechiedrich, 1987, Biochemistry.

The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.

N. Osheroff, A. McClendon, A. Mcclendon, 2006, Biochemistry.

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

N. Osheroff, C. Anklin, R. Bender, 2007, Biochemistry.

Etoposide, topoisomerase II and cancer.

N. Osheroff, E. L. Baldwin, E L Baldwin, 2005, Current medicinal chemistry. Anti-cancer agents.

Purification and characterization of a periplasmic oligopeptide binding protein from Escherichia coli.

N. Osheroff, C. A. Guyer, J. V. Staros, 1985, The Journal of biological chemistry.

Use of singly modified cytochrome c derivatives to determine the site for electron transfer in reactions with inorganic complexes

E. Margoliash, N. Osheroff, W. Koppenol, 1981 .

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

N. Osheroff, B. Bax, P. Chan, 2019, ACS infectious diseases.

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

N. Osheroff, J. Deweese, 2008, Nucleic acids research.

Topoisomerase II and the etiology of chromosomal translocations.

N. Osheroff, C. Felix, Christos P. Kolaris, 2006, DNA repair.

Apurinic Sites Are Position-specific Topoisomerase II Poisons*

N. Osheroff, P. Kingma, 1997, The Journal of Biological Chemistry.

Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation.

N. Osheroff, A. Corbett, A. Fernald, 1993, Biochemistry.

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

N. Osheroff, C. Monneret, D. Dauzonne, 2006, Nucleic acids research.

Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.

N. Osheroff, W. Earnshaw, S. Kandels-Lewis, 2002, Nucleic acids research.

DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer

N. Osheroff, R. Bender, Ryan P. Bender, 2008 .

Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers.

N. Osheroff, A. L. Pathiranage, J. Stubblefield, 2014, Bioorganic & medicinal chemistry letters.

Topoisomerase II and leukemia

N. Osheroff, C. Felix, D. Grimwade, 2014, Annals of the New York Academy of Sciences.

Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

N. Osheroff, A. Ketron, 2014, Phytochemistry Reviews.

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

N. Osheroff, C. Anklin, C. Monneret, 2011, Biochemistry.

Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II

N. Osheroff, A. Corbett, A. Berger, 2005, Nucleic acids research.

Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.

N. Osheroff, M. Sabourin, K. Tatebayashi, 2003, Nucleic acids research.

Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.

N. Osheroff, K. R. Vann, Alexandria A. Oviatt, 2021, Biochemistry.

Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases

N. Osheroff, J. Gopas, Carl A. Sedgeman, 2015, Biochemistry.

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

N. Osheroff, S. Mercer, N. A. Smith, 2014, Biochemistry.

Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

N. Osheroff, A. Ketron, 2013, Phytochemistry Reviews.

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

N. Osheroff, A. Burgin, J. Deweese, 2009, Biochemistry.

SURVEY AND SUMMARY The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

N. Osheroff, J. Deweese, 2009 .

Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement.

N. Osheroff, O. Bandele, S. Clawson, 2008, Chemical research in toxicology.

(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases.

N. Osheroff, O. Bandele, 2008, Chemical research in toxicology.

Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.

N. Osheroff, A. McClendon, A. C. Rodríguez, 2005, The Journal of biological chemistry.

Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.

N. Osheroff, J. Dickey, 2005, Biochemistry.

A Two-drug Model for Etoposide Action against Human Topoisomerase IIα*

N. Osheroff, K. Bromberg, A. Burgin, 2003, The Journal of Biological Chemistry.

Positioning the 3′-DNA Terminus for Topoisomerase II-mediated Religation*

N. Osheroff, Amy M. Wilstermann, 2001, The Journal of Biological Chemistry.

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

M. Segal, N. Osheroff, C. Felix, 2005, The New England journal of medicine.

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

P. Nowell, N. Osheroff, E. Rappaport, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Topoisomerase IIα Binding Domains of Adenomatous Polyposis Coli Influence Cell Cycle Progression and Aneuploidy

N. Osheroff, R. Coffey, K. Neufeld, 2010, PloS one.

Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition.

N. Osheroff, K. Neufeld, D. Moore, 2008, Molecular biology of the cell.

Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.

Y. Pommier, N. Osheroff, T. Rebbeck, 2001, Biochemistry.

Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives.

Sevil Zencir, Neil Osheroff, Yavuz Ergün, 2016, Bioorganic & medicinal chemistry letters.

Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

N. Osheroff, E. Rappaport, B. Gregory, 2017, Genome research.

Activation of the DNA-Dependent Protein Kinase by Drug-Induced and Radiation-Induced DNA Strand Breaks

N. Osheroff, O. Hammarsten, J. Nygren, 2003, Radiation research.

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events

N. Osheroff, Y. Ho, B. Knudsen, 2017, Nucleic acids research.

Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing

N. Osheroff, E. Rappaport, T. Ried, 2003, Oncogene.

Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage.

N. Osheroff, S. J. Froelich-Ammon, Kevin C. Gale, 1994, The Journal of biological chemistry.

Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.

N. Osheroff, K. Bromberg, A. Burgin, 2002, The Journal of biological chemistry.

Base Excision Repair Intermediates as Topoisomerase II Poisons*

N. Osheroff, Amy M. Wilstermann, 2001, The Journal of Biological Chemistry.

The response of eukaryotic topoisomerases to DNA damage.

N. Osheroff, P. Kingma, 1998, Biochimica et biophysica acta.

Human Topoisomerase IIα Possesses an Intrinsic Nucleic Acid Specificity for DNA Ligation

N. Osheroff, K. Bromberg, A. Burgin, 2002, The Journal of Biological Chemistry.

Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions.

N. Osheroff, M. Sabourin, 2000, Nucleic acids research.

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

James M. Dewar, N. Osheroff, J. Dewar, 2019, Cell reports.

Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II

N. Osheroff, L. Marnett, A. Corbett, 1995, The Journal of Biological Chemistry.

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.

N. Osheroff, S. Jhanwar, C. Felix, 2008, Blood.

The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.

N. Osheroff, J. Nitiss, A. Rose, 1998, Biochemistry.

Regulation of DNA Topology by Topoisomerases: Mathematics at the Molecular Level

N. Osheroff, Rachel E. Ashley, 2016, Knots, Low-Dimensional Topology and Applications.

Mechanism of action of topoisomerase II-targeted antineoplastic drugs.

N. Osheroff, A. Corbett, M. Robinson, 1994, Advances in pharmacology.

Structure and Mechanism of Eukaryotic Type IIA Topoisomerases

N. Osheroff, J. Berger, 2012 .

The use of divalent metal ions by type II topoisomerases.

N. Osheroff, J. Deweese, 2010, Metallomics : integrated biometal science.

Cleavage of plasmid DNA by eukaryotic topoisomerase II.

N. Osheroff, O. Bandele, 2009, Methods in molecular biology.

Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage

N. Osheroff, A. Burgin, J. Deweese, 2008, Nucleic acids research.

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.

N. Osheroff, A. Burgin, J. Deweese, 2008, Biochemistry.

Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.

N. Osheroff, A. Ham, R. Bender, 2007, Biochemistry.

Etoposide and 4 Cleavage / Religation and Sensitivity to the Antineoplastic Drugs Protein Kinase C : Effects on Enzyme-mediated DNA Phosphorylation of Topoisomerase II by Casein Kinase II and Updated Version

N. Osheroff, A. Corbett, Russell, 2006 .

Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes

N. Osheroff, M. Westergaard, A. Corbett, 2004, Cancer Chemotherapy and Pharmacology.

A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential

N. Osheroff, A. Corbett, P. Pflieger, 1993, Antimicrobial Agents and Chemotherapy.

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

James M. Dewar, N. Osheroff, R. Zhao, 2021, bioRxiv.

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Felicie F. Andersen, N. Osheroff, A. McClendon, 2007, Nucleic acids research.

Communication between the ATPase and Cleavage/Religation Domains of Human Topoisomerase IIα*

N. Osheroff, A. Andersen, Lotte Bjergbaek, 2000, The Journal of Biological Chemistry.

Topoisomerase II from Chlorella Virus PBCV-1

J. V. Van Etten, N. Osheroff, R. Lloyd, 2000, The Journal of Biological Chemistry.

DNA topoisomerase protocols

N. Osheroff, M. Bjornsti, 1999 .

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage*

N. Osheroff, P. Kingma, 1997, The Journal of Biological Chemistry.

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I

N. Osheroff, S. Juul, B. Knudsen, 2010, Nucleic acids research.

Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison.

N. Osheroff, R. Bender, R. H. Lindsey, 2005, Chemical research in toxicology.

Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.

N. Osheroff, A. Corbett, D. Hong, 1993, The Journal of biological chemistry.

Purification and Characterization of a Periplasmic Oligopeptide Binding Protein from Escherichia coZi*

N. Osheroff, C. A. Guyer, D. Morgan, 2001 .

Topoisomerase-Induced DNA Damage

Y. Pommier, N. Osheroff, 2012 .

Oxidative metabolites of curcumin poison human type II topoisomerases.

N. Osheroff, C. Schneider, Odaine N. Gordon, 2013, Biochemistry.

The presteady state reaction of chemically modified cytochromes c with cytochrome oxidase.

E. Margoliash, N. Osheroff, E. Veerman, 1983, The Journal of biological chemistry.

Lactoperoxidase-catalyzed iodination of horse cytochrome c:monoiodotyrosyl 74 cytochrome c.

E. Margoliash, N. Osheroff, M. Morrison, 1977, The Journal of biological chemistry.

Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination.

N. Osheroff, K. Gale, 1992, The Journal of biological chemistry.

Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

Ashley H. Hardin, N. Osheroff, K. Neuman, 2011, Nucleic acids research.

Activities of gyrase and topoisomerase IV on positively supercoiled DNA

N. Osheroff, A. Dittmore, C. Turnbough, 2017, Nucleic acids research.

The Relation between the Dipole Moment of Cytochrome c and the Activity with Cytochrome c Reductase and Cytochrome c Oxidase

E. Margoliash, N. Osheroff, W. Koppenol, 1982 .

Topoisomerase IB-DNA interactions: X marks the spot.

N. Osheroff, L. Zechiedrich, 2010, Structure.

Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain.

N. Osheroff, A. McClendon, A. Andersen, 2008, Biochemistry.

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

N. Osheroff, Sanghwa Lee, S. Hohng, 2012, Proceedings of the National Academy of Sciences.

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism

N. Osheroff, S. Mercer, J. Deweese, 2014, Biochemistry.

Getting stressed over topoisomerase I poisons.

N. Osheroff, 2021, Cell chemical biology.

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II

Marco de Vivo, Jissy A. Kuriappan, Neil Osheroff, 2019, J. Chem. Inf. Model..

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ.

Jissy A. Kuriappan, N. Osheroff, A. Minarini, 2018, Bioorganic & medicinal chemistry letters.

Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα*♦

N. Osheroff, K. Neuman, Yeonee Seol, 2013, The Journal of Biological Chemistry.

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

B. Schmidt, N. Osheroff, J. Berger, 2010, Nature.

Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine.

N. Osheroff, T. Macdonald, S. D. Cline, 1997, Biochemistry.

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.

N. Osheroff, A. Burgin, F. Guengerich, 2009, Biochemistry.

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase

N. Osheroff, J. Berger, T. R. Blower, 2017, Biochemistry.

Purification of DNA topoisomerase II from Drosophila melanogaster.

N. Osheroff, P. Kingma, S. J. Froelich-Ammon, 1999, Methods in molecular biology.

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

N. Osheroff, K. Neuman, A. Burgin, 2011, Nucleic acids research.

Bacillus anthracis GrlAV96A Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge

N. Osheroff, C. Turnbough, R. Kerns, 2014, Antimicrobial Agents and Chemotherapy.

Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

N. Osheroff, K. Neuman, M. Strub, 2014, Biochemistry.

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Mark J. Mitton-Fry, N. Osheroff, M. Hazbón, 2022, ACS medicinal chemistry letters.

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase

N. Osheroff, K. Chibale, G. Basarab, 2023, ACS infectious diseases.

IV: A Quinolone Resistance Mutation that Does Not Affect the

N. Osheroff, R. Kerns, L. Charles, 2014 .

Integrating Foundational Sciences in a Clinical Context in the Post-clerkship Curriculum

N. Osheroff, M. Weinger, L. Nanney, 2018, Medical science educator.

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.

N. Osheroff, J. Deweese, 2009, Biochemistry.

Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017.

N. Osheroff, J. Bernstein, J. Lindsley, 2017, Medical science educator.

Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c.

E. Margoliash, N. Osheroff, D. Brautigan, 1980, The Journal of biological chemistry.

DNA Ligation Catalyzed by Human Topoisomerase IIα

N. Osheroff, K. Bromberg, R. Vélez-Cruz, 2004 .

DNA ligation catalyzed by human topoisomerase II alpha.

N. Osheroff, K. Bromberg, A. Burgin, 2004, Biochemistry.

Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases

N. Osheroff, Jeffrey Y. Jian, Jeffrey Y Jian, 2023, International journal of molecular sciences.

Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα

N. Osheroff, Rachel E. Ashley, 2014, Chemical research in toxicology.

N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.

N. Osheroff, R. Bender, D. Burden, 2004, Biochemistry.

Gyrase and Topoisomerase IV as Targets for Antibacterial Drugs

N. Osheroff, R. H. Lindsey, A. Ketron, 2014 .

DNA untangled Topoisomerase enzymes remove our genetic knots

N. Osheroff, 2020, Research Outreach.

Two-Dimensional Gel Electrophoresis to Resolve DNA Topoisomers.

N. Osheroff, E. Gibson, Alexandria A. Oviatt, 2020, Methods in molecular biology.

Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.

N. Osheroff, J. A. Byl, J. Byl, 2013, Chemical research in toxicology.

Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback

N. Osheroff, W. Cutrer, R. Carnahan, 2017, Medical science educator.

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Mark J. Mitton-Fry, N. Osheroff, Jessica A Collins, 2023, International journal of molecular sciences.

DNA Topoisomerases: Type II

N. Osheroff, A. Gentry, 2004 .

DNA topoisomerases.

N. Osheroff, 1998, Biochimica et Biophysica Acta.

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

N. Osheroff, R. Bender, H. Lehmler, 2006, Biochemistry.

Human Topoisomerase IIα Rapidly Relaxes Positively Supercoiled DNA

N. Osheroff, A. McClendon, A. C. Rodriguez, 2005, Journal of Biological Chemistry.

Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta.

N. Osheroff, L. V. Van Eldik, J. Norden, 1994, Brain research. Molecular brain research.

Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

N. Osheroff, N. Ahn, J. Wilsbacher, 1999, Molecular and Cellular Biology.

Phosphorylation Mechanism Independent of through a Α Activates Topoisomerase Ii Extracellular Signal-regulated Kinase

N. Osheroff, N. Ahn, J. Wilsbacher, 1999 .

From Theory to Practice: Utilizing Competency-Based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-clerkship Medical School Curriculum

N. Osheroff, K. Lomis, Cathleen C. Pettepher, 2016, Medical science educator.

Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.

N. Osheroff, C. Bailly, M. Jablonský, 2011, Biochemistry.

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.

N. Osheroff, J. Berger, B. Bax, 2018, ACS infectious diseases.

Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

N. Osheroff, L. Marnett, F. Guengerich, 2005, Biochemistry.

DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison.

N. Osheroff, S. D. Cline, M. Stone, 1999, Biochemistry.

DNA Topoisomerases: Type II

N. Osheroff, R. Vélez-Cruz, 2004 .