J. Huguenard

发表

Functional Autaptic Neurotransmission in Fast-Spiking Interneurons: A Novel Form of Feedback Inhibition in the Neocortex

D. Prince, A. Bacci, J. Huguenard, 2003, The Journal of Neuroscience.

A model of spike initiation in neocortical pyramidal neurons

T. Sejnowski, Z. Mainen, J. Huguenard, 1995, Neuron.

A call for transparent reporting to optimize the predictive value of preclinical research

S. Lazic, O. Steward, Story C. Landis, 2012, Nature.

A model of the electrophysiological properties of thalamocortical relay neurons.

D. McCormick, J. Huguenard, 1992, Journal of neurophysiology.

Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons.

D. McCormick, J. Huguenard, 1992, Journal of neurophysiology.

Closed-loop optogenetic control of thalamus as a new tool to interrupt seizures after cortical injury

Thomas J. Davidson, K. Deisseroth, J. Huguenard, 2012, Nature Neuroscience.

Reciprocal Inhibitory Connections Regulate the Spatiotemporal Properties of Intrathalamic Oscillations

J. Huguenard, V. Sohal, M. Huntsman, 2000, The Journal of Neuroscience.

Dendritic Low-Threshold Calcium Currents in Thalamic Relay Cells

A. Destexhe, D. Ulrich, J. Huguenard, 1998, The Journal of Neuroscience.

Neurotransmitter control of neocortical neuronal activity and excitability.

D. McCormick, J. Huguenard, Z. Wang, 1993, Cerebral cortex.

Astrocytes as Gatekeepers of GABAB Receptor Function

J. Huguenard, M. Beenhakker, 2010, The Journal of Neuroscience.

GABA A receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex

D. Prince, J. Huguenard, Z. Xiang, 1998 .

GABAA receptor‐mediated currents in interneurons and pyramidal cells of rat visual cortex

D. Prince, J. Huguenard, Z. Xiang, 1998, The Journal of physiology.

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

D. Geschwind, Stephen J. Smith, J. Huguenard, 2015, Nature Methods.

Enhancement of Spike-Timing Precision by Autaptic Transmission in Neocortical Inhibitory Interneurons

A. Bacci, J. Huguenard, 2006, Neuron.

Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy

Alex H. Williams, Jordan M. Sorokin, S. Ganguli, 2020, bioRxiv.

Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

Thomas J. Davidson, Jordan M. Sorokin, K. Deisseroth, 2017, Neuron.

Two classes of excitatory synaptic responses in rat thalamic reticular neurons.

J. Huguenard, C. Deleuze, 2016, Journal of neurophysiology.

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4

C. Mahaffey, J. Huguenard, W. Frankel, 2008, Human molecular genetics.

Reciprocal inhibitory connections and network synchrony in the mammalian thalamus.

J. Huguenard, M. Huntsman, G. Homanics, 1999, Science.

Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action.

J. Huguenard, 1999, Advances in neurology.

Neocortical excitation/inhibition balance in information processing and social dysfunction

Lief E. Fenno, Thomas J. Davidson, K. Deisseroth, 2011, Nature.

Major Differences in Inhibitory Synaptic Transmission onto Two Neocortical Interneuron Subclasses

D. Prince, A. Bacci, J. Huguenard, 2003, The Journal of Neuroscience.

Reliability of axonal propagation: the spike doesn't stop here.

J. Huguenard, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Assembly of functionally integrated human forebrain spheroids

Jonathan A. Bernstein, John R. Huguenard, Wu Wei, 2017, Nature.

Distinct Electrical and Chemical Connectivity Maps in the Thalamic Reticular Nucleus: Potential Roles in Synchronization and Sensation

Charlotte Deleuze, John R Huguenard, J. Huguenard, 2006, The Journal of Neuroscience.

A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy

Karl Deisseroth, Ofer Yizhar, Jeanne T Paz, 2011, Nature Neuroscience.

Reliability of human 3D cortical organoid generation

John R. Huguenard, Aaron Gordon, Daniel H. Geschwind, 2018, Nature Methods.

Differentiation and Maturation of Oligodendrocytes in Human Three-Dimensional Neural Cultures

John R. Huguenard, Yuki Miura, J. Huguenard, 2018, Nature Neuroscience.

Mechanism for Hypocretin-mediated sleep-to-wake transitions

R. Huerta, J. Huguenard, L. de Lecea, 2012, Proceedings of the National Academy of Sciences.

Absence seizure susceptibility correlates with pre-ictal β oscillations

Jeanne T. Paz, John R. Huguenard, Jordan M. Sorokin, 2016, Journal of Physiology-Paris.

Thalamic synchrony and dynamic regulation of global forebrain oscillations

John R. Huguenard, David A. McCormick, D. McCormick, 2007, Trends in Neurosciences.

Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy?

John R. Huguenard, J. Huguenard, M. Beenhakker, 2009, Neuron.

Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems

John Huguenard, Liqun Luo, Drew Friedmann, 2018, Cell.

Modulation of neocortical interneurons: extrinsic influences and exercises in self-control

John R. Huguenard, Alberto Bacci, D. Prince, 2005, Trends in Neurosciences.

Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex.

Ulf Knoblich, Mriganka Sur, James Schummers, 2012, Cerebral cortex.

Enhanced Excitatory Synaptic Connectivity in Layer V Pyramidal Neurons of Chronically Injured Epileptogenic Neocortex in Rats

Xiaoming Jin, John R Huguenard, D. Prince, 2006, The Journal of Neuroscience.

Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study.

J R Huguenard, D. Ulrich, J. Huguenard, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Gamma Oscillations Are Generated Locally in an Attention-Related Midbrain Network

Eric I. Knudsen, Devarajan Sridharan, John R. Huguenard, 2012, Neuron.

Which Formalism to Use for Modeling Voltage- Dependent Conductances?

A. Destexhe, J. Huguenard, 2000 .

Desynchronization of Neocortical Networks by Asynchronous Release of GABA at Autaptic and Synaptic Contacts from Fast-Spiking Interneurons

John R. Huguenard, Frédéric Manseau, Alberto Bacci, 2010, PLoS biology.

Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex.

John R Huguenard, D. Prince, J. Huguenard, 2002, Journal of neurophysiology.

Barrel Cortex Microcircuits: Thalamocortical Feedforward Inhibition in Spiny Stellate Cells Is Mediated by a Small Number of Fast-Spiking Interneurons

John R Huguenard, D. Prince, J. Huguenard, 2006, The Journal of Neuroscience.

Microcircuits and their interactions in epilepsy: is the focus out of focus?

Jeanne T Paz, John R Huguenard, J. Huguenard, 2015, Nature Neuroscience.

Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types.

Vikaas S Sohal, John R Huguenard, J. Huguenard, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cholinergic Control of Gamma Power in the Midbrain Spatial Attention Network

Eric I Knudsen, John R Huguenard, C. A. Goddard, 2015, The Journal of Neuroscience.

Chapter 5 : Modeling voltage-dependent channels

A. Destexhe, J. Huguenard, 2007 .

Recurrent Circuits in Layer II of Medial Entorhinal Cortex in a Model of Temporal Lobe Epilepsy

Xiaoming Jin, John R Huguenard, J. Huguenard, 2007, The Journal of Neuroscience.

Pathway-Specific Differences in Subunit Composition of Synaptic NMDA Receptors on Pyramidal Neurons in Neocortex

John R Huguenard, J. Huguenard, Sanjay S Kumar, 2003, The Journal of Neuroscience.

Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex.

Xiaoming Jin, John R Huguenard, D. Prince, 2011, Cerebral cortex.

Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms.

J. Huguenard, Stephen D. Smith, D. M. Porcello, 2003, Journal of neurophysiology.

Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

J. Huguenard, C. D. Makinson, J. Du Bois, 2020, Nature Communications.

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

Anna K Koster, J. Huguenard, Y. Kuryshev, 2020, bioRxiv.

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

Anna K Koster, J. Huguenard, Y. Kuryshev, 2020, bioRxiv.

Chapter Five - Endozepines

J. Huguenard, R. Reimer, Zoya Farzampour, 2015 .

Pilocarpine-Treated Rats Inhibition in Hilar Ectopic Granule Cells of High Ratio of Synaptic Excitation to Synaptic

Wei Zhang, J. Huguenard, J. Nadler, 2015 .

Modeling and In Vitro Electrophysiology Spread Intrathalamic Oscillations: Computational Long-Range Connections Synchronize Rather Than

Terrence J. Sejnowski, Giulio Tononi, Alain Destexhe, 2015 .

Maladaptive myelination promotes generalized epilepsy progression

J. Huguenard, M. Monje, L. Tam, 2022, Nature Neuroscience.

Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus.

J. Huguenard, S. Pangratz-Fuehrer, U. Rudolph, 2007, Journal of neurophysiology.

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel.

Anna K Koster, J. Huguenard, Y. Kuryshev, 2020, Proceedings of the National Academy of Sciences of the United States of America.

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

J. Huguenard, D. Kaufer, A. Becker, 2015, Neurobiology of Disease.

Neurotransmitter Supply and Demand in Epilepsy

J. Huguenard, 2003 .

Neurotransmitter Supply and Demand in Epilepsy

J. Huguenard, 2003, Epilepsy currents.

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Ian H. Guldner, J. Huguenard, Róbert Pálovics, 2022, bioRxiv.

Maturation and circuit integration of transplanted human cortical organoids

K. Deisseroth, J. Huguenard, Kevin W. Kelley, 2022, Nature.

Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome

L. Luo, J. Huguenard, M. Tessier-Lavigne, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Ian H. Guldner, J. Huguenard, Róbert Pálovics, 2022, bioRxiv.

A Thalamic Sleep Tonic

J. Huguenard, K. Staley, 2006, Epilepsy currents.

Modeling Voltage-Dependent Channels

Alain Destexhe, John R. Huguenard, A. Destexhe, 2009 .

Optogenetics and Epilepsy: Past, Present and Future

J. Huguenard, J. Paz, 2015, Epilepsy currents.

EPSCs in Layer I Neurons of Rat Neocortex Rapid Kinetics and Inward Rectification of Miniature

S. Hestrin, A. Bacci, J. Huguenard, 2015 .

Enhanced NMDA Receptor-Dependent Thalamic Excitation and Network Oscillations in Stargazer Mice

John R Huguenard, J. Huguenard, C. J. Lacey, 2012, The Journal of Neuroscience.

Reemerging role of cable properties in action potential initiation

Yunyong Ma, John R Huguenard, J. Huguenard, 2013, Proceedings of the National Academy of Sciences.

Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons.

J. Huguenard, Fran Shen, Jieun Shin, 2005, Journal of neurophysiology.

A CMOS-based highly scalable flexible neural electrode interface

A. Hierlemann, N. Melosh, J. Huguenard, 2022, bioRxiv.

Nonlinear Thermodynamic Models of Voltage-Dependent Currents

Alain Destexhe, John R. Huguenard, A. Destexhe, 2000, Journal of Computational Neuroscience.

LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition

K. Deisseroth, Joanna Mattis, J. Huguenard, 2016, eNeuro.

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

D. Prince, J. Huguenard, D. Coulter, 1989, Neuroscience Letters.

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

J. Huguenard, C. Garner, J. Montgomery, 2018, Front. Mol. Neurosci..

Rat Neocortex Mediated by the Corpus Callosum in the Developing Properties of Excitatory Synaptic Connections

J. Huguenard, Anne E. Takesian, V. Kotak, 2015 .

by the Corpus Callosum in the Developing Rat Neocortex Properties of Excitatory Synaptic Connections Mediated

J. Huguenard, Sanjay S Kumar, Sanjay S. Kumar, 2013 .

A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons

Alberto Bacci, Viktor Kharazia, John R Huguenard, 2002, The Journal of Neuroscience.

Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex.

J R Huguenard, J. Huguenard, S S Kumar, 2001, Journal of neurophysiology.

SlicesAlkaline Shifts in Rat Hippocampal Effect of Divalent Cations on AMPA-Evoked

J. Huguenard, M. Chesler, S. Makani, 2015 .

Transient Ca2+ currents in neurons isolated from rat lateral habenula.

M. Gutnick, D. Prince, J. Huguenard, 1993, Journal of neurophysiology.

A fast transient potassium current in thalamic relay neurons: kinetics of activation and inactivation.

J R Huguenard, D. Prince, J. Huguenard, 1991, Journal of neurophysiology.

Properties of the Low-Threshold Calcium Current in Thalamic Relay Neurons: Recovery from Inactivation in Relation to the Control of Repetitive Burst Generation

D. Prince, J. Huguenard, D. Coulter, 1991 .

Mechanism of Block of Thalamic T-Type Ca2+ Channels by Petit Mal Anticonvulsants

D. Prince, J. Huguenard, D. Coulter, 1991 .

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade

D. Prince, J. Huguenard, D. Coulter, 1990, British journal of pharmacology.

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction

D. Prince, J. Huguenard, D. Coulter, 1990, British journal of pharmacology.

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

J. Huguenard, M. Monje, L. Liau, 2021, Nature.

Thalamocortical Circuits and Excitability

John Huguenard, J. Huguenard, 2001, Epilepsy currents.

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

J. Huguenard, A. Taylor-Weiner, R. Reimer, 2014, Neuron.

Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neurons

D. Prince, J. Huguenard, D. Coulter, 1989, Annals of neurology.

Chronic Valproic Acid Treatment Triggers Increased Neuropeptide Y Expression and Signaling in Rat Nucleus Reticularis Thalami

J. Huguenard, R. Fernald, J. Brill, 2006, The Journal of Neuroscience.

Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids

John R. Huguenard, Alberto Bacci, D. Prince, 2004, Nature.

Long Term Maturation of Human Cortical Organoids Matches Key Early Postnatal Transitions

S. Horvath, D. Geschwind, J. Huguenard, 2021, Nature Neuroscience.

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

D. Geschwind, J. Rapoport, R. Dolmetsch, 2020, Nature Medicine.

Regulation of Thalamic and Cortical Network Synchrony by Scn8a

John R. Huguenard, Jordan M. Sorokin, A. L. Goldin, 2017, Neuron.

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

D. Geschwind, J. Rapoport, R. Dolmetsch, 2020, Nature medicine.

Assembly of Functional Forebrain Spheroids from Human Pluripotent Cells

H. C. Fan, L. Steinmetz, J. Huguenard, 2017 .

Localization of CCK receptors in thalamic reticular neurons: a modeling study.

V S Sohal, J R Huguenard, J. Huguenard, 1998, Journal of neurophysiology.

Neurons : A Modeling Study Localization of CCK Receptors in Thalamic Reticular

John R. Huguenard, Charles L. Cox, Vikaas S. Sohal, 1998 .

Differentiation and Maturation of Oligodendrocytes in Human Three-Dimensional Neural Cultures

J. Huguenard, Qingyun Li, S. Sloan, 2018, Nature Neuroscience.

Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide Activate Hyperpolarization-Activated Cationic Current and Depolarize Thalamocortical Neurons In Vitro

D. Prince, J. Huguenard, Qian-Quan Sun, 2003, The Journal of Neuroscience.

Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor

J. Huguenard, S. Pangratz-Fuehrer, Kathy Peng, 2013, Neuron.

Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling

J. Huguenard, C. Christian, 2013, Proceedings of the National Academy of Sciences.

Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations

J. Huguenard, P. Fogerson, P. Michelle Fogerson, 2016, Neuron.

Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex.

John R Huguenard, D. Prince, J. Huguenard, 2006, Journal of neurophysiology.

Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons

D. Prince, A. Bacci, J. Huguenard, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Imaging of glutamate in brain slices using FRET sensors

John R. Huguenard, Sakiko Okumoto, Wolf B. Frommer, 2008, Journal of Neuroscience Methods.

Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy

D. Prince, J. Huguenard, A. Bandrowski, 2007, Neurobiology of Disease.

Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.

J. Huguenard, M. Beenhakker, Astra S. Bryant, 2009, Journal of neurophysiology.

Glutamine Is Required for Persistent Epileptiform Activity in the Disinhibited Neocortical Brain Slice

J. Huguenard, R. Reimer, C. Dulla, 2010, The Journal of Neuroscience.

Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.

S. Mcconnell, J. Huguenard, E. Ferenczi, 2015, Cerebral cortex.

Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation

J. Huguenard, R. Reimer, C. Dulla, 2013, Neurobiology of Disease.

Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus.

J. Huguenard, S. Pangratz-Fuehrer, I. Parada, 2016, Journal of neurophysiology.

Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat

R. Fisher, J. Huguenard, Alli C. Kraus, 2006, Neuropharmacology.

Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex.

D. Prince, J. Huguenard, Xiaoming Jin, 2005, Journal of neurophysiology.

Inhibitory Interconnections Control Burst Pattern and Emergent Network Synchrony in Reticular Thalamus

J. Huguenard, V. Sohal, 2003, The Journal of Neuroscience.

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway

J. Huguenard, M. Porteus, S. Pașca, 2023, bioRxiv.

The Endocannabinoid 2-Arachidonoylglycerol Is Responsible for the Slow Self-Inhibition in Neocortical Interneurons

D. Prince, A. Bacci, J. Huguenard, 2008, The Journal of Neuroscience.

With Time After Kainate Treatment Excitatory Synaptic Input to Granule Cells Increases

F. Dudek, Wei Zhang, J. Huguenard, 2015 .

Abnormal in a Rat Model of Posttraumatic Epilepsy Presynaptic Inhibitory Terminals Are Functionally

D. Prince, J. Huguenard, 2010 .

Low-threshold calcium currents in central nervous system neurons.

J R Huguenard, J. Huguenard, 1996, Annual review of physiology.

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures

Max Kleiman-Weiner, John R Huguenard, J. Huguenard, 2009, Proceedings of the National Academy of Sciences.

Dynamic GABAA Receptor Subtype-Specific Modulation of the Synchrony and Duration of Thalamic Oscillations

J. Huguenard, V. Sohal, R. Keist, 2003, The Journal of Neuroscience.

Peptidergic Modulation of Intrathalamic Circuit Activity In Vitro: Actions of Cholecystokinin

D. Prince, J. Huguenard, D A Prince, 1997, The Journal of Neuroscience.

Dendritic calcium currents in thalamic relay cells

Alain Destexhe, John R. Huguenard, Mike Neubig, 1998 .

Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons.

J. Huguenard, B. Alger, 1986, Journal of neurophysiology.

Granule and Unipolar Brush Cells NMDA Receptor-Mediated Currents in Rat Cerebellar

Charly V. Rousseau, J. Rothman, R. Silver, 2015 .

Breathing control center neurons that promote arousal in mice

John R. Huguenard, Liqun Luo, Jack L. Feldman, 2017, Science.

Anatomical and physiological considerations in thalamic rhythm generation

J R Huguenard, J. Huguenard, 1998, Journal of sleep research.

GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus.

J R Huguenard, D. Ulrich, J. Huguenard, 1997, Journal of neurophysiology.

Optogenetics: 10 years after ChR2 in neurons—views from the community

Christof Koch, Antoine Adamantidis, Jessica A. Cardin, 2015, Nature Neuroscience.

Low-voltage-activated (T-type) calcium-channel genes identified

J. Huguenard, 1998, Trends in Neurosciences.

Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus

D. Prince, J. Huguenard, D A Prince, 1996, The Journal of comparative neurology.

Synergistic roles of GABAA receptors and SK channels in regulating thalamocortical oscillations.

Max Kleiman-Weiner, John R Huguenard, J. Huguenard, 2009, Journal of neurophysiology.

Martinotti Cells: Community Organizers

J. Huguenard, C. K. Lee, 2011, Neuron.

Purinergic inhibition of GABA and glutamate release in the thalamus: Implications for thalamic network activity

D. Ulrich, J. Huguenard, 1995, Neuron.

Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic network oscillations

J. Huguenard, Max Kleiman-Weiner, M. Beenhakker, 2020, bioRxiv.

COMPUTATIONAL MODELS CONSTRAINED BY VOLTAGE-CLAMP DATA FOR INVESTIGATING DENDRITIC CURRENTS

Alain Destexhe, John Huguenard, Diego Contreras, 1998 .

Sleep and Epilepsy: A Summary of the 2011 Merritt-Putnam Symposium

R. Stickgold, G. Holmes, B. Bourgeois, 2013, Epilepsy currents.

Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor β1 subunit

J. Huguenard, M. Huntsman, 2006, The Journal of physiology.

Reliability of human 3D cortical organoid generation

D. Geschwind, H. C. Fan, J. Huguenard, 2019 .

An Evolving-Dynamic Network Activity Approach to Epileptic Seizure Prediction using Machine Learning

Surya Ganguli, John Huguenard, Jordan M. Sorokin, 2020, bioRxiv.

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Ian H. Guldner, J. Huguenard, Róbert Pálovics, 2023, bioRxiv.

PKC and polyamine modulation of GluR2‐deficient AMPA receptors in immature neocortical pyramidal neurons of the rat

J. Huguenard, Fran Shen, Jieun Shin, 2007, The Journal of physiology.

Block of T-Type Ca2+ Channels Is an Important Action of Succinimide Antiabsence Drugs

J. Huguenard, 2002, Epilepsy currents.

Intrinsic and Synaptic Dynamics Interact to Generate Emergent Patterns of Rhythmic Bursting in Thalamocortical Neurons

Vikaas S Sohal, John R Huguenard, J. Huguenard, 2006, The Journal of Neuroscience.

NPY signaling through Y1 receptors modulates thalamic oscillations

J. Huguenard, J. Brill, Gunnar F. Kwakye, 2007, Peptides.

Au th or ' s pe rs on al co py NPY signaling through Y 1 receptors modulates thalamic oscillations

J. Huguenard, J. Brill, Gunnar F. Kwakye, 2007 .

Increased Excitatory Synaptic Input to Granule Cells from Hilar and CA3 Regions in a Rat Model of Temporal Lobe Epilepsy

Wei Zhang, John R. Huguenard, Wei Zhang, 2012, The Journal of Neuroscience.

Neuropeptide Y receptors differentially modulate G‐protein‐activated inwardly rectifying K+ channels and high‐voltage‐activated Ca2+ channels in rat thalamic neurons

D. Prince, J. Huguenard, Q. Sun, 2001, The Journal of physiology.

Current Review In Basic Science Opsinology History : Where Do Opsins Come From ?

Jeanne T. Paz, John R. Huguenard, J. Huguenard, 2022 .

Prefrontal PV interneurons facilitate attention and are linked to attentional dysfunction in a mouse model of absence epilepsy

J. Huguenard, Brielle R. Ferguson, 2022, bioRxiv.

Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.

J. Huguenard, M. Huntsman, G. Homanics, 2003, Journal of neurophysiology.

Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.

J. Huguenard, J. Brill, Julia Brill, 2010, Cerebral cortex.

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target

Kristina D. Micheva, Stephen J. Smith, K. Micheva, 2015, Brain : a journal of neurology.

Target-Specific Neuropeptide Y-Ergic Synaptic Inhibition and Its Network Consequences within the Mammalian Thalamus

D. Prince, J. Huguenard, Qian-Quan Sun, 2003, The Journal of Neuroscience.

Somatostatin Inhibits Thalamic Network Oscillations In Vitro: Actions on the GABAergic Neurons of the Reticular Nucleus

D. Prince, J. Huguenard, Qian-Quan Sun, 2002, The Journal of Neuroscience.

Maladaptive myelination promotes epileptogenesis in absence epilepsy

J. Huguenard, M. Monje, L. Tam, 2020, bioRxiv.

Focal Cortical Infarcts Alter Intrinsic Excitability and Synaptic Excitation in the Reticular Thalamic Nucleus

Jeanne T Paz, John R Huguenard, D. Prince, 2010, The Journal of Neuroscience.

Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model

R. Fisher, J. Huguenard, Huifang Li, 2007, Neurobiology of Disease.

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish

J. Huguenard, R. Fernald, Yunyong Ma, 2015, Proceedings of the National Academy of Sciences.

Modulation of Short-Term Plasticity in the Corticothalamic Circuit by Group III Metabotropic Glutamate Receptors

J. Huguenard, Christine L. Kyuyoung, 2014, The Journal of Neuroscience.

Differential effects of Na+–K+ ATPase blockade on cortical layer V neurons

D. Prince, J. Huguenard, Trent R. Anderson, 2010, The Journal of physiology.

Cellular Actions of Petit Mal Anticonvulsants: Implication of Thalamic Low-Threshold Calcium Current in Generation of Spike-Wave Discharge

D. Prince, J. Huguenard, D. Coulter, 1990 .

Sequential Changes in AMPA Receptor Targeting in the Developing Neocortical Excitatory Circuit

J. Huguenard, J. Brill, Julia Brill, 2008, The Journal of Neuroscience.

Satb 2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex

S. Mcconnell, J. Huguenard, E. Ferenczi, 2014 .

Catching a wave

P Michelle Fogerson, John R Huguenard, J. Huguenard, 2016, eLife.

GABA(B) and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro.

D. Ulrich, J. Huguenard, R. B. Jacobsen, 2001, Journal of neurophysiology.

REORGANIZATION OF BARREL CIRCUITS LEADS TO THALAMICALLY-EVOKED CORTICAL EPILEPTIFORM ACTIVITY.

D. Prince, J. Huguenard, Qian-Quan Sun, 2005, Thalamus & related systems.

GABA Affinity Shapes IPSCs in Thalamic Nuclei

J. Huguenard, C. M. Schofield, Claude M. Schofield, 2007, The Journal of Neuroscience.

Parallel Midbrain Microcircuits Perform Independent Temporal Transformations

John Huguenard, Eric Knudsen, J. Huguenard, 2014, The Journal of Neuroscience.

Resting Our Cortices by Going DOWN to Sleep

J. Huguenard, E. Mignot, 2009, Neuron.

Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus.

Eric I Knudsen, John R Huguenard, J. Huguenard, 2007, Journal of neurophysiology.

CHAPTER 7 – Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures

J. Huguenard, H. Pape, T. Budde, 2006 .

Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology.

V S Sohal, J R Huguenard, J. Huguenard, 1998, Journal of neurophysiology.

Nucleus-Specific Chloride Homeostasis in Rat Thalamus

J R Huguenard, D. Ulrich, J. Huguenard, 1997, The Journal of Neuroscience.

Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development.

J. Huguenard, M. Huntsman, Molly M. Huntsman, 2000, Journal of neurophysiology.

Spatially Reciprocal Inhibition of Inhibition within a Stimulus Selection Network in the Avian Midbrain

Eric I. Knudsen, John R. Huguenard, Shreesh P. Mysore, 2014, PloS one.

Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

J. Huguenard, Max Kleiman-Weiner, M. Beenhakker, 2020, eLife.

Electrophysiology of the Neuron: An Interactive Tutorial

John R. Huguenard, David A. McCormick, D. McCormick, 1994 .

Subunit δ in Mice Lacking Neurosteroid Modulation of Thalamic Relay Neurons Intact Synaptic GABAergic Inhibition and Altered

J. Huguenard, M. Huntsman, G. Homanics, 2015 .

Intact Fast Synaptic GABAergic Inhibition and Altered Neurosteroid Modulation of Thalamic Relay Neurons in Mice Lacking the Subunit

J. Huguenard, M. Huntsman, G. Homanics, 2002 .

Epileptiform Activity in Rat Hippocampal Slices Excitation in Proximal Subiculum, But Not

R. Palmiter, D. Prince, A. Bacci, 2015 .

Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons

D. Prince, J. Huguenard, Qian-Quan Sun, 2001, The Journal of physiology.

Robust Short-Latency Perisomatic Inhibition onto Neocortical Pyramidal Cells Detected by Laser-Scanning Photostimulation

J. Huguenard, J. Brill, Julia Brill, 2009, The Journal of Neuroscience.

Seizing upon Mechanisms for Impaired Consciousness

J. Huguenard, Zoya Farzampour, 2015, Neuron.

Attentional flexibility in the thalamus: now we're getting SOMwhere

J. Huguenard, C. D. Makinson, Christopher D. Makinson, 2014, Nature Neuroscience.

Frequency-Dependent, Cell Type-Divergent Signaling in the Hippocamposeptal Projection

Talia N. Lerner, Karl Deisseroth, Minsuk Hyun, 2014, The Journal of Neuroscience.

Sniffer patch laser uncaging response (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance.

J. Huguenard, C. Christian, 2013, Journal of neurophysiology.

Who let the spikes out?

J. Huguenard, C. Dulla, 2009, Nature Neuroscience.

Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism.

John R Huguenard, J. Huguenard, C. Ho, 2002, Journal of neurophysiology.

Sodium Channels Grit, Determination, and Persistence

J. Huguenard, 2002, Neuron.

Circuit Mechanisms of Spike‐Wave Discharge: Are There Similar Underpinnings for Centrotemporal Spikes?

J R Huguenard, J. Huguenard, 2000, Epilepsia.

Excitability changes in thalamic and neocortical neurons after injury.

D. Prince, J. Huguenard, J. Chung, 1996, Epilepsy research. Supplement.

T-Channel Defects in Patients with Childhood Absence Epilepsy

J. Huguenard, 2004, Epilepsy currents.

Determination of state-dependent processing in Thalamus by single neuron properties and neuromodulators

John R. Huguenard, David A. McCormick, Ben W. Strowbridge, 1992 .

In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons

T J Sejnowski, J R Huguenard, D Contreras, 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Ian H. Guldner, J. Huguenard, Róbert Pálovics, 2023, Cell.

Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.

Taro Kiritani, Benjamin A. Suter, D James Surmeier, 2011, Journal of neurophysiology.

Normal sleep homeostasis and lack of epilepsy phenotype in GABAA receptor α3 subunit-knockout mice

J. Huguenard, V. Vyazovskiy, J. Huguenard, 2008, Neuroscience.

The role of H-current in regulating strength and frequency of thalamic network oscillations.

John R Huguenard, J. Huguenard, Brian W Yue, 2001, Thalamus & related systems.

Cholinergic switching within neocortical inhibitory networks.

D. Prince, J. Huguenard, J. Huguenard, 1998, Science.

Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons.

D. Prince, J. Huguenard, J. Huguenard, 2000, Journal of neurophysiology.

Adult Gene Therapy for Epilepsy in a Model of Angelman Syndrome: Hope or Hype?

J. Huguenard, 2023, Epilepsy Currents.

Reciprocal inhibition controls the oscillatory state in thalamic networks

John R. Huguenard, Vikaas S. Sohal, J. Huguenard, 2002, Neurocomputing.

Results NPY Exerts a Differential Action on IPSCs and EPSCs in Pyramidal Neurons

D. Prince, A. Bacci, J. Huguenard, 2002 .

A call for transparent reporting to optimize the predictive value of preclinical research

S. Lazic, O. Steward, Story C. Landis, 2012, Nature.

R U OK? the Novel Therapeutic Potential of R Channels in Epilepsy

J. Huguenard, J. Paz, J. Choi, 2012, Epilepsy currents.

Anatomical and physiological considerations in thalamic rhythm generation

J. Huguenard, 1998, Journal of sleep research.

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4

C. Mahaffey, J. Huguenard, W. Frankel, 2008, Human molecular genetics.

GABAA receptor-mediated Cl- currents in rat thalamic reticular and relay neurons.

D. Prince, J. Huguenard, J. Huguenard, 1997, Journal of neurophysiology.

Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus.

D. Prince, J. Huguenard, J. Huguenard, 1997, Proceedings of the National Academy of Sciences of the United States of America.

GABAB receptor‐mediated responses in GABAergic projection neurones of rat nucleus reticularis thalami in vitro.

J R Huguenard, D. Ulrich, J. Huguenard, 1996, The Journal of physiology.

Gamma Oscillations Are Generated Locally in an Attention-Related Midbrain Network

J. Huguenard, E. Knudsen, D. Sridharan, 2012, Neuron.

Slow inactivation of a TEA-sensitive K current in acutely isolated rat thalamic relay neurons.

D. Prince, J. Huguenard, J. Huguenard, 1991, Journal of neurophysiology.

Microcircuits and their interactions in epilepsy: is the focus out of focus?

J. Huguenard, J. Paz, 2015, Nature Neuroscience.

Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression.

D. Prince, H. Schulman, J. Huguenard, 2001, Journal of neurophysiology.

Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex.

D. Prince, J. Huguenard, J. Huguenard, 1991, Cerebral cortex.

Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex.

D. Prince, J. Huguenard, J. Huguenard, 2003, Journal of neurophysiology.

Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor

J. Huguenard, Kathy Peng, U. Rudolph, 2013, Neuron.

Adrenergic modulation of GABAA receptor-mediated inhibition in rat sensorimotor cortex.

D. Prince, J. Huguenard, B. D. Bennett, 1998, Journal of neurophysiology.

Printed in Great Britain

D. Prince, J. Huguenard, J. Huguenard, 2005 .

Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component.

D. Prince, J. Huguenard, J. Huguenard, 1988, Journal of neurophysiology.

Sodium channels in dendrites of rat cortical pyramidal neurons.

D. Prince, J. Huguenard, J. Huguenard, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Spindle-Like Oscillations in Rat Thalamus In Vitro and NMDA Receptors Contribute to

G. Mato, B. Morris, J. Pratt, 2015 .

Tonic GABAergic Inhibition of Sympathetic Preganglionic Neurons: A Novel Substrate for

J. Deuchars, J. Huguenard, Y. Chang, 2015 .

It Takes T to Tango

John R. Huguenard, Vikaas S. Sohal, J. Huguenard, 2001, Neuron.

Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex

J. Huguenard, Gil Vantomme, Gabrielle Devienne, 2024, bioRxiv.

Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy?

J. Huguenard, 2020, Epilepsy currents.

Development and validation of a potent and specific inhibitor provides evidence for the CLC-2 chloride channel as a potential epilepsy target

J. Huguenard, Y. Kuryshev, M. Beenhakker, 2022 .

Cross-regional coordination of activity in the human brain during autobiographical self-referential processing.

James R. Stieger, R. N. Spreng, J. Huguenard, 2024, Proceedings of the National Academy of Sciences of the United States of America.

Cholecystokinin depolarizes rat thalamic reticular neurons by suppressing a K+ conductance.

D. Prince, J. Huguenard, J. Huguenard, 1995, Journal of neurophysiology.

587 with 8 Text-figures Calcium Currents in Rat Thalamocortical Relay Neurones: Kinetic Properties of the Transient, Low-threshold Current

J. Huguenard, D. A. Prince, D. A. Coulter, 2022 .