H. Eklund

发表

Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.

M. Eriksson, U. Uhlin, S. Ramaswamy, 1997, Structure.

Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases.

Bjørn Dalhus, Hans Eklund, Kenth Johansson, 2002, Journal of molecular biology.

Light/Dark Regulation of Chloroplast Metabolism

H. Eklund, P. Schürmann, S. Dai, 2007 .

The three-dimensional structures of two toxins from snake venom throw light on the anticoagulant and neurotoxic sites of phospholipase A2.

H. Eklund, E. Carredano, B. Westerlund, 1998, Toxicon : official journal of the International Society on Toxinology.

Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.

T. A. Jones, H. Eklund, J. Samama, 1981, Journal of molecular biology.

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

H. Eklund, J. Samama, C. Brändén, 1982, The Journal of biological chemistry.

Crystallization and preliminary crystallographic studies of Saccharomyces cerevisiae alcohol dehydrogenase I.

S. Ramaswamy, H. Eklund, A. D. Hershey, 1994, Journal of molecular biology.

Structures of Horse Liver Alcohol Dehydrogenase Complexed with NAD+ and Substituted Benzyl Alcohols

S. Ramaswamy, H. Eklund, B. Plapp, 1994 .

Medium- and short-chain dehydrogenase/reductase gene and protein families

S. Ramaswamy, H. Eklund, 2008, Cellular and Molecular Life Sciences.

Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution.

H. Eklund, D. LeMaster, S. Katti, 1990, Journal of molecular biology.

Structural and functional relations among thioredoxins of different species

H. Eklund, A. Holmgren, F. K. Gleason, 1991, Proteins.

Crystallizations of novel forms of alcohol dehydrogenase.

S. Ramaswamy, H. Eklund, H. Jörnvall, 1995, Advances in experimental medicine and biology.

A single‐residue exchange gives human recombinant ββ alcohol dehydrogenase γγ isozyme properties

H. Eklund, H. Jörnvall, J. Höög, 1992 .

Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron

H. Eklund, A. Karlsson, D. Gibson, 2003, Science.

Di-iron-carboxylate proteins.

H. Eklund, P. Nordlund, P. Nordlund, 1995, Current opinion in structural biology.

Three-dimensional structures of MDR alcohol dehydrogenases

S. Ramaswamy, H. Eklund, 2008 .

Structure of Salmonella typhimurium nrdF ribonucleotide reductase in its oxidized and reduced forms.

M. Eriksson, H. Eklund, A. Jordan, 1998, Biochemistry.

Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase.

H. Eklund, J. Piškur, K. Johansson, 2003, Biochemistry.

Active site specific cadmium(II)-substituted horse liver alcohol dehydrogenase: crystal structures of the free enzyme, its binary complex with NADH, and the ternary complex with NADH and bound p-bromobenzyl alcohol.

H. Eklund, G. Schneider, S. Knight, 1985, Biochemistry.

A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines

H. Eklund, J. Piškur, K. Johansson, 2002, The EMBO journal.

The structure of horse liver alcohol dehydrogenase

H. Eklund, C. Brändén, E. Zeppezauer, 1974, FEBS letters.

Crystal structure of sorbitol dehydrogenase.

S. Ramaswamy, H. Eklund, H. Jörnvall, 2001, Chemico-biological interactions.

New crystal forms of the small subunit of ribonucleotide reductase from Escherichia coli

U. Uhlin, B. Sjöberg, H. Eklund, 1989, FEBS letters.

Crystallization and Crystallographic Investigations of Ferredoxin:Thioredoxin Reductase from Synechocystis SP. PCC6803

S. Ramaswamy, H. Eklund, P. Schürmann, 1998 .

Crystallization and preliminary crystallographic data of ribonucleotide reductase protein B2 from Escherichia coli.

U. Uhlin, B. Sjöberg, H. Eklund, 1984, The Journal of biological chemistry.

Subunit conformation of yeast alcohol dehydrogenase.

H. Eklund, H. Jörnvall, C. Brändén, 1978, The Journal of biological chemistry.

The reduction of the Rieske iron-sulfur cluster in naphthalene dioxygenase by X-rays.

H. Eklund, A. Karlsson, D. Gibson, 2000, Journal of inorganic biochemistry.

Binding of salicylate in the adenosine-binding pocket of dehydrogenases.

H. Eklund, C. Brändén, R. Einarsson, 1974, European journal of biochemistry.

Preliminary crystallographic data for an extracellular proteolytic enzyme from a strain of arthrobacter.

H. Eklund, C. Brändén, M. Zeppezauer, 1968, Journal of molecular biology.

Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli.

S. Ramaswamy, H. Eklund, M. Fontecave, 1999, Biochemistry.

Electrostatic effects of bound NADH and NAD+ on ionizing groups in liver alcohol dehydrogenase.

H. Eklund, G. Pettersson, 1987, European journal of biochemistry.

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution.

S. Ramaswamy, H. Eklund, S. Dai, 1996, Journal of molecular biology.

Three-dimensional structure of the free radical protein of ribonucleotide reductase

Hans Eklund, Pär Nordlund, B. Sjöberg, 1990, Nature.

Structure and function of the Escherichia coli ribonucleotide reductase protein R2.

H. Eklund, P. Nordlund, H Eklund, 1993, Journal of molecular biology.

Substitution of manganese for iron in ribonucleotide reductase from Escherichia coli. Spectroscopic and crystallographic characterization.

H. Eklund, P. Nordlund, M. Fontecave, 1994, The Journal of biological chemistry.

Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.

J. Hajdu, K. Regnström, H. Eklund, 1996, Structure.

Structure and function of the radical enzyme ribonucleotide reductase.

U. Uhlin, H. Eklund, P. Nordlund, 2001, Progress in biophysics and molecular biology.

The redox centers of ribonucleotide reductase of Escherichia coli.

H. Eklund, P. Nordlund, M. Fontecave, 1992, Advances in enzymology and related areas of molecular biology.

Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase.

D T Gibson, H. Eklund, D. Gibson, 1998, Structure.

Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase.

H. Eklund, J. Samama, T. Jones, 1984, Biochemistry.

Crystal structure determinations of coenzyme analogue and substrate complexes of liver alcohol dehydrogenase: binding of 1,4,5,6-tetrahydronicotinamide adenine dinucleotide and trans-4-(N,N-dimethylamino)cinnamaldehyde to the enzyme.

H. Eklund, J. Samama, E. Cedergren-Zeppezauer, 1982, Biochemistry.

Pyrazole binding in crystalline binary and ternary complexes with liver alcohol dehydrogenase.

H. Eklund, J. Samama, L. Wallen, 1982, Biochemistry.

Substrate binding site of naphthalene 1,2-dioxygenase: functional implications of indole binding.

D T Gibson, H. Eklund, D. Choudhury, 2000, Journal of molecular biology.

Unusual clustering of carboxyl side chains in the core of iron-free ribonucleotide reductase

H. Eklund, P. Nordlund, A. Åberg, 1993, Nature.

Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster.

S. Ramaswamy, H. Eklund, P. Schürmann, 2000, Science.

Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution.

H. Eklund, O. Tapia, C. Brändén, 1976, Journal of molecular biology.

Structural differences between apo- and holoenzyme of horse liver alcohol dehydrogenase.

H. Eklund, C. Brändén, 1979, The Journal of biological chemistry.

Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors.

U. Uhlin, H. Eklund, M. Färnegårdh, 2003, Journal of molecular biology.

Crystallography of liver alcohol dehydrogenase complexed with substrates.

H. Eklund, C. Brändén, B. Plapp, 1978, Journal of molecular biology.

3 Alcohol Dehydrogenases

H. Eklund, C. Brändén, B. Furugren, 1975 .

Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase.

H. Eklund, C. Brändén, T. Jones, 1984, The Journal of biological chemistry.

Structure of Liver Alcohol Dehydrogenase at 2.9-Å Resolution

Hans Eklund, H. Eklund, C. Brändén, 1973 .

Molecular aspects of functional differences between alcohol and sorbitol dehydrogenases.

H. Eklund, H. Jörnvall, E. Horjales, 1985, Biochemistry.

X-ray studies of the binding of Cibacron blue F3GA to liver alcohol dehydrogenase.

H. Eklund, J. Samama, C. Brändén, 1979, European journal of biochemistry.

Structural comparisons of mammalian, yeast and bacillar alcohol dehydrogenases.

H. Eklund, H. Jörnvall, C. Brändén, 1976, Journal of molecular biology.

Computer‐graphics interpretations of residue exchanges between the α, β and γ subunits of human‐liver alcohol dehydrogenase class I isozymes

H. Eklund, H. Jörnvall, E. Horjales, 1987 .

Copper amine oxidase: a novel use for a tyrosine.

H. Eklund, M. Fontecave, 1995, Structure.

Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols.

S. Ramaswamy, H. Eklund, B. Plapp, 1994, Biochemistry.

Tetrameric NAD-dependent alcohol dehydrogenase.

H. Eklund, H. Jörnvall, K. Johansson, 2003, Chemico-biological interactions.

Crystal structure of cod liver class I alcohol dehydrogenase: Substrate pocket and structurally variable segments

S. Ramaswamy, H. Eklund, H. Jörnvall, 1996, Protein science : a publication of the Protein Society.

Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode.

M Karplus, M. Karplus, H. Eklund, 1979, The Journal of biological chemistry.

Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system

H. Eklund, R. Friemann, D. Gibson, 2008, Acta crystallographica. Section D, Biological crystallography.

Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.

H. Eklund, R. Friemann, D. Gibson, 2005, Journal of molecular biology.

Cofactor mobility determines reaction outcome in the IMPDH/GMPR (β/α)8 barrel enzymes

H. Eklund, P. Nordlund, L. Hedstrom, 2011, Nature chemical biology.

Crystal structure of plant pectin methylesterase

H. Eklund, H. Jörnvall, K. Johansson, 2002, FEBS letters.

Structure of ribonucleotide reductase protein R1

U. Uhlin, H. Eklund, 1994, Nature.

Structural Basis of Redox Signaling in Photosynthesis: Structure and Function of Ferredoxin:thioredoxin Reductase and Target Enzymes

H. Eklund, P. Schürmann, S. Dai, 2004, Photosynthesis Research.

Coenzyme-induced conformational changes and substrate binding in liver alcohol dehydrogenase.

H. Eklund, C. Brändén, 1977, Ciba Foundation symposium.

Protein B1 of ribonucleotide reductase. Direct analytical data and comparisons with data indirectly deduced from the nucleotide sequence of the Escherichia coli nrdA gene.

B. Sjöberg, H. Eklund, H. Jörnvall, 1985, European journal of biochemistry.

Structural basis for substrate specificities of cellular deoxyribonucleoside kinases

H. Eklund, J. Piškur, K. Johansson, 2001, Nature Structural Biology.

Structures of thymidine kinase 1 of human and mycoplasmic origin

H. Eklund, S. Eriksson, M. Welin, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D

H. Eklund, J. Piškur, T. Skovgaard, 2005, The FEBS journal.

Identification of the stable free radical tyrosine residue in ribonucleotide reductase

B. Sjöberg, H. Eklund, J. Ruderman, 1985, FEBS letters.

Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding

H. Eklund, J. Piškur, S. Eriksson, 2007, The FEBS journal.

Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme.

H. Eklund, S. Eriksson, Liya Wang, 2005, The FEBS journal.

Functional studies of active‐site mutants from Drosophila melanogaster deoxyribonucleoside kinase

H. Eklund, B. Munch‐Petersen, Louise Egeblad-Welin, 2007, The FEBS journal.

Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme

H. Eklund, S. Eriksson, Liya Wang, 2005 .

Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine.

H. Eklund, J. Piškur, A. Clausen, 2009, Biochemical and Biophysical Research Communications - BBRC.

Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase

H. Eklund, B. Munch‐Petersen, N. Mikkelsen, 2008, The FEBS journal.

KENTH JOHANSSON,' MUSTAPHA EL-AHMAD,',' S. RAMASWAMY,' LARS HJELMQVIST,'

S. Ramaswamy, H. Eklund, H. Jörnvall, 2002 .

Glycyl radical enzymes: a conservative structural basis for radicals.

H. Eklund, M. Fontecave, 1999, Structure.

Crystal structure of thioredoxin-2 from Anabaena.

H. Eklund, M. Saarinen, F. K. Gleason, 1995, Structure.

Crystal structure analysis of a mutant Escherichia coli thioredoxin in which lysine 36 is replaced by glutamic acid.

H. Eklund, J. Fuchs, F. K. Gleason, 1993, Biochemistry.

Coenzyme binding in alcohol dehydrogenase.

H. Eklund, 1989, Biochemical Society Transactions.

Structural basis for substrate specificities of cellular deoxyribosenucleoside kinases - correction

H. Eklund, J. Piškur, K. Johansson, 2001 .

Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms.

H. Eklund, P. Schürmann, J. Jacquot, 2009, Trends in plant science.

Structure of thioredoxin from Trypanosoma brucei brucei

H. Eklund, R. Krauth-Siegel, R. Friemann, 2003, FEBS letters.

How does light regulate chloroplast enzymes? Structure–function studies of the ferredoxin/thioredoxin system

S. Ramaswamy, H. Eklund, P. Schürmann, 2000, Quarterly Reviews of Biophysics.

Comparison of three classes of human liver alcohol dehydrogenase. Emphasis on different substrate binding pockets.

H. Eklund, H. Jörnvall, E. Horjales, 1990, European Journal of Biochemistry.

The major piscine liver alcohol dehydrogenase has class-mixed properties in relation to mammalian alcohol dehydrogenases of classes I and III.

H. Eklund, H. Jörnvall, O. Danielsson, 1992, Biochemistry.

The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution.

H. Eklund, V. Bianchi, M. Ingelman, 1997, Journal of molecular biology.

Structural snapshots along the reaction pathway of ferredoxin–thioredoxin reductase

H. Eklund, P. Schürmann, S. Dai, 2007, Nature.

Site-directed mutagenesis of mammalian alcohol and sorbitol dehydrogenases map functional differences within the enzyme family.

H. Eklund, H. Jörnvall, Christina Karlsson, 1993, Advances in experimental medicine and biology.

Enzyme and isozyme developments within the medium-chain alcohol dehydrogenase family.

H. Eklund, H. Jörnvall, X. Parés, 1993, Advances in experimental medicine and biology.

Comparison of computer modelling and X-ray results of the binding of a pyrazole derivative to liver alcohol dehydrogenase.

H. Eklund, E. Horjales, C. Brändén, 1987, Journal of molecular biology.

Structural studies of horse liver alcohol dehydrogenase: Coenzyme, substrate and inhibitor binding

H. Eklund, 1983, Pharmacology Biochemistry and Behavior.

Structure and mechanism of liver alcohol dehydrogenase, lactate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase.

H. Eklund, C. Brändén, 1980, Experientia. Supplementum.

Structure of the complex of active site metal‐depleted horse liver alcohol dehydrogenase and NADH.

H. Eklund, G. Schneider, M. Zeppezauer, 1983, The EMBO journal.

Structure of betaine aldehyde dehydrogenase at 2.1 Å resolution

S. Ramaswamy, H. Eklund, H. Jörnvall, 1998, Protein Science.

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.

S. Ramaswamy, H. Eklund, L. Thelander, 1996, Journal of molecular biology.

Crystal structure of E.coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme.

H. Eklund, C. Cambillau, S. Spinelli, 2004, Journal of molecular biology.

Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form.

S. Ramaswamy, H. Eklund, M. Saarinen, 1999, Biochemistry.

Reactivity of the tyrosyl radical of Escherichia coli ribonucleotide reductase -- control by the protein.

H. Eklund, M. Fontecave, C. Gerez, 1997, European journal of biochemistry.

Ribonucleotide reductase--structural studies of a radical enzyme.

M. Eriksson, U. Uhlin, H. Eklund, 1997, Biological chemistry.

The Ten-stranded β/α Barrel in Ribonucleotide Reductase Protein R1

U. Uhlin, H. Eklund, 1996 .

The structure of a reduced mutant T4 glutaredoxin

H. Eklund, P. Nordlund, M. Ingelman, 1995, FEBS letters.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

H. Eklund, P. Nordlund, S. Eriksson, 2010, The FEBS journal.

The ten-stranded beta/alpha barrel in ribonucleotide reductase protein R1.

U. Uhlin, H. Eklund, 1996, Journal of molecular biology.

Crystallographic investigations of ribonucleotide reductase.

U. Uhlin, H. Eklund, P. Nordlund, 1993, Biochemical Society transactions.

The active site structure of methane monooxygenase is closely related to the binuclear iron center of ribonucleotide reductase

H. Eklund, H. Dalton, P. Nordlund, 1992, FEBS letters.

Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity.

H. Eklund, S. Eriksson, M. Welin, 2007, Journal of molecular biology.

Correlation of exons with structural domains in alcohol dehydrogenase.

H. Eklund, C. Brändén, C. Cambillau, 1984, The EMBO journal.

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

H. Eklund, C. Brändén, A. Holmgren, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.

H. Eklund, P. Nordlund, M. Nikkola, 1992, Journal of molecular biology.

Micro diffusion cells for the growth of single protein crystals by means of equilibrium dialysis.

H. Eklund, M. Zeppezauer, E. Zeppezauer, 1968, Archives of biochemistry and biophysics.

Conformational and functional similarities between glutaredoxin and thioredoxins.

B. Sjöberg, H. Eklund, H. Jörnvall, 1984, The EMBO journal.

NO binding to naphthalene dioxygenase

H. Eklund, A. Karlsson, D. Gibson, 2005, JBIC Journal of Biological Inorganic Chemistry.

Structure of liver alcohol dehydrogenase at 2.9-angstrom resolution.

H. Eklund, C. Brändén, Å. Åkeson, 1973, Proceedings of the National Academy of Sciences of the United States of America.

A single-residue exchange gives human recombinant beta beta alcohol dehydrogenase gamma gamma isozyme properties.

H. Eklund, H. Jörnvall, J. Höög, 1992, European journal of biochemistry.

Amino acid sequence determination and three-dimensional modelling of thioredoxin from the photosynthetic bacterium Rhodobacter sphaeroides Y.

H. Eklund, F. Lederer, H. Jörnvall, 1988, European journal of biochemistry.

Structure of Escherichia coli YhdH, a putative quinone oxidoreductase.

H. Eklund, R. Vincentelli, C. Cambillau, 2004, Acta crystallographica. Section D, Biological crystallography.

Modifications of the active center of T4 thioredoxin by site-directed mutagenesis.

B. Sjöberg, H. Eklund, T. Joelson, 1990, The Journal of biological chemistry.

X-ray crystal structure of benzoate 1,2-dioxygenase reductase from Acinetobacter sp. strain ADP1.

H. Eklund, A. Karlsson, E. Neidle, 2002, Journal of molecular biology.

The three‐dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 Å resolution

U. Uhlin, H. Eklund, D. Eaker, 1992, FEBS letters.

Structure of the Thioredoxin 2 from Anabaena sp. pcc7120

H. Eklund, F. K. Gleason, M. Saarinen, 1995 .

Crystallisation and crystallographic investigations of cod alcohol dehydrogenase class I and class III enzymes

S. Ramaswamy, H. Eklund, H. Jörnvall, 1994, FEBS letters.

Crystallographic investigations of alcohol dehydrogenases.

S. Ramaswamy, H. Eklund, H. Jörnvall, 1994, EXS.

Crystallization and crystallographic investigations of ribonucleotide reductase protein R1 from Escherichia coli

U. Uhlin, H. Eklund, T. Uhlin, 1993, FEBS letters.

Crystallization and crystallographic investigations of the small subunit of mouse ribonucleotide reductase

H. Eklund, L. Thelander, M. Thelander, 1995, FEBS letters.

An elongated form of T4 glutaredoxin with four extra residues.

H. Eklund, A. Engström, M. Saarinen, 1993, Biochemistry.