S. Hubbard

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

S. Hubbard, 1997, The EMBO journal.

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

S. Hubbard, J. Schlessinger, M. Mohammadi, 1997, Science.

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

S. Hubbard, J. Schlessinger, M. Mohammadi, 1998, The EMBO journal.

Crystal structure of the tyrosine kinase domain of the human insulin receptor

S. Hubbard, W. Hendrickson, Lei Wei, 1994, Nature.

Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase

S. Hubbard, S. Bishop, J. Till, 2001, The Journal of Biological Chemistry.

Oncogenic Mutations in B-Raf Some Losses Yield Gains

S. Hubbard, 2004, Cell.

Protein tyrosine kinase structure and function.

S. Hubbard, J. Till, S R Hubbard, 2000, Annual review of biochemistry.

X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution.

S. Hubbard, S. Boxer, W. Hendrickson, 1990, Journal of molecular biology.

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

Yibing Shan, Eric T. Kim, S. Hubbard, 2014, Nature Structural &Molecular Biology.

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Stevan R. Hubbard, S. Hubbard, F. Urano, 2002, Nature.

Identification and characterization of zinc binding sites in protein kinase C.

W. R. Bishop, S. Hubbard, W. Hendrickson, 1991, Science.

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations

S. Hubbard, O. Silvennoinen, Bobin George Abraham, 2019, The Journal of allergy and clinical immunology.

The Juxtamembrane Region of EGFR Takes Center Stage

S. Hubbard, 2009, Cell.

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

S. Hubbard, Michael Loran Dustin, S. Burden, 2008, Cell.

Unlocking the secrets to Janus kinase activation.

S. Hubbard, R. Levine, 2022, Science.

Small-angle x-ray scattering investigation of the solution structure of troponin C.

K. Hodgson, S. Hubbard, S. Doniach, 1988, The Journal of biological chemistry.

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.

S. Hubbard, O. Silvennoinen, 2015, Blood.

New insights into the structure and function of the pseudokinase domain in JAK2.

S. Hubbard, O. Silvennoinen, D. Ungureanu, 2013, Biochemical Society transactions.

New insights into the structure and function of the pseudokinase domain in JAK 2

S. Hubbard, O. Silvennoinen, D. Ungureanu, 2013 .

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

S. Hubbard, O. Silvennoinen, R. Skoda, 2011, Nature Structural &Molecular Biology.

corrigendum: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

S. Hubbard, F. Urano, D. Ron, 2002, Nature.

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

S. Hubbard, D. Thiele, T. Hunter, 2016, eLife.

IRAK4 activation: a cautious embrace.

S. Hubbard, 2014, Molecular cell.

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)*

Wei Zhang, S. Hubbard, Anne-Sophie Coldefy, 2011, The Journal of Biological Chemistry.

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity

S. Hubbard, P. Cao, Ruonan Zhang, 2014, PloS one.

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

S. Hubbard, M. Mulligan, N. Landau, 2021, bioRxiv.

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

S. Hubbard, K. Garcia, Vivek Sharma, 2020, Science.

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.

S. Hubbard, S. Burden, A. L. Stiegler, 2006, Journal of molecular biology.

Closing in on a mechanism for activation

S. Hubbard, W. Miller, 2014, eLife.

Structure of the Insulin-like Growth Factor 1 Receptor Kinase

S. Hubbard, W. Miller, J. Till, 2001 .

How IRE1 Reacts to ER Stress

S. Hubbard, D. Ron, 2008, Cell.

constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.

S. Hubbard, W. Miller, S. Sarabipour, 2014 .

Structural biology: Insulin meets its receptor

S. Hubbard, 2013, Nature.

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.

L. Aravind, S. Gygi, S. Hubbard, 2015, Molecular cell.

Anomalous small-angle x-ray scattering from a sulfonated polystyrene ionomer

K. Hodgson, S. Hubbard, S. Cooper, 1988 .

Theme and variations: juxtamembrane regulation of receptor protein kinases.

S. Hubbard, 2001, Molecular cell.

Agrin / MuSK signaling: willing and Abl

S. Hubbard, C. Fuhrer, S. Burden, 2003, Nature Neuroscience.

Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.

S. Hubbard, G. Mcmahon, L. Sun, 2000, Journal of medicinal chemistry.

[13] Characterization of the cysteine-rich zinc-binding domains of protein kinase C by X-ray absorption spectroscopy

S. Hubbard, 1995 .

Small‐molecule inhibition and activation‐loop trans‐phosphorylation of the IGF1 receptor

S. Hubbard, W. Miller, B. Craddock, 2008, The EMBO journal.

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

Stevan R. Hubbard, S. Hubbard, W. Miller, 2001, Nature Structural Biology.

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

Cherrington, R A Blake, S. Hubbard, 2000, Cancer research.

KRAS4A Directly Regulates Hexokinase 1

A. Balmain, S. Hubbard, E. Gottlieb, 2019, Nature.

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Charis Eng, Zhou Songyang, Kermit L. Carraway, 1995, Nature.

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state

S. Hubbard, W. Miller, M. Bowen, 2015, Nature Communications.

Structural Basis for FGF Receptor Dimerization and Activation

S. Hubbard, J. Schlessinger, M. Mohammadi, 1999, Cell.

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain

S. Hubbard, W. Paul, K. Nelms, 1999, Mammalian Genome.

Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course.

S. Hubbard, M. Vihinen, A. Meindl, 1998, Pediatrics.

Receptor tyrosine kinases: mechanisms of activation and signaling.

S. Hubbard, W. Miller, Stevan R Hubbard, 2007, Current opinion in cell biology.

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.

S. Hubbard, R. Ghirlando, A. Saltiel, 2003, Molecular cell.

Juxtamembrane autoinhibition in receptor tyrosine kinases

Stevan R. Hubbard, S. Hubbard, 2004, Nature Reviews Molecular Cell Biology.

Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.

S. Hubbard, Yun Lu, J. Till, 2002, Structure.

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.

S. Hubbard, 2013, Cold Spring Harbor perspectives in biology.

Expression, Characterization, and Crystallization of the Catalytic Core of the Human Insulin Receptor Protein-tyrosine Kinase Domain (*)

S. Hubbard, W. Hendrickson, Lei Wei, 1995, The Journal of Biological Chemistry.

Structure and Mechanism of the Insulin Receptor Tyrosine Kinase

S. Hubbard, 2010 .

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.

D. Barford, S. Hubbard, J. Chernoff, 2005, Structure.

Structural and Biochemical Evidence for an Autoinhibitory Role for Tyrosine 984 in the Juxtamembrane Region of the Insulin Receptor*

S. Hubbard, J. Till, Shiqing Li, 2003, Journal of Biological Chemistry.

CHAPTER 53 – Structure and Mechanism of the Insulin Receptor Tyrosine Kinase

S. Hubbard, 2003 .

Autoinhibitory mechanisms in receptor tyrosine kinases.

S. Hubbard, 2002, Frontiers in bioscience : a journal and virtual library.

MECHANISMS IN RECEPTOR TYROSINE KINASES

S. Hubbard, 2002 .

Targeting the Inactive Conformation of JAK2 in Hematological Malignancies.

S. Hubbard, O. Silvennoinen, 2015, Cancer cell.

Mechanism-based design of a protein kinase inhibitor

S. Hubbard, K. Parang, P. Cole, 2001, Nature Structural Biology.

Autoregulatory Mechanisms in Protein-tyrosine Kinases*

S. Hubbard, J. Schlessinger, M. Mohammadi, 1998, The Journal of Biological Chemistry.

Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design.

S. Hubbard, K. Parang, P. Cole, 2005, Bioorganic chemistry.

Structure-guided identification of a laminin binding site on the laminin receptor precursor.

S. Hubbard, D. Meruelo, K. Jamieson, 2011, Journal of molecular biology.

Crystal Structure of the Human Laminin Receptor Precursor*

S. Hubbard, D. Meruelo, Jinhua Wu, 2008, Journal of Biological Chemistry.

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

S. Hubbard, V. Boussiotis, M. Philips, 2012, The Journal of cell biology.

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

Joseph Schlessinger, S. Hubbard, J. Schlessinger, 1996, Cell.

Structures of Serine/Threonine and Tyrosine Kinases

S. Hubbard, 2010 .

EGF Receptor Activation: Push Comes to Shove

S. Hubbard, 2006, Cell.

Probing the Catalytic Mechanism of the Insulin Receptor Kinase with a Tetrafluorotyrosine-containing Peptide Substrate*

S. Hubbard, K. Parang, P. Cole, 2000, The Journal of Biological Chemistry.

Protein kinase superfamily — comparisons of sequence data with three-dimensional structures

S. Hubbard, Lei Wei, Randall F. Smith, 1994 .

Crystal structure of the ARF‐GAP domain and ankyrin repeats of PYK2‐associated protein β

S. Hubbard, J. Schlessinger, V. Mandiyan, 1999, The EMBO journal.

Protein tyrosine kinases: autoregulation and small-molecule inhibition.

S. Hubbard, 2002, Current opinion in structural biology.

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.

S. Hubbard, S. Burden, Peter T. Hallock, 2010, Molecular cell.

KRAS4A directly regulates hexokinase 1

A. Balmain, S. Hubbard, E. Gottlieb, 2019, Nature.

Crystal Structure of the Frizzled-like Cysteine-rich Domain of the Receptor Tyrosine Kinase Musk Nih Public Access Structure of Musk Fz-crd N-linked Glycosylation Comparison with Frizzled Crds Wnt Binding

S. Hubbard, S. Burden, A. L. Stiegler, 2022 .

Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins*

S. Hubbard, Junjie Hu, 2005, Journal of Biological Chemistry.

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1

S. Hubbard, S. Corbalán-García, T. Ji, 2018, PloS one.

Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

Joseph Schlessinger, S. Hubbard, J. Schlessinger, 2000, Cell.

Structural analysis of receptor tyrosine kinases.

S. Hubbard, 1999, Progress in biophysics and molecular biology.

Structural models of full-length JAK2 kinase

S. Hubbard, D. Shaw, Y. Shan, 2019, bioRxiv.

Mycobacterium tuberculosis Prokaryotic Ubiquitin-like Protein-deconjugating Enzyme Is an Unusual Aspartate Amidase*

S. Gygi, S. Hubbard, J. Mintseris, 2012, The Journal of Biological Chemistry.

Is an Unusual Aspartate Amidase Ubiquitin-like Protein-deconjugating Prokaryotic Mycobacterium tuberculosis Protein Synthesis and Degradation :

S. Gygi, S. Hubbard, J. Mintseris, 2012 .

Molecular analysis of the prokaryotic ubiquitin‐like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

S. Hubbard, W. Bishai, M. J. Pearce, 2010, Molecular microbiology.

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

S. Hubbard, E. G. Stein, T. A. Gustafson, 2001, FEBS letters.

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

S. Hubbard, R. Depetris, Jinhua Wu, 2009, Nature Structural &Molecular Biology.

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.

S. Hubbard, E. Bergamin, Jinhua Wu, 2006, Structure.

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.

S. Hubbard, R. Daly, L. J. Holt, 2005, Molecular cell.

Induces Regression of Established Tumors SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Updated

S. Hubbard, A. Ullrich, N. Shenoy, 2000 .

SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors 1

S. Hubbard, A. Ullrich, N. Shenoy, 2000 .

Crystal structures of the Jak2 pseudokinase domain and the pathogenic mutant V617F

Yibing Shan, Stevan R. Hubbard, David E. Shaw, 2012, Nature Structural &Molecular Biology.

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

S. Hubbard, O. Silvennoinen, R. Skoda, 2015, Proceedings of the National Academy of Sciences.

Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras

S. Hubbard, R. Qamra, 2013, PloS one.

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.

S. Hubbard, Junjie Hu, 2006, Journal of molecular biology.

Structural Basis for Dimerization of the Grb10 Src Homology 2 Domain

S. Hubbard, R. Ghirlando, E. G. Stein, 2003, The Journal of Biological Chemistry.

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

S. Hubbard, 2018, Front. Endocrinol..

Small‐angle x‐ray scattering/diffraction system for studies of biological and other materials at the Stanford Synchrotron Radiation Laboratorya)

K. Hodgson, S. Hubbard, M. Rice, 1992 .

Structural basis of Janus kinase trans-activation

S. Hubbard, R. A. Saxton, D. Waghray, 2023, Cell reports.

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

S. Hubbard, P. Sampathkumar, T. Haikarainen, 2023, Pharmaceuticals.

Src autoinhibition: let us count the ways

Stevan R. Hubbard, S. Hubbard, 1999, Nature Structural Biology.

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

S. Hubbard, M. White, T. Neubert, 2008, Nature Structural &Molecular Biology.

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.

Michael J. Marcel, Gina M. Butrico, S. Hubbard, 2016, The Journal of clinical investigation.

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.

S. Hubbard, K. Gnanasambandan, Kavitha Gnanasambandan, 2013, Biochimica et biophysica acta.

The MuSK Receptor Family

S. Hubbard, Wei Zhang, S. Burden, 2015 .

EGF receptor inhibition: attacks on multiple fronts.

S. Hubbard, 2005, Cancer cell.

Lit Lunch 3_27_15 KEITH: Non-native, N-terminal Hsp70 Molecular Motor Recognition Elements in Transit Peptides Support Plastid Protein Translocation

Aravind, S. Gygi, S. Hubbard, 2015 .

Insulin receptor Thr 1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Michael J. Marcel, Gina M. Butrico, S. Hubbard, 2018 .

Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.

S. Hubbard, S. Burden, A. L. Stiegler, 2009, Journal of molecular biology.