S. De Flora

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Smoke‐induced microRNA and related proteome alterations. Modulation by chemopreventive agents

S. De Flora, R. Balansky, F. D'Agostini, 2012, International journal of cancer.

Cancer biomarkers in human atherosclerotic lesions: no evidence of p53 involvement.

S. De Flora, F. D'Agostini, A. Izzotti, 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke

George A Calin, Patrizio Arrigo, Alberto Izzotti, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Yearly variations of demographic indices and mortality data in Italy from 1901 to 2008 as related to the caloric intake.

S. De Flora, M. Vercelli, A. Quaglia, 2013, International journal of hygiene and environmental health.

Genotoxic, carcinogenic, and teratogenic hazards in the marine environment, with special reference to the Mediterranean Sea.

S. De Flora, M. Bagnasco, P. Zanacchi, 1991, Mutation research.

Mutagenicity of sediments along the Po River and genotoxicity biomarkers in fish from polluted areas.

S. De Flora, F. D'Agostini, A. Izzotti, 2002, Mutation research.

Synergism between N‐acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models

S. De Flora, A. Albini, F. Agostini, 1996, International journal of cancer.

Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition

S. De Flora, D. Noonan, A. Albini, 2015, International journal of nanomedicine.

Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

S. De Flora, F. D'Agostini, M. Ghio, 2012, Archives of Dermatological Research.

Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine.

S. De Flora, F. D'Agostini, D. Noonan, 2001, Cancer research.

Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype

J. Lewtas, S. De Flora, C. Cartiglia, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview.

S. De Flora, S. Flora, C. Ramel, 1988, Mutation research.

Mutagenicity of polycyclic aromatic hydrocarbon fractions extracted from urban air particulates.

S. De Flora, F. D'Agostini, A. Izzotti, 1989, Mutation research.

Incidence of infection-associated cancers in Italy and prevention strategies.

S. De Flora, P. Bonanni, E. Crocetti, 2015, Epidemiologia e prevenzione.

Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6.

S. De Flora, F. D'Agostini, P. Fiallo, 2007, Journal of dermatological science.

In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens.

S. De Flora, A. De Flora, A. Morelli, 1984, Carcinogenesis.

In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds.

S. De Flora, A. De Flora, A. Morelli, 1985, Carcinogenesis.

Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells.

S. De Flora, F. D'Agostini, A. Izzotti, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanistic aspects of chromium carcinogenicity.

S. De Flora, S. Flora, P. Zanacchi, 1989, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice

S. De Flora, R. Balansky, V. Steele, 2016, Archives of Toxicology.

Specificity and inducibility of the metabolic reduction of chromium(VI) mutagenicity by subcellular fractions of rat tissues.

S. De Flora, S. Flora, P. Zanacchi, 1985, Cancer research.

Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI).

S. De Flora, F. D'Agostini, A. Izzotti, 2002, Carcinogenesis.

DNA fragmentation, DNA-protein crosslinks, postlabeled nucleotidic modifications, and 8-hydroxy-2'-deoxyguanosine in the lung but not in the liver of rats receiving intratracheal instillations of chromium(VI). Chemoprevention by oral N-acetylcysteine.

S. De Flora, A. Izzotti, M. Bagnasco, 1998, Mutation research.

Cytosolic activation of aromatic and heterocyclic amines. Inhibition by dicoumarol and enhancement in viral hepatitis B.

S. De Flora, F. D'Agostini, A. Izzotti, 1994, Environmental health perspectives.

Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved?

S. De Flora, K. Wetterhahn, J. Aiyar, 1992, Carcinogenesis.

Metabolic reduction of chromium as a threshold mechanism limiting its in vivo activity.

S. De Flora, F. Petrilli, 1988, The Science of the total environment.

Activity profiles of antimutagens: in vitro and in vivo data.

M. Waters, S. De Flora, H. Brockman, 1996, Mutation research.

Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer.

S. De Flora, F. D'Agostini, A. Izzotti, 1991, The American journal of medicine.

Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains.

S. De Flora, S. Flora, P. Zanacchi, 1984, Mutation research.

Mutagenic and DNA damaging activity in muscle of trout exposed in vivo to nitrite.

S. De Flora, A. Arillo, 1983, Cancer letters.

Effects of N‐acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate

S. De Flora, R. Balansky, F. D'Agostini, 2002, International journal of cancer.

Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth.

S. De Flora, R. Balansky, F. D'Agostini, 2015, Carcinogenesis.

Effect of cigarette smoke on DNA damage, oxidative stress, and morphological alterations in mouse testis and spermatozoa.

S. De Flora, S. La Maestra, R. Micale, 2015, International journal of hygiene and environmental health.

Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents.

S. De Flora, C. Cartiglia, A. Izzotti, 1999, Cancer research.

Mechanisms of antimutagenesis and anticarcinogenesis: role in primary prevention.

S. De Flora, A. Izzotti, C. Bennicelli, 1993, Basic life sciences.

Pulmonary metabolism of mutagens and its relationship with lung cancer and smoking habits.

S. De Flora, M. Romano, S. Flora, 1987, Cancer research.

Pulmonary alveolar macrophages in molecular epidemiology and chemoprevention of cancer.

S. De Flora, R. Balansky, F. D'Agostini, 1993, Environmental health perspectives.

Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine.

S. De Flora, S. Flora, C. Bennicelli, 1986, Cancer letters.

What's in a name? The argument for changing the name of IAEMS and its affiliated societies.

S. De Flora, D. DeMarini, 2010, Mutation research.

Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China

S. De Flora, A. Muñoz, G. Gordon, 1997, Journal of cellular biochemistry. Supplement.

Overview of mechanisms of cancer chemopreventive agents.

S. De Flora, L. Ferguson, 2005, Mutation research.

Genotoxicity assay of oil dispersants in bacteria (mutation, differential lethality, SOS DNA-repair) and yeast (mitotic crossing-over).

S. De Flora, P. Zanacchi, A. Camoirano, 1985, Mutation research.

Mutagenicity and toxicity of chromyl chloride and its vapours.

S. De Flora, M. A. Battaglia, A. Camoirano, 1980, Carcinogenesis.

Study of 106 organic and inorganic compounds in the Salmonella/microsome test.

S. De Flora, 1981, Carcinogenesis.

Enhanced liver metabolism of mutagens and carcinogens in fish living in polluted seawater.

S. De Flora, A. Arillo, M. Bagnasco, 1991, Mutation research.

Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?

Brandy M Heckman, S. De Flora, V. Steele, 2011, Oncology reports.

Multiple genotoxicity biomarkers in fish exposed in situ to polluted river water.

S. De Flora, F. D'Agostini, L. Viganò, 1993, Mutation research.

Metabolism of mutagens and carcinogens in woodchuck liver and its relationship with hepatitis virus infection.

S. De Flora, M. Romano, I. Millman, 1987, Cancer research.

Metabolic and genetic effects of marine pollution on aquatic organisms.

S. De Flora, A. Levis, M. Bagnasco, 1991, Progress in clinical and biological research.

N-acetylcysteine inhibits endothelial cell invasion and angiogenesis.

S. De Flora, F. D'Agostini, G. Fontanini, 1999, Laboratory investigation; a journal of technical methods and pathology.

Biomarker alterations produced in rat lung by intratracheal instillations of air particulate extracts and chemoprevention with oral N-acetylcysteine.

S. De Flora, F. D'Agostini, A. Izzotti, 1996, Cancer research.

Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients.

S. De Flora, C. Cartiglia, A. Izzotti, 2003, The American journal of medicine.

Mechanistic approaches to chemoprevention of mutation and cancer.

S. De Flora, L. Ferguson, G. Bronzetti, 2005, Mutation research.

Multiple drug resistance, antimutagenesis and anticarcinogenesis.

S. De Flora, L. Ferguson, 2005, Mutation research.

Interactions between N‐acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis

S. De Flora, R. Balansky, F. D'Agostini, 2000, International journal of cancer.

Diet-derived phytochemicals: from cancer chemoprevention to cardio-oncological prevention.

S. De Flora, D. Noonan, A. Albini, 2011, Current drug targets.

In vitro inhibition by N-acetylcysteine of oxidative DNA modifications detected by 32P postlabeling.

S. De Flora, C. Cartiglia, A. Izzotti, 1998, Free radical research.

Cancer biomarkers in human atherosclerotic lesions: detection of DNA adducts.

J. Lewtas, S. De Flora, A. Izzotti, 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Mutagenesis and cardiovascular diseases Molecular mechanisms, risk factors, and protective factors.

S. De Flora, A. Izzotti, 2007, Mutation research.

Modulation of light-induced skin tumors by N-acetylcysteine and/or ascorbic acid in hairless mice.

S. De Flora, R. Balansky, F. D'Agostini, 2005, Carcinogenesis.

Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin.

S. De Flora, F. D'Agostini, A. Albini, 2000, Anticancer research.

Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 2015, Current cancer drug targets.

Assay of phenacetin genotoxicity using in vitro and in vivo test systems.

S. De Flora, S. Parodi, P. Russo, 1985, Journal of toxicology and environmental health.

Chemopreventive properties and mechanisms of N‐acetylcysteine. The experimental background

S. De Flora, R. Balansky, F. D'Agostini, 1995, Journal of cellular biochemistry. Supplement.

Interactions between ethanol and cigarette smoke in a mouse lung carcinogenesis model.

S. De Flora, R. Balansky, V. Steele, 2016, Toxicology.

Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment.

S. De Flora, L. Carati, C. Grassi, 1997, The European respiratory journal.

Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and N-acetylcysteine

S. De Flora, R. Balansky, F. D'Agostini, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions.

S. De Flora, A. Izzotti, H. Bartsch, 2007, Mutation research.

Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.

S. De Flora, C. Cartiglia, A. Izzotti, 2001, Mutation research.

Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19

S. De Flora, R. Balansky, S. La Maestra, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Blood and lung microRNAs as biomarkers of pulmonary tumorigenesis in cigarette smoke-exposed mice

S. De Flora, R. Balansky, M. Longobardi, 2016, Oncotarget.

Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N‐acetylcysteine

S. De Flora, R. Balansky, F. D'Agostini, 1995, International journal of cancer.

No effect of treatment with carcinogens on cytosine methylation of mitochondrial DNA isolated from rat organs by phenol-free alkaline extraction.

S. De Flora, R. Balansky, A. Izzotti, 1995, Cancer letters.

Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms.

S. De Flora, A. Izzotti, M. Vercelli, 2007, Mutation research.

Proteomic analysis as related to transcriptome data in the lung of chromium(VI)-treated rats.

S. De Flora, C. Cartiglia, M. Longobardi, 2004, International journal of oncology.

Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 1994, Mutation research.

Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium.

S. De Flora, H. Rosenkranz, G. Klopman, 1994, Mutagenesis.

Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung

S. De Flora, Delshanee Kotandeniya, N. Tretyakova, 2020, Scientific Reports.

Balance between oxidants and antioxidants in human diseases

S. De Flora, R. Balansky, S. La Maestra, 2021 .

Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients.

S. De Flora, H. Bartsch, C. Giuntini, 1991, Mutation research.

Methodology for Evaluating Oxidative DNA Damage and Metabolic Genotypes in Human Trabecular Meshwork

S. De Flora, C. Cartiglia, A. Izzotti, 2003, Toxicology mechanisms and methods.

Chemoprevention of smoke-related DNA adduct formation in rat lung and heart.

S. De Flora, R. Balansky, F. D'Agostini, 1992, Carcinogenesis.

Mutagenicity of active oxygen species in bacteria and its enzymatic or chemical inhibition.

S. De Flora, F. D'Agostini, P. Zanacchi, 1989, Mutation research.

Enhanced levels of DNA adducts in the liver of woodchucks infected with hepatitis virus.

J. Lewtas, S. De Flora, A. Izzotti, 1995, Chemico-biological interactions.

Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005.

S. De Flora, H. Bartsch, G. Tortora, 2006, European journal of cancer.

Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus.

S. De Flora, A. Izzotti, H. Bartsch, 1989, Carcinogenesis.

Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling.

S. De Flora, D. Proctor, L. Haws, 2016, Toxicology and applied pharmacology.

Salmonella typhimurium

S. De Flora, F. Petrilli, S. De Flora, 2022 .

Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test.

S. De Flora, P. Zanacchi, A. Camoirano, 1984, Mutation research.

Genotoxicity of mercury compounds. A review.

S. De Flora, S. Flora, M. Bagnasco, 1994, Mutation research.

Prominent role of DT-diaphorase as a cellular mechanism reducing chromium(VI) and reverting its mutagenicity.

S. De Flora, A. De Flora, A. Morelli, 1985, Cancer research.

DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine.

J. Lewtas, S. De Flora, R. Balansky, 1996, Mutation research.

Genotoxicity of chromium compounds. A review.

S. De Flora, M. Bagnasco, P. Zanacchi, 1990, Mutation research.

Mechanisms of inhibitors of mutagenesis and carcinogenesis.

S. De Flora, 1998, Mutation research.

Selective induction of gene expression in rat lung by hexavalent chromium

S. De Flora, R. Balansky, F. D'Agostini, 2002, Molecular carcinogenesis.

Induction of alopecia in mice exposed to cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 2000, Toxicology letters.

Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption.

S. De Flora, A. Izzotti, M. Gobbi, 2015, Aquatic toxicology.

Genotoxic activity of five antidepressant hydrazines in a battery of in vivo and in vitro short-term tests.

S. De Flora, G. Brambilla, L. Robbiano, 1982, Journal of toxicology and environmental health.

In vivo and in vitro genotoxicity of three antihypertensive hydrazine derivatives (hydralazine, dihydralazine, and endralazine).

S. De Flora, G. Brambilla, P. Zanacchi, 1982, Environmental mutagenesis.

Detection of p53 and histopathological classification of skin tumours induced by halogen lamps in hairless mice.

S. De Flora, F. D'Agostini, P. Fiallo, 1994, Cancer letters.

Interactions between N–acetylcysteine and sodium selenite in modulating the clastogenicity of urethane and 2–acetylaminofluorene in mice

S. De Flora, R. Balansky, 2004, International journal of cancer.

Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points.

S. De Flora, R. Balansky, F. D'Agostini, 2001, Carcinogenesis.

DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity.

S. De Flora, S. Parodi, S. Flora, 1981, Cancer research.

The prevention of infection-associated cancers.

Paolo Bonanni, S. De Flora, P. Bonanni, 2011, Carcinogenesis.

Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.

S. De Flora, C. Cartiglia, A. Camoirano, 1997, Mutagenesis.

Protection by N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke.

S. De Flora, F. D'Agostini, P. Zanacchi, 1992, Cancer letters.

Modulation of the mutagenic response in prokaryotes.

S. De Flora, R. Balansky, F. D'Agostini, 1992, Mutation research.

Prevention by N-acetylcysteine of benzo[a]pyrene clastogenicity and DNA adducts in rats.

S. De Flora, R. Balansky, F. D'Agostini, 1991, Mutation research.

Metabolic activation of food hepatocarcinogens in hepatitis B virus-infected humans and animals.

S. De Flora, A. Izzotti, H. Bartsch, 1990, Progress in clinical and biological research.

Effects of aminothiols in 2-acetylaminofluorene-treated rats. II. Glutathione cycle and liver cytosolic activities.

S. De Flora, M. Romano, L. Scarabelli, 1987, In vivo.

Effects of aminothiols in 2-acetylaminofluorene-treated rats. I. Damage and repair of liver DNA, hyperplastic foci, and Zymbal gland tumors.

S. De Flora, M. Bagnasco, M. Orunesu, 1987, In vivo.

Detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or aroclor.

S. De Flora, A. Morelli, M. Romano, 1986, Anticancer research.

Bacterial genotoxicity of nitrosated famotidine.

S. De Flora, P. Zanacchi, A. Camoirano, 1986, Mutagenesis.

Genotoxicity of nitrosated ranitidine.

S. De Flora, P. Zanacchi, A. Camoirano, 1983, Carcinogenesis.

Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke

S. De Flora, R. Balansky, C. Cartiglia, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues.

S. De Flora, H. Vainio, S. Flora, 1999, Mutagenesis.

Hepatitis B in subjects treated with a drug containing immunoglobulins.

S. De Flora, P. Crovari, F. Petrilli, 1977, The Journal of infectious diseases.

Interplay of Cell and Serum Immunologic Markers in Chronic Persistent or Active Hepatitis B

S. De Flora, P. Crovari, A. Picciotto, 1981, Journal of medical virology.

Detection of animal viruses in coastal seawater and sediments.

S. De Flora, G. De Renzi, G. Badolati, 1975, Applied microbiology.

Coclastogenicity of ethanol with cigarette smoke in rat erythroblasts and anticlastogenicity in alveolar macrophages.

S. De Flora, R. Balansky, P. Blagoeva, 1993, Cancer letters.

Modulation by Phenethyl Isothiocyanate and Budesonide of Molecular and Histopathologic Alterations Induced by Environmental Cigarette Smoke in Mice

S. De Flora, R. Balansky, F. D'Agostini, 2009, Cancer Prevention Research.

Transplacental clastogenic and epigenetic effects of gold nanoparticles in mice.

S. De Flora, R. Balansky, M. Longobardi, 2013, Mutation research.

Rationale and mechanisms of cancer chemoprevention.

S. De Flora, M. Bagnasco, C. Bennicelli, 1999, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Chemoprevention of Cigarette Smoke–Induced Alterations of MicroRNA Expression in Rat Lungs

George A Calin, Alberto Izzotti, S. De Flora, 2010, Cancer Prevention Research.

Modulation of multigene expression and proteome profiles by chemopreventive agents.

S. De Flora, C. Cartiglia, M. Longobardi, 2005, Mutation research.

Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers.

S. De Flora, F. D'Agostini, A. Izzotti, 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.

S. De Flora, R. Balansky, A. Izzotti, 2001, Cancer research.

Oxidative damage in human epithelial alveolar cells exposed in vitro to oil fly ash transition metals.

S. De Flora, P. Primerano, A. Di Pietro, 2009, International journal of hygiene and environmental health.

S. De Flora, R. Balansky, C. Cartiglia, 1999, Mutation research.

Prevention of cigarette smoke–induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N‐acetylcysteine

S. De Flora, R. Balansky, V. Steele, 2009, International journal of cancer.

Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus

S. De Flora, R. Balansky, P. Blagoeva, 1994, Journal of cellular biochemistry.

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

S. De Flora, D. Noonan, A. Albini, 2010, Journal of the National Cancer Institute.

Bacterial mutagenicity of cigarette smoke and its interaction with ethanol.

S. De Flora, A. Camoirano, L. Gasparini, 1995, Mutagenesis.

‘Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents

S. De Flora, A. Albini, N. Ferrari, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

DNA damage in exfoliated cells and histopathological alterations in the urinary tract of mice exposed to cigarette smoke and treated with chemopreventive agents.

S. De Flora, R. Balansky, F. D'Agostini, 2013, Carcinogenesis.

Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice.

S. De Flora, F. D'Agostini, A. Albini, 1998, International journal of oncology.

Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life.

S. De Flora, A. Izzotti, 2009, Mutation research.

Multiple points of intervention in the prevention of cancer and other mutation-related diseases.

S. De Flora, R. Balansky, F. D'Agostini, 2001, Mutation research.

The Role of the Thiol N-Acetylcysteine in the Prevention of Tumor Invasion and Angiogenesis

S. De Flora, F. D'Agostini, A. Albini, 1999, The International journal of biological markers.

Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice.

S. De Flora, R. Balansky, F. D' Agostini, 1999, Carcinogenesis.

Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions.

S. De Flora, A. Izzotti, G. Fronza, 1996, Chemico-biological interactions.

Carcinogen metabolism studies in human bronchial and lung parenchymal tissues.

S. De Flora, A. Izzotti, H. Bartsch, 1989, The American review of respiratory disease.

Extracellular vesicles in biological fluids. A biomarker of exposure to cigarette smoke and treatment with chemopreventive drugs

S. De Flora, A. Izzotti, V. Bollati, 2019, Journal of preventive medicine and hygiene.

Induction by carcinogens and chemoprevention by N-acetylcysteine of adducts to mitochondrial DNA in rat organs.

S. De Flora, R. Balansky, F. D'Agostini, 1996, Cancer research.

Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung.

S. De Flora, C. Cartiglia, M. Longobardi, 2011, Mutation research.

Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.

S. De Flora, R. Balansky, F. D'Agostini, 2001, Carcinogenesis.

Genotoxic damage in the oral mucosa cells of subjects carrying restorative dental fillings

S. De Flora, G. Visalli, R. Micale, 2013, Archives of Toxicology.

Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.

S. De Flora, F. D'Agostini, V. Steele, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung.

Ulrich Pfeffer, Alberto Izzotti, S. De Flora, 2010, Carcinogenesis.

Potent carcinogenicity of cigarette smoke in mice exposed early in life.

S. De Flora, R. Balansky, F. D'Agostini, 2007, Carcinogenesis.

Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung.

S. De Flora, R. Balansky, C. Cartiglia, 2005, European journal of cancer.

Genotoxic damage in the oral mucosal cells of subjects carrying restorative dental fillings

S. De Flora, A. Di Pietro, G. Visalli, 2013, Archives of Toxicology.

Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice.

S. De Flora, R. Balansky, V. Steele, 2009, Carcinogenesis.

Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke.

S. De Flora, F. D'Agostini, V. Steele, 2008, Current cancer drug targets.

High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light.

S. De Flora, R. Balansky, F. D'Agostini, 2008, Mutation research.

S. De Flora, R. Balansky, C. Cartiglia, 2003, Mutation research.

Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice.

S. De Flora, R. Balansky, F. D'Agostini, 2003, Carcinogenesis.

Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 2003, Cancer research.

Less than additive interaction between cigarette smoke and chromium(VI) in inducing clastogenic damage in rodents.

S. De Flora, R. Balansky, F. D'Agostini, 2000, Carcinogenesis.

Metabolic reduction of chromium by alveolar macrophages and its relationships to cigarette smoke.

S. De Flora, A. De Flora, M. Romano, 1986, The Journal of clinical investigation.

Benzo[a]pyrene diolepoxide-DNA adducts in alveolar macrophages of smokers.

S. De Flora, A. Izzotti, S. Flora, 1991, Carcinogenesis.

Rationale and Approaches to the Prevention of Smoking-Related Diseases: Overview of Recent Studies on Chemoprevention of Smoking-Induced Tumors in Rodent Models

S. De Flora, R. Balansky, F. D'Agostini, 2014, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit.

S. De Flora, R. Balansky, F. D'Agostini, 2007, Cancer research.

Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 2006, Cancer research.

Modulation of apoptosis by cancer chemopreventive agents.

S. De Flora, R. Balansky, F. D'Agostini, 2005, Mutation research.

Gene Expression in the Lung of p53 Mutant Mice Exposed to Cigarette Smoke

S. De Flora, C. Cartiglia, M. Longobardi, 2004, Cancer Research.

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses

S. De Flora, R. Balansky, K. Kirov, 2016, PloS one.

Differential carcinogenicity of cigarette smoke in mice exposed either transplacentally, early in life or in adulthood

S. De Flora, R. Balansky, V. Steele, 2012, International journal of cancer.

Oral chromium(VI) does not affect the frequency of micronuclei in hematopoietic cells of adult mice and of transplacentally exposed fetuses.

S. De Flora, R. Balansky, M. Iltcheva, 2006, Mutation research.

Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung

S. De Flora, Delshanee Kotandeniya, N. Tretyakova, 2020, Scientific Reports.

Development and application of biomarkers exploitable for human exposure monitoring.

S. De Flora, 1990, Teratogenesis, carcinogenesis, and mutagenesis.

Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke

P. Denev, M. Kratchanova, S. De Flora, 2012, International journal of cancer.

MicroRNAs as targets for dietary and pharmacological inhibitors of mutagenesis and carcinogenesis.

S. De Flora, C. Cartiglia, V. Steele, 2012, Mutation research.

Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.

S. De Flora, C. Cartiglia, T. Kensler, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Influence of liver S-9 preparations from rats and rainbow trout on the activity of four mutagens.

S. De Flora, A. Arillo, P. Zanacchi, 1982, Toxicology letters.

Detoxification of genotoxic compounds as a threshold mechanism limiting their carcinogenicity.

S. De Flora, 1984, Toxicologic pathology.

Circadian reduction of chromium in the gastric environment.

S. De Flora, S. Flora, V. Savarino, 1987, Mutation research.

Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence.

S. De Flora, R. Balansky, V. Steele, 2016, Trends in pharmacological sciences.

The virological monitoring of water. I. Drinking water.

S. De Flora, P. Crovari, A. Vannucci, 1974, Bollettino dell'Istituto sieroterapico milanese.

Formation of mutagenic derivatives from nitrite and two primary amines.

S. De Flora, V. Boido, P. Zanacchi, 1980, Toxicology letters.

Metabolic activation of a cigarette smoke condensate by woodchuck liver, as related to sex, pregnancy, hepatitis virus infection and primary hepatocellular carcinoma.

S. De Flora, R. Balansky, F. D'Agostini, 1994, Mutation research.

Molecular epidemiology of atherosclerosis

J. Lewtas, S. De Flora, A. Izzotti, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke.

S. De Flora, F. D'Agostini, C. Cartiglia, 1999, Carcinogenesis.

Release of MicroRNAs into Body Fluids from Ten Organs of Mice Exposed to Cigarette Smoke

S. De Flora, R. Balansky, F. D'Agostini, 2018, Theranostics.

Epidemiology of cancers of infectious origin and prevention strategies

S. De Flora, S. La Maestra, 2015, Journal of preventive medicine and hygiene.

Induction and Modulation of Lung Tumors: Genomic and Transcriptional Alterations in Cigarette Smoke-exposed Mice

S. De Flora, F. D'Agostini, A. Izzotti, 2004, Experimental lung research.

Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a case--control multicenter study on lung cancer patients.

S. De Flora, H. Bartsch, C. Giuntini, 1992, Environmental health perspectives.

Photoactivation of mutagens.

S. De Flora, F. D'Agostini, A. Izzotti, 1989, Carcinogenesis.

Metabolic activation and deactivation of mutagens and carcinogens.

S. De Flora, 1979, The Italian journal of biochemistry.

Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity.

S. De Flora, S. Flora, B. Kerger, 1997, Carcinogenesis.

Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice.

S. De Flora, F. D'Agostini, A. Izzotti, 2009, Mutation research.

Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents.

S. De Flora, R. Balansky, F. D'Agostini, 2013, Carcinogenesis.

Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.

S. De Flora, R. Balansky, F. D'Agostini, 2003, Mutation research.

Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth

S. De Flora, R. Balansky, F. D'Agostini, 2008, International journal of cancer.

K-ras MUTATIONS IN LUNG TUMORS FROM p53 MUTANT MICE EXPOSED TO CIGARETTE SMOKE

S. De Flora, F. D'Agostini, A. Izzotti, 2005, Experimental lung research.

Carcinogenic response and other histopathological alterations in mice exposed to cigarette smoke for varying time periods after birth

S. De Flora, R. Balansky, Emilia Dimitrova, 2018, Carcinogenesis.

Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice.

S. De Flora, R. Balansky, F. D'Agostini, 2001, International journal of oncology.

Aspirin abrogates impairment of mammary gland differentiation induced by early in life second-hand smoke in mice

S. De Flora, R. Balansky, J. Russo, 2018, Carcinogenesis.

Early and late effects of aspirin and naproxen on microRNAs in the lung and blood of mice, either unexposed or exposed to cigarette smoke

S. De Flora, R. Balansky, F. D'Agostini, 2017, Oncotarget.

Interaction between polycyclic aromatic hydrocarbons, crude oil and oil dispersants in the Salmonella mutagenesis assay.

S. De Flora, F. Petrilli, G. De Renzi, 1980, Carcinogenesis.

Multigenerational mitochondrial alterations in pneumocytes exposed to oil fly ash metals.

S. De Flora, A. Di Pietro, G. Visalli, 2011, International journal of hygiene and environmental health.

Antioxidants and COVID-19

S. De Flora, R. Balansky, S. La Maestra, 2021, Journal of preventive medicine and hygiene.

Estimates of the incidence of infection-related cancers in Italy and Italian regions in 2018

S. De Flora, F. Bianconi, E. Crocetti, 2019, Journal of preventive medicine and hygiene.

Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive Environment

S. De Flora, F. D'Agostini, S. Garibaldi, 2022, Cells.

Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.

S. De Flora, R. Balansky, V. Steele, 2011, Mutation research.

High sensitivity of Salmonella TA102 in detecting hexavalent chromium mutagenicity and its reversal by liver and lung preparations.

S. De Flora, S. Petruzzelli, P. Zanacchi, 1983, Mutation research.

S. De Flora, M. Vercelli, A. Quaglia, 2014, PloS one.

Chemoprevention by N‐acetylcysteine of urethane‐induced clastogenicity and lung tumors in mice

S. De Flora, R. Balansky, 1998, International journal of cancer.

Oxidation of inactive trivalent chromium to the mutagenic hexavalent form.

S. De Flora, F. Petrilli, 1978, Mutation research.

Metabolic deactivation of hexavalent chromium mutagenicity.

S. De Flora, F. Petrilli, 1978, Mutation research.

Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water.

S. De Flora, R. Balansky, F. D'Agostini, 2008, Mutation research.

Influence of DT diaphorase on the mutagenicity of organic and inorganic compounds.

S. De Flora, P. Hochstein, A. Camoirano, 1988, Carcinogenesis.

Interpretations on chromium mutagenicity and carcinogenicity.

S. De Flora, F. Petrilli, 1983, Progress in clinical and biological research.

Effect of human gastric juice on the mutagenicity of chemicals.

S. De Flora, V. Boido, 1980, Mutation research.

Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity.

S. De Flora, D. Proctor, M. Suh, 2016, Toxicology and applied pharmacology.

Problems and prospects in antimutagenesis and anticarcinogenesis.

S. De Flora, 1988, Mutation research.

Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light

S. De Flora, V. Steele, A. Izzotti, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Growth and decline of the COVID‐19 epidemic wave in Italy from March to June 2020

S. De Flora, S. La Maestra, 2020, Journal of medical virology.

Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A.

S. De Flora, F. D'Agostini, C. Cartiglia, 2010, Current cancer drug targets.

Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine.

S. De Flora, F. D'Agostini, A. Izzotti, 2006, International journal of oncology.

Chemoprevention of carcinogen-DNA adducts and chronic degenerative diseases.

S. De Flora, R. Balansky, F. D'Agostini, 1994, Cancer research.

Modulation of genomic and epigenetic end-points by celecoxib

S. De Flora, R. Balansky, A. Izzotti, 2018, Oncotarget.

Circadian monitoring of gastric juice mutagenicity.

S. De Flora, G. Garibotto, V. Savarino, 1987, Mutagenesis.

Smokers and urinary genotoxins: Implications for selection of cohorts and modulation of endpoints in chemoprevention trials

S. De Flora, N. van Zandwijk, G. Qian, 1996, Journal of cellular biochemistry. Supplement.

Epidemiological trends of COVID‐19 epidemic in Italy over March 2020: From 1000 to 100 000 cases

S. De Flora, A. Abbondandolo, S. La Maestra, 2020, Journal of medical virology.

Assay of lapatinib in murine models of cigarette smoke carcinogenesis.

S. De Flora, R. Balansky, F. D'Agostini, 2014, Carcinogenesis.

Cytogenetic analysis of gingival epithelial cells, as related to smoking habits and occurrence of periodontal disease.

S. De Flora, F. D'Agostini, S. La Maestra, 2013, International journal of hygiene and environmental health.

Potent carcinogenicity of uncovered halogen lamps in hairless mice.

S. De Flora, F. D'Agostini, 1994, Cancer research.

The epidemiological revolution of the 20th century

S. De Flora, M. Vercelli, A. Quaglia, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa.

S. De Flora, C. Cartiglia, M. Longobardi, 2006, Carcinogenesis.

Threshold mechanisms and site specificity in chromium(VI) carcinogenesis.

S. De Flora, 2000, Carcinogenesis.

Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy?

S. De Flora, R. Balansky, G. Ganchev, 2012, Current cancer drug targets.

Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke.

S. De Flora, R. Balansky, F. D'Agostini, 2009, Oncology reports.

Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta.

S. De Flora, R. Balansky, F. D'Agostini, 2008, Mutation research.

Post-mortem stability of benzo[a]pyrene diolepoxide--DNA adducts in rat organs.

S. De Flora, A. Izzotti, M. Bagnasco, 1993, Carcinogenesis.

Detection of Animal Viruses in Coastal Seawater and Sediments

S. De Flora, G. De Renzi, G. Badolati, 1975 .

The Plaque-Antiserum Method: an Assay of Virus Infectivity and an Experimental Model of Virus Infection

S. De Flora, 1974, Applied microbiology.

The virological monitoring of water. II. Sea water.

S. De Flora, P. Crovari, A. Vannucci, 1974, Bollettino dell'Istituto sieroterapico milanese.

[Concentration of poliomyelitis and influenza viruses studied with insoluble polyelectrolytes. Preliminary note].

S. De Flora, A. Vannucci, F. Petrilli, 1971, Giornale di igiene e medicina preventiva.

Genotoxicity of volatile and secondary reactive oxygen species generated by photosensitization

S. De Flora, T. Dahl, S. Flora, 1993, Environmental and molecular mutagenesis.

Reversal of sodium-azide mutagenicity by liver preparations and by gastric juice.

S. De Flora, P. Zanacchi, C. Bennicelli, 1979, Mutation research.

Adducts to nuclear DNA and mitochondrial DNA as biomarkers in chemoprevention.

S. De Flora, R. Balansky, A. Izzotti, 1996, IARC scientific publications.

Inhibition by N-acetylcysteine of carcinogen-DNA adducts in the tracheal epithelium of rats exposed to cigarette smoke.

S. De Flora, R. Balansky, A. Izzotti, 1995, Carcinogenesis.

Metabolic, desmutagenic and anticarcinogenic effects of N-acetylcysteine.

S. De Flora, A. De Flora, G. Rossi, 1986, Respiration; international review of thoracic diseases.

Genomic and post‐genomic effects of cigarette smoke: Mechanisms and implications for risk assessment and prevention strategies

S. De Flora, H. Bartsch, 2012, International journal of cancer.

Metabolic deactivation of mutagens in the Salmonella-microsome test

S. De Flora, 1978, Nature.

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice

S. De Flora, R. Balansky, V. Steele, 2016, Archives of Toxicology.

Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice

S. De Flora, R. Balansky, F. D'Agostini, 2014, Cancer medicine.

Inhibition of the 'spontaneous' mutagenicity in Salmonella typhimurium TA102 and TA104.

S. De Flora, A. Camoirano, C. Bennicelli, 1994, Mutation research.

Detection of the '4977 bp' mitochondrial DNA deletion in human atherosclerotic lesions.

S. De Flora, A. Izzotti, A. Abbondandolo, 1999, Mutagenesis.

Clastogenic effects of cigarette smoke and urethane and their modulation by olive oil, curcumin and carotenoids in adult mice and foetuses.

S. De Flora, R. Balansky, S. La Maestra, 2021, Food and Chemical Toxicology.

Thermal inactivation of untreated and gamma-irradiated A2-Aichi-2-68 influenza virus.

S. De Flora, G. Badolati, 1973, The Journal of general virology.

Inactivation of A2-Hong Kong influenza virus by heat and by freeze-thawing. Comparison of untreated and gamma-irradiated preparations.

S. De Flora, G. Badolati, 1973, Bollettino dell'Istituto sieroterapico milanese.

Differential carcinogenicity of cigarette smoke in mice exposed either transplacentally, early in life or in adulthood

S. De Flora, R. Balansky, V. Steele, 2012, International journal of cancer.

Transplacental clastogenic and epigenetic effects of gold nanoparticles in mice.

S. De Flora, R. Balansky, M. Longobardi, 2013, Mutation research.

Assay of lapatinib in murine models of cigarette smoke carcinogenesis.

S. De Flora, R. Balansky, F. D'Agostini, 2014, Carcinogenesis.

Relationships between mutagenic potency, reversion mechanism and metabolic behaviour within a class of chemicals (hydrazine derivatives).

S. De Flora, A. Mugnoli, 1981, Cancer letters.

Relationships between metabolic deactivation of ICR compounds and their differential mutagenicity in bacteria and cultured mammalian cells.

S. De Flora, A. Camoirano, C. Basso, 1986, Mutation research.

Metabolic activation of hepatocarcinogens in chronic hepatitis B.

S. De Flora, M. Romano, A. Picciotto, 1985, Mutation research.