P. Nordlund

发表

Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II.

K. Walldén, P. Nordlund, 2011, Journal of molecular biology.

CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity.

Ying Yu Liang, P. Nordlund, C. Coffill, 2021, Cell chemical biology.

Tracking cancer drugs in living cells by thermal profiling of the proteome

G. Drewes, B. Kuster, P. Nordlund, 2014, Science.

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

P. Nordlund, R. Dovega, S. Tsutakawa, 2014, PloS one.

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Jesper Z. Haeggström, Eva Ohlson, Andrew A. McCarthy, 2007, Nature.

Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020.

P. Nordlund, Lingyun Dai, Zhijie Li, 2020, Pharmacology & therapeutics.

The cellular thermal shift assay for evaluating drug target interactions in cells

P. Nordlund, D. M. Molina, R. Jafari, 2014, Nature Protocols.

Protein production and purification

K. Gunsalus, G. Montelione, J. Bray, 2008, Nature Methods.

Colony filtration blotting for screening soluble expression in Escherichia coli

P. Nordlund, S. Dahlroth, T. Cornvik, 2006, Nature Protocols.

Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation

Jesper Z. Haeggström, Pär Nordlund, P. Nordlund, 2001, Nature Structural Biology.

Crystal Structure of YegS, a Homologue to the Mammalian Diacylglycerol Kinases, Reveals a Novel Regulatory Metal Binding Site*

P. Nordlund, Kenneth A. Johnson, A. Kelly, 2007, Journal of Biological Chemistry.

X‐ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold

Pär Nordlund, P. Nordlund, B. Hallberg, 2004, FEBS letters.

The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism.

P. Nordlund, P. Stenmark, M. Moche, 2007, Journal of molecular biology.

Crystal Structure of Human Inosine Triphosphatase

P. Nordlund, S. Gräslund, P. Kursula, 2007, Journal of Biological Chemistry.

Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP 29 and BAP 31

P. Nordlund, E. Quistgaard, C. Löw, 2019 .

The Radical Site in Chlamydial Ribonucleotide Reductase Defines a New R2 Subclass

P. Nordlund, A. Gräslund, M. Högbom, 2004, Science.

Di-iron-carboxylate proteins.

H. Eklund, P. Nordlund, P. Nordlund, 1995, Current opinion in structural biology.

A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans

P. Nordlund, P. Stenmark, 2003, FEBS letters.

The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain.

P. Nordlund, S. Douthwaite, Kenneth A. Johnson, 2006, Journal of molecular biology.

Title Structure of the C-terminal domain of the multifunctionalICP 27 protein from herpes simplex virus 1

P. Nordlund, S. Dahlroth, T. Cornvik, 2017 .

VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies

P. Nordlund, S. Dahlroth, T. Cornvik, 2015, The Journal of general virology.

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe

P. Nordlund, O. Surova, M. O’Reilly, 2019 .

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.

P. Nordlund, J. Torres, N. Jain, 2015, Virology.

Mechanism of substrate dephosphorylation in low Mr protein tyrosine phosphatase

P. Nordlund, J. Åqvist, J. Åqvist, 1999, Proteins.

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA

P. Nordlund, D. Tenen, Lingyun Dai, 2019, Redox biology.

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer*

P. Nordlund, Martin Hammarström, P. Stenmark, 2008, Journal of Biological Chemistry.

The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins.

P. Nordlund, J. Weigelt, Martin Hammarström, 2008, Protein expression and purification.

The crystal structure of a human PP 2 A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions

P. Nordlund, Martin Hammarström, H. Berglund, 2006 .

CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

J. Bergh, J. Hartman, P. Nordlund, 2019, Scientific Reports.

Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways

P. Nordlund, C. Verma, Dilraj Lama, 2021 .

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.

Raymond J Owens, Pedro M Alzari, C Cambillau, 2006, Acta crystallographica. Section D, Biological crystallography.

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

P. Nordlund, C. Verma, Dilraj Lama, 2022, Nature Communications.

The low M r phosphotyrosine protein phosphatase behaves differently when phosphorylated at Tyr131 or Tyr132 by Src kinase

P. Nordlund, M. Bucciantini, G. Ramponi, 1999, FEBS letters.

Expression, purification and preliminary crystal analysis of the human low M r phosphotyrosine protein phosphatase isoform 1

P. Nordlund, M. Bucciantini, N. Taddei, 1998, FEBS letters.

New crystal forms of the small subunit of ribonucleotide reductase from Escherichia coli

U. Uhlin, B. Sjöberg, H. Eklund, 1989, FEBS letters.

Structures of BIR domains from human NAIP and cIAP2.

P. Nordlund, I. Johansson, L. Trésaugues, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Expression, purification, crystallization and preliminary diffraction studies of the tRNA pseudouridine synthase TruD from Escherichia coli.

P. Nordlund, B. Engvall, B. Hallberg, 2004, Acta crystallographica. Section D, Biological crystallography.

Thermofluor based high throughput stability optimisation of proteins for structural and functional studies

P. Nordlund, G. DeTitta, N. Dekker, 2006 .

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

P. Nordlund, O. Fedorov, C. Arrowsmith, 2006, Proceedings of the National Academy of Sciences.

Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism.

P. Nordlund, M. Welin, 2010, Biochemical and biophysical research communications.

Crystallisation of a low molecular weight phosphotyrosine protein phosphatase from bovine liver

P. Nordlund, M. Bucciantini, N. Taddei, 1994, FEBS letters.

Crystal Structure of Human Inosine Triphosphatase

P. Nordlund, S. Gräslund, P. Kursula, 2006, Journal of Biological Chemistry.

Structural insights into substrate recognition in proton‐dependent oligopeptide transporters

P. Nordlund, C. Löw, L. Trésaugues, 2013, EMBO reports.

Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization.

P. Nordlund, M. Högbom, P. Stenmark, 2004, Acta crystallographica. Section D, Biological crystallography.

An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries

M. Ekberg, P. Nordlund, B. Engvall, 2006, Proteins.

Structural studies of tri-functional human GART

P. Nordlund, P. Stenmark, L. Lehtiö, 2010, Nucleic acids research.

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

A. M. Riley, P. Nordlund, Mark P Thomas, 2012, ACS chemical biology.

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

P. Nordlund, L. Abrahmsén, K. Wiman, 2021, Cell Death & Disease.

Three-dimensional structure of the free radical protein of ribonucleotide reductase

Hans Eklund, Pär Nordlund, B. Sjöberg, 1990, Nature.

Structure and function of the Escherichia coli ribonucleotide reductase protein R2.

H. Eklund, P. Nordlund, H Eklund, 1993, Journal of molecular biology.

Substitution of manganese for iron in ribonucleotide reductase from Escherichia coli. Spectroscopic and crystallographic characterization.

H. Eklund, P. Nordlund, M. Fontecave, 1994, The Journal of biological chemistry.

Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.

J. Hajdu, K. Regnström, H. Eklund, 1996, Structure.

Structure and function of the radical enzyme ribonucleotide reductase.

U. Uhlin, H. Eklund, P. Nordlund, 2001, Progress in biophysics and molecular biology.

The redox centers of ribonucleotide reductase of Escherichia coli.

H. Eklund, P. Nordlund, M. Fontecave, 1992, Advances in enzymology and related areas of molecular biology.

Autocatalytic generation of dopa in the engineered protein R2 F208Y from Escherichia coli ribonucleotide reductase and crystal structure of the dopa-208 protein.

B. Sjöberg, P. Nordlund, M. Ormö, 1993, Biochemistry.

Unusual clustering of carboxyl side chains in the core of iron-free ribonucleotide reductase

H. Eklund, P. Nordlund, A. Åberg, 1993, Nature.

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

P. Nordlund, P. Artursson, D. M. Molina, 2016, Nature Communications.

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

P. Nordlund, L. Sreekumar, Yihai Cao, 2013, Science.

Crystal structure of common type acylphosphatase from bovine testis.

P. Nordlund, N. Taddei, G. Ramponi, 1997, Structure.

A protein carboxylate coordinated oxo‐centered tri‐nuclear iron complex with possible implications for ferritin mineralization

P. Nordlund, M. Högbom, 2004, FEBS letters.

Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes.

B. Sjöberg, P. Nordlund, M. Högbom, 2002, Biochemistry.

Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase

P. Nordlund, D. Logan, P. Reichard, 2004, Nature Structural &Molecular Biology.

Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-Å x-ray data

P. Nordlund, M. Högbom, W. Hofbauer, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli

G. von Heijne, P. Nordlund, J. de Gier, 2001, FEBS letters.

HF-EPR, Raman, UV/VIS Light Spectroscopic, and DFT Studies of the Ribonucleotide Reductase R2 Tyrosyl Radical from Epstein-Barr Virus

P. Nordlund, N. Andersen, A. Barra, 2011, PloS one.

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

P. Nordlund, T. Walz, Zongli Li, 2011, Nature Structural &Molecular Biology.

A novel lipoprotein nanoparticle system for membrane proteins

John A.G. Briggs, Yifan Cheng, Christian Löw, 2016, Nature Methods.

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

P. Nordlund, C. Löw, E. Quistgaard, 2016, Nature Reviews Molecular Cell Biology.

Thermofluor-based high-throughput stability optimization of proteins for structural studies.

George T Detitta, Pär Nordlund, P. Nordlund, 2006, Analytical biochemistry.

Cofactor mobility determines reaction outcome in the IMPDH/GMPR (β/α)8 barrel enzymes

H. Eklund, P. Nordlund, L. Hedstrom, 2011, Nature chemical biology.

Structural and functional characterization of two mutated R2 proteins of Escherichia coli ribonucleotide reductase.

B. Sjöberg, P. Nordlund, M. Sahlin, 1996, European journal of biochemistry.

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase[S]

P. Nordlund, A. Jansson, A. Roos, 2013, Journal of Lipid Research.

Energetics of nucleophile activation in a protein tyrosine phosphatase.

P. Nordlund, J. Åqvist, T. Hansson, 1997, Journal of molecular biology.

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

P. Nordlund, N. Taddei, G. Ramponi, 1994, Nature.

Human steroidogenic acute regulatory protein

P. Nordlund, C. Arrowsmith, J. Weigelt, 2010 .

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

P. Nordlund, S. Gräslund, S. Eriksson, 2012, PloS one.

Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase.

K. Walldén, P. Nordlund, V. Bianchi, 2005, Structure.

Re-engineering the diiron site in rubrerythrin towards that in ribonucleotide reductase

Xiaoyuan Cui, Pär Nordlund, P. Nordlund, 1997 .

The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains

Pär Nordlund, P. Nordlund, D. Kurtz, 1996, Nature Structural Biology.

A glycyl radical site in the crystal structure of a class III ribonucleotide reductase.

B. Sjöberg, P. Nordlund, D. Logan, 1999, Science.

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

P. Nordlund, A. Jansson, Dan Chen, 2017, The Journal of Biological Chemistry.

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

P. Nordlund, S. Dahlroth, T. Cornvik, 2015, PloS one.

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

P. Nordlund, L. Sreekumar, Lingyun Dai, 2018, PloS one.

Crystal structure of a human mitochondrial deoxyribonucleotidase

P. Nordlund, P. Reichard, V. Bianchi, 2002, Nature Structural Biology.

Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors.

P. Nordlund, J. Balzarini, P. Reichard, 2004, Molecular pharmacology.

Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus

P. Nordlund, S. Dahlroth, T. Cornvik, 2016, Journal of Virology.

The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor

P. Nordlund, S. Dahlroth, T. Cornvik, 2013, Nucleic acids research.

Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi’s sarcoma‐associated herpesvirus

P. Nordlund, H. Erlandsen, J. Haas, 2009, The FEBS journal.

New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop.

Catherine Mahony, Sebastian Maurer-Stroh, Thomas B Knudsen, 2020, Regulatory toxicology and pharmacology : RTP.

Structural studies of trifunctional human GART

P. Nordlund, P. Stenmark, L. Lehtiö, 2010 .

Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase*

P. Nordlund, J. Haeggström, D. M. Molina, 2010, The Journal of Biological Chemistry.

Structure of the C‐terminal domain of nsp4 from feline coronavirus

P. Tucker, P. Nordlund, B. Coutard, 2009, Acta crystallographica. Section D, Biological crystallography.

Structural and Biochemical Characterization of Human PR 70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2 A

P. Nordlund, R. Dovega, S. Tsutakawa, 2018 .

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

P. Nordlund, E. Quistgaard, M. Anandapadamanaban, 2014, Biological chemistry.

The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle

P. Nordlund, S. Gräslund, D. Ogg, 2009, Proteins.

Title Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase

P. Nordlund, M. Akke, C. Löw, 2019 .

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD

P. Nordlund, M. Akke, C. Löw, 2016, BMC Biology.

Structural and mutational studies of the carboxylate cluster in iron-free ribonucleotide reductase R2.

B. Sjöberg, P. Nordlund, X. Su, 2004, Biochemistry.

Retraction of mechanistic basis for Epstein-Barr Virus ribonucleotide-reductase small-subunit function.

P. Nordlund, S. Dahlroth, Daniel Gurmu, 2012, ACS chemical biology.

High‐resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

P. Nordlund, C. Löw, E. Quistgaard, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

P. Nordlund, S. Gräslund, T. Lundbäck, 2015, PloS one.

Recent advances in proteome‐wide label‐free target deconvolution for bioactive small molecules

P. Nordlund, W. Tam, Lingyun Dai, 2021, Medicinal research reviews.

Molecular and Structural Basis for Redox Regulation of β-Actin

P. Nordlund, C. Schutt, A. Holmgren, 2007 .

proteome Tracking cancer drugs in living cells by thermal profiling of the

G. Drewes, B. Kuster, P. Nordlund, 2014 .

The VIZIER project: Preparedness against pathogenic RNA viruses

D I Stuart, A. M. Leontovich, T A Jones, 2007, Antiviral Research.

Modulation of Protein-Interaction States through the Cell Cycle

Pär Nordlund, P. Nordlund, Lingyun Dai, 2018, Cell.

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

Chern Han Yong, Johan Lengqvist, Vinay Tergaonkar, 2018, Science.

The structure of human collapsin response mediator protein 2, a regulator of axonal growth

P. Nordlund, D. Ogg, P. Kursula, 2007, Journal of neurochemistry.

Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome

P. Nordlund, Zbynek Bozdech, Lingyun Dai, 2020, Nature Protocols.

CETSA in integrated proteomics studies of cellular processes.

P. Nordlund, Lingyun Dai, N. Prabhu, 2019, Current opinion in chemical biology.

Optimisation of Over-Expression in E. coli and Biophysical Characterisation of Human Membrane Protein Synaptogyrin 1

P. Nordlund, C. Löw, M. Kovermann, 2012, PloS one.

The impact of protein characterization in structural proteomics

D I Svergun, Matthias Wilmanns, S. Sainsbury, 2006, Acta crystallographica. Section D, Biological crystallography.

Ribonucleotide reductases.

Pär Nordlund, P. Nordlund, P. Reichard, 2006, Annual review of biochemistry.

Leukotriene A4 hydrolase: analysis of structure–function relationships by site-directed mutagenesis and X-ray crystallography

Martin J. Mueller, P. Nordlund, J. Haeggström, 2002 .

Functional Properties and Molecular Architecture of Leukotriene A4 Hydrolase, a Pivotal Catalyst of Chemotactic Leukotriene Formation

P. Nordlund, J. Haeggström, M. Thunnissen, 2002, TheScientificWorldJournal.

Fragment-based ligand design of novel potent inhibitors of tankyrases.

P. Nordlund, A. Poulsen, F. Ng, 2013, Journal of medicinal chemistry.

Hot CoFi Blot: A High-Throughput Colony-Based Screen for Identifying More Thermally Stable Protein Variants.

P. Nordlund, S. Dahlroth, Ignacio Asial, 2019, Methods in molecular biology.

A simple strategy towards membrane protein purification and crystallization.

P. Nordlund, D. Niegowski, S. Eshaghi, 2006, International journal of biological macromolecules.

Crystal Structure of a Divalent Metal Ion Transporter CorA at 2.9 Angstrom Resolution

P. Nordlund, A. Kohl, D. M. Molina, 2006, Science.

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.

Daniel Martinez Molina, Pär Nordlund, P. Nordlund, 2016, Annual review of pharmacology and toxicology.

Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1

P. Nordlund, S. Dahlroth, T. Cornvik, 2015, Journal of Virology.

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface

P. Nordlund, Martin Hammarström, L. Lehtiö, 2010, PloS one.

Application of the use of high‐throughput technologies to the determination of protein structures of bacterial and viral pathogens

R. Owens, D. Stuart, P. Nordlund, 2006, Acta Crystallographica Section D: Biological Crystallography.

Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues.

K. Walldén, P. Nordlund, V. Bianchi, 2007, Biochemistry.

The crystal structure of human cleavage and polyadenylation specific factor‐5 reveals a dimeric Nudix protein with a conserved catalytic site

P. Nordlund, Martin Hammarström, S. Gräslund, 2008, Proteins.

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

P. Nordlund, Zbynek Bozdech, Lingyun Dai, 2019, Science Translational Medicine.

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

P. Nordlund, O. Sampetrean, H. Saya, 2017, Nature Communications.

CycleDNN - A Novel Deep Neural Network Model for CETSA Feature Prediction cross Cell Lines

P. Nordlund, Zeng Zeng, Lingyun Dai, 2022, 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).

CETSA Feature Based Clustering for Protein Outlier Discovery by Protein-to-Protein Interaction Prediction

P. Nordlund, B. Veeravalli, Zeng Zeng, 2022, 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.

P. Nordlund, Zbynek Bozdech, Lingyun Dai, 2019 .

Identification of an inhibitory pocket in falcilysin bound by chloroquine provides a new avenue for malaria drug development

P. Nordlund, Zbynek Bozdech, N. Prabhu, 2021, bioRxiv.

Assessing the Efficacy of Mdm 2 / Mdm 4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays Ban

P. Nordlund, D. Lane, C. Brown, 2017 .

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays

P. Nordlund, D. Lane, C. Brown, 2015, Scientific Reports.

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

Henrik Engman, Pär Nordlund, P. Nordlund, 2013, Nature Communications.

Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA).

P. Nordlund, S. Bacanu, A. D. Ramos, 2019, Annual review of biochemistry.

Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development

P. Nordlund, Zbynek Bozdech, N. Prabhu, 2021, bioRxiv.

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.

J. Hajdu, P. Nordlund, C. Schofield, 1994, Journal of molecular biology.

Completing the family portrait of the anti‐apoptotic Bcl‐2 proteins: Crystal structure of human Bfl‐1 in complex with Bim

Pär Nordlund, Tomas Nyman, P. Nordlund, 2008, FEBS letters.

Screening colonies of pooled ORFeomes (SCOOP): a rapid and efficient strategy for expression screening ORFeomes in Escherichia coli.

P. Nordlund, J. Haas, S. Dahlroth, 2009, Protein expression and purification.

Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates

P. Nordlund, H. Berglund, A. Magnusdottir, 2009, Nature Methods.

Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli

Pär Nordlund, M. Ekberg, P. Nordlund, 2005, Nature Methods.

Screening for soluble expression of recombinant proteins in a 96-well format.

P. Nordlund, P Nordlund, R K Knaust, 2001, Analytical biochemistry.

Protein Production for Structural Genomics - Strategies for the Next Phase

P. Nordlund, H. Berglund, T. Cornvik, 2007 .

An efficient strategy for high‐throughput expression screening of recombinant integral membrane proteins

P. Nordlund, T. Hammarberg, S. Eshaghi, 2005, Protein science : a publication of the Protein Society.

Substrate specificity and oligomerization of human GMP synthetase.

P. Nordlund, Martin Hammarström, S. Gräslund, 2013, Journal of molecular biology.

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

P. Nordlund, C. Löw, L. Trésaugues, 2013, Nature Structural &Molecular Biology.

Structural basis for adenosylcobalamin activation in AdoCbl-dependent ribonucleotide reductases.

P. Nordlund, D. Logan, K. Larsson, 2010, ACS chemical biology.

Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases.

B. Sjöberg, P. Nordlund, D. Logan, 2001, Structure.

Expression, purification, crystallization and preliminary X-ray analysis of ORF60, the small subunit (R2) of ribonucleotide reductase from Kaposi's sarcoma-associated herpesvirus (KSHV).

P. Nordlund, H. Erlandsen, J. Haas, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structures of oxidized dinuclear manganese centres in Mn-substituted class I ribonucleotide reductase from Escherichia coli: carboxylate shifts with implications for O2 activation and radical generation

Pär Nordlund, P. Nordlund, M. Högbom, 2001, JBIC Journal of Biological Inorganic Chemistry.

The Crystal Structure of an Azide Complex of the Diferrous R2 Subunit of Ribonucleotide Reductase Displays a Novel Carboxylate Shift with Important Mechanistic Implications for Diiron-Catalyzed Oxygen Activation

Pär Nordlund, B. Sjöberg, P. Nordlund, 1999 .

Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.

B. Sjöberg, P. Nordlund, D. Logan, 1998, Biochemistry.

Ribonucleotide reductase--structural studies of a radical enzyme.

M. Eriksson, U. Uhlin, H. Eklund, 1997, Biological chemistry.

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2

P. Nordlund, C. Löw, M. Raba, 2014, Nature Structural &Molecular Biology.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

H. Eklund, P. Nordlund, S. Eriksson, 2010, The FEBS journal.

Crystallographic investigations of ribonucleotide reductase.

U. Uhlin, H. Eklund, P. Nordlund, 1993, Biochemical Society transactions.

Screening for functional expression and overexpression of a family of diiron‐containing interfacial membrane proteins using the univector recombination system

P. Nordlund, P. Stenmark, D. A. Berthold, 2003, Protein science : a publication of the Protein Society.

Structural basis for recognition by an in vitro evolved affibody

P. Nordlund, M. Högbom, M. Eklund, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

P. Nordlund, Martin Hammarström, S. Gräslund, 2014, Structure.

Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.

H. Eklund, P. Nordlund, M. Nikkola, 1992, Journal of molecular biology.

EPR Studies of the Mitochondrial Alternative Oxidase

P. Nordlund, A. Gräslund, P. Stenmark, 2002, The Journal of Biological Chemistry.

Mechanism of methane monooxygenase – a structural and quantum chemical perspective

Robert H. Crabtree, Pär Nordlund, P. Nordlund, 1998, JBIC Journal of Biological Inorganic Chemistry.

A High Throughput Method for the Detection of Metalloproteins on a Microgram Scale*

Robert Lam, Pär Nordlund, P. Nordlund, 2005, Molecular & Cellular Proteomics.

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a – an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity

P. Nordlund, L. Trésaugues, Sing Mei Lim, 2016, The FEBS journal.

Efficiency of hit generation and structural characterization in fragment-based ligand discovery.

Andreas Larsson, Anders Åberg, Pär Nordlund, 2011, Current opinion in chemical biology.

Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of Human Cleavage Factor Im

P. Nordlund, C. Bountra, C. Arrowsmith, 2010 .

Crystal Structure of Human Cytosolic 5′-Nucleotidase II

K. Walldén, P. Nordlund, S. Gräslund, 2007, Journal of Biological Chemistry.

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02754d

P. Nordlund, O. Surova, M. O’Reilly, 2018, Chemical science.

Nanobody Mediated Crystallization of an Archeal Mechanosensitive Channel

P. Nordlund, E. Pardon, J. Steyaert, 2013, PloS one.

Molecular and structural basis for redox regulation of beta-actin.

P. Nordlund, C. Schutt, A. Holmgren, 2007, Journal of molecular biology.

High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.

P. Nordlund, J. Haeggström, A. Wetterholm, 2008, Protein expression and purification.

Engineering membrane protein overproduction in Escherichia coli

P. Nordlund, J. Haeggström, D. M. Molina, 2008, Protein science : a publication of the Protein Society.

The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins

P. Nordlund, A. Holmgren, H. Erlandsen, 2009, Proteins.

Crystallisation and preliminary X‐ray analysis of the ‘common‐type’ acylphosphatase

P. Nordlund, N. Taddei, G. Ramponi, 1995, FEBS letters.

Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31

P. Nordlund, C. Löw, E. Quistgaard, 2013, PloS one.

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family

P. Nordlund, B. Potter, G. Cozier, 2016, Biochemistry.

4 Membrane Protein Production Strategies for Structural Genomics

P. Nordlund, S. Eshaghi, 2006 .

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.

P. Nordlund, Martin Hammarström, P. Kursula, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure of the C‐terminal domain of nsp4 from feline coronavirus

P. Tucker, P. Nordlund, B. Coutard, 2009, Acta crystallographica. Section D, Biological crystallography.

High-throughput analytical gel filtration screening of integral membrane proteins for structural studies.

P. Nordlund, Jens Frauenfeld, L. Haneskog, 2013, Biochimica et biophysica acta.

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

P. Nordlund, Martin Hammarström, S. Gräslund, 2014, Structure.

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer*

P. Nordlund, Martin Hammarström, P. Stenmark, 2008, Journal of Biological Chemistry.

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD

P. Nordlund, M. Akke, U. Weininger, 2016, BMC Biology.

Tracking cancer drugs in living cells by thermal profiling of the proteome

G. Drewes, B. Kuster, P. Nordlund, 2014, Science.

Structural insights into substrate recognition in proton‐dependent oligopeptide transporters

P. Nordlund, L. Trésaugues, C. Jegerschöld, 2013, EMBO reports.

Structural studies of three cell signaling proteins

P. Nordlund, L. Poellinger, S. Malik, 2007 .

Abstract 2045: Exploring the potential of cellular thermal shift assay (CETSA) to study drug resistance during cancer therapy

P. Nordlund, L. Sreekumar, Y. Lim, 2017 .

Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide

P. Nordlund, C. Bountra, C. Arrowsmith, 2009 .

The Crystal Structure of a Human PP2A Phosphatase Activator Reveals a Novel Fold and Highly Conserved Cleft Implicated in Protein-Protein Interactions*

Martin Hammarström, Helena Berglund, Pär Nordlund, 2006, Journal of Biological Chemistry.

Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.

P. Nordlund, E. Quistgaard, P. Moberg, 2013, Journal of structural biology.