M. Gething

发表

Addition of carbohydrate side chains at novel sites on influenza virus hemagglutinin can modulate the folding, transport, and activity of the molecule

P. Gallagher, J. Henneberry, I. Wilson, 1988, The Journal of cell biology.

HSP70 Binding Sites in the Tumor Suppressor Protein p53*

J. Sambrook, M. Gething, T. Hupp, 1997, The Journal of Biological Chemistry.

The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.

P. Silver, M. Gething, E. Nice, 2006, Molecular biology of the cell.

Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation.

M. Gething, M. Waterfield, J. White, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Serpin-resistant mutants of human tissue-type plasminogen activator

E. Goldsmith, J. Sambrook, M. Gething, 1989, Nature.

Mutants of human time-type plasminogen activator that are resistant to inhibition by the serpin PAI-1

E. Goldsmith, J. Sambrook, M. Gething, 1989 .

Restoration of serine protease-inhibitor interaction by protein engineering.

E. Goldsmith, J. Sambrook, M. Gething, 1990, The Journal of biological chemistry.

Membrane Insertion and Intracellular Transport of Influenza Virus Glycoproteins

J. Sambrook, M. Gething, M. Roth, 1989 .

BiP Binding Sequences in Antibodies (*)

M. Gething, J. Buchner, S. Modrow, 1995, The Journal of Biological Chemistry.

Common and divergent peptide binding specificities of hsp70 molecular chaperones.

J. Sambrook, M. Gething, A. Fourie, 1994, The Journal of biological chemistry.

ChorismateMutase/Prephenate Dehydratase from Escherichia coli K12

B. E. Davidson, M. Gething, 1976 .

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

M. Gething, T. Braciale, M. Sweetser, 1987, Immunological reviews.

The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.

J. Sambrook, M. Gething, J Sambrook, 1990, The Journal of biological chemistry.

Posttranslational translocation of influenza virus hemagglutinin across microsomal membranes

J. Sambrook, M. Gething, P. Bird, 1987, Molecular and cellular biology.

Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity

J. Sambrook, M. Gething, C. Slaughter, 1989, Journal of Cell Science.

A 22 bp cis‐acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

J. Sambrook, M. Gething, K. Mori, 1992, The EMBO journal.

Formation of protein micelles from amphiphilic membrane proteins.

M. Gething, A. Helenius, M. Sarvas, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Cell-free synthesis of enzymically active tissue-type plasminogen activator. Protein folding determines the extent of N-linked glycosylation.

J. Sambrook, M. Gething, R. Bassel-Duby, 1992, The Biochemical journal.

Presenilin mutants subvert chaperone function

M. Gething, 2000, Nature Cell Biology.

Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers.

J. Sambrook, M. Gething, A. Fourie, 1993, The Journal of biological chemistry.

Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

M. Gething, A. Purcell, T. Gordon, 2003, Clinical and experimental immunology.

Expression of Proteins on the Cell Surface Using Mammalian Vectors

J. Sambrook, M. Gething, J. Sambrook, 1983 .

The Yeast Inositol Polyphosphate 5-Phosphatases Inp52p and Inp53p Translocate to Actin Patches following Hyperosmotic Stress: Mechanism for Regulating Phosphatidylinositol 4,5-Bisphosphate at Plasma Membrane Invaginations

M. Gething, C. Mitchell, P. Gleeson, 2000, Molecular and Cellular Biology.

On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes

L. Hood, M. Gething, T. Braciale, 1987, The Journal of experimental medicine.

Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser.

E. Goldsmith, J. Sambrook, M. Gething, 1993, Science.

Processing of normal lysosomal and mutant N-acetylgalactosamine 4-sulphatase: BiP (immunoglobulin heavy-chain binding protein) may interact with critical protein contact sites.

M. Gething, D. Brooks, J. Hopwood, 1999, The Biochemical journal.

Interleukin-1 promotes hyperglycemia and insulitis in mice normally resistant to streptozotocin-induced diabetes.

J. Sambrook, M. Gething, S. Zunino, 1994, The American journal of pathology.

Addition of truncated oligosaccharides to influenza virus hemagglutinin results in its temperature-conditional cell-surface expression

J. Sambrook, M. Gething, J. Hearing, 1989, The Journal of cell biology.

Isolation of Chinese hamster ovary cell lines temperature conditional for the cell-surface expression of integral membrane glycoproteins

J. Sambrook, M. Gething, L. Rodgers, 1989, The Journal of cell biology.

Influenza virus hemagglutinin expression is polarized in cells infected with recombinant SV40 viruses carrying cloned hemagglutinin DNA

J. Sambrook, M. Gething, M. Roth, 1983, Cell.

Proline isomerases function during heat shock.

J. Sambrook, M. Gething, K. Sykes, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants

M. Gething, T. Braciale, J. Sambrook, 1993, The Journal of experimental medicine.

Influenza virus haemagglutinin signal sequence

M. Gething, J. Skehel, J. Bye, 1979, FEBS letters.

The cellular response to unfolded proteins: intercompartmental signaling.

J. Sambrook, M. Gething, D. McMillan, 1994, Current opinion in biotechnology.

Chapter 2 Mutational Analysis of the Structure and Function of the Influenza Virus Hemagglutinin

J. Sambrook, M. Gething, M. Roth, 1985 .

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

J. Sambrook, M. Gething, K. Orth, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of intraocular tumors arising in transgenic mice.

J. Sambrook, M. Gething, I. McLean, 1994, Investigative ophthalmology & visual science.

Rejection of intraocular tumors from transgenic mice by tumor-infiltrating lymphocytes.

J. Sambrook, M. Gething, S. Comerford, 1994, Current eye research.

Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer

M. Gething, T. Braciale, J. Sambrook, 1984, The Journal of experimental medicine.

Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity

M. Gething, M. Waterfield, U. Koszinowski, 1978, Nature.

12 – Studies on the Mechanism of Membrane Fusion

M. Gething, R. Doms, A. Helenius, 1973 .

The Saccharomyces cerevisiae DPM1 gene encoding dolichol-phosphate-mannose synthase is able to complement a glycosylation-defective mammalian cell line

J. Sambrook, M. Gething, P. Orlean, 1990, Molecular and cellular biology.

RECOGNITION OF VIRAL GLYCOPROTEINS BY INFLUENZA A-SPECIFIC CROSS-REACTIVE CYTOLYTIC T LYMPHOCYTES

M. Gething, H. Klenk, M. Waterfield, 2003 .

Construction of intergeneric hybrids using bacteriophage P1CM: transfer of the Klebsiella aerogenes ribitol dehydrogenase gene to Escherichia coli

M. Gething, P. Rigby, B. Hartley, 1976, Journal of bacteriology.

The Saccharomyces cerevisiae DPM 1 Gene Encoding Dolichol-Phosphate-Mannose Synthase Is Able To Complement a Glycosylation-Defective Mammalian Cell Line

M. Gething, P. Orlean, P. Beck, 2022 .

Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors1

M. Gething, M. Waterfield, U. Koszinowski, 2018, Neoplasia.

Protein transport and secretion

M. Gething, 1983, Journal of Cellular Biochemistry.

Protein folding and intracellular transport: evaluation of conformational changes in nascent exocytotic proteins.

J. Sambrook, M. Gething, K. McCammon, 1989, Methods in cell biology.

Variants of human tissue‐type plasminogen activator that lack specific structural domains of the heavy chain.

J. Sambrook, M. Gething, L. M. Roman, 1988, The EMBO journal.

Cloned copy of the haemagglutinin gene codes for human influenza antigenic determinants in E. coli

M. Gething, I. Heiland, 1981, Nature.

Protein folding: The difference with prokaryotes

M. Gething, 1997, Nature.

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator.

J. Sambrook, M. Gething, K. Orth, 1994, The Journal of biological chemistry.

Tissue-type plasminogen activator-induced invasion and metastasis of murine melanomas.

J. Sambrook, M. Gething, J. Niederkorn, 1995, Current eye research.

Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent

J. Sambrook, M. Gething, J Sambrook, 1987, The Journal of cell biology.

Protein folding in the cell

J. Sambrook, M. Gething, Mary-Jane Gething, 1992, Nature.

Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Effect of phenylalanine, NaCl and pH on the protein conformation.

B. E. Davidson, M. Gething, 1978, European journal of biochemistry.

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

J. Sambrook, M. Gething, K. McCammon, 1986, Cell.

Protein structure. Chaperones, paperones.

J. Sambrook, M. Gething, 1989, Nature.

Expression of a full-length cDNA coding for human intestinal lactase-phlorizin hydrolase reveals an uncleaved, enzymatically active, and transport-competent protein.

J. Sambrook, M. Gething, H. Naim, 1991, The Journal of biological chemistry.

Capacity of simian virus 40 T antigen to induce self-tolerance but not immunological privilege in the anterior chamber of the eye.

J. Sambrook, M. Gething, S. Comerford, 1994, Transplantation.

Chorismate mutase/prephenate dehydratase from Escherichia coli K12. 1. The effect of NaCl and its use in a new purification involving affinity chromatography on sepharosyl-phenylalanine.

B. E. Davidson, M. Gething, T. Dopheide, 1976, European journal of biochemistry.

Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta.

J. Fiddes, M. Gething, K. Talmadge, 1984, Nucleic acids research.

The molar absorption coefficient of reduced Ellman's reagent : 3-carboxylato-4-nitro-thiophenolate

M. Gething, 1972 .

Generation of virus‐specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations

M. Gething, U. Koszinowski, Ulrich H. Koszinowski, 1980, European journal of immunology.

Haemagglutinin of influenza virus expressed from a cloned gene promotes membrane fusion

M. Gething, A. Helenius, Judy White, 1982, Nature.

Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Modification with 5,5'-dithio-bis(2-nitrobenzoic acid).

B. E. Davidson, M. Gething, 1977, European journal of biochemistry.

Substrate Binding Induces Depolymerization of the C-terminal Peptide Binding Domain of Murine GRP78/BiP*

M. Gething, S. Blond, Chengyi Wang, 1998, The Journal of Biological Chemistry.

5 Structure, Function, and Regulation of the Endoplasmic Reticulum Chaperone, BiP

J. Sambrook, M. Gething, K. Mori, 1994 .

Variant influenza virus hemagglutinin that induces fusion at elevated pH

J. Henneberry, M. Gething, R. Doms, 1986, Journal of virology.

SV40 T antigen and the exocytotic pathway.

J. Sambrook, M. Gething, L. Rodgers, 1985, The EMBO journal.

Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene

J. Sambrook, M. Gething, 1981, Nature.

Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus

M. Gething, J. Skehel, J. Bye, 1980, Nature.

Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein

J. Sambrook, M. Gething, 1982, Nature.

SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.

M. Gething, B. Pal, W. Tansey, 2006, Molecular biology of the cell.

The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple Importins

P. Silver, M. Gething, E. Nice, 2006 .

A transmembrane protein with a cdc2+ CDC28 -related kinase activity is required for signaling from the ER to the nucleus

J. Sambrook, M. Gething, Wenzhen Ma, 1993, Cell.

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum

J. Sambrook, M. Gething, K. Mori, 1993, Molecular and cellular biology.

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

J. Sambrook, M. Gething, Y. Kozutsumi, 1989, Cell.

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

S. Sprang, J. Sambrook, M. Gething, 1993, Cell.

Lobe IB of the ATPase domain of Kar2p/BiP interacts with Ire1p to negatively regulate the unfolded protein response in Saccharomyces cerevisiae.

M. Gething, Alicia Todd-Corlett, E. Jones, 2007, Journal of molecular biology.

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

J. Sambrook, M. Gething, Y. Kozutsumi, 1988, Nature.

Complementing mutant alleles define three loci involved in mannosylation of Man5-GlcNAc2-P-P-dolichol in Chinese hamster ovary cells

J. Sambrook, M. Gething, M. Lehrman, 1990, Somatic cell and molecular genetics.

Influenza virus RNA segment 7 has the coding capacity for two polypeptides.

M. Gething, M. Waterfield, J. McCauley, 1980, Virology.

Transport and assembly processes in the endoplasmic reticulum.

J. Sambrook, M. Gething, Gething Mj, 1990, Seminars in cell biology.

Expression of Cloned Influenza Virus Genes

J. Sambrook, M. Gething, 1983 .

Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus

M. Gething, R. Doms, J. White, 1986, The Journal of cell biology.

Guidebook to the molecular chaperones and protein-folding catalysts

M. Gething, 1997 .

Normal protein folding machinery.

M. Gething, D. Hartman, 1996, EXS.

Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1.

E. Goldsmith, J. Sambrook, M. Gething, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Lines of BPV‐transformed murine cells that constitutively express influenza virus hemagglutinin.

J. Sambrook, M. Gething, L. Rodgers, 1985, The EMBO journal.

Role and regulation of the ER chaperone BiP.

M. Gething, 1999, Seminars in cell & developmental biology.

Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin

J. Sambrook, M. Gething, C. Doyle, 1986, The Journal of cell biology.

The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes

R. Hammer, J. Sambrook, M. Gething, 1990, Cell.

Experimental Medicine Edited by R Recognition of Viral Glycoproteins by Influenza Α-specific Cross-reactive Cytolytic Τ Lymphocytes* Materials and Methods

T. Kindt, M. Gething, J. Sprent, 2022 .

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway

J. Sambrook, M. Gething, M. Roth, 1986, The Journal of cell biology.

Disulfide bond formation during the folding of influenza virus hemagglutinin

J. Sambrook, M. Gething, J. Bye, 1992, The Journal of cell biology.

Mutations in the cytoplasmic domain of the influenza virus hemagglutinin affect different stages of intracellular transport

J. Sambrook, M. Gething, M. Roth, 1985, The Journal of cell biology.

The pro region of human intestinal lactase-phlorizin hydrolase.

J. Sambrook, M. Gething, R. Jacob, 1994, The Journal of biological chemistry.

The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site.

J. Sambrook, M. Gething, R. Gerard, 1989, Biochemistry.

Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor.

J. Sambrook, M. Gething, R. Shohet, 1992, The Journal of biological chemistry.

Inhibitor-Resistant Tissue-Type Plasminogen Activator: An Improved Thrombolytic Agent In Vitro

J. Sambrook, M. Gething, R. Shohet, 1994, Thrombosis and Haemostasis.

The Yeast Inositol Polyphosphate 5-Phosphatase Inp54p Localizes to the Endoplasmic Reticulum via a C-terminal Hydrophobic Anchoring Tail

J. Whisstock, J. Sambrook, M. Gething, 2001, The Journal of Biological Chemistry.

Relationship between the messenger RNAs transcribed from two overlapping genes of influenza virus.

M. Gething, C. Brown, S. Inglis, 1980, Nucleic acids research.

BiP-binding Sequences in HIV gp160

M. Gething, J. Buchner, A. Todd, 1999, The Journal of Biological Chemistry.

Glycosylation requirements for intracellular transport and function of the hemagglutinin of influenza virus

P. Gallagher, J. Henneberry, J. Sambrook, 1992, Journal of virology.

Molecular chaperones: individualists or groupies?

M. Gething, 1991, Current opinion in cell biology.

Molecular chaperones: Clasping the prize

M. Gething, 1996, Current Biology.

T-cell cytotoxicity in the absence of viral protein synthesis in target cells

M. Gething, M. Waterfield, U. Koszinowski, 1977, Nature.

ANALYSIS OF REQUIREMENTS FOR CELL MEDIATED LYSIS INTERACTION BETWEEN VIRAL GLYCOPROTEINS AND CELL PLASMA MEMBRANES

M. Gething, M. Waterfield, U. Koszinowski, 1979 .

Expression of lactase-phlorizin hydrolase in sheep is regulated at the RNA level.

J. Sambrook, M. Gething, R. Magness, 1994, The Biochemical journal.

Chapter 11 Fusion Activity of the Hemagglutinin of Influenza Virus

J. Henneberry, J. Sambrook, M. Gething, 1988 .

Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Effects of chemical modification on the enzymic activities and allosteric inhibition.

B. E. Davidson, M. Gething, 1977, European journal of biochemistry.

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes

M. Gething, H. Klenk, M. Waterfield, 1980, The Journal of experimental medicine.

Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent

M. Gething, Phillip Bird, Joseph Sambrook, 1987, The Journal of cell biology.

Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Binding studies with the allosteric effector phenylalanine.

B. E. Davidson, M. Gething, 1978, European journal of biochemistry.

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway

M. Gething, Joseph Sambrook, Carolyn Doyle, 1986, The Journal of cell biology.

Binding sites for Hsp70 molecular chaperones in natural proteins.

J. Sambrook, M. Gething, J. Buchner, 1995, Cold Spring Harbor symposia on quantitative biology.