D. Guertin

发表

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Anne E Carpenter, In Han Kang, P. Golland, 2006, Genome Biology.

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells

Anne E Carpenter, D. Guertin, D. Sabatini, 2004, Nature Methods.

David M Sabatini, D. Guertin, D. Sabatini, 2005, Trends in molecular medicine.

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

D. Guertin, D. Sabatini, H. Erdjument-Bromage, 2004, Current Biology.

Cytokinesis in Eukaryotes

D. Guertin, D. McCollum, S. Trautmann, 2002, Microbiology and Molecular Biology Reviews.

The role of the Sid1p kinase and Cdc14p in regulating the onset of cytokinesis in fission yeast

K. Gould, D. Guertin, D. McCollum, 2000, The EMBO journal.

Interaction between the Noncatalytic Region of Sid1p Kinase and Cdc14p Is Required for Full Catalytic Activity and Localization of Sid1p*

D. Guertin, D. McCollum, 2001, The Journal of Biological Chemistry.

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).

K. Gould, D. Guertin, D. McCollum, 2002, Developmental cell.

De Novo Lipogenesis as a Source of Second Messengers in Adipocytes

D. Guertin, W. Hsiao, 2019, Current Diabetes Reports.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Christian M. Metallo, D. Guertin, S. Gujja, 2018, Cell metabolism.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

Christian M. Metallo, D. Guertin, D. Nomura, 2018, Nature Chemical Biology.

Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue

D. Guertin, S. Fried, Mi-Jeong Lee, 2016, Molecular metabolism.

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

D. Guertin, Cholsoon Jang, Su Myung Jung, 2021, Cell reports.

The Complex Roles of mTOR in Adipocytes and Beyond

D. Guertin, Su Myung Jung, P. Lee, 2017 .

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

D. Guertin, Su Myung Jung, Peter L. Lee, 2017, Trends in Endocrinology & Metabolism.

Metabolic Network 1-3-2017 Amplification of Adipogenic Commitment by VSTM 2 A Blandine Secco

D. Guertin, M. Laplante, Blandine Secco, 2017 .

Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

S. Armstrong, D. Guertin, D. Scadden, 2011 .

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.

K. Kaestner, D. Guertin, D. Sabatini, 2011, Cell metabolism.

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

D. Guertin, L. Zhu, K. Wellen, 2020, Cell reports.

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

S. Armstrong, D. Guertin, D. Scadden, 2012, Cell stem cell.

Raptor / mTORC 1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

D. Guertin, Yuefeng Tang, Peter L. Lee, 2017 .

Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

D. Guertin, Yuefeng Tang, Peter L. Lee, 2016, Molecular metabolism.

Lamming and Uncoupled from Longevity Rapamycin-Induced Insulin Resistance Is Mediated by mTORC 2 Loss

D. Guertin, D. Sabatini, P. Katajisto, 2012 .

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

D. Guertin, A. Kettenbach, Su Myung Jung, 2022, The Journal of biological chemistry.

signaling S 6 K pathway − TORC 1 Drosophila melanogaster regulators of Genome-scale RNAi on living-cell microarrays identifies novel Material Supplemental

Anne E Carpenter, Katherine L. Madden, T. Jones, 2011 .

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.

D. Guertin, H. Chi, G. Neale, 2013, Immunity.

Oncogenic AKTivation by methylation

D. Guertin, A. Luciano, 2019, Nature Cell Biology.

mTORC1 gRABs the Golgi.

D. Guertin, J. Sanchez-Gurmaches, 2014, Cancer cell.

Author Correction: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

D. Guertin, J. Villén, K. Wellen, 2020, Nature Communications.

Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics.

D. Guertin, J. Cotton, Huawei Li, 2012, Methods in molecular biology.

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Dudley Lamming, D. Guertin, D. Sabatini, 2012, Science.

Insulin PACS a Punch in SIRT1 Activity.

D. Guertin, Su Myung Jung, 2018, Molecules and Cells.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

D. Guertin, J. Moffat, D. Sabatini, 2006, Developmental cell.

A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis

D. Guertin, R. Friedline, L. Zhu, 2022, Nature communications.

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

D. Guertin, D. Sabatini, Siraj M. Ali, 2005, Science.

Defining the role of mTOR in cancer.

David M Sabatini, D. Guertin, D. Sabatini, 2007, Cancer cell.

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Anne E Carpenter, Katherine L. Madden, D. Guertin, 2011, Cell.

Spatiotemporal structure of cell fate decisions in murine neural crest

Chika Yokota, Christoph Bock, Peter V. Kharchenko, 2019, Science.

Adipocyte lineages: tracing back the origins of fat.

D. Guertin, J. Sanchez-Gurmaches, 2014, Biochimica et biophysica acta.

PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.

D. Guertin, Yuefeng Tang, C. A. Sparks, 2012, Cell metabolism.

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

D. Guertin, D. Sabatini, Hong Wu, 2009, Cancer cell.

mTOR-dependent cell survival mechanisms.

D. Guertin, C. A. Sparks, Luisa García-Haro, 2012, Cold Spring Harbor perspectives in biology.

Brown Adipose Tissue Development and Metabolism.

D. Guertin, J. Sanchez-Gurmaches, S. M. Jung, 2019, Handbook of experimental pharmacology.

Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division

D. Guertin, D. Sabatini, G. Bell, 2006, Current Biology.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Anne E Carpenter, David M Sabatini, Thouis R Jones, 2011, Genome research.

The Pharmacology of mTOR Inhibition

D. Guertin, D. Sabatini, 2009, Science Signaling.

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6

D. Guertin, J. Qi, J. Bradner, 2015, Nucleic acids research.

Chapter 12 – Cell Growth

D. Guertin, D. Sabatini, 2008 .

7 Growth Control through the mTOR Network

D. Guertin, D. Sabatini, Do-Hyung Kim, 2004 .

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

D. Guertin, C A Sparks, D A Guertin, 2010, Oncogene.

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

A. Colman-Lerner, D. Guertin, M. Gaestel, 2021, Frontiers in Cell and Developmental Biology.

Initiation of Cytokinesis Is Controlled through Multiple Modes of Regulation of the Sid2p-Mob1p Kinase Complex

D. Guertin, D. McCollum, M. Hou, 2004, Molecular and Cellular Biology.

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

D. Guertin, J. Spinelli, Peter Cruz-Gordillo, 2023, bioRxiv.

Rictor / mTORC 2 Loss in the Myf 5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease

D. Guertin, A. Wagers, C. Clish, 2017 .

Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.

D. Guertin, A. Wagers, C. Clish, 2014, Cell reports.

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Christian M. Metallo, D. Guertin, C. Metallo, 2016, Nature Communications.

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells

Christine M. Miller, D. Guertin, R. Bronson, 2011, Proceedings of the National Academy of Sciences.

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

D. Guertin, J. Sanchez-Gurmaches, 2014, Nature Communications.

A novel batokine Breg controls adipose thermogenesis and glucose homeostasis

D. Guertin, L. Zhu, Yong-Xu Wang, 2022, bioRxiv.

Acetyl-CoA metabolism in cancer

D. Guertin, K. Wellen, 2023, Nature Reviews Cancer.

Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling*

D. Guertin, R. T. Lawrence, C. Hung, 2020, Molecular & Cellular Proteomics.

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

D. Guertin, K. Wellen, S. Trefely, 2020, Nature Communications.

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

D. Guertin, K. Wellen, S. Trefely, 2020, Nature Communications.

Cold-Induced Thermogenesis Increases Acetylation on the Brown Fat Proteome and Metabolome

D. Guertin, R. T. Lawrence, M. Czech, 2018, bioRxiv.

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Christian M. Metallo, John M. Viola, D. Guertin, 2019, Cell reports.

Emerging Complexities in Adipocyte Origins and Identity.

D. Guertin, C. Hung, J. Sanchez-Gurmaches, 2016, Trends in cell biology.

Amplification of Adipogenic Commitment by VSTM2A

Y. Bossé, D. Guertin, E. Haddad, 2017, Cell reports.

Integrating adipocyte insulin signaling and metabolism in the multi-omics era.

D. Guertin, D. Fazakerley, C. M. Calejman, 2022, Trends in biochemical sciences.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

Christian M. Metallo, D. Guertin, Bárbara Martínez-Pastor, 2019, Molecular cell.

Brown fat organogenesis and maintenance requires AKT1 and AKT2

D. Guertin, J. Sanchez-Gurmaches, C. Martínez Calejman, 2019, Molecular metabolism.

Highly Selective In Vivo Labeling of Subcutaneous White Adipocyte Precursors with Prx1-Cre

D. Guertin, W. Hsiao, J. Sanchez-Gurmaches, 2015, Stem cell reports.

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

D. Guertin, M. Poidinger, N. Ketheesan, 2019, EBioMedicine.

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

D. Guertin, J. Spinelli, K. Sarosiek, 2023, bioRxiv.

CellProfiler : image analysis software for identifying and quantifying cell phenotypes Citation

Anne E Carpenter, In Han Kang, P. Golland, 2006 .

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis

D. Guertin, Cholsoon Jang, J. Spinelli, 2023, Nature Metabolism.

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females Maintain Metabolic Homeostasis in Females

Christian M. Metallo, John M. Viola, D. Guertin, 2021 .

Escholarship@umms Cell and Developmental Biology Publications and Presentations Cell and Developmental Biology Transcriptional and Post-transcriptional Control of Adipocyte Differentiation by Jumonji Domain- Containing Protein 6 Repository Citation Transcriptional and Post-transcriptional Control of

D. Guertin, J. Qi, J. Bradner, 2022 .

A new era of understanding in vivo metabolic flux in thermogenic adipocytes.

D. Guertin, John A Haley, Cholsoon Jang, 2023, Current opinion in genetics & development.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Christian M. Metallo, D. Guertin, C. Schéele, 2018, Cell metabolism.

Brown Adipose Tissue Development and Metabolism.

D. Guertin, J. Sanchez-Gurmaches, Su Myung Jung, 2019, Handbook of experimental pharmacology.

Adipocyte lineages: tracing back the origins of fat.

D. Guertin, J. Sanchez-Gurmaches, 2014, Biochimica et biophysica acta.

Cell Size Control

D. Guertin, D. Sabatini, 2006 .

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Christian M. Metallo, John M. Viola, D. Guertin, 2019, Cell reports.

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

D. Guertin, D. Sabatini, H. Erdjument-Bromage, 2004, Current Biology.

Mtor Complex 1 Regulates Lipin 1 Localization to Control the Srebp Pathway

Katherine L. Madden, D. Guertin, T. Harris, 2022 .

Mtor Complex 1 Regulates Lipin 1 Localization to Control the Srebp Pathway

Katherine L. Madden, D. Guertin, T. Harris, 2022 .

Ampliﬁcation of Adipogenic Commitment by VSTM2A

D. Guertin, Kıvanç Birsoy, Blandine Secco, 2022 .

Adipose tissue mTORC2 regulates ChREBP-driven de novo Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism lipogenesis and hepatic glucose metabolism how to this benefits you.

Christian M. Metallo, D. Guertin, W. Hsiao, 2022 .

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Metabolism and Protects Mice against Obesity and Metabolic Disease Disease

D. Guertin, C. Clish, C. M. Calejman, 2022 .

Adipose Tissue Mtorc2 Regulates Chrebp- Driven De Novo Lipogenesis and Hepatic Glucose Metabolism Repository Citation

Christian M. Metallo, D. Guertin, W. Hsiao, 2022 .

Stable Isotope Tracing and Metabolomics to Study In Vivo Brown Adipose Tissue Metabolic Fluxes.

D. Guertin, Cholsoon Jang, Grace Park, 2022, Methods in molecular biology.