C. Pál

发表

Coevolution with viruses drives the evolution of bacterial mutation rates

C. Pál, M. Maciá, A. Oliver, 2007, Nature.

Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast

C. Pál, L. Hurst, B. Papp, 2004, Nature.

Plasticity of genetic interactions in metabolic networks of yeast

S. Oliver, C. Pál, B. Papp, 2007, Proceedings of the National Academy of Sciences.

Chance and necessity in the evolution of minimal metabolic networks

S. Oliver, C. Pál, L. Hurst, 2006, Nature.

The Genetic Landscape of a Cell

Gary D Bader, Philip M. Kim, Eric D. Spear, 2010, Science.

Dosage sensitivity and the evolution of gene families in yeast

C. Pál, L. Hurst, B. Papp, 2003, Nature.

Genomic function: Rate of evolution and gene dispensability.

C. Pál, L. Hurst, B. Papp, 2003, Nature.

The evolutionary dynamics of eukaryotic gene order

C. Pál, L. Hurst, M. Lercher, 2004, Nature Reviews Genetics.

An integrated approach to characterize genetic interaction networks in yeast metabolism

S. Oliver, M. Jelasity, C. Myers, 2011, Nature Genetics.

An integrated view of protein evolution

C. Pál, M. Lercher, B. Papp, 2006, Nature Reviews Genetics.

Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations

Richard A. Notebaart, J. F. Poyatos, P. Kemmeren, 2020, Molecular biology and evolution.

The Genomic Landscape of Compensatory Evolution

Balázs Papp, Gábor Boross, Károly Kovács, 2014, PLoS biology.

Phenotypic heterogeneity promotes adaptive evolution

Manuel A. S. Santos, Gabriela R. Moura, Gábor Balázsi, 2017, PLoS biology.

Epigenetic inheritance, genetic assimilation and speciation.

C. Pál, I. Miklós, C Pál, 1999, Journal of theoretical biology.

Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

Attila Tóth, Lars Juhl Jensen, Attila Csikász-Nagy, 2009, Molecular systems biology.

Network-level architecture and the evolutionary potential of underground metabolism

Richard A. Notebaart, E. Ruppin, C. Pál, 2014, Proceedings of the National Academy of Sciences.

Systematic genome reductions: theoretical and experimental approaches.

C. Pál, B. Papp, G. Pósfai, 2007, Chemical reviews.

Highly expressed genes in yeast evolve slowly.

C. Pál, L. Hurst, B. Papp, 2001, Genetics.

Adaptive evolution of bacterial metabolic networks by horizontal gene transfer

C. Pál, M. Lercher, B. Papp, 2005, Nature Genetics.

Natural selection promotes the conservation of linkage of co-expressed genes.

C. Pál, L. Hurst, E. J. Williams, 2002, Trends in genetics : TIG.

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

C. Pál, B. Papp, Bálint Csörgő, 2018, Nature Microbiology.

Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

C. Pál, B. Papp, Bálint Csörgő, 2019, Nature Communications.

Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network

B. Kégl, R. Busa-Fekete, C. Pál, 2014, Nature Communications.

Bacterial evolution of antibiotic hypersensitivity

B. Kégl, R. Busa-Fekete, C. Pál, 2013, Molecular systems biology.

Evolution of complex adaptations in molecular systems

C. Pál, B. Papp, Balázs Papp, 2017, Nature Ecology & Evolution.

Adaptive evolution of complex innovations through stepwise metabolic niche expansion

C. Pál, M. Lercher, B. Papp, 2016, Nature communications.

ssDNA recombineering boosts in vivo evolution of nanobodies displayed on bacterial surfaces

V. de Lorenzo, C. Pál, Á. Nyerges, 2021, Communications Biology.

Do genome-scale models need exact solvers or clearer standards?

Ronan M. T. Fleming, Adam M. Feist, Jason A. Papin, 2015, Molecular systems biology.

Systems-biology approaches for predicting genomic evolution

Balázs Papp, Richard A. Notebaart, Csaba Pál, 2011, Nature Reviews Genetics.

Differential impact of simultaneous migration on coevolving hosts and parasites

Csaba Pal, C. Pál, A. Buckling, 2007, BMC Evolutionary Biology.

Genomic function (communication arising): Rate of evolution and gene dispensability

Laurence D. Hurst, Balázs Papp, Csaba Pál, 2003, Nature.

Evolution of cis-regulatory elements in duplicated genes of yeast.

Balázs Papp, Csaba Pál, C. Pál, 2003, Trends in genetics : TIG.

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.

C. Pál, T. Révész, Ž. Skok, 2019, European journal of medicinal chemistry.

Efflux Pump Control Alters Synthetic Gene Circuit Function.

Daniel A. Charlebois, C. Pál, G. Balázsi, 2016, ACS synthetic biology.

Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover

Manuel A. S. Santos, C. Pál, I. Gut, 2015, PLoS biology.

Chemical-genetic profiling reveals cross-resistance and collateral sensitivity between antimicrobial peptides

C. Pál, S. Phanse, M. Babu, 2019, bioRxiv.

Multiple-site diversification of regulatory sequences enables inter-species operability of genetic devices

V. de Lorenzo, C. Pál, B. Calles, 2019 .

Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations

C. Pál, B. Papp, Bálint Csörgő, 2019, Molecular biology and evolution.

Mismatch repair hierarchy of Pseudomonas putida revealed by mutagenic ssDNA recombineering of the pyrF gene.

V. de Lorenzo, C. Pál, E. Martínez-García, 2019, Environmental microbiology.

CRISPR-interference based modulation of mobile genetic elements in bacteria

C. Pál, B. Bálint, Á. Nyerges, 2018, bioRxiv.

Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity

C. Pál, B. Papp, L. Kemény, 2020, Nature Cancer.

Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II alleles

C. Pál, B. Papp, V. Müller, 2018, bioRxiv.

Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

C. Pál, S. Phanse, M. Babu, 2019, Nature Communications.

Improved bacterial recombineering by parallelized protein discovery

Christopher J. Gregg, Gabriel T. Filsinger, G. Church, 2020, Proceedings of the National Academy of Sciences.

Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota

C. Pál, B. Papp, T. Molnár, 2018, Nature Microbiology.

CRISPR-interference-based modulation of mobile genetic elements in bacteria

C. Pál, B. Bálint, Á. Nyerges, 2018, bioRxiv.

Targeted mutagenesis of multiple chromosomal regions in microbes

C. Pál, Bálint Csörgő, Á. Nyerges, 2020, Current opinion in microbiology.

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

Liam P. Shaw, C. Pál, M. Czikkely, 2022, bioRxiv.

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

C. Pál, B. Papp, Balázs Szappanos, 2019, eLife.

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

C. Pál, T. Révész, Ž. Skok, 2020, Pharmaceutics.

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

C. Pál, Ž. Skok, J. Ilaš, 2019, ChemMedChem.

Collateral sensitivity of antibiotic-resistant microbes.

Balázs Papp, Csaba Pál, C. Pál, 2015, Trends in microbiology.

Rational design of balanced dual-targeting antibiotics with limited resistance

C. Pál, T. Révész, B. Kintses, 2020, PLoS biology.

Hsp70-associated chaperones have a critical role in buffering protein production costs

Péter Horváth, Balázs Papp, Gábor Boross, 2018, eLife.

A standardized workflow for surveying recombinases expands bacterial genome‐editing capabilities

V. de Lorenzo, C. Pál, E. Martínez-García, 2017, Microbial biotechnology.

Evidence for purifying selection acting on silent sites in BRCA1.

C. Pál, L. Hurst, C Pál, 2001, Trends in genetics : TIG.

Final report Genomic prediction of essential genes : an in silico approach

C. Pál, 2008 .

Evidence for co-evolution of gene order and recombination rate

Laurence D. Hurst, Csaba Pál, C. Pál, 2003, Nature Genetics.

Does the recombination rate affect the efficiency of purifying selection? The yeast genome provides a partial answer.

C. Pál, L. Hurst, B. Papp, 2001, Molecular biology and evolution.

Epigenetic Inheritance and Evolutionary Adaptation

C. Pál, L. Hurst, Csaba Pál, 2004 .

Can Genes Explain Biological Complexity?

Ferenc Jordán, Eörs Szathmáry, Csaba Pál, 2001, Science.

Evidence against the selfish operon theory.

Csaba Pál, C. Pál, L. Hurst, 2004, Trends in genetics : TIG.

Perturbation of Iron Homeostasis Promotes the Evolution of Antibiotic Resistance

C. Pál, B. Papp, Bálint Csörgő, 2014, Molecular biology and evolution.

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

R. Busa-Fekete, C. Pál, B. Papp, 2014, Antimicrobial Agents and Chemotherapy.

Enzyme promiscuity shapes adaptation to novel growth substrates

Adam M. Feist, Bernhard O Palsson, Zachary A. King, 2019, Molecular systems biology.

Enzyme promiscuity shapes evolutionary innovation and optimization

Zachary A. King, Richard A. Notebaart, Ryan A. LaCroix, 2018, bioRxiv.

The dawn of evolutionary genome engineering

Balázs Papp, Csaba Pál, C. Pál, 2014, Nature Reviews Genetics.

Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains

C. Pál, B. Papp, R. Herczeg, 2023, Nature Microbiology.

Evolthon: A community endeavor to evolve lab evolution

Aditya M. Kunjapur, Katarzyna P. Adamala, Michael M. Desai, 2019, PLoS biology.

Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis.

István Nagy, Tamás Fehér, Csaba Pál, 2017, ACS synthetic biology.

Competition between transposable elements and mutator genes in bacteria.

C. Pál, L. Hurst, B. Papp, 2012, Molecular biology and evolution.

Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining.

F. Blattner, C. Pál, B. Papp, 2016, Molecular biology and evolution.

Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

Balázs Papp, Gábor Boross, Csaba Pál, 2019, PLoS biology.

New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

C. Pál, Ž. Skok, J. Ilaš, 2018, European journal of medicinal chemistry.

From passengers to drivers

C. Pál, B. Papp, Balázs Papp, 2013, Mobile genetic elements.

Molecular chaperones as regulatory elements of cellular networks.

C. Pál, P. Csermely, B. Papp, 2005, Current opinion in cell biology.

Cotranslational assembly imposes evolutionary constraints on homomeric proteins

S. Teichmann, M. Babu, N. Sugimoto, 2016, bioRxiv.

Recombineering and MAGE

Farren J. Isaacs, George M. Church, Andrew D. Ellington, 2021, Nature Reviews Methods Primers.

Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations

C. Pál, T. Révész, M. Czikkely, 2019, Antimicrobial Agents and Chemotherapy.

Antibiotic usage promotes the evolution of resistance against gepotidacin, a novel multi-targeting drug

C. Pál, T. Révész, M. Czikkely, 2018 .

Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast

C. Pál, P. Horváth, B. Papp, 2022, Nature Ecology & Evolution.

Plasticity, memory and the adaptive landscape of the genotype

C. Pál, Csaba Pál, 1998, Proceedings of the Royal Society of London. Series B: Biological Sciences.

Mismatch repair hierarchy of Pseudomonas putida revealed by mutagenic ssDNA recombineering of the pyrF gene

V. de Lorenzo, C. Pál, E. Martínez-García, 2019, bioRxiv.

Supplementary Information an Integrated Approach to Characterize Genetic Interaction Networks in Yeast Metabolism Supplementary Figures 1-4. Supplementary Tables 1-3. Supplementary Note

S. Oliver, C. Myers, C. Pál, 2022 .

Genomewide Screen for Modulators of Evolvability under Toxic Antibiotic Exposure

C. Pál, Bálint Csörgő, Balázs Bogos, 2013, Antimicrobial Agents and Chemotherapy.

The evolution of gene number: are heritable and non-heritable errors equally important?

C. Pál, L. Hurst, Csaba Pál, 2000, Heredity.

Integration of horizontally transferred genes into regulatory interaction networks takes many million years.

C. Pál, M. Lercher, Csaba Pál, 2008, Molecular biology and evolution.

A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species

István Nagy, Csaba Pál, C. Pál, 2016, Proceedings of the National Academy of Sciences.

Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

C. Pál, Á. Kittel, P. Szabó-Révész, 2019, Pharmaceutics.

The molecular evolution of signal peptides.

C. Pál, L. Hurst, E. J. Williams, 2000, Gene.

Multiple-site diversification of regulatory sequences enables inter-species operability of genetic devices.

V. de Lorenzo, C. Pál, B. Calles, 2019, ACS synthetic biology.

Plasticity and Stereotypic Rewiring of the Transcriptome Upon Bacterial Evolution of Antibiotic Resistance

C. Pál, B. Papp, Viktória Lázár, 2023, Molecular biology and evolution.

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

C. Pál, B. Papp, Bálint Csörgő, 2018, Nature Microbiology.

A genome-wide screen for modulators of evolvability under toxic 1 antibiotic exposure 2 3

C. Pál, Balázs Bogos, Orsolya Méhi, 2013 .

Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome

C. Pál, K. Farkas, F. Nagy, 2020, Pharmaceuticals.

Second generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.

C. Pál, R. Enriz, Ž. Skok, 2020, Future medicinal chemistry.

Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance

István Nagy, Balázs Papp, Dávid Balogh, 2018, Proceedings of the National Academy of Sciences.

Horizontal gene transfer depends on gene content of the host

Martin J. Lercher, Balázs Papp, Csaba Pál, 2005, ECCB/JBI.

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

S. Teichmann, M. Babu, N. Sugimoto, 2018, Nature Structural & Molecular Biology.

Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization

Lukács J. Németh, C. Pál, B. Jójárt, 2021, Molecular systems design & engineering.

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Guido V. Janssen, C. Pál, L. Pardo, 2023, Journal of medicinal chemistry.

New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

C. Pál, T. Révész, Ž. Skok, 2021, European journal of medicinal chemistry.

The hows and whys

C. Pál, L. Hurst, 2009 .

Conditional DNA repair mutants enable highly precise genome engineering

István Nagy, Csaba Pál, C. Pál, 2014, Nucleic acids research.

Antibiotics of the future are prone to resistance in Gram-negative pathogens

Szilvia Juhász, C. Pál, B. Papp, 2023, bioRxiv.

Metabolic complexity increases adaptability

F. Jarre, C. Pál, M. Lercher, 2023, bioRxiv.

Systems biology of epistasis: Shedding light on genetic interaction network “hubs”

C. Pál, B. Papp, 2011, Cell cycle.

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

C. Pál, B. Papp, Balázs Szappanos, 2019, eLife.

Proteome-wide landscape of solubility limits in a bacterial cell

C. Pál, P. Horváth, Balázs Szappanos, 2021, Scientific Reports.

Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis.

C. Pál, G. Pósfai, R. Herczeg, 2017, ACS synthetic biology.