C. Ioannides

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A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program.

D. Lewis, C. Ioannides, D. Parke, 1990, Mutagenesis.

Inhibition of rat hepatic aryl hydrocarbon hydroxylase activity by a series of 7-hydroxy coumarins: QSAR studies.

D. Lewis, C. Ioannides, D. Parke, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

Molecular dimensions of the substrate binding site of cytochrome P-448.

D. Lewis, C. Ioannides, D. Parke, 1986, Biochemical pharmacology.

Food, nutrition and chemical toxicity

C. Ioannides, D. Parke, R. Walker, 1993 .

Cytochromes P450 Metabolic and Toxicological Aspects

C. Ioannides, 1996 .

Neuroprotective Effects of 7-Geranyloxycinnamic Acid from Melicope lunu ankenda Leaves

C. Ioannides, N. Nordin, A. F. Abdull Razis, 2020, Molecules.

Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalysed mixed function oxidases in the rat: induction by 3-methylcholanthrene.

C. Ioannides, P. Lum, S. Walker, 1985, Toxicology.

An improved method for the extraction of mutagens from human urine and cooked meat using blue rayon.

C. Ioannides, V. Yoxall, Judith Wilson, 2004, Mutation research.

Effect of black tea intake on the excretion of mutagens in the urine of volunteers taking a beef meal.

C. Ioannides, V. R. Yoxall, Jacquie Bishop, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

COMPACT and ENACT Procedures in Predicting the Formation of Reactive Intermediates by Cytochrome P450 Metabolism

C. Ioannides, D. Parke, D. F. Lewis, 2007 .

An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients.

C. Ioannides, D. Anderson, T. Yu, 1998, Mutation research.

Drug–phytochemical interactions

C. Ioannides, 2003, InflammoPharmacology.

Mechanism of the protective action of n-acetylcysteine and methionine against paracetamol toxicity in the hamster

C. Ioannides, S. Pratt, 1985, Archives of Toxicology.

A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.

C. Ioannides, N. Coldham, M. Sauer, 2001, Biochemical pharmacology.

Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat

C. Ioannides, M. Clifford, L. J. King, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay.

C. Ioannides, Diana Anderson, M. Clifford, 2002, Mutation research.

Modulation of the mutagenicity of food carcinogens by oligomeric and polymeric procyanidins isolated from grape seeds: synergistic genotoxicity with N-nitrosopyrrolidine

C. Ioannides, M. Clifford, V. Cheynier, 2000 .

Differential modulation of the genotoxicity of food carcinogens by naturally occurring monomeric and dimeric polyphenolics

C. Ioannides, M. Clifford, C. Santos-Buelga, 2000, Environmental and molecular mutagenesis.

Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action.

C. Ioannides, R. Walker, A. Ayrton, 1988, Mutation research.

Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.

C. Ioannides, N. Coldham, M. Sauer, 2009, Chemico-biological interactions.

Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties.

C. Ioannides, A. F. Abdull Razis, N. Konsue, 2015, Asian Pacific journal of cancer prevention : APJCP.

Diaminonaphthalenes and related aminocompounds: mutagenicity, CYP1A induction and interaction with the Ah receptor.

D. Lewis, C. Ioannides, Y. Cheung, 1997, Toxicology.

The effects of nutrition on chemical toxicity.

C. Ioannides, D. Parke, 1994, Drug metabolism reviews.

Antimutagenic activity of tea: role of polyphenols

C. Ioannides, V. Yoxall, 2003, Current opinion in clinical nutrition and metabolic care.

Induction of cytochrome P 450 I and its influences in chemical carcinogenesis.

C. Ioannides, 1990, Biochemical Society transactions.

Antimutagenicity of ellagic acid towards the food mutagen IQ: investigation into possible mechanisms of action.

D. Lewis, C. Ioannides, R. Walker, 1992, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Proliferation of hepatic peroxisomes in rats following the intake of green or black tea.

C. Ioannides, M. Clifford, R. Walker, 1999, Toxicology letters.

Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity.

C. Ioannides, D. Parke, A. Ayrton, 1991, Biochemical pharmacology.

Pharmacokinetic interactions between herbal remedies and medicinal drugs

C. Ioannides, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

Role of metabolism in chemical toxicity.

Nico P. E. Vermeulen, C. Ioannides, N. Vermeulen, 1996 .

Xenobiotic-metabolizing enzyme systems and aging.

C. Ioannides, C. Barnett, 2000, Methods in molecular medicine.

Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape.

C. Ioannides, D. Pushparajah, Dfv Lewis, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Erratum to: A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase

C. Ioannides, E. Pagnotta, R. Iori, 2013, European Journal of Nutrition.

A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase

C. Ioannides, E. Pagnotta, R. Iori, 2012, European Journal of Nutrition.

Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.

C. Ioannides, N. Plant, M. Bagatta, 2012, Journal of agricultural and food chemistry.

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.

C. Ioannides, N. Plant, A. F. Abdull Razis, 2012, Molecular nutrition & food research.

Exposure to Isothiocyanates Suppresses Urinary Mutagenicity in Rats Treated With Heterocyclic Amine IQ: Lack of Association With CYP1 Activity

C. Ioannides, N. Coldham, M. Sauer, 2011, Nutrition and cancer.

4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent

C. Ioannides, E. Pagnotta, R. Iori, 2011, Archives of Toxicology.

Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.

C. Ioannides, M. Bagatta, R. Iori, 2011, Lung cancer.

Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.

C. Ioannides, N. Konsue, Nattaya Konsue, 2010, Toxicology.

Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.

C. Ioannides, M. Bagatta, R. Iori, 2010, Toxicology.

Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450

C. Ioannides, N. Konsue, 2010, Archives of Toxicology.

Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.

C. Ioannides, N. Konsue, Nattaya Konsue, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Induction of hepatic microsomal CYP4A activity and of peroxisomal β-oxidation by two non-steroidal anti-inflammatory drugs

D. Lewis, C. Ioannides, G. Gibson, 1994, Archives of Toxicology.

Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.

C. Ioannides, V. Yoxall, Judith Wilson, 2005, Mutagenesis.

Short-term black tea intake modulates the excretion of urinary mutagens in rats treated with 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ): role of CYP1A2 upregulation

C. Ioannides, D. A. Parker, V. Yoxall, 2004, Archives of Toxicology.

Cytochrome P450 expression and testosterone metabolism in the liver of deer.

C. Ioannides, N. Coldham, M. Sauer, 2003, Toxicology.

Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins.

C. Ioannides, M. Clifford, N. McArdle, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evidence for the presence of a microsomal NADH-dependent enzyme system that can bioactivate aromatic amines in the liver of rats and mice.

C. Ioannides, T. Marczylo, 1999, Toxicology.

Modulation of hepatic cytochrome P450 activity and carcinogen bioactivation by black and decaffeinated black tea.

C. Ioannides, M. Clifford, R. Walker, 1999, Environmental toxicology and pharmacology.

Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits.

C. Ioannides, A. Irizar, 1998, Toxicology.

Contribution of theafulvins to the antimutagenicity of black tea: their mechanism of action.

C. Ioannides, M. Clifford, F. Catterall, 1998, Mutagenesis.

Induction of the rat hepatic cytosolic arylamine oxidase by a series of polychlorinated biphenyls: association with the Ah locus.

C. Ioannides, T. Marczylo, 1997, Toxicology letters.

Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats.

C. Ioannides, P. Flatt, J. Snelling, 1996, Toxicology letters.

A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect.

C. Ioannides, M. Clifford, R. Walker, 1996, Mutagenesis.

CYP1 induction, binding to the hepatic aromatic hydrocarbon receptor and mutagenicity of a series of 11-alkoxy cyclopenta[a]phenanthren-17-ones: a structure activity relationship.

C. Ioannides, M. Coombs, G. Boyd, 1995, Toxicology.

Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus.

D. Lewis, C. Ioannides, M. Clifford, 1995, Biochimica et biophysica acta.

Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus.

C. Ioannides, A. Irizar, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.

C. Ioannides, A. Irizar, P. Flatt, 1995, European journal of pharmacology.

Evaluation of the antimutagenic potential of anthracene: in vitro and ex vivo studies.

C. Ioannides, R. Walker, A. Bu-Abbas, 1994, Mutation research.

Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes.

C. Ioannides, P. Flatt, C. Barnett, 1994, Journal of biochemical toxicology.

Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins.

C. Ioannides, S. Rudd, P. Flatt, 1993, Biochemical pharmacology.

Effects of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney.

C. Ioannides, D. Parke, J. Shavila, 1993, Biochemical pharmacology.

Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potency.

C. Ioannides, Y. Cheung, T. Gray, 1993, Toxicology.

The metabolism and activation of 15,16-dihydrocyclopenta[a]phenanthren-17-one by cytochrome P-450 proteins.

C. Ioannides, R. Harvey, R. Young, 1993, European journal of pharmacology.

Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: their role in diabetes-induced changes in cytochrome P450 proteins.

C. Ioannides, P. Flatt, C. Barnett, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes.

C. Ioannides, C. Bailey, P. Flatt, 1992, Biochemical pharmacology.

Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity.

C. Ioannides, C. Wolf, P. Flatt, 1992, Biochemical pharmacology.

Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: possible relationship to their carcinogenicity.

C. Ioannides, R. Walker, M. McFarlane, 1990, Toxicology.

Feprazone: an inducer of the P450 II B family of proteins in the rat.

D. Lewis, C. Ioannides, J. Chown, 1990, Journal of biochemical toxicology.

Induction of the rat hepatic microsomal mixed-function oxidases by cimetidine.

A. D. Rodrigues, C. Ioannides, D. Parke, 1989, Toxicology letters.

Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline.

A. D. Rodrigues, D. Lewis, C. Ioannides, 1989, European Journal of Biochemistry.

Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.

C. Ioannides, J. Trinick, R. Walker, 1988, Chemico-biological interactions.

Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities.

C. Ioannides, P. Flatt, C. Barnett, 1988, Biochimica et biophysica acta.

Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid.

C. Ioannides, R. Walker, A. Ayrton, 1988, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.

A. D. Rodrigues, D. Lewis, C. Ioannides, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity.

D. Lewis, C. Ioannides, R. Walker, 1987, Biochimica et biophysica acta.

Effects of brotizolam on mixed-function oxidases and glutathione metabolism in the rat.

H. A. Masson, C. Ioannides, D. Parke, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Induction of cytochrome P-448 activity as exemplified by the O-deethylation of ethoxyresorufin. Effects of dose, sex, tissue and animal species.

C. Ioannides, D. Parke, P. Lum, 1986, Biochemical pharmacology.

Cytochrome P-448 and the activation of toxic chemicals and carcinogens.

C. Ioannides, D. Parke, P. Lum, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibition of rat hepatic mixed function oxidases by antimalarial drugs: selectivity for cytochromes P-450 and P-448.

C. Ioannides, M. I. Thabrew, 1984, Chemico-biological interactions.

A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity.

C. Ioannides, D. Parke, M. Delaforge, 1983, Toxicology.

Xenobiotic conjugation systems in deer compared with cattle and rat.

C. Ioannides, M. Sauer, S. Sivapathasundaram, 2003, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices

D. Lewis, C. Ioannides, D. Skene, 2001, Journal of pineal research.

Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.

C. Ioannides, D. Parke, D. Lewis, 1998, Environmental health perspectives.

The substrate specificity of the rat hepatic cytosolic arylamine oxidase catalyzing the bioactivation of aromatic amines.

C. Ioannides, T. Marczylo, 1998, Cancer letters.

Erratum to: Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals

C. Ioannides, E. Masini, P. Mannaioni, 1998, Inflammation Research.

Effect of high fat diet on liver microsomal oxygenations in ferret.

C. Ioannides, D. Parke, J. Shavila, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

Hepatic mixed-function oxidases of ferret.

C. Ioannides, D. Parke, J. Shavila, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450.

A. D. Rodrigues, C. Ioannides, C. Wolf, 1988, Toxicology.

Alkoxyresorufin O-dealkylases: association with the murine Ah locus.

C. Ioannides, P. Lum, R. Mayer, 1986, Cancer letters.

Ligand-complex formation between cytochromes P-450 and P-448 and methylenedioxyphenyl compounds.

C. Ioannides, D. Parke, M. Delaforge, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

The modulation by arylamines of the in vitro formation of superoxide anion radicals and hydrogen peroxide by rat liver microsomes.

C. Ioannides, M. Manno, G. Gibson, 1985, Toxicology letters.

Interactions of safrole and isosafrole and their metabolites with cytochromes P-450.

C. Ioannides, D. Parke, M. Delaforge, 1985, Chemico-biological interactions.

Active metabolites in toxicology: the role of cytochrome P-448 and flavoprotein oxidases.

C. Ioannides, D. Parke, 1984, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Species variation in the metabolic activation of paracetamol to toxic intermediates: role of cytochromes p-450 and p-448.

C. Ioannides, D. Parke, C. M. Steele, 1983, Toxicology letters.

Selective inhibition of the safrole-induced mixed-function oxidase activities by 9-hydroxyellipticine.

C. Ioannides, D. Parke, M. Delaforge, 1982, Chemico-biological interactions.

Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats.

C. Ioannides, D. Parke, M. Delaforge, 1980, Chemico-biological interactions.

Contribution of phenols, quinones and reactive oxygen species to the mutagenicity of white grape juice in the Ames test.

C. Ioannides, M. Clifford, A. Patrineli, 1996, Food and Chemical Toxicology.

Adverse reactions of imidazole antifungal agents: computer graphic studies of cytochrome P-450 interactions.

A. D. Rodrigues, C. Ioannides, D. Parke, 1989, Journal of biochemical toxicology.

Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.

C. Ioannides, N. Konsue, 2010, Molecular nutrition & food research.

Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea.

C. Ioannides, M. Clifford, R. Walker, 1994, Carcinogenesis.

Isothiocyanates: A Chemical Class of Potential Nutraceuticals

C. Ioannides, N. Konsue, N. Hanlon, 2010 .

Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers.

C. Ioannides, N. Coldham, M. Sauer, 2009, Cancer letters.

Expression and inducibility of cytochrome P450 proteins in the liver of chick embryo

C. Ioannides, M. Machala, A. Irizar, 1996, Archives of Toxicology.

The role of nutrition in toxicology.

C. Ioannides, D. Parke, 1981, Annual review of nutrition.

Effects of black tea theafulvins on aflatoxin B(1) mutagenesis in the Ames test.

C. Ioannides, M. Clifford, F. Catterall, 2003, Mutagenesis.

Consumption of tea modulates the urinary excretion of mutagens in rats treated with IQ. Role of caffeine.

C. Ioannides, M. Clifford, N. McArdle, 1999, Mutation research.

Contribution of caffeine and flavanols in the induction of hepatic Phase II activities by green tea.

C. Ioannides, M. Clifford, R. Walker, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Metabolic activation of paracetamol by highly purified forms of cytochrome P-450.

H. A. Masson, C. Ioannides, G. Gibson, 1983, Research communications in chemical pathology and pharmacology.

The role of highly purified cytochrome P-450 isozymes in the activation of 4-aminobiphenyl to mutagenic products in the Ames test.

H. A. Masson, C. Ioannides, G. Gibson, 1983, Carcinogenesis.

Fractionation of green tea extracts: correlation of antimutagenic effect with flavanol content

C. Ioannides, M. Clifford, R. Walker, 1997 .

Evaluation of the contribution of flavanols and caffeine to the anticarcinogenic potential of tea.

M. Garg, C. Ioannides, N. Temple, 1999 .

Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates

C. Ioannides, D. Parke, COSTAS IOANNIDES, 1975, The Journal of pharmacy and pharmacology.

Effect of antioxidant flavonoids and a food mutagen on lymphocytes of a thalassemia patient without chelation therapy in the Comet assay.

C. Ioannides, A. Dhawan, D. Anderson, 2001, Teratogenesis, carcinogenesis, and mutagenesis.

Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis.

C. Ioannides, D. Parke, 1993, Drug metabolism reviews.

Nitrosamine carcinogenesis: rodent assays, quantitative structure-activity relationships, and human risk assessment.

C. Ioannides, D. Parke, R. Walker, 1997, Drug metabolism reviews.

Safety evaluations of food chemicals by "COMPACT". 1. A study of some acyclic terpenes.

D. Lewis, C. Ioannides, D. Parke, 1994, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The induction of P450 I proteins by aromatic amines may be related to their carcinogenic potential.

C. Ioannides, R. Walker, M. McFarlane, 1990, Carcinogenesis.

Determination of cytochrome P-448 activity in biological tissues.

C. Ioannides, D. Parke, P. Lum, 1984, The Biochemical journal.

Isothiocyanates and Xenobiotic Detoxification

C. Ioannides, A. F. Abdull Razis, N. Konsue, 2018, Molecular nutrition & food research.

A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism

C. Ioannides, N. Konsue, 2015, Drug metabolism reviews.

Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats

C. Ioannides, J. Trinick, P. Flatt, 1989, Diabetologia.

Induction of hepatic microsomal P450 I and IIB proteins by hyperketonaemia.

C. Ioannides, P. Flatt, C. Barnett, 1990, Biochemical pharmacology.

Mice convert melatonin to 6-sulphatoxymelatonin.

C. Ioannides, D. Skene, B. Middleton, 2006, General and comparative endocrinology.

Haloalkylamine-induced renal papillary necrosis: a histopathological study of structure-activity relationships.

C. Ioannides, J. Bridges, P. Grasso, 1991, International journal of experimental pathology.

Drug metabolism in the ferret: effects of age, sex and strain.

C. Ioannides, D. Parke, B. Sweatman, 1977, General pharmacology.

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats.

C. Ioannides, L. J. King, N. Kuhnert, 2010, Molecular nutrition & food research.

The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat.

C. Ioannides, N. Coldham, M. Sauer, 2009, Molecular nutrition & food research.

Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes.

C. Ioannides, C. Wolf, G. Gibson, 1990, The Biochemical journal.

Differential effects of chronic alcohol administration to rats on the activation of aromatic amines to mutagens in the Ames test.

C. Ioannides, C. M. Steele, 1986, Carcinogenesis.

Role of mixed-function oxidases in the formation of biological reactive intermediates.

C. Ioannides, D. Parke, 1981, Advances in experimental medicine and biology.

COMPARATIVE MUTAGENICITY STUDIES ON FRIED MINCED BEEF, GRILLED SAUSAGE AND GRILLED HAMBURGERS

C. Ioannides, R. Walker, A. Abu‐Shakra, 1988 .

Marked antimutagenic potential of aqueous green tea extracts: mechanism of action.

C. Ioannides, M. Clifford, R. Walker, 1994, Mutagenesis.

Enhancement of hepatic microsomal drug metabolism in vitro following ethanol administration.

C. Ioannides, D. Parke, B. Lake, 1975, Xenobiotica; the fate of foreign compounds in biological systems.

Mutagenicity and CYP1A induction by azobenzenes correlates with their carcinogenicity.

C. Ioannides, S. Puddicombe, Y. Cheung, 1994, Carcinogenesis.

Stability of Phase II Conjugation Systems in Cultured Precision-cut Rat Hepatic Slices.

C. Ioannides, E. Hashemi, C. Till, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Chapter 53 Activation mechanisms of chemical toxicity

C. Ioannides, 1997 .

Role of tissue glutathione in prevention of surgical trauma.

C. Ioannides, D. Parke, A. Symons, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

ELIMINATION OF GLYCERYL TRINITRATE: EFFECTS OF SEX, AGE, SPECIES AND ROUTE OF ADMINISTRATION

C. Ioannides, D. Parke, I. Taylor, 1982, British journal of pharmacology.

INDUCTION OF CYTOCHROME-P450III AND CYTOCHROME-P450IV FAMILY PROTEINS IN STREPTOZOTOCIN-INDUCED DIABETES

C. Ioannides, C. Wolf, G. Gibson, 1990 .

METABOLISM AND TOXICITY OF CHEMICALS IN DIABETES

C. Ioannides, 1990 .

Potential drug interactions with melatonin

C. Ioannides, D. Skene, E. Papagiannidou, 2014, Physiology & Behavior.

Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals

C. Ioannides, E. Masini, P. Mannaioni, 1998, Inflammation Research.

Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor.

C. Ioannides, D. Pushparajah, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Precision‐Cut Tissue Slices: A Suitable In Vitro System for the Study of the Induction of Drug‐Metabolizing Enzyme Systems

C. Ioannides, B. Lake, 2012 .

The natural chemopreventive phytochemical R‐sulforaphane is a far more potent inducer of the carcinogen‐detoxifying enzyme systems in rat liver and lung than the S‐isomer

C. Ioannides, R. Iori, A. F. Abdull Razis, 2011, International journal of cancer.

Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung.

C. Ioannides, N. Plant, K. Plant, 2008, Mutagenesis.

Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities.

C. Ioannides, N. Plant, K. Plant, 2007, Toxicology.

Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h.

C. Ioannides, M. Umachandran, 2006, Toxicology.

The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites.

J. Ashby, J. Styles, C. Ioannides, 1983, Toxicology letters.

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size.

D. Lewis, C. Ioannides, N. Plant, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships.

D. Lewis, C. Ioannides, D. Parke, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

A rationale for the non-mutagenicity of 2- and 3-aminobiphenyls.

D. Lewis, C. Ioannides, J. Trinick, 1989, Carcinogenesis.

The 1990 Pharmaceutical Manufacturers Association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals.

D. Lewis, C. Ioannides, D. Parke, 1991, Canadian journal of physiology and pharmacology.

Molecular pathology of drug-disease interactions in chronic autoimmune inflammatory diseases

D. Lewis, C. Ioannides, D. Parke, 1991, InflammoPharmacology.

Improvement of barbiturate gas chromatography by formic acid: Possible mechanism

C. Ioannides, D. Parke, J. Chakraborty, 1974 .

Structural requirements for substrates of cytochromes P-450 and P-448.

C. Ioannides, D. Parke, D. F. Lewis, 1987, Chemico-biological interactions.

Impairment of absorption of ascorbic acid following ingestion of aspirin in guinea pigs.

C. Ioannides, T. K. Basu, A. N. Stone, 1982, Biochemical pharmacology.

The Effect of Ethanol Administration on Drug Oxidations and Possible Mechanism of Ethanol-Barbiturate Interactions

C. Ioannides, D. Parke, 1973 .

Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins.

A. D. Rodrigues, C. Ioannides, D. Parke, 1987, Biochemical pharmacology.

Inhibition of gastrointestinal mucosal glycoprotein synthesis by the beta-adrenergic blocking drug, practolol.

C. Ioannides, D. Parke, L. Okine, 1982, Biochemical pharmacology.

Extrapolation of in vitro antimutagenicity to the in vivo situation: the case for anthraflavic acid.

D. Lewis, C. Ioannides, R. Walker, 1993, Basic life sciences.

Mechanism of the ketoconazole-cyclosporin interaction

C. Ioannides, L. J. King, E. Ah-Sing, 2005, Archives of Toxicology.

Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells

C. Ioannides, R. Iori, A. F. Abdull Razis, 2018, Nutrients.

Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus.

C. Ioannides, R. Walker, C. Papaparaskeva-Petrides, 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acute toxicity of 3-deoxy-4-sulphohexosulose in rats and mice, and in vitro mutagenicity in the Ames test.

C. Ioannides, R. Walker, M. Mendoza-Garcia, 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The metabolism and bioactivation of agaritine and of other mushroom hydrazines by whole mushroom homogenate and by mushroom tyrosinase.

C. Ioannides, R. Walker, M. Coombs, 2001, Toxicology.

Bioactivation of mushroom hydrazines to mutagenic products by mammalian and fungal enzymes.

C. Ioannides, R. Walker, M. Coombs, 1997, Mutation research.

Bioactivation of the mushroom hydrazine, agaritine, to intermediates that bind covalently to proteins and induce mutations in the Ames test.

C. Ioannides, R. Walker, M. Coombs, 1997, Carcinogenesis.

Fate of the Mushroom Hydrazine Agaritine in the Rat and Mouse

C. Ioannides, L. J. King, R. Walker, 2000, Nutrition and cancer.

Effect of baking and freeze-drying on the direct and indirect mutagenicity of extracts from the edible mushroom Agaricus bisporus.

C. Ioannides, R. Walker, K. Walton, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Agaritine does not mediate the mutagenicity of the edible mushroom Agaricus bisporus.

C. Ioannides, R. Walker, C. Papaparaskeva, 1991, Mutagenesis.

Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450.

C. Ioannides, D. Parke, M. Delaforge, 1981, Food and cosmetics toxicology.

Nutrition and chemical toxicity

C. Ioannides, 1998 .

The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens.

C. Ioannides, D. Parke, C. E. Phillipson, 1985, The International journal of biochemistry.

Bioactivation of chemicals by cytochromes P 450 3 Cytochromes

C. Ioannides, 2007 .

Molecular orbital studies of oxygen activation and mechanisms of cytochromes P-450-mediated oxidative metabolism of xenobiotics.

C. Ioannides, D. Parke, D. F. Lewis, 1989, Chemico-biological interactions.

Prediction of chemical carcinogenicity from molecular and electronic structures: a comparison of MINDO/3 and CNDO/2 molecular orbital methods.

C. Ioannides, D. Parke, D. F. Lewis, 1989, Toxicology letters.

Quantitative structure–activity relationships in a series of endogenous and synthetic steroids exhibiting induction of CYP3A activity and hepatomegaly associated with increased DNA synthesis

C. Ioannides, D. Parke, R. Schulte‐Hermann, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448.

C. Ioannides, D. Parke, C. Parkinson, 1981, Xenobiotica; the fate of foreign compounds in biological systems.

Cytochrome p450 expression in the liver of food-producing animals.

C. Ioannides, 2006, Current drug metabolism.

Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality

C. Ioannides, M. Bagatta, R. Iori, 2011, Archives of Toxicology.

Erratum to: Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals

C. Ioannides, E. Masini, P. Mannaioni, 1998, Inflammation Research.

Induction of Apoptosis and Cytotoxicity by Raphasatin in Human Breast Adenocarcinoma MCF-7 Cells

C. Ioannides, R. Iori, A. F. Abdull Razis, 2018, Molecules.

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

C. Ioannides, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor

C. Ioannides, N. Plant, R. Iori, 2012, Archives of Toxicology.

Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane.

C. Ioannides, N. Coldham, M. Sauer, 2008, Journal of agricultural and food chemistry.

Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat

C. Ioannides, L. J. King, N. Coldham, 2008, British Journal of Nutrition.

Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity

C. Ioannides, N. Coldham, M. Sauer, 2005, International journal of cancer.

Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures.

C. Ioannides, M. Dobrota, E. Hashemi, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Cytosolic activation of 2-aminoanthracene: implications in its use as diagnostic mutagen in the Ames test.

C. Ioannides, A. Ayrton, S. Neville, 1992, Mutation research.

Mechanism of the in vitro antimutagenic action of retinol.

D. Lewis, C. Ioannides, R. Walker, 1990, Mutagenesis.

The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals.

C. Ioannides, D. Parke, 1990, Drug metabolism reviews.

A comparison of bisoprolol and atenolol in the treatment of mild to moderate hypertension.

C. Ioannides, D. McDevitt, R. Lewis, 1988, British journal of clinical pharmacology.

The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis.

C. Ioannides, D. Parke, C Ioannides, 1987, Biochemical pharmacology.

Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTP.

D. Lewis, C. Ioannides, D. Parke, 1993, Mutation research.

The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis.

C. Ioannides, D. Parke, 1976, Chemico-biological interactions.

Micro determination of glyceryl trinitrate in biological fluids; effect of deuteration of glyceryl trinitrate on its pharmacokinetic properties

C. Ioannides, D. Parke, R. U. Koenigsberger, 1981, The Journal of pharmacy and pharmacology.

Cytochromes P450 in the bioactivation of chemicals.

D. Lewis, C. Ioannides, 2004, Current topics in medicinal chemistry.

Enzyme Systems that Metabolise Drugs and Other Xenobiotics

C. Ioannides, 2001 .

Functional integrity of precision-cut liver slices from deer and cattle.

C. Ioannides, M. Sauer, S. Sivapathasundaram, 2004, Journal of veterinary pharmacology and therapeutics.

Studies on the possible mutagenicity of β-adrenergic blocker drugs

C. Ioannides, D. Parke, L. Okine, 1983 .

Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D.

C. Ioannides, D. Parke, B. Lake, 1994, Drug metabolism reviews.

Metabolic Activation of Carcinogens and Toxic Chemicals

C. Ioannides, D F Lewis, C Ioannides, 1988, Human toxicology.

Effect of diet and nutrition on the expression of cytochromes P450.

C. Ioannides, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Impact of diseases on detoxication

C. Ioannides, K. Renton, R. A. Blouin, 1999, Journal of biochemical and molecular toxicology.

Effect of some beta-adrenergic blocking agents on tissue guanylate cyclase and cyclic nucleotides in the rat.

C. Ioannides, D. Parke, L. Okine, 1983, Toxicology letters.

Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes

C. Ioannides, B. Cooke, M. Hall, 2012, Drug Metabolism and Disposition.

Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction.

C. Ioannides, J. Smith, A. Ayrton, 1987, Carcinogenesis.

Safety evaluation of nitrosatable drugs and chemicals

C. Ioannides, G. Gibson, 1981 .

Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices.

C. Ioannides, N. Plant, K. Plant, 2008, Mutation research.

Handbook of pharmacokinetics : toxicity assessment of chemicals

C. Ioannides, J. Labaune, G. Tyas, 1989 .

A comparative study of the bioactivation of nitrosamines to mutagens by various animal species including man.

C. Ioannides, C. E. Phillipson, 1984, Carcinogenesis.

Mutagenicity testing of 9-N-substituted adenines and their N-oxidation products.

C. Ioannides, C Ioannides, J W Gorrod, 1993, Environmental health perspectives.

COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.

C. Ioannides, D. Parke, D F Lewis, 1996, Environmental health perspectives.

Bioactivation of chemicals by cytochromes P450

C. Ioannides, 2007 .

Cytochromes P 450 in the Bioactivation of Chemicals

D. Lewis, C. Ioannides, 2004 .

Expression and inducibility of cytochrome P450 proteins belonging to families 2,3 and 4 in the rabbit aorta.

C. Ioannides, A. Irizar, 1995, Biochemical and biophysical research communications.

Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man.

C. Ioannides, C. E. Phillipson, 1989, Mutation research.

Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane.

C. Ioannides, N. Coldham, M. Sauer, 2008, Toxicology.

Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices.

C. Ioannides, J. V. van Delft, F. V. van Schooten, 2008, Mutagenesis.

Modulation of gene expression and DNA-adduct formation in precision-cut liver slices exposed to polycyclic aromatic hydrocarbons of different carcinogenic potency.

C. Ioannides, J. V. van Delft, F. V. van Schooten, 2007, Mutagenesis.

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision‐cut rat liver slices

C. Ioannides, N. Plant, K. Plant, 2017, Environmental toxicology.

The in vitro metabolic activation of the 11-trifluoromethyl analogue of the potent carcinogen 15,16-dihydro-11-methyl-cyclopenta[a]-phenanthren-17-one to mutagens.

C. Ioannides, H. Zepik, M. Coombs, 1993, Carcinogenesis.

Effect of 2-amino-9H-pyrido[2,3-b]indole (AalphaC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice.

C. Ioannides, E. Oviedo-Orta, A. Bermúdez-Fajardo, 2009, Toxicology letters.

Induction of the hepatic mixed-function oxidases by Aroclor 1254 in the hamster: comparison of Aroclor-induced rat and hamster preparations in the activation of pre-carcinogens in the Ames test.

C. Ioannides, R. Hyde, J. Smith, 1987, Mutagenesis.

Cytosolic potentiation of the rat hepatic microsome mediated mutagenicity of benzidine.

C. Ioannides, J. Smith, 1987, Mutagenesis.

Induction of rat hepatic mixed function oxidases by aromatic amines and its relationship to their bioactivation to mutagens.

C. Ioannides, C. M. Steele, Steele Cm, 1986, Mutation research.

Activation of aromatic amines to mutagens by various animal species including man.

C. Ioannides, C. E. Phillipson, 1983, Mutation research.

Metabolic activation of dimethylnitrosamine to mutagens: role of cytochromes P-450 and P-448.

C. Ioannides, D. Parke, C. E. Phillipson, 1982, Toxicology letters.

An improved and updated version of the compact procedure for the evaluation of P450-mediated chemical activation.

C. Ioannides, D. Parke, D. F. Lewis, 1998, Drug metabolism reviews.

Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes. A comparison with their non-heterocyclic analogues.

C. Ioannides, J. Trinick, J. Smith, 1988, Biochemical pharmacology.

Metabolism of 2-amino-3-methylimidazol [4,5,f]quinoline by precision-cut rat liver slices

C. Ioannides, D. Stevenson, N. Kuhnert, 2007 .

Mutagenicity of white grape juice in the Ames test.

C. Ioannides, M. Clifford, R. Walker, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Computer modelling and in vitro tests in the safety evaluation of chemicals-Strategic applications.

C. Ioannides, D. Parke, D F Lewis, 1990, Toxicology in vitro : an international journal published in association with BIBRA.

Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices.

C. Ioannides, E. Hashemi, C. Till, 2000, Toxicology.

Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens.

C. Ioannides, P. Flatt, C. Barnett, 1990, Chemico-biological interactions.

Single oral dose pharmacokinetics of bisoprolol 10 mg in liver disease.

C. Ioannides, P. Thomas, D. Jenkins, 1987, European heart journal.

The single dose pharmacokinetics of bisoprolol (10 mg) in renal insufficiency: the clinical significance of balanced clearance.

C. Ioannides, J. Fox, P. Thomas, 1987, European heart journal.

Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases.

C. Ioannides, D. Parke, I. Taylor, 1989, The International journal of biochemistry.

4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent

C. Ioannides, E. Pagnotta, R. Iori, 2012, Archives of Toxicology.

A Study of the Mutagenicity of Melatonin and 6‐Hydroxymelatonin

C. Ioannides, J. Arendt, S. Neville, 1989, Journal of pineal research.

Stimulation of rat hepatic UDP-glucuronosyl transferase activity following treatment with green tea.

C. Ioannides, M. Clifford, R. Walker, 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of the mutagenicity of aromatic amines by the plant flavonoid (+)-catechin.

C. Ioannides, M. Lalies, C. M. Steele, 1985, Cancer research.

POTENTIAL ANTI-MUTAGENICITY AND ANTI-CARCINOGENICITY OF SOME PLANT PHENOLS

C. Ioannides, R. Walker, A. Ayrton, 1993 .

Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobiotics

C. Ioannides, 2008 .

Studies on the substrate-binding sites of liver microsomal cytochrome P-448.

C. Ioannides, D. Parke, M. Delaforge, 1982, The Biochemical journal.

METABOLIC-ACTIVATION OF POLYCYCLIC AROMATIC-HYDROCARBONS

C. Ioannides, 1988 .

Quantitative structure-activity relationships and COMPACT analysis of a series of food mutagens.

D. Lewis, C. Ioannides, D. Parke, 1995, Food additives and contaminants.