J. Santos-Sacchi

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Auditory collusion and a coupled couple of outer hair cells

Hong-Bo Zhao, J. Santos-Sacchi, 1999, Nature.

Chapter 25 – Audition

J. Santos-Sacchi, M. C. Brown, M. C. Brown, 2013 .

An evaluation of normal strial capillary transport using the electron-opaque tracers ferritin and iron dextran.

J. Santos-Sacchi, W. Marovitz, 1980, Acta oto-laryngologica.

Whole cell currents and mechanical responses of isolated outer hair cells

J. Santos-Sacchi, J. Dilger, J Santos-Sacchi, 1988, Hearing Research.

Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ

J. Santos-Sacchi, Lei Song, 2011 .

Prestin's anion transport and voltage-sensing capabilities are independent.

J. Santos-Sacchi, P. Aronson, J. Bai, 2009, Biophysical journal.

Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation

J. Santos-Sacchi, S. Kleinstein, Mohamed Uduman, 2010, PloS one.

Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.

J. Santos-Sacchi, Xian-Tao Li, Alexei A. Surguchev, 2012, American journal of physiology. Cell physiology.

Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish

J. Santos-Sacchi, Lei Song, D. Zenisek, 2013, The Journal of Neuroscience.

Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ

J. Santos-Sacchi, S. Maune, Sakaorat Blasits, 2000, Pflügers Archiv.

A re-evaluation of cell coupling in the organ of Corti

J. Santos-Sacchi, 1984, Hearing Research.

Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss

J. Santos-Sacchi, 2022, bioRxiv.

Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point

J. Santos-Sacchi, W. Tan, Winston J. T. Tan, 2021, Hearing Research.

Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion

J. Santos-Sacchi, Lei Song, J. Bai, 2020, Neuroscience.

The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin

J. Santos-Sacchi, W. Tan, Winston J. T. Tan, 2018, The Journal of Neuroscience.

Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse

J. Santos-Sacchi, D. Navaratnam, H. Shinkawa, 2007, Journal of Membrane Biology.

The still magnificent outer hair cell

J. Santos-Sacchi, 2007 .

Temperature dependence of non-linear capacitance in human embryonic kidney cells transfected with prestin, the outer hair cell motor protein

J. Santos-Sacchi, J. Meltzer, 2001, Neuroscience Letters.

Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice

J. Santos-Sacchi, B. Ehrlich, E. Bilsky, 2021, Scientific Reports.

A Two-Channel Patch-Clamp System on a Chip

E. Culurciello, J. Santos-Sacchi, F. Sigworth, 2010 .

MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium

J. Santos-Sacchi, D. Navaratnam, Corey S. Frucht, 2011, Neuroscience Letters.

An electronmicroscopic study of microtubules in the development of marginal cells of the mouse stria vascularis

J. Santos-Sacchi, 1982, Hearing Research.

Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

Amanda M. Lauer, Maxwell D. Sanderford, J. Santos-Sacchi, 2020, Current Biology.

Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ

Hong-Bo Zhao, J. Santos-Sacchi, 1998, The Journal of general physiology.

Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigm

J. Kong, J. Santos-Sacchi, M. Castellano-Muñoz, 2011, Communicative & integrative biology.

Induction of the acrosome reaction in guinea pig spermatozoa by cGMP analogues

J. Santos-Sacchi, M. Gordon, 1980, The Journal of cell biology.

Cochlear Mechanics: No Shout but a Twist in the Absence of Prestin

J. Santos-Sacchi, 2008, Current Biology.

Electrical coupling differs in the in vitro and in vivo organ of Corti

J. Santos-Sacchi, 1987, Hearing Research.

Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2

J. Santos-Sacchi, Yukihiro Sato, 1994, Hearing Research.

Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism.

J. Santos-Sacchi, T. Pozzan, R. Fiorotto, 2005, Gastroenterology.

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.

J. Santos-Sacchi, J. Liao, D. Zenisek, 2016, Cell reports.

Calcium-Dependent Synaptic Vesicle Trafficking Underlies Indefatigable Release at the Hair Cell Afferent Fiber Synapse

J. Kong, J. Santos-Sacchi, M. Castellano-Muñoz, 2011, Neuron.

Determination of cell capacitance using the exact empirical solution of partial differential Y/partial differential Cm and its phase angle.

J. Santos-Sacchi, 2004, Biophysical journal.

Immunocytochemical demonstration of astrocytes in the eighth cranial nerve of the red-eared turtle

J. Santos-Sacchi, Debra A. Marbey, 1986, Experimental Neurology.

A ferritin-containing cell type in the stria vascularis of the mouse inner ear.

J. Santos-Sacchi, W. Marovitz, 1985, Acta oto-laryngologica.

Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity

J. Santos-Sacchi, D. Navaratnam, S. Bian, 2013, PloS one.

The temperature dependence of electrical coupling in the organ of Corti

J. Santos-Sacchi, 1986, Hearing Research.

Tuning in to the Amazing Outer Hair Cell: Membrane Wizardry with a Twist and Shout

J. Santos-Sacchi, F. Kalinec, S. Kakehata, 2006, The Journal of Membrane Biology.

Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility

J. Santos-Sacchi, R. Raphael, D. Oliver, 2017 .

Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein*

J. Santos-Sacchi, Lei Song, J. Bai, 2010, The Journal of Biological Chemistry.

Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.

J. Santos-Sacchi, D. Corey, T. Hasson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Single particle cryo-EM structure of the outer hair cell motor protein prestin

J. Santos-Sacchi, C. Butan, J. Bai, 2021, Nature Communications.

Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium

J. Santos-Sacchi, S. Kleinstein, Mohamed Uduman, 2011, Journal of the Association for Research in Otolaryngology.

Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.

J. Santos-Sacchi, W. Yarbrough, Lei Song, 2017, Antioxidants & redox signaling.

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology

J. B. Levitt, Yael H. Edrey, Amanda M. Lauer, 2021, Biological reviews of the Cambridge Philosophical Society.

Efferent feedback controls bilateral auditory spontaneous activity

M. Crair, J. Santos-Sacchi, Lei Song, 2021, Nature Communications.

Efferent feedback enforces bilateral coupling of spontaneous activity in the developing auditory system

M. Crair, J. Santos-Sacchi, Lei Song, 2020 .

Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

J. Santos-Sacchi, Lei Song, 2016, Biophysical journal.

Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear

J. Santos-Sacchi, J Santos-Sacchi, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Ultrasonic measures of prestin (SLC26a5) charge movements in membrane patches

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2022, bioRxiv.

On the frequency response of prestin charge movement in membrane patches.

J. Santos-Sacchi, Winston J. T. Tan, 2022, Biophysical Journal.

State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitance

J. Santos-Sacchi, D. Navaratnam, Winston J. T. Tan, 2020, Scientific Reports.

Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension

J. Santos-Sacchi, Winston J. T. Tan, 2020, Scientific Reports.

Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2019, Scientific Reports.

Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance

J. Santos-Sacchi, K. Iwasa, Winston J. T. Tan, 2019, The Journal of general physiology.

Current carried by the Slc26 family member prestin does not flow through the transporter pathway

J. Santos-Sacchi, F. Sigworth, J. Bai, 2017, Scientific Reports.

Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein.

J. Santos-Sacchi, Lei Song, 2014, Biophysical journal.

Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance

J. Santos-Sacchi, Lei Song, 2014, The Journal of Biological Chemistry.

Fast electromechanical amplification in the lateral membrane of the outer hair cell.

J. Santos-Sacchi, Lei Song, E. Navarrete, 2009, Biophysical journal.

Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor

J. Santos-Sacchi, E. Navarrete, 2002, Pflügers Archiv.

Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein

J. Santos-Sacchi, Jing Zheng, P. Dallos, 2001, The Journal of physiology.

Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig

J. Santos-Sacchi, S. Kakehata, S. Takahashi, 1998, The Journal of physiology.

Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation.

J. Santos-Sacchi, J Santos-Sacchi, G J Huang, 1997, Biophysical journal.

Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge.

J. Santos-Sacchi, S. Kakehata, Seiji Kakehata, 1995, Biophysical journal.

Reversible inhibition of voltage-dependent outer hair cell motility and capacitance

J. Santos-Sacchi, J Santos-Sacchi, 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Physiology and biophysics of outer hair cells: The cells of Dallos

J. Santos-Sacchi, D. Navaratnam, 2022, Hearing Research.

Single particle cryo-EM structure of the outer hair cell motor protein prestin

J. Santos-Sacchi, C. Butan, J. Bai, 2022, Nature Communications.

IR laser-induced perturbations of the voltage-dependent solute carrier protein SLC26a5.

Joseph Santos-Sacchi, J. Santos-Sacchi, Oluwarotimi Okunade, 2013, Biophysical journal.

Physiology of the Ear

Joseph Santos-Sacchi, J. Santos-Sacchi, Anthony F. Jahn, 1990 .

Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge

J. Santos-Sacchi, S. Kakehata, 1996, The Journal of Neuroscience.

The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti

J. Santos-Sacchi, 1985, Hearing Research.

Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activation

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2020, Physiological reports.

Calcium induced calcium release in proximity to hair cell BK channels revealed by PKA activation

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2019, bioRxiv.

Conformational state-dependent anion binding in prestin: evidence for allosteric modulation.

J. Santos-Sacchi, Lei Song, 2010, Biophysical journal.

Patch-clamp amplifiers on a chip

Eugenio Culurciello, Fred J. Sigworth, Pujitha Weerakoon, 2010, Journal of Neuroscience Methods.

Intercellular communication in the supporting cells of the organ of Corti

J. Santos-Sacchi, P. Dallos, 1983, Hearing Research.

Anion control of voltage sensing by the motor protein prestin in outer hair cells.

Joseph Santos-Sacchi, J. Santos-Sacchi, V. Rybalchenko, 2008, Biophysical journal.

Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig.

Joseph Santos-Sacchi, J. Santos-Sacchi, V. Rybalchenko, 2003 .

Allosteric Modulation of the Outer Hair Cell Motor Protein Prestin by Chloride

J. Santos-Sacchi, V. Rybalchenko, 2003 .

On the frequency limit and phase of outer hair cell motility: effects of the membrane filter

J. Santos-Sacchi, J Santos-Sacchi, 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

A Genetically-Encoded YFP Sensor with Enhanced Chloride Sensitivity, Photostability and Reduced pH Interference Demonstrates Augmented Transmembrane Chloride Movement by Gerbil Prestin (SLC26a5)

Joseph Santos-Sacchi, J. Santos-Sacchi, D. Navaratnam, 2014, PloS one.

Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.

J. Santos-Sacchi, Lei Song, G. Shadel, 2015, The American journal of pathology.

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

J. Santos-Sacchi, Lei Song, G. Shadel, 2012, Cell.

Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best

J. Santos-Sacchi, Winston J. T. Tan, 2019, iScience.

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2005, Biophysical journal.

On membrane motor activity and chloride flux in the outer hair cell: lessons learned from the environmental toxin tributyltin.

J. Santos-Sacchi, Lei Song, Achim Seeger, 2005, Biophysical journal.

New tunes from Corti’s organ: the outer hair cell boogie rules

J. Santos-Sacchi, 2003, Current Opinion in Neurobiology.

Tuning, and Two-Tone Suppression in the Mouse Development of Cochlear Amplification, Frequency

J. Santos-Sacchi, E. Walsh, S. Bian, 2015 .

Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line

J. Santos-Sacchi, D. Navaratnam, S. Bian, 2011 .

A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events.

J. Santos-Sacchi, D. Navaratnam, S. Bian, 2010, American journal of physiology. Cell physiology.

Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice

L. Kaczmarek, J. Santos-Sacchi, C. Large, 2019, The Journal of Neuroscience.

Control of Mammalian Cochlear Amplification by Chloride Anions

Joseph Santos-Sacchi, Jiefu Zheng, Alfred L Nuttall, 2006, The Journal of Neuroscience.

Voltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic Channels

Hong-Bo Zhao, J. Santos-Sacchi, J. Santos-Sacchi, 2000, The Journal of Membrane Biology.

Furosemide alters nonlinear capacitance in isolated outer hair cells

Joseph Santos-Sacchi, Seiji Kakehata, J. Santos-Sacchi, 2001, Hearing Research.

Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti

J. Santos-Sacchi, J Santos-Sacchi, 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

J. Santos-Sacchi, A. Shanker, Winston J. T. Tan, 2023, Antioxidants.

Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5

J. Santos-Sacchi, Lei Song, 2013, Proceedings of the National Academy of Sciences.

J. Santos-Sacchi, Lei Song, Qiang Song, 2021, Hearing Research.

Dye coupling in the organ of Corti

J. Santos-Sacchi, 2004, Cell and Tissue Research.

Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation.

J. Santos-Sacchi, G. Huang, Guoije Huang, 1993, Biophysical journal.

Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imaging

J. Santos-Sacchi, D. Toomre, A. Rivetta, 2018, Journal of Neuroscience Methods.

Intracellular recordings from cochlear outer hair cells.

P Dallos, J. Santos-Sacchi, P. Dallos, 1982, Science.

Cl− flux through a non‐selective, stretch‐sensitive conductance influences the outer hair cell motor of the guinea‐pig

Joseph Santos-Sacchi, J. Santos-Sacchi, V. Rybalchenko, 2003, The Journal of physiology.

On the effect of prestin on the electrical breakdown of cell membranes.

J. Santos-Sacchi, E. Navarrete, 2006, Biophysical journal.

Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductance

J. Santos-Sacchi, J. Santos-Sacchi, 1991, Hearing Research.

Determination of Cell Capacitance Using the Exact Empirical Solution of ∂Y/∂Cm and Its Phase Angle

J. Santos-Sacchi, 2004 .

High frequency measures of OHC nonlinear capacitance (NLC) and their significance: Why measures stray away from predictions

J. Santos-Sacchi, 2018 .

Outer hair cell function is normal in βV spectrin knockout mice

J. Santos-Sacchi, Lei Song, J. Morrow, 2021, Hearing Research.

En block C-terminal charge cluster reversals in prestin (SLC26A5): Effects on voltage-dependent electromechanical activity

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2006, Neuroscience Letters.

Distortion Component Analysis of Outer Hair Cell Motility-Related Gating Charge

J. Santos-Sacchi, J. Santos-Sacchi, S. Takahashi, 1999, The Journal of Membrane Biology.

Protein- and Lipid-Reactive Agents Alter Outer Hair Cell Lateral Membrane Motor Charge Movement

J. Santos-Sacchi, M. Wu, 2004, The Journal of Membrane Biology.

On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin

J. Santos-Sacchi, Lei Song, V. Rybalchenko, 2006, Pflügers Archiv.

Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequency

Tomonori Takasaka, Joseph Santos-Sacchi, Yukio Katori, 1998, Neuroscience Letters.

Effects of Lipophilic Ions on Outer Hair Cell Membrane Capacitance and Motility

J. Santos-Sacchi, M. Wu, 1998, The Journal of Membrane Biology.

Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

J. Santos-Sacchi, Lei Song, 2016, Biophysical journal.

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

J. Santos-Sacchi, Lei Song, G. Shadel, 2012, Cell.

The magnificent outer hair cell of Corti's organ

J. Santos-Sacchi, 1999 .

Temperature dependence of outer hair cell nonlinear capacitance

J. Santos-Sacchi, Guojie Huang, 1998, Hearing Research.

Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane.

J. Santos-Sacchi, J Santos-Sacchi, G Huang, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Fast Outer Hair Cell Motility: How Fast is Fast?

Joseph Santos-Sacchi, J. Santos-Sacchi, 1990 .

Differential effects of primary fixation with glutaraldehyde and osmium upon the membranous systems of the strial and external sulcus cells.

J. Santos-Sacchi, 1978, Acta oto-laryngologica.

Tyrosine motifs are required for prestin basolateral membrane targeting

J. Santos-Sacchi, J. Bai, D. Navaratnam, 2015, Biology Open.

Membrane-bound voltage sensor-motor elements contrl OHC length

J. Santos-Sacchi, T. Takasaka, S. Kakehata, 1997 .

Harmonics of outer hair cell motility.

J. Santos-Sacchi, J Santos-Sacchi, 1993, Biophysical journal.

Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane

J. Santos-Sacchi, Shin Takahashi, 2000, Pflügers Archiv.

Relations between dc and ac mechanical responses of the outer hair cell.

J. Santos-Sacchi, 1991 .

AC receptor potentials from hair cells in the low-frequency region of the guinea pig cochlea

Joseph Santos-Sacchi, J. Santos-Sacchi, P. Dallos, 1983 .

A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells.

J. Santos-Sacchi, Lei Song, 2016, Methods in molecular biology.

Potentiation of the cGMP-induced guinea pig acrosome reaction by zinc.

J. Santos-Sacchi, W. L. Williams, M. Gordon, 1980, The Journal of experimental zoology.