P. Distefano

发表

The PYRIN domain: a novel motif found in apoptosis and inflammation proteins

J. Bertin, P. Distefano, P. DiStefano, 2000, Cell Death and Differentiation.

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

S. R. Datta, M. Greenberg, P. Distefano, 2002, Science.

An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis

Laurence Ettwiller, P. Distefano, L. Ettwiller, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Neurotrophin trafficking by anterograde transport

C. Altar, P. Distefano, C. Altar, 1998, Trends in Neurosciences.

A Novel Membrane Potential-Sensitive Fluorescent Dye Improves Cell-Based Assays for Ion Channels

Rory Curtis, Dejan Bojanic, P. Distefano, 2002, Journal of biomolecular screening.

Translating the human microbiome

Rob Knight, Jeroen Raes, Curtis Huttenhower, 2013, Nature Biotechnology.

Neurotrophins Suppress Apoptosis Induced by Deafferentation of an Avian Motor-Cortical Region

Frank Johnson, P. Distefano, S. Bottjer, 1997, The Journal of Neuroscience.

Identification of a truncated form of the nerve growth factor receptor.

P. Distefano, E. Johnson, Eugene M. Johnson, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Consistent repeated M‐ and H‐wave recording in the hind limb of rats

P. Distefano, K. D. Cliffer, S. Bodine, 1998, Muscle & nerve.

Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice

P. Distefano, K. Longo, Yong Qi, 2008, Regulatory Peptides.

A Novel Nervous System β Subunit that Downregulates Human Large Conductance Calcium-Dependent Potassium Channels

P. Distefano, I. Levitan, F. T. Clark, 2000, The Journal of Neuroscience.

Axotomy Upregulates the Anterograde Transport and Expression of Brain-Derived Neurotrophic Factor by Sensory Neurons

P. Distefano, K. D. Cliffer, T. Nguyen, 1998, The Journal of Neuroscience.

Axonal transport of neurotrophins by visceral afferent and efferent neurons of the vagus nerve of the rat

P. Distefano, H. Zhuo, C. Helke, 1998, The Journal of comparative neurology.

Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons

P. Distefano, M. Korte, R. Lindsay, 2022, Frontiers in Molecular Neuroscience.

A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2

J. Bertin, P. Distefano, G. Khursigara, 2001, The Journal of Neuroscience.

Differential distribution of exogenous BDNF, NGF, and NT‐3 in the brain corresponds to the relative abundance and distribution of high‐affinity and low‐affinity neurotrophin receptors

P. Distefano, S. Wiegand, K. Anderson, 1995, The Journal of comparative neurology.

Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity

P. Distefano, M. Navia, J. Hixon, 2011, Journal of Pharmacology and Experimental Therapeutics.

Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps

P. Distefano, J. Hixon, J. Saunders, 2011, BMC Physiology.

Chapter 2. Pharmacology of Neurotrophic Factors in Models of Neurodegenerative Disease

P. Distefano, 1993 .

Reduced Ia-Afferent-Mediated Hoffman Reflex in Streptozotocin-Induced Diabetic Rats

P. Distefano, K. D. Cliffer, S. Bodine, 2001, Experimental Neurology.

Localization and regulation of MuSK at the neuromuscular junction.

P. Distefano, G. Yancopoulos, S. Bodine, 1998, Developmental biology.

Neurotrophin Sensitivity of Prevertebral and Paravertebral Rat Sympathetic Autonomic Ganglia

P. Distefano, R. Schmidt, K. Roth, 1998, Journal of neuropathology and experimental neurology.

A requirement for CARMA1 in TCR-induced NF-κB activation

J. Bertin, P. Distefano, G. Núñez, 2002, Nature Immunology.

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

R. Lerner, P. Distefano, N. Wu, 2018, Proceedings of the National Academy of Sciences.

Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin.

P. Distefano, J. Hixon, A. Napper, 2005, Methods.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

P. Distefano, S. Scherer, N. Ip, 1994, Neuron.

Co-infusion with a TrkB-Fc Receptor Body Carrier Enhances BDNF Distribution in the Adult Rat Brain

P. Distefano, J. Siuciak, S. Wiegand, 1998, Experimental Neurology.

Neurotrophin-3 Administration Attenuates Deficits of Pyridoxine-Induced Large-Fiber Sensory Neuropathy

P. Distefano, K. D. Cliffer, S. Wiegand, 1997, The Journal of Neuroscience.

Increased Expression of CNTF Receptor α in Denervated Human Skeletal Muscle

P. Distefano, S. Züchner, N. Stahl, 1998 .

Increased expression of CNTF receptor alpha in denervated human skeletal muscle.

P. Distefano, S. Züchner, N. Stahl, 1998, Journal of neuropathology and experimental neurology.

Aldose Reductase Inhibition Increases CNTF-Like Bioactivity and Protein in Sciatic Nerves From Galactose-Fed and Normal Rats

P. Distefano, N. Calcutt, N. Calcutt, 1997, Diabetes.

Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

P. Distefano, G. Yancopoulos, D. J. Parry, 1994, Cell.

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

P. Distefano, R. Lindsay, R. Curtis, 1993, Nature.

CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis*

J. Bertin, P. Distefano, S. Srinivasula, 2002, The Journal of Biological Chemistry.

Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor

P. Distefano, J. Schweitzer, E. Johnson, 1985, The Journal of cell biology.

A requirement for CARMA1 in TCR-induced NF-kappa B activation.

J. Bertin, P. Distefano, G. Núñez, 2002, Nature immunology.

Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.

P. Distefano, K. Gilbride, T. Scheuer, 2001, Molecular and cellular neurosciences.

Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan.

P. Distefano, R. Curtis, B. Geddes, 2007, Current Alzheimer research.

Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC

P. Distefano, S. Wyatt, Y. Barde, 2022, Journal of neurochemistry.

Ciliary Neurotrophic Factor Induces Down-regulation of Its Receptor and Desensitization of Signal Transduction Pathways in Vivo

P. Distefano, R. Lindsay, T. Boulton, 1996, The Journal of Biological Chemistry.

Exogenous NT-3 mitigates the transganglionic neuropeptide Y response to sciatic nerve injury

P. Distefano, R. Schmidt, S. Ohara, 1995, Brain Research.

Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo

P. Distefano, J. McKelvy, C. Schick, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Regulation of schwann cell surface and truncated nerve growth factor receptors in vitro by axonal components

P. Distefano, D. M. Chelsea, 1990, Brain Research.

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

P. Distefano, G. Yancopoulos, D. Glass, 1996, Cell.

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

P. Distefano, O. H. Lowry, R. Schmidt, 1988, The Journal of cell biology.

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

P. Distefano, M. Navia, J. Hixon, 2005, Journal of medicinal chemistry.

Agrin Acts via a MuSK Receptor Complex

P. Distefano, G. Yancopoulos, C. Radziejewski, 1996, Cell.

CARD9 Is a Novel Caspase Recruitment Domain-containing Protein That Interacts With BCL10/CLAP and Activates NF-κB*

J. Bertin, P. Distefano, S. Srinivasula, 2000, The Journal of Biological Chemistry.

Expression and possible function of nerve growth factor receptors on Schwann cells

P. Distefano, Eugene M. Johnson, M. Taniuchi, 1988, Trends in Neurosciences.

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

J. Bertin, P. Distefano, D. Philpott, 2003, Science.

Neurotrophic factors: from molecule to man

Stanley J. Wiegand, Ronald M. Lindsay, P. Distefano, 1994, Trends in Neurosciences.

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

P. Distefano, W. Catterall, T. Scheuer, 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.

TRPV3 is a calcium-permeable temperature-sensitive cation channel

David E. Clapham, Rory Curtis, D. Clapham, 2002, Nature.

Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat

P. Distefano, K. D. Cliffer, J. Siuciak, 1998, Annals of neurology.

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

John Bertin, J. Bertin, P. Distefano, 2004, Nature Immunology.

CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

J. Bertin, P. Distefano, G. Stark, 2001 .

Genome-Wide RNAi Screen Identifies Letm 1 as a Mitochondrial Ca 2 + / H + Antiporter

P. Distefano, G. O'Connor, R. Curtis, 2009 .

Substrate-specific Activation of Sirtuins by Resveratrol*

S. Fields, B. Kennedy, P. Distefano, 2005, Journal of Biological Chemistry.

Differential Modulation of Sodium Channel Gating and Persistent Sodium Currents by the β1, β2, and β3 Subunits

P. Distefano, W. Catterall, K. Gilbride, 2001, Molecular and Cellular Neuroscience.

The 24-hour respiratory quotient predicts energy intake and changes in body mass.

P. Distefano, K. Longo, T. McDonagh, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB*

Emad S. Alnemri, Jean-Luc Poyet, Srinivasa M. Srinivasula, 2001, The Journal of Biological Chemistry.

Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury

P. Distefano, M. L. Beau, N. Copeland, 1995, Neuron.

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.

P. Distefano, G. Yancopoulos, N. Stahl, 1993, Science.

Sodium Channel β4, a New Disulfide-Linked Auxiliary Subunit with Similarity to β2

P. Distefano, W. Catterall, T. Scheuer, 2003, The Journal of Neuroscience.

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

Stanley J. Wiegand, Ronald M. Lindsay, P. Distefano, 1992, Neuron.

Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage

P. Distefano, R. Curtis, J. Solomon, 2006, Molecular and Cellular Biology.

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing*

J. Bertin, P. Distefano, Jill M. Grenier, 2002, The Journal of Biological Chemistry.

PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB*

J. Bertin, P. Distefano, J. Lora, 2002, The Journal of Biological Chemistry.

CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-κB*

Emad S. Alnemri, Jean-Luc Poyet, John Bertin, 2001, The Journal of Biological Chemistry.

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

J. Bertin, P. Distefano, Jill M. Grenier, 2002, FEBS letters.

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

P. Distefano, G. Yancopoulos, C. Radziejewski, 1991, Cell.

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

J. Bertin, P. Distefano, G. Stark, 2001, EMBO reports.

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

J. Apfeld, P. Distefano, G. O'Connor, 2004, Genes & development.

Chapter 4 Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury

P. Distefano, R. Curtis, 1994 .

Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury.

P. Distefano, R. Curtis, 1994, Progress in brain research.

Neuronal Injury Increases Retrograde Axonal Transport of the Neurotrophins to Spinal Sensory Neurons and Motor Neurons via Multiple Receptor Mechanisms

P. Distefano, K. D. Cliffer, R. Lindsay, 1998, Molecular and Cellular Neuroscience.

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

Pamela F. Jones, Greg Lemke, P. Distefano, 1995, Cell.

A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics

P. Campochiaro, P. Distefano, R. Curtis, 1998, Brain Research.

Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and Schwann cells in vitro

P. Distefano, R. Lindsay, R. Curtis, 2000, Brain Research.

Differential activation of NGF receptor and early response genes in neural crest-derived cells.

P. Distefano, J. Milbrandt, C. Matheny, 1992, Brain research. Molecular brain research.

Neurotrophin-3 Is Required for the Survival–Differentiation of Subsets of Developing Enteric Neurons

T. P. Rothman, P. Distefano, L. Tessarollo, 2001, The Journal of Neuroscience.

Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain

P. Distefano, K. Rhodes, M. Covarrubias, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Ageing and metabolism: drug discovery opportunities

P. Distefano, B. J. Geesaman, R. Curtis, 2005, Nature Reviews Drug Discovery.

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB*

J. Bertin, P. Distefano, K. Robison, 1999, The Journal of Biological Chemistry.

Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.

J. Bertin, P. Distefano, W. Huang, 2001, Biochemical and biophysical research communications.

Aging networks in Caenorhabditis elegans: AMP‐activated protein kinase (aak‐2) links multiple aging and metabolism pathways

P. Distefano, G. O'Connor, R. Curtis, 2006, Aging cell.

SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

P. Distefano, M. McBurney, T. McDonagh, 2010, Future medicinal chemistry.

Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency.

P. Distefano, K. Longo, J. Kopchick, 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Neurotropic factors, retrograde axonal transport and cell signalling.

P. Distefano, R. Curtis, 1994, Trends in cell biology.

Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase

B. Ozenberger, P. Distefano, Jill M. Grenier, 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Functional characterization of Narc 1, a novel proteinase related to proteinase K.

B. Ozenberger, P. Distefano, Jill M. Grenier, 2003, Archives of biochemistry and biophysics.

Kinetic Modulation of Kv4-Mediated A-Current by Arachidonic Acid Is Dependent on Potassium Channel Interacting Proteins

P. Distefano, K. Rhodes, M. Holmqvist, 2001, The Journal of Neuroscience.

Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins

R. Jaenisch, P. Distefano, G. Weskamp, 1995, Neuron.

Developmental regulation of human truncated nerve growth factor receptor

P. Distefano, M. Clagett-Dame, R. Loy, 1991, Annals of neurology.

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.

P. Distefano, G. Yancopoulos, D. Glass, 1996, Cold Spring Harbor symposia on quantitative biology.

Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease.

P. Tariot, P. Distefano, J. Miller, 1993, Archives of neurology.

Decreased accumulation of endogenous brain-derived neurotrophic factor against constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed rats

P. Distefano, A. Mizisin, J. Tonra, 1999, Neuroscience Letters.

BDNF Attenuates Functional and Structural Disorders in Nerves of Galactose‐fed Rats

P. Distefano, N. Calcutt, A. Mizisin, 1997, Journal of neuropathology and experimental neurology.

Monoclonal antibodies to the cell surface and a soluble form of the human nerve growth factor receptor

P. Distefano, M. Chao, M. Clagett-Dame, 1990, Journal of neuroscience research.

Localization of NGF receptors in normal and Alzheimer's basal forebrain with monoclonal antibodies against the truncated form of the receptor

P. Distefano, M. Clagett-Dame, R. Loy, 1990, Journal of neuroscience research.

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

C. Altar, P. Distefano, S. Wiegand, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.