J. Arnold

发表

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

M. Vignuzzi, J. Stone, J. Arnold, 2006, Nature.

Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG

J. Arnold, C. Cameron, L. Marnett, 2010, Nucleic acids research.

Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity.

J. Arnold, C. Cameron, D. Sterner, 2006, Analytical biochemistry.

Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli.

Thomas J. Wisniewski, J. Arnold, C. Cameron, 1999, Protein expression and purification.

Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides

G. Ning, J. Arnold, C. Cameron, 2018, PLoS pathogens.

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

J. Arnold, C. Cameron, S. Almo, 2021, eLife.

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

J. Arnold, C. Cameron, S. Almo, 2020, bioRxiv : the preprint server for biology.

Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.

J. Arnold, C. Cameron, O. Flint, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

J. Arnold, C. Cameron, Divakaran Murugesapillai, 2017, bioRxiv.

Predicting Off‐Target Effects of Therapeutic Antiviral Ribonucleosides

J. Arnold, C. Cameron, 2018 .

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

J. Arnold, C. Cameron, A. Gnatt, 2012, PLoS pathogens.

Single-nucleotide resolution of RNA strands in the presence of their RNA complements.

S. Ghosh, J. Arnold, C. Cameron, 1999, BioTechniques.

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

J. Arnold, C. Cameron, D. Dulin, 2022, bioRxiv.

Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance.

J. Arnold, Xiaorong Yang, David D. Boehr, 2010, Biochemistry.

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

J. Arnold, C. Cameron, E. Snijder, 2011, Nucleic Acids Research.

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

J. Arnold, C. Cameron, N. Yennawar, 2022, bioRxiv.

2′-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase

J. Arnold, C. Cameron, H. Oh, 2019, The Journal of Biological Chemistry.

IRES-independent, eIF2A/eIF2D-dependent translation of the enterovirus genome

J. Arnold, C. Cameron, Hyejeong Kim, 2022, bioRxiv.

Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses.

M. Vignuzzi, J. Arnold, C. Cameron, 2021, Molecular cell.

Viperin Reveals Its True Function.

J. Arnold, C. Cameron, S. Almo, 2020, Annual review of virology.

Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2.

Hsin Wang, J. Arnold, C. Cameron, 2014, Journal of molecular biology.

Human Rhinovirus Type 14 Gain-of-Function Mutants for oriI Utilization Define Residues of 3C(D) and 3Dpol That Contribute to Assembly and Stability of the Picornavirus VPg Uridylylation Complex

J. Arnold, C. Cameron, S. Lemon, 2007, Journal of Virology.

Structure-Function Relationships of the RNA-dependent RNA Polymerase from Poliovirus (3Dpol)

J. Arnold, C. Cameron, A. Paul, 2002, The Journal of Biological Chemistry.

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

J. Arnold, C. Cameron, D. Dulin, 2022, Nucleic acids research.

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

L. Chodosh, J. Arnold, C. Cameron, 2016, Oncotarget.

Nucleic acid polymerases employ a general acid for nucleotidyl transfer

J. Arnold, C. Cameron, E. Smidansky, 2008, Nature Structural &Molecular Biology.

Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases

J. Arnold, C. Cameron, E. Smidansky, 2007, Proceedings of the National Academy of Sciences.

Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition.

J. Arnold, C. Cameron, E. Smidansky, 2012, Biochimica et biophysica acta.

Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+.

J. Arnold, C. Cameron, 2004, Biochemistry.

Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection.

J. Arnold, C. Cameron, D. Gohara, 2004, Biochemistry.

Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+.

J. Arnold, C. Cameron, D. Gohara, 2004, Biochemistry.

Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?

J. Arnold, C. Cameron, I. Moustafa, 2009, Current Opinion in Structural Biology.

The nucleotide addition cycle of the SARS-CoV-2 polymerase

J. Arnold, C. Cameron, M. Depken, 2021, Cell Reports.

The nucleotide addition cycle of the SARS-CoV-2 polymerase

J. Arnold, C. Cameron, M. Depken, 2021, bioRxiv.

Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases*

J. Arnold, C. Cameron, Xiaorong Yang, 2017, The Journal of Biological Chemistry.

Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus.

J. Arnold, C. Cameron, I. Moustafa, 2016, The Enzymes.

Poliovirus RNA-dependent RNA Vaccine-derived Mutation in Motif D of Enzymology:

J. Arnold, E. Smidansky, Xiaorong Yang, 2014 .

Vaccine-derived Mutation in Motif D of Poliovirus RNA-dependent RNA Polymerase Lowers Nucleotide Incorporation Fidelity*

J. Arnold, C. Cameron, E. Smidansky, 2013, The Journal of Biological Chemistry.

Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition.

J. Arnold, C. Cameron, E. Smidansky, 2012, Structure.

Nucleic Acid Polymerase Fidelity and Viral Population Fitness

J. Arnold, C. Cameron, E. Smidansky, 2008 .

Structure-function relationships among RNA-dependent RNA polymerases.

J. Arnold, C. Cameron, K. Ng, 2008, Current topics in microbiology and immunology.

Remote Site Control of an Active Site Fidelity Checkpoint in a Viral RNA-dependent RNA Polymerase*

M. Vignuzzi, J. Stone, J. Arnold, 2005, Journal of Biological Chemistry.

Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds.

J. Arnold, C. Cameron, E. Smidansky, 2011, Biochemistry.

A naturally occurring antiviral ribonucleotide encoded by the human genome

J. Arnold, C. Cameron, S. Almo, 2018, Nature.

Expanding the Proteome of an RNA Virus by Phosphorylation of an Intrinsically Disordered Viral Protein*

G. Ning, J. Arnold, C. Cameron, 2014, The Journal of Biological Chemistry.

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

J. Arnold, C. Cameron, R. Andino, 2000, Nature Medicine.

Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses

J. Arnold, C. Cameron, N. Dekker, 2020, bioRxiv.

Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

J. Arnold, C. Cameron, L. Kramer, 2015, PLoS pathogens.

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.

J. Arnold, C. Cameron, S. Sturla, 2021, Journal of medicinal chemistry.

Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

Armando Arias, J. Arnold, C. Cameron, 2008, Journal of Virology.

Picornavirus Genome Replication

J. Arnold, C. Cameron, I. Goodfellow, 2008, Journal of Biological Chemistry.

Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection.

J. Arnold, C. Cameron, S. Ghosh, 1999, The Journal of biological chemistry.

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

J. Arnold, C. Cameron, S. Almo, 2020, bioRxiv.

Poliovirus RNA-Dependent RNA Polymerase (3Dpol): Structure, Function, and Mechanism

J. Arnold, C. Cameron, D. Gohara, 2002 .

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

J. Arnold, C. Cameron, L. Linares, 2018, Molecular cell.

A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus

J. Arnold, C. Cameron, R. Woods, 2018, bioRxiv.

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

J. Arnold, C. Cameron, R. Woods, 2018, bioRxiv.

Insight into Poliovirus Genome Replication and Encapsidation Obtained from Studies of 3B-3C Cleavage Site Mutants

J. Arnold, C. Cameron, I. Goodfellow, 2009, Journal of Virology.

Single-Cell Virology: On-Chip Investigation of Viral Infection Dynamics.

C. Wilke, J. Arnold, C. Cameron, 2017, Cell reports.

Poliovirus RNA-dependent RNA Polymerase (3Dpol) Is Sufficient for Template Switchingin Vitro *

J. Arnold, C. Cameron, 1999, The Journal of Biological Chemistry.

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

J. Arnold, C. Cameron, C. Lacroix, 2015, PLoS pathogens.

Picornavirus Genome Replication IDENTIFICATION OF THE SURFACE OF THE POLIOVIRUS (PV) 3C DIMER THAT INTERACTS WITH PV 3Dpol DURING VPg URIDYLYLATION AND CONSTRUCTION OF A STRUCTURAL MODEL FOR THE PV 3C 2 -3Dpol COMPLEX *

J. Arnold, C. Cameron, Z. Reitman, 2007 .

Hepatitis C Virus Nonstructural Protein 5A (NS5A) Is an RNA-binding Protein*

J. Arnold, C. Cameron, M. R. Hargittai, 2005, Journal of Biological Chemistry.

Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase

J. Arnold, C. Cameron, G. Belliot, 2005, Journal of Virology.

Identification of the oriI-Binding Site of Poliovirus 3C Protein by Nuclear Magnetic Resonance Spectroscopy

J. Arnold, C. Cameron, M. Foster, 2008, Journal of Virology.

Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination

J. Arnold, C. Cameron, David J. Evans, 2016, Nucleic acids research.

Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective☆

J. Arnold, C. Cameron, C. Castro, 2004, Virus Research.

Genetic recombination of poliovirus facilitates subversion of host barriers to infection

J. Arnold, C. Cameron, R. Andino, 2018, bioRxiv.

A Polymerase Mechanism-based Strategy for Viral Attenuation and Vaccine Development*

J. Arnold, C. Cameron, E. Smidansky, 2012, The Journal of Biological Chemistry.

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

J. Arnold, C. Cameron, E. Snijder, 2009, Nucleic acids research.

Poliovirus RNA-dependent RNA Polymerase (3Dpol)

J. Arnold, C. Cameron, R. Andino, 2000, The Journal of Biological Chemistry.

Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub).

J. Arnold, C. Cameron, 2000, The Journal of biological chemistry.

Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein.

J. Arnold, C. Cameron, David D. Boehr, 2016, Structure.

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

M. Vignuzzi, J. Arnold, B. Baron, 2010, PLoS pathogens.

Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase*

Janna K. Maranas, J. Arnold, C. Cameron, 2014, The Journal of Biological Chemistry.

RNA-Dependent RNA Polymerase Speed and Fidelity are not the Only Determinants of the Mechanism or Efficiency of Recombination

J. Arnold, C. Cameron, Hyejeong Kim, 2019, bioRxiv.

Structure, Dynamics, and Fidelity of RNA-Dependent RNA Polymerases

J. Arnold, C. Cameron, David D. Boehr, 2014 .

Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro

J. Arnold, C. Cameron, G. Shadel, 2012, Proceedings of the National Academy of Sciences.

Expression and Purification of Mitochondrial RNA Polymerase and Transcription Factor A from Drosophila melanogaster.

J. Arnold, C. Cameron, T. Salminen, 2016, Methods in molecular biology.

Identification of Multiple Rate-limiting Steps during the Human Mitochondrial Transcription Cycle in Vitro*

J. Arnold, C. Cameron, M. F. Lodeiro, 2010, The Journal of Biological Chemistry.

Picornavirus Genome Replication

J. Arnold, C. Cameron, Z. Reitman, 2008, Journal of Biological Chemistry.

Picornavirus Genome Replication

J. Arnold, C. Cameron, M. R. Hargittai, 2007, Journal of Biological Chemistry.

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases

J. Arnold, C. Cameron, M. Depken, 2020, bioRxiv.

UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication

J. Arnold, C. Cameron, Jen-Ren Wang, 2017, PLoS pathogens.

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

J. Arnold, C. Cameron, T. van Laar, 2017, Cell Reports.

RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence*

M. Vignuzzi, J. Arnold, C. Cameron, 2014, The Journal of Biological Chemistry.

Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase

J. Arnold, C. Cameron, K. Raney, 2009, Nucleic acids research.

Picornavirus Genome Replication ROLESOFPRECURSORPROTEINSANDRATE-LIMITINGSTEPSINoriI-DEPENDENT VPgURIDYLYLATION *

J. Arnold, C. Cameron, I. Goodfellow, 2008 .

Crystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA Polymerase

J. Arnold, C. Cameron, D. Filman, 2007, Journal of Virology.

Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1.

J. Arnold, K. Tran, M. Teng, 2008, Protein expression and purification.

More than efficacy revealed by single-cell analysis of antiviral therapeutics

C. Wilke, J. Arnold, C. Cameron, 2019, Science Advances.

Signatures of Nucleotide A nalog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers Graphical

J. Arnold, C. Cameron, M. Depken, 2017 .

Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics.

J. Arnold, C. Cameron, Xiaorong Yang, 2019, Biochemistry.

Maintenance of a host-specific minority mutation in the West Nile virus NS3

J. Arnold, C. Cameron, C. A. Koetzner, 2023, iScience.

Hepatitis C Virus Nonstructural Protein 5A (NS5A) Is an RNA-binding Protein*

J. Arnold, C. Cameron, M. R. Hargittai, 2005, Journal of Biological Chemistry.

Polymerase Mechanism-Based Method of Viral Attenuation

J. Arnold, C. Cameron, A. August, 2015, Methods in molecular biology.

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

J. Arnold, C. Cameron, Xiaorong Yang, 2015, Viruses.

Amiloride Is a Competitive Inhibitor of Coxsackievirus B3 RNA Polymerase

J. Arnold, C. Cameron, S. Petrou, 2011, Journal of Virology.

Abstract 1245: Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

J. Arnold, C. Cameron, N. Yennawar, 2023, Journal of Biological Chemistry.

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

J. Arnold, C. Cameron, Divakaran Murugesapillai, 2017, bioRxiv.

Nucleic acid polymerases employ a general acid for nucleotidyl transfer

J. Arnold, C. Cameron, E. Smidansky, 2008, Nature Structural &Molecular Biology.