Xu Shen

发表

Lys169 of Human Glucokinase Is a Determinant for Glucose Phosphorylation: Implication for the Atomic Mechanism of Glucokinase Catalysis

Jian Zhang, Kaixian Chen, Hualiang Jiang, 2009, PloS one.

Virtual screening on natural products for discovering active compounds and target information.

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2003, Current medicinal chemistry.

Peptide deformylase is a potential target for anti‐Helicobacter pylori drugs: Reverse docking, enzymatic assay, and X‐ray crystallography validation

Jian Zhang, Kaixian Chen, Hualiang Jiang, 2006, Protein science : a publication of the Protein Society.

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

Jian Zhang, Xiaomin Luo, Weiliang Zhu, 2006, Journal of combinatorial chemistry.

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

Hualiang Jiang, Xu Shen, Hong Liu, 2005, Bioorganic & Medicinal Chemistry.

SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.

Hualiang Jiang, Xu Shen, Honglin Li, 2011, Journal of medicinal chemistry.

Hyrtiosal, a PTP1B Inhibitor from the Marine Sponge Hyrtios erectus, Shows Extensive Cellular Effects on PI3K/AKT Activation, Glucose Transport, and TGFβ/Smad2 Signaling

Kaixian Chen, Hualiang Jiang, Xu Shen, 2007, Chembiochem : a European journal of chemical biology.

Protein tyrosine phosphatase 1B regulates TGF beta 1-induced Smad2 activation through PI3 kinase-dependent pathway.

Fei Ye, Xu Shen, Hualiang Jiang, 2006, Cytokine.

Discovering Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors: Virtual Screening, Surface Plasmon Resonance, and Fluorescence Resonance Energy Transfer Assays

Xu Shen, Jianhua Shen, Shuai Chen, 2006, SLAS Discovery.

Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.

Fang Liu, Kaixian Chen, Hualiang Jiang, 2010, Journal of medicinal chemistry.

The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1

Kaixian Chen, Hualiang Jiang, Xu Shen, 2005, FEBS Letters.

Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.

Honglin Li, Kunqian Yu, Mingyue Zheng, 2009, Journal of medicinal chemistry.

Malonyl‐CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein

Kaixian Chen, Hualiang Jiang, Xu Shen, 2007, Protein science : a publication of the Protein Society.

In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS

Fei Ye, Jing Chen, Xu Shen, 2004, Biophysical Chemistry.

Interaction Models of a Series of Oxadiazole-Substituted α-Isopropoxy Phenylpropanoic Acids Against PPARα and PPARγ: Molecular Modeling and Comparative Molecular Similarity Indices Analysis Studies

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2009 .

Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/release

Kunqian Yu, Hualiang Jiang, Xu Shen, 2005, Acta Pharmacologica Sinica.

Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

Jian Li, Hong Liu, Bing Xiong, 2006, Acta Pharmacologica Sinica.

Natural products as a gold mine for selective matrix metalloproteinases inhibitors.

Honglin Li, Jin Huang, Weidong Zhang, 2012, Bioorganic & medicinal chemistry.

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Cheng Luo, Weiliang Zhu, Jian Li, 2006, Bioorganic & Medicinal Chemistry.

Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro

Christian Drosten, Burkhard Ludewig, Elke Scandella, 2005, Journal of Virology.

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A

Cheng Luo, Jingkang Shen, Suxin Zheng, 2004, Biochemical and Biophysical Research Communications - BBRC.

Quantitative Characterization of 15-Deoxy- Delta(12,14)-Prostaglandin J2 in Regulating EGFPSmad2 Translocation in CHO Cells Through PPARγ /TGFβ/Smad2 Pathway

Kaixian Chen, Hualiang Jiang, Xu Shen, 2006, Cellular Physiology and Biochemistry.

Ligand‐binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology‐based kinetic analysis correlated with molecular dynamics simulation

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2005, Protein science : a publication of the Protein Society.

Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease.

Jing Chen, Xu Shen, Ruoming Wu, 2014, Bioorganic & medicinal chemistry.

Helicobacter pylori acyl carrier protein: expression, purification, and its interaction with beta-hydroxyacyl-ACP dehydratase.

Hualiang Jiang, Xu Shen, J. Chen, 2007, Protein expression and purification.

Synthesis, modification, and evaluation of (R)-de-O-methyllasiodiplodin and analogs as nonsteroidal antagonists of mineralocorticoid receptor.

Xu Shen, Li-li Chen, T. Kurtán, 2011, Bioorganic & medicinal chemistry letters.

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

Hualiang Jiang, Xu Shen, Yu Zhang, 2008, Cellular Physiology and Biochemistry.

Binding analyses between Human PPARgamma-LBD and ligands.

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2004, European journal of biochemistry.

Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: inhibition by salvianolic acid B from Salvia miltiorrhiza.

Xu Shen, Wan-ying Wu, D. Guo, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats

Hualiang Jiang, Xu Shen, H. Chen, 2013, PloS one.

Potentiation of Tumor Necrosis Factor-α-induced Tumor Cell Apoptosis by a Small Molecule Inhibitor for Anti-apoptotic Protein hPEBP4

Hualiang Jiang, Xu Shen, Nan Li, 2010, The Journal of Biological Chemistry.

Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis.

Jing Chen, Xu Shen, Hai-Bin Luo, 2003, Acta pharmacologica Sinica.

An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development.

Weiliang Zhu, Kaixian Chen, Hualiang Jiang, 2006, Current pharmaceutical design.

Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2003, Protein Expression and Purification.

The conserved residue Phe273(282) of PPARα(γ), beyond the ligand-binding site, functions in binding affinity through solvation effect

Fei Ye, Xu Shen, Hualiang Jiang, 2005 .

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists.

Xu Shen, Lihong Hu, Li-li Chen, 2014, Bioorganic & medicinal chemistry.

BBT improves glucose homeostasis by ameliorating β-cell dysfunction in type 2 diabetic mice.

Xu Shen, P. Wan, J. Chen, 2015, The Journal of endocrinology.

A New Assay Based on Fluorescence Resonance Energy Transfer to Determine the Binding Affinity of Bcl-xL Inhibitors

Kaixian Chen, Hualiang Jiang, Xu Shen, 2008, Bioscience, biotechnology, and biochemistry.

Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteins.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2008, Journal of biochemistry.

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).

Xu Shen, Ren Wen, Jianhua Shen, 2006, Bioorganic & medicinal chemistry letters.

Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability

Xu Shen, Jing Chen, Li-li Chen, 2013, Steroids.

Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro

Xu Shen, J. Chen, Li-Hong Hu, 2013, Acta Pharmacologica Sinica.

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.

Hualiang Jiang, Xu Shen, Honglin Li, 2012, Bioorganic & medicinal chemistry letters.

Characterization and inhibitor discovery of one novel malonyl‐CoA: Acyl carrier protein transacylase (MCAT) from Helicobacter pylori

Kaixian Chen, Hualiang Jiang, Xu Shen, 2006, FEBS letters.

Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

Xu Shen, Zhiwei Cao, Jianrong Xu, 2016, Cell Research.

The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

Hualiang Jiang, Xu Shen, Weihong Jiang, 2004, Cell Research.

The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation

Hualiang Jiang, Xu Shen, Li-Hong Hu, 2009, Acta Pharmacologica Sinica.

Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.

Xu Shen, J. Chen, Lihong Hu, 2017, Bioorganic & medicinal chemistry letters.

A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2009, Analytical biochemistry.

Three flavonoids targeting the β‐hydroxyacyl‐acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay

Hualiang Jiang, Xu Shen, Dalei Wu, 2008, Protein science : a publication of the Protein Society.

Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling

Xu Shen, J. Chen, D. Guo, 2010, BMC pharmacology.

Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2006, Biochemistry.

SR-rich motif plays a pivotal role in recombinant SARS coronavirus nucleocapsid protein multimerization.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2005, Biochemistry.

Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction

Kaixian Chen, Hualiang Jiang, Xu Shen, 2005, The International Journal of Biochemistry & Cell Biology.

Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways

Xu Shen, Li-Hong Hu, Ruo-ming Wu, 2014, Acta Pharmacologica Sinica.

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Xu Shen, J. Chen, Jinpei Zhou, 2018, Biochemical and biophysical research communications.

Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.

Xu Shen, Lihong Hu, S. Shen, 2013, Bioorganic & medicinal chemistry.

D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.

Hualiang Jiang, Xu Shen, Cong Han, 2008, International journal of antimicrobial agents.

Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori.

Hualiang Jiang, Xu Shen, Cong Han, 2007, Journal of biochemistry.

Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis

Hualiang Jiang, Xu Shen, T. Hu, 2008, Protein science : a publication of the Protein Society.

Structural Basis for Catalytic and Inhibitory Mechanisms of β-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ)*

Kaixian Chen, Hualiang Jiang, Xu Shen, 2008, Journal of Biological Chemistry.

Identification and Evaluation of Coronavirus Replicase Inhibitors Using a Replicon Cell Line

Xiaomin Luo, Hualiang Jiang, Jianhua Shen, 2006, Advances in experimental medicine and biology.

Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

Hualiang Jiang, Xu Shen, Lihong Hu, 2011, PloS one.

Structural Basis for Retinoic X Receptor Repression on the Tetramer*

Hualiang Jiang, Xu Shen, J. Chen, 2011, The Journal of Biological Chemistry.

Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase.

A. Danchin, Kunqian Yu, Hualiang Jiang, 2007, The Journal of antimicrobial chemotherapy.

Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor*

Peng Liu, Xin Xu, Xing Xu, 2015, The Journal of Biological Chemistry.

Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus.

Xu Shen, Lihong Hu, Xinpeng Liu, 2019, European journal of medicinal chemistry.

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.

Weiliang Zhu, Kaixian Chen, Hualiang Jiang, 2010, Journal of inorganic biochemistry.

Steered molecular dynamics simulations of protein-ligand interactions

Xiaomin Luo, Kaixian Chen, Hualiang Jiang, 2004 .

Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models.

Hualiang Jiang, Chenjing Li, Xu Shen, 2013, Journal of ethnopharmacology.

Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways

Xu Shen, Li-Hong Hu, Xu Wang, 2010, Acta Pharmacologica Sinica.

Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188

Xu Shen, J. Sakayaroj, S. Phongpaichit, 2017 .

Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187

Xu Shen, J. Sakayaroj, S. Phongpaichit, 2017 .

β-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp. PSU-ES123

Xu Shen, J. Sakayaroj, S. Phongpaichit, 2016 .

Penicillanthone and penicillidic acids A–C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

Xu Shen, J. Sakayaroj, S. Phongpaichit, 2016 .

Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A.

Hualiang Jiang, Xu Shen, J. Chen, 2006, Chemical & pharmaceutical bulletin.

1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator.

Hualiang Jiang, Ting Shi, Xu Shen, 2012, Biochemical and biophysical research communications.

Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.

Xu Shen, Lei Ma, Jun-hua Liu, 2011, Bioorganic & medicinal chemistry.

Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice.

Xu Shen, J. Chen, Wan-ying Wu, 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Structure and Dynamics of Sars Coronavirus Main Proteinase (MPRO)

Hualiang Jiang, Xu Shen, R. Hilgenfeld, 2006, Advances in experimental medicine and biology.

Structure assembly of Bcl-x(L) through alpha5-alpha5 and alpha6-alpha6 interhelix interactions in lipid membranes.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2009, Biochimica et biophysica acta.

Establishment of high throughput screening model for epidermal growth factor receptor tyrosine kinase inhibitor: Establishment of high throughput screening model for epidermal growth factor receptor tyrosine kinase inhibitor

Xu Shen, Haibin Luo, C. Mei, 2010 .

A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein.

Kaixian Chen, Hualiang Jiang, Xu Shen, 2009, Archives of biochemistry and biophysics.

Total synthesis of gymnorrhizol, an unprecedented 15-membered macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza.

Hualiang Jiang, Xu Shen, K. Krohn, 2007, Organic letters.

Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.

Xu Shen, Xiao-min Luo, Yu Zhou, 2016, European journal of medicinal chemistry.

pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (Mpro) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses

Kaixian Chen, Hualiang Jiang, Yechun Xu, 2005, Journal of Molecular Biology.

Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions

Hualiang Jiang, Xu Shen, J. Li, 2010, Molecules.

Total Synthesis of Cytosporone B

Hualiang Jiang, Xu Shen, Hong Liu, 2010 .

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.

Xu Shen, Huibin Zhang, Jinpei Zhou, 2017, European journal of medicinal chemistry.

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Weiliang Zhu, Jian Li, Honglin Li, 2011, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease.

Xu Shen, Lihong Hu, Junwei Wang, 2018, European journal of medicinal chemistry.

Novel approaches to drug discovery for the treatment of type 2 diabetes

Xu Shen, Li-li Chen, Gaihong Wang, 2014, Expert opinion on drug discovery.

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Ying Yu, Zhenting Gao, Wenzhong Yan, 2012, Journal of medicinal chemistry.

Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.

Hualiang Jiang, Xu Shen, Xu Zhang, 2010, Bioorganic & medicinal chemistry.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Honglin Li, Jin Huang, Jin Zhu, 2009, Journal of medicinal chemistry.

Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A.

Hualiang Jiang, Xu Shen, J. Chen, 2006, Chemical & pharmaceutical bulletin.

Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives

Hualiang Jiang, Xu Shen, Xiao-min Luo, 2007, Acta Pharmacologica Sinica.

Putative hAPN receptor binding sites in SARS_CoV spike protein.

Cheng Luo, Guo-Ping Zhao, Zong-Ming Guo, 2003, Acta pharmacologica Sinica.

Discovery and structure-activity relationships study of thieno[2,3-b]pyridine analogues as hepatic gluconeogenesis inhibitors.

Xu Shen, Lihong Hu, Jian Liu, 2018, European journal of medicinal chemistry.

A new dolabellane diterpenoid from the Hainan soft coral Spongodes sp.

Xu Shen, Yue‐Wei Guo, Xiao‐Hong Yan, 2007, Natural product research.

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Li Zhang, Yu Qin, Jingkang Shen, 2006, Bioorganic & Medicinal Chemistry.

Swietenia mahagony extract shows agonistic activity to PPAR γ and gives ameliorative effects on diabetic db/db mice

Hualiang Jiang, Jianhua Shen, Xu Shen, 2005, Acta Pharmacologica Sinica.

Diastereoisomeric macrocyclic polydisulfides from the mangrove Bruguiera gymnorrhiza.

Xu Shen, Yu Zhang, Qi Wang, 2009, Phytochemistry.

Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization

Xu Shen, Cong Han, Li-hong Hu, 2008, Acta Pharmacologica Sinica.

Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)

Chenjing Li, Xu Shen, Lihong Hu, 2011, Journal of enzyme inhibition and medicinal chemistry.

(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice

Jing Chen, Jiming Ye, Mingyue Zheng, 2012, PloS one.

Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant

Cheng Luo, Mingyue Zheng, Zhongjie Liang, 2011, PloS one.

Determining PPARγ-ligand binding affinity using fluorescent assay with cis-parinaric acid as a probe

Kaixian Chen, Hualiang Jiang, Jianhua Shen, 2005 .

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance

Hualiang Jiang, Chenjing Li, Xu Shen, 2013, The Journal of Neuroscience.

Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori

Kunqian Yu, Kaixian Chen, Hualiang Jiang, 2006, The FEBS journal.

A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases

Hualiang Jiang, Xu Shen, Yu Zhang, 2009, Acta Pharmacologica Sinica.

A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.

Xu Shen, Yu Zhang, Y. Li, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors.

Xu Shen, Li-li Chen, D. Bai, 2008, Chemical & pharmaceutical bulletin.

Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.

Xu Shen, Yue‐Wei Guo, Shui-Chun Mao, 2006, Bioorganic & medicinal chemistry letters.

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

Luhua Lai, Jianfeng Pei, Jin Huang, 2009, Journal of medicinal chemistry.

L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells

Xu Shen, Ye-chun Xu, Li-li Chen, 2012, Acta Pharmacologica Sinica.

FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway

Xu Shen, Lihong Hu, Xing Xu, 2020, Aging.

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies

Xu Shen, Li-Hong Hu, V. Rukachaisirikul, 2016, Acta Pharmacologica Sinica.

The Dipeptide H‐Trp‐Glu‐OH Shows Highly Antagonistic Activity against PPARγ: Bioassay with Molecular Modeling Simulation

Fei Ye, Xu Shen, Hai-Bin Luo, 2006, Chembiochem : a European journal of chemical biology.

A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist.

Hualiang Jiang, Jianhua Shen, Xu Shen, 2004, Analytical biochemistry.

Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1

Hualiang Jiang, Xu Shen, Li-li Chen, 2011, Protein science : a publication of the Protein Society.

Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori.

Hualiang Jiang, Xu Shen, Cong Han, 2004, Biochemical and biophysical research communications.

Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase

Zhili Zuo, Weiliang Zhu, Xu Shen, 2005 .

Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice

Xu Shen, J. Chen, Jin Ren, 2019, Acta Pharmacologica Sinica.

Identification of probable genomic packaging signal sequence from SARS-CoV genome by bioinformatics analysis.

Cheng Luo, Guo-Ping Zhao, Zong-Ming Guo, 2003, Acta pharmacologica Sinica.

Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization

Hualiang Jiang, Xu Shen, Jianping Ding, 2009, BMC Microbiology.

Activation of Protein Serine/Threonine Phosphatase PP2Cα Efficiently Prevents Liver Fibrosis

Xu Shen, Lihong Hu, Xu Wang, 2010, PloS one.

Two Novel Aromatic Valerenane‐Type Sesquiterpenes from the Chinese Green Alga Caulerpa taxifolia.

Xu Shen, Yue‐Wei Guo, Shui-Chun Mao, 2006 .

DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway.

Xu Shen, Li-Hong Hu, V. Rukachaisirikul, 2017, Journal of molecular endocrinology.

Supplemental Information Structural Basis for the Regulation of Cysteine-Protease Activity by a New Class of Protease Inhibitors in Plasmodium

Hualiang Jiang, Xu Shen, Honglin Li, 2011 .

Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode.

Li Li, Xu Shen, Hualiang Jiang, 2011, Journal of molecular biology.

Structural Insights into Cellulolytic and Chitinolytic Enzymes Revealing Crucial Residues of Insect β-N-acetyl-D-hexosaminidase

Qing Yang, Wei Chen, Xu Shen, 2012, PloS one.

Techniques used for the discovery of therapeutic compounds: The case of SARS

Xu Shen, Hualiang Jiang, Kaixian Chen, 2006, Drug Discovery Today: Technologies.

Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections.

Zhiqiang Qin, Antoine Danchin, Yang Wu, 2006, BMC microbiology.

7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation

Hualiang Jiang, Xu Shen, Jin Huang, 2009, Acta Pharmacologica Sinica.

Identification of an epitope of SARS-coronavirus nucleocapsid protein

Yuan WANG, Hualiang Jiang, Jianhua Shen, 2003, Cell Research.

Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidentate inhibitor

Jianhua Shen, Xu Shen, Guixia Liu, 2006, Acta Pharmacologica Sinica.

Crystal Structure of HAb18G/CD147

Ning Wen, Jian Zhang, Xu Shen, 2008, Journal of Biological Chemistry.

HL005—A new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7

Xu Shen, Honglin Li, Hualiang Jiang, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Enzymatic characterization and crystal structure analysis of the D‐alanine‐D‐alanine ligase from Helicobacter pylori

Hualiang Jiang, Xu Shen, Dalei Wu, 2008, Proteins.

Residues on the Dimer Interface of SARS Coronavirus 3C-like Protease: Dimer Stability Characterization and Enzyme Catalytic Activity Analysis

Jian Zhang, Kaixian Chen, Hualiang Jiang, 2007, Journal of biochemistry.

Regulation of prostaglandin F2α against β amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia.

Xu Shen, Li-li Chen, Jing Chen, 2013, Prostaglandins & other lipid mediators.

Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism.

Hualiang Jiang, Xu Shen, Yu Zhang, 2008, Biochemical pharmacology.

Small molecules from natural sources, targeting signaling pathways in diabetes.

Xu Shen, Li-li Chen, L. Hu, 2010, Biochimica et biophysica acta.

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

Xu Shen, Li-Hong Hu, V. Rukachaisirikul, 2016, Acta Pharmacologica Sinica.

Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum*

Xu Shen, Rolf Hilgenfeld, Hualiang Jiang, 2006, Journal of Biological Chemistry.

Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.

Xiaomin Luo, Weiliang Zhu, Kaixian Chen, 2005, Bioorganic & Medicinal Chemistry.

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

Xu Shen, Li-Hong Hu, V. Rukachaisirikul, 2017, Acta Pharmacologica Sinica.

Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.

Xiaomin Luo, Weiliang Zhu, Hualiang Jiang, 2008, European journal of medicinal chemistry.

Conformational transition pathway in the allosteric process of human glucokinase

Jian Zhang, Weiliang Zhu, Kaixian Chen, 2006, Proceedings of the National Academy of Sciences.

Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure☆

Hualiang Jiang, Xu Shen, T. Hu, 2009, Virology.

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease

Jian Zhang, Kaixian Chen, Hualiang Jiang, 2008, Journal of Biological Chemistry.

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Li Du, Jing Chen, Xu Shen, 2005, Journal of Biological Chemistry.

Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists.

Xu Shen, Lihong Hu, Li-li Chen, 2015, Bioorganic & medicinal chemistry.

Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice

Xu Shen, J. Chen, Li-Hong Hu, 2019, Acta Pharmacologica Sinica.

Hyrtiosal, from the Marine Sponge Hyrtios erectus, Inhibits HIV‐1 Integrase Binding to Viral DNA by a New Inhibitor Binding Site

Hualiang Jiang, Xu Shen, Yun Tang, 2008, ChemMedChem.

Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.

Li Du, Xu Shen, Kaixian Chen, 2006, Journal of biochemistry.

Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases.

Qing Yang, Xu Shen, Fengyi Liu, 2011, Biochemical Journal.

Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells

Xu Shen, Xiao-min Luo, Chuan Xu, 2015, Acta Pharmacologica Sinica.

Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling.

Jian Zhang, Xu Shen, Cong Han, 2007, Bioorganic & medicinal chemistry.

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

Honglin Li, Jin Huang, Yufang Xu, 2012, Journal of medicinal chemistry.

NDB stabilizes hFXR homodimerization

Xu Shen, P. Liu, Jing Chen, 2015 .

Structural basis for small molecule NDB as a selective antagonist of Farnesoid X receptor ( FXR ) in stabilizing the homodimerization of the receptor

Xu Shen, Lihong Hu, Li-li Chen, 2015 .

Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production

Chenjing Li, Xu Shen, Li-Hong Hu, 2010, Acta Pharmacologica Sinica.

Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ

Hualiang Jiang, Xu Shen, Lihong Hu, 2011, PloS one.

Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor β agonist and induces GLUT4 expression in CHO-K1 cells

Jin Huang, Xu Shen, Hong Shen, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor*

Hualiang Jiang, Chenjing Li, Xu Shen, 2010, The Journal of Biological Chemistry.

Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice

Xu Shen, Li-li Chen, Gaihong Wang, 2013, Diabetologia.

An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for β-amyloid peptide as a monomer

Kaixian Chen, Hualiang Jiang, Yechun Xu, 2010, Analytical and bioanalytical chemistry.

The Effect of the Potential PhoQ Histidine Kinase Inhibitors on Shigella flexneri Virulence

Jian Zhang, Hualiang Jiang, Xu Shen, 2011, PloS one.

Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway

Hualiang Jiang, Xu Shen, Yu Zhang, 2011, Acta Pharmacologica Sinica.

Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways

Hualiang Jiang, Xu Shen, Yu Zhang, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma.

Hualiang Jiang, Xu Shen, Jin Huang, 2008, Biochemical pharmacology.

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Jianhua He, Orly Dym, Joel L Sussman, 2012, Acta crystallographica. Section D, Biological crystallography.

Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

Fei Ye, Jing Chen, Xu Shen, 2005, Acta Pharmacologica Sinica.

A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling.

Hualiang Jiang, Xu Shen, Cong Han, 2005, Biochemical and biophysical research communications.

A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.

Cheng Luo, Jing Chen, Xu Shen, 2003, Acta pharmacologica Sinica.

HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter.

Xu Shen, Lihong Hu, Li-li Chen, 2018, Metabolism: clinical and experimental.

Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation

Xu Shen, Li-li Chen, Cheng-Shi Jiang, 2013, Acta Pharmacologica Sinica.

Folding of the SARS coronavirus spike glycoprotein immunological fragment (SARS_S1b): thermodynamic and kinetic investigation correlating with three-dimensional structural modeling.

Hualiang Jiang, Jianhua Shen, Xu Shen, 2005, Biochemistry.

Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide.

Jianpeng Ma, Xu Shen, Kaixian Chen, 2006, Biochemistry.

2,2′,4′‐Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

Hualiang Jiang, Chenjing Li, Xu Shen, 2010, Journal of neurochemistry.

X‐ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis

Hualiang Jiang, Xu Shen, Cong Han, 2009, The FEBS journal.

Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: Molecular modeling with biological evaluation

Xiaomin Luo, Xu Shen, Li-li Chen, 2013, Steroids.

Flexibility of the flap in the active site of BACE 1 as revealed by crystal structures and molecular dynamics simulations

Hualiang Jiang, Yechun Xu, Xu Shen, 2011 .

Protein tyrosine phosphatase 1B regulates TGFβ1-induced Smad2 activation through PI3 kinase-dependent pathway

Kaixian Chen, Hualiang Jiang, Xu Shen, 2006 .

Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives.

Xu Shen, Lihong Hu, Min Lei, 2016, Bioorganic & medicinal chemistry letters.

Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors.

Xu Shen, Li-li Chen, D. Bai, 2008, Chemical & pharmaceutical bulletin.

SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways

Xu Shen, P. Wan, J. Chen, 2016, Cell Death and Disease.

Structural Proteomics of Emerging Viruses: The Examples of SARS-CoV and Other Coronaviruses

Hualiang Jiang, Xu Shen, R. Hilgenfeld, 2008 .

Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.

Xu Shen, Kai-Xian Chen, Jianhua Shen, 2004, Acta pharmacologica Sinica.

Aza analogues of equol: novel ligands for estrogen receptor beta.

Xu Shen, Ming-Wei Wang, Chunhao Yang, 2007, Bioorganic & medicinal chemistry.

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Hualiang Jiang, Yechun Xu, Xu Shen, 2012, Acta crystallographica. Section D, Biological crystallography.

D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.

Hualiang Jiang, Xu Shen, Cong Han, 2008, International journal of antimicrobial agents.

Characterization of peptide deformylase homologues from Staphylococcus epidermidis.

Kunqian Yu, Hualiang Jiang, Xu Shen, 2010, Microbiology.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Hualiang Jiang, Xu Shen, Honglin Li, 2009, Journal of medicinal chemistry.

Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.

Xu Shen, Lei Ma, Jun-hua Liu, 2011, Bioorganic & medicinal chemistry.

Small molecules from natural sources, targeting signaling pathways in diabetes.

Xu Shen, Li-li Chen, L. Hu, 2010, Biochimica et biophysica acta.

Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)?

Cheng Luo, Jianpeng Ma, Weiliang Zhu, 2009, Cell Research.

COMPARISON OF THREE 3D-QSAR METHODS USING A NOVEL CLASS OF MURF INHIBITORS

Xu Shen, De-Xin Kong, Weiliang Zhu, 2007 .

The Catalytic Intermediate Stabilized by a “Down” Active Site Loop for Diaminopimelate Decarboxylase from Helicobacter pylori

Hualiang Jiang, Xu Shen, T. Hu, 2008, Journal of Biological Chemistry.

Inhibitory mode of indole-2-carboxamide derivatives against HLGPa: molecular docking and 3D-QSAR analyses.

Hong Liu, Xu Shen, Hualiang Jiang, 2004, Bioorganic & medicinal chemistry.

Crystal Structure of HAb18G/CD147

Jian Zhang, Hualiang Jiang, Xu Shen, 2008, Journal of Biological Chemistry.