J. Leysen

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Nuclei and subnuclei gene expression profiling in mammalian brain

P. Bonaventure, Hongqing Guo, Bin Tian, 2002, Brain Research.

Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.

J. Leysen, P. Janssen, P A Janssen, 1981, Life sciences.

The Dopamine Stabilizer (−)-OSU6162 Occupies a Subpopulation of Striatal Dopamine D2/D3 Receptors: An [11C]Raclopride PET Study in Healthy Human Subjects

H. Berendse, J. Leysen, A. Lammertsma, 2015, Neuropsychopharmacology.

BRIEF ARTICLE First Evaluation of ( 11 C)R116301 as an In Vivo Tracer of NK1 Receptors in Man

R. Boellaard, J. Leysen, D. Veltman, 2009 .

Partition coefficients of dopamine antagonists in brain membranes and liposomes.

J. Leysen, A. Carvalho, C. R. Oliveira, 1989, Biochemical pharmacology.

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

M. Jurzak, J. Leysen, J. Schuurkes, 2001, European journal of pharmacology.

Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.

J. Leysen, G. Haegeman, I. van de Weyer, 1996, Molecular pharmacology.

Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study

P. Bonaventure, J. Leysen, X. Langlois, 1998, Neuroscience Letters.

Seasonal Variation in Platelet [3H]Paroxetine Binding in Healthy Volunteers

J. Leysen, M. Maes, S. Scharpe, 1996, Neuropsychopharmacology.

Distinction between adrenergic and serotonergic receptor subtypes: specificity of drugs and absence of cooperative interactions between adrenergic and serotonergic receptor binding sites.

J. Leysen, W. Gommeren, P. van Gompel, 1988, Journal of cardiovascular pharmacology.

A serotonergic component of neuroleptic receptors.

J. Leysen, C. Niemegeers, P. Laduron, 1977, Archives internationales de pharmacodynamie et de therapie.

Rapid desensitization and down-regulation of 5-HT2 receptors by DOM treatment.

J. Leysen, C. Niemegeers, P. Janssen, 1989, European journal of pharmacology.

5‐HT2 Receptors, Roles and Regulation

J. Leysen, P. Pauwels, 1990, Annals of the New York Academy of Sciences.

Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells.

J. Leysen, P. Pauwels, P. van Gompel, 1990, Life sciences.

Receptor interactions of dopamine and serotonin antagonists: binding in vitro and in vivo and receptor regulation.

J. Leysen, P. Janssen, W. Gommeren, 1988, Psychopharmacology series.

Survey on the pharmacodynamics of the new antipsychotic risperidone

J. Leysen, A. Megens, T. Meert, 1994, Psychopharmacology.

Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease.

J. C. Stoof, J. Leysen, B. Drukarch, 1988, Life sciences.

Reductive N‐alkylation of secondary amines with [2‐11C]acetone

J. Leysen, J. A. Jablonowski, N. Carruthers, 2003 .

Specific in vivo binding of neuroleptic drugs in rat brain.

J. Leysen, P. Laduron, 1977, Biochemical pharmacology.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

J. Leysen, A. Megens, P. Herdewijn, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants.

J. Leysen, R. Gordon, P. Verhasselt, 1999, European journal of biochemistry.

Labelling and evaluation of new stabilised neurotensin (8–13) analogues for single photon emission tomography (SPET)

J. Leysen, A. Bossuyt, J. Schuurkes, 1999 .

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats.

J. Leysen, A. Lammertsma, R. Schuit, 2009, Nuclear medicine and biology.

Review on neuroleptic receptors: specificity and multiplicity of in vitro binding related to pharmacological activity

J. Leysen, 1981 .

Chronic neuroleptic treatment specifically alters the number of dopamine receptors in rat brain.

C. Marsden, J. Leysen, P. Jenner, 1981, Life sciences.

Differential distribution of opiate and neuroleptic receptors and dopamine-sensitive adenylate cyclase in rat brain.

J. Leysen, P. Laduron, 1977, Life sciences.

Symposium on: receptors of dopamine antagonists: new biochemical approaches. July 6-8, 1978, Beerse, Belgium.

J. Leysen, P. Laduron, 1978, Life sciences.

Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain

J. Leysen, P. Laduron, A. Schotte, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.

J. Leysen, M. Pangalos, I. van der Linden, 2000, The Journal of biological chemistry.

Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas.

J. Leysen, P. Laduron, W. Gommeren, 1979, Biochemical pharmacology.

In vitro binding properties of 3H-sufentanil, a superior ligand for the mu-opiate receptor.

J. Leysen, W. Gommeren, 1982, Archives internationales de pharmacodynamie et de therapie.

Interaction of des-tyrosine-γ-endorphin (DTγE,β-LPH62–77) with neuroleptic binding sites in various areas of rat brain

J. Leysen, J. M. Ree, A. Witter, 1978 .

Further validation of in vivo and in vitro pharmacological procedures for assessing the α2/α1-selectivity of test compounds: (1) α-adrenoceptor antagonists

J. Leysen, A. Megens, C. Niemegeers, 1986 .

Receptors: binding assays

J. Leysen, A. Lammertsma, X. Langlois, 2010 .

Expression and regulation of interleukin‐10 and interleukin‐10 receptor in rat astroglial and microglial cells

J. Leysen, A. Wierinckx, A. van Dam, 2002, The European journal of neuroscience.

Structure of the Human Serotonin 5‐HT4 Receptor Gene and Cloning of a Novel 5‐HT4 Splice Variant

M. Jurzak, J. Leysen, P. Verhasselt, 2000, Journal of neurochemistry.

Cloning and Expression of a Human Serotonin 5‐HT4 Receptor cDNA

M. Jurzak, J. Leysen, P. Verhasselt, 1997, Journal of neurochemistry.

Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain.

J. Leysen, A. Schotte, 1989, Journal of chemical neuroanatomy.

Human β1- and β2-adrenergic receptor binding and mediated accumulation of cAMP in transfected chinese hamster ovary cells: Profile of nebivolol and known β-adrenergic blockers

J. Leysen, P. Pauwels, Paul Van Compel, 1991 .

Identification of beta-adrenoceptors in bovine teat muscles by 3H-dihydroalprenolol binding.

J. Leysen, E. Roets, G. Peeters, 1984, Archives internationales de pharmacodynamie et de therapie.

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

J. Leysen, P. Janssen, F. De Clerck, 1985, Journal of Biological Chemistry.

Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor.

J. Leysen, H. Moereels, W. Luyten, 1993, Biochemical and biophysical research communications.

Heterologous Expression of G Protein-Coupled Receptors in Yeasts: an Approach to Facilitate Drug Discovery

J. Leysen, W. Luyten, B. Francken, 1997 .

Identification of non-serotonergic [3H]ketanserin binding sites on human platelets and their role in serotonin release.

J. Leysen, P. Janssen, W. Gommeren, 1991, European journal of pharmacology.

Ketanserin reduces a particular monoamine pool in peripheral tissues.

J. Leysen, P. Janssen, J. Wynants, 1989, Molecular pharmacology.

Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids

J. Leysen, M. Moeremans, P. Pauwels, 1992, Synapse.

Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5‐HT1B and 5‐HT1D receptors expressed in various mammalian cell lines

J. Leysen, G. Haegeman, W. Luyten, 1998, British journal of pharmacology.

Platelet 3H-paroxetine binding in depressed patients

J. Leysen, H. D’haenen, M. Waele, 1988, Psychiatry Research.

Evidence for functional 5-HT2 receptor sites on human blood platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Biochemical pharmacology.

Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist.

M. Bakker, M. Jurzak, J. Leysen, 2006, Bioorganic & medicinal chemistry.

Characterization of an enzyme yielding formaldehyde from‐5‐methyltetrahydrofolic acid

J. Leysen, P. Laduron, 1974, FEBS letters.

Attenuation of neurotoxicity following anoxia or glutamate receptor activation in EGF- and hippocampal extract-treated neuronal cultures.

J. Leysen, P. Pauwels, H. P. van Assouw, 1989, Cellular signalling.

The pharmacological and biochemical basis of neuroleptic treatment in schizophrenia

J. Leysen, C. Niemegeers, 1982, Pharmaceutisch Weekblad.

Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone

J. Leysen, P. Janssen, R. Woestenborghs, 2004, Psychopharmacology.

Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone.

M. Jurzak, J. Leysen, W. Luyten, 2001, European journal of pharmacology.

6.2 Role and localization of serotonin-5HT2 receptors

J. Leysen, A. Schotte, 1992 .

Differential regulation of dopamine-D2 and serotonin-S2 receptors by chronic treatment with the serotonin-S2 antagonists, ritanserin, and setoperone.

J. Leysen, P. Laduron, W. Gommeren, 1987, Psychopharmacology series.

Impact of Janssen drugs for the identification of brain receptors

J. Leysen, P. Laduron, J. van Dun, 1986 .

Differential photoaffinity labelling of serotonin‐S2 receptors and histamine‐H1 receptors using 7‐azidoketanserin

J. Leysen, J. van Dun, W. Wouters, 1985, FEBS letters.

Photoaffinity labelling of serotonin-S2 receptors with 7-azidoketanserin.

J. Leysen, J. van Dun, W. Wouters, 1985, European journal of pharmacology.

Serotonin-S2 receptor binding sites and functional correlates

J. Leysen, C. Niemegeers, F. Clerck, 1984, Neuropharmacology.

Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists

J. Leysen, C. Niemegeers, F. Colpaert, 1983 .

In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain.

J. Leysen, P. Laduron, P. Janssen, 1982, European journal of pharmacology.

Chapter 1. Biochemical Models for Serotonin Receptors

J. Leysen, J. Tollenaere, J. Mcdermed, 1982 .

Evidence that pimozide is not a partial agonist of dopamine receptors.

J. Leysen, P. Janssen, J. van Nueten, 1979, Life sciences.

Characterization of specific in vivo binding of neuroleptic drugs in rat brain.

J. Leysen, P. Laduron, P. Janssen, 1978, Life sciences.

Different kinetic properties of neuroleptic receptor binding in the rat striatum and frontal cortex.

J. Leysen, W. Gommeren, 1978, Life sciences.

Endogenous dopamine limits the binding of antipsychotic drugs to D3 receptors in the rat brain: a quantitative autoradiographic study

P. Bonaventure, J. Leysen, A. Schotte, 1996, The Histochemical Journal.

Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐[3H]3methoxy phenyl)‐N′‐methylguanidine ([3H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist

R. Boellaard, J. Leysen, A. Windhorst, 2019, Pharmacology research & perspectives.

Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors.

J. Leysen, A. Lammertsma, R. Schuit, 2014, Nuclear medicine and biology.

Initial evaluation of123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects

J. Leysen, R. Kerwin, M. Travis, 1997, European Journal of Nuclear Medicine.

Design, Structure-Activity, Labelling and Purity in the Development of Receptor Interacting Radiohalogenated Tracers

J. Leysen, H. Moereels, J. Mertens, 1995 .

Radiosynthesis of a new radioiodinated ligand for serotonin‐5HT2‐receptors, a promising tracer for γ‐emission tomography

J. Leysen, P. Janssen, J. Mertens, 1994 .

Gaps and peculiarities in 5-HT2 receptor studies.

J. Leysen, Josée E. Leysen, 1990, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Drug‐receptor dissociation time, new tool for drug research: Receptor binding affinity and drug‐receptor dissociation profiles of serotonin‐S2, Dopamine‐D2, histamine‐H1 antagonists, and opiates

J. Leysen, W. Gommeren, 1986 .

Autoradiographic evidence for the occlusion of rat brain dopamine D3 receptors in vivo.

J. Leysen, W. Luyten, W. Gommeren, 1992, European journal of pharmacology.

Internalization of Human 5-HT4a and 5-HT4b Receptors is Splice Variant Dependent

M. Jurzak, J. Leysen, A. Lesage, 2004, Bioscience reports.

Differences in Signal Transduction of Two 5-HT4Receptor Splice Variants: Compound Specificity and Dual Coupling with Gαs- and Gαi/o-Proteins

M. Jurzak, J. Leysen, A. Lesage, 2002 .

Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.

M. Jurzak, J. Leysen, A. Lesage, 2002, Molecular pharmacology.

Synthesis and biodistribution of [11C]R116301, a promising PET ligand for central NK1 receptors

F. Sommen, M. Jurzak, J. Leysen, 2005 .

Towards an improved survival of rat brain neurons in culture by cerebrospinal fluid of patients with senile dementia of Alzheimer's type

J. Leysen, P. Pauwels, R. Dom, 1993, Brain Research.

Blockade of apomorphine's discriminative stimulus properties: Relation to neuroleptic activity in neuropharmacological and biochemical assays

J. Leysen, C. Niemegeers, P. Janssen, 1976, Pharmacology Biochemistry and Behavior.

Receptor-based assays.

J. Leysen, A. Strosberg, 1991, Current opinion in biotechnology.

Vesamicol and some of its derivatives: questionable ligands for selectively labelling acetylcholine transporters in rat brain.

J. C. Stoof, J. Leysen, J. Herscheid, 1997, European journal of pharmacology.

Serotonergic receptor subtypes and vascular reactivity.

J. Leysen, P. Vanhoutte, F. De Clerck, 1984, Journal of Cardiovascular Pharmacology.

Aminergic receptors in astrogliotic plaques from patients with multiple sclerosis

J. Leysen, X. Langlois, N. Wilczak, 2002, Neuroscience Letters.

Isoform

P. Shizgal, L. Wilkinson, J. Leysen, 2020, Definitions.

In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole.

J. Leysen, P. Laduron, W. Gommeren, 1982, Molecular pharmacology.

Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study

M. Jurzak, J. Leysen, X. Langlois, 2001, Neuropharmacology.

Beta-adrenoceptor-mediated cAMP accumulation in cardiac cells: effects of nebivolol.

J. Leysen, P. Janssen, P. Pauwels, 1989, European journal of pharmacology.

Serotonin receptor binding sites: is there pharmacological and clinical significance?

J. Leysen, 1983, Medical biology.

KETANSERIN: A SELECTIVE ANTAGONIST OF 5-HT2 SEROTONINERGIC RECEPTORS

J. Leysen, J. Schuurkes, P. Vanhoutte, 1983, The Lancet.

Serotonergic responses in vascular and non-vascular tissues.

J. Leysen, P. Vanhoutte, P. Janssen, 1982, Archives internationales de pharmacodynamie et de therapie.

[3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord.

J. Leysen, C. Niemegeers, W. Gommeren, 1983, European journal of pharmacology.

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

P. F. M. Janssen, J. Leysen, W. Luyten, 1996, Psychopharmacology.

Identification of 5-HT2 receptors, alpha 1-adrenoceptors and amine release sites in rat brain by autoradiography with [125I]7-amino-8-iodo-ketanserin.

J. Leysen, A. Schotte, 1989, European journal of pharmacology.

Partition of Ca2+ antagonists in brain plasma membranes.

J. Leysen, A. Carvalho, C. R. Oliveira, 1989, Biochemical pharmacology.

Opposite regulation of serotonin-S2 and dopamine-D2 receptors in rat brain following chronic receptor blockade.

J. Leysen, C. Niemegeers, P. van Gompel, 1987, Journal of receptor research.

Specific effect of haloperidol on dopamine turnover in the frontal cortex

J. Leysen, P. Laduron, K. D. Bie, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Demonstration of a complex subunit composition of a unitary dopamine receptor: effects of lesions and proteolytic enzymes on stereospecific binding.

J. Leysen, W. Gommeren, P. van Gompel, 1983, Advances in biochemical psychopharmacology.

Initial evaluation of 123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects.

J. Leysen, R. Kerwin, M. Travis, 1997, European Journal of Nuclear Medicine.

Evaluation of radioiodo-4-amino-N-[1-[3-(4-fluorophenoxy)-propyl]-4- methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide as a potential 5HT2 receptor tracer for SPE(C)T.

J. Leysen, P. Janssen, J. Mertens, 1995, Nuclear medicine and biology.

Effects of some derivatives of 2-aminotetralin on dopamine-sensitive adenylate cyclase and on the binding of (3H)haloperidol to neuroleptic receptors in the rat striatum.

J. Leysen, B. Costall, R. Naylor, 1978, Biochemical pharmacology.

Ontogenetic development of a 5-methyltetrahydrofolate requiring enzyme in rats and mice

J. Leysen, P. Laduron, G. Aerts, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation.

J. Leysen, P. Laduron, 1975, Biochemical pharmacology.

Identification of alkaloids; the condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid.

J. Leysen, P. Laduron, W. Lauwers, 1975, Biomedical mass spectrometry.

N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor.

J. Leysen, P. Laduron, W. Gommeren, 1974, Biochemical pharmacology.

Epidural and Intravenous Sufentanil in the Rat: Analgesia, Opiate Receptor Binding, and Drug Concentrations in Plasma and Brain

J. Leysen, F. Colpaert, R. H. van den Hoogen, 1986, Anesthesiology.

Narcotic Dosage and Central Nervous System Opiate Receptor Binding

J. Leysen, C. Niemegeers, N. Pace, 1983, Anesthesia and Analgesia.

Interaction of peptides and morphine-like narcotic analgesics with specifically labelled mu- and delta-opiate receptor binding sites.

J. Leysen, W. Gommeren, W. De Potter, 1983, Archives internationales de pharmacodynamie et de therapie.

Novel computational model for the interaction of dopamine with the D2 receptor.

J. Leysen, H. Moereels, 1993, Receptors & channels.

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.

J. Leysen, A. Megens, F. Bischoff, 2000, Bioorganic & medicinal chemistry letters.

New 2-Substituted 1,2,3,4-Tetrahydrobenzofuro[3,2-c]pyridine Having Highly Active and Potent Central α2-Antagonistic Activity as Potential Antidepressants.

J. Leysen, A. Megens, F. Bischoff, 2000 .

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

J. Leysen, C. Niemegeers, P. Laduron, 1982, Molecular pharmacology.

5-HT7 receptors: current knowledge and future prospects.

J. Leysen, G. Haegeman, P. Vanhoenacker, 2000, Trends in pharmacological sciences.

Apomorphine: chemistry, pharmacology, biochemistry.

J. Leysen, F. Colpaert, W. V. van Bever, 1976, International review of neurobiology.

Antagonist‐induced supersensitivity of mGlu1 receptor signalling in cerebellar granule cells

J. Leysen, H. Lavreysen, A. Lesage, 2005, The European journal of neuroscience.

Daphnane-type diterpene orthoesters and their biological activities.

J. Leysen, G. Appendino, N. de Kimpe, 2002, Mini reviews in medicinal chemistry.

Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain.

J. Leysen, X. Langlois, G. Gessa, 2000, Brain research. Molecular brain research.

Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127

J. Leysen, X. Langlois, H. Lavreysen, 2004, Neuropharmacology.

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

Xavier Langlois, Hilde Lavreysen, J. Leysen, 2003, Molecular pharmacology.

In vivo formation of epinine in adrenal medulla

J. Leysen, P. Laduron, P. Gompel, 1974, Naunyn-Schmiedeberg's Archives of Pharmacology.

STEREOSPECIFIC IN VlTRO BINDING OF [3H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS

J. Leysen, P. Laduron, M. Ver Wimp, 1979, Journal of neurochemistry.

Dopaminergic potency of apomorphine homologues in mice with unilateral lesions of the caudate nucleus

J. Leysen, P. Laduron, 2011 .

Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.

J. Leysen, P. Laduron, W. Gommeren, 1985, Molecular pharmacology.

Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.

J. Leysen, G. Appendino, N. de Kimpe, 2002, Bioorganic & medicinal chemistry.

Central and Peripheral 5-HT2Receptors: Role in Physiological Versus Pathological Conditions

J. Leysen, P. Pauwels, 1990 .

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii.

J. Leysen, I. van der Linden, G. Appendino, 2000, Journal of natural products.

In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used.

P. Bonaventure, J. Leysen, A. Schotte, 1995, Japanese journal of pharmacology.

Optimal Conditions for [3H]Apomorphine Binding and Anomalous Equilibrium Binding of [3H]Apomorphine and [3H]Spiperone to Rat Striatal Membranes: Involvement of Surface Phenomena Versus Multiple Binding Sites

J. Leysen, W. Gommeren, 1981, Journal of neurochemistry.

Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor.

J. Leysen, J. Booij, R. Knol, 2011, Journal of medicinal chemistry.

Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding.

J. Leysen, P. Laduron, W. Gommeren, 1978, Biochemical pharmacology.

Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor

J. Leysen, A. Lammertsma, A. Windhorst, 2013, EJNMMI Research.

Melatonin modulates the sensitivity of 5-hydroxytryptamine-2 receptor-mediated sleep—wakefulness regulation in the rat

J. Leysen, C. Dugovic, A. Wauquier, 1989, Neuroscience Letters.

Excitatory Amino Acids and Their Antagonists

P. Shizgal, S. Nieuwenhuis, Sarah L Parylak, 2015 .

Solubilization of rat brain serotonin-S2 receptors using CHAPS/salt.

J. Leysen, J. van Dun, W. Wouters, 1985, European journal of pharmacology.

Spiperone: a ligand of choice for neuroleptic receptors. 2. Regional distribution and in vivo displacement of neuroleptic drugs.

J. Leysen, P. Laduron, P. Janssen, 1978, Biochemical pharmacology.

5-HT2A and 5-HT2C receptors and their atypical regulation properties.

J. Leysen, W. Luyten, D. Van Oekelen, 2003, Life sciences.

Muscarinic receptor: multiple sites or unitary concept?

J. Leysen, P. Laduron, H. Gorissen, 1981, Archives internationales de pharmacodynamie et de therapie.

Pharmacological Profile of (2R-trans)-4-[1-[3,5-bis(Trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an Orally and Centrally Active Neurokinin-1 Receptor Antagonist

M. Jurzak, J. Leysen, A. Megens, 2002, Journal of Pharmacology and Experimental Therapeutics.

Ten years of antisense inhibition of brain G-protein-coupled receptor function

J. Leysen, W. Luyten, D. V. Oekelen, 2003, Brain Research Reviews.

Differentiation of opiate and neuroleptic receptor binding in rat brain.

J. Leysen, P. Laduron, M. Koch, 1977, European journal of pharmacology.

Dopamine receptor‐mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time

J. Leysen, J. Taymans, H. K. Kia, 2004, The European journal of neuroscience.

Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions

J. Leysen, X. Langlois, J. Taymans, 2003, Journal of neurochemistry.

Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand.

J. Leysen, J. A. Jablonowski, N. Carruthers, 2006, Nuclear medicine and biology.

Studies in organic mass spectrometry. XV. Mass fragmentographic identification of epinine in adrenal medulla and as a product of an in vitro enzymic methylation.

J. Leysen, M. Claeys, P. Laduron, 1974, Biomedical mass spectrometry.

Muscarinic Cholinergic Receptor Agonists and Antagonists

C. Buhusi, P. Shizgal, T. Robbins, 2015 .

71 – DOMPERIDONE, A NOVEL GASTROKINETIC AND ANTI-NAUSEANT DRUG, INTERACTS SELECTIVELY WITH DOPAMINE RECEPTORS

J. Leysen, P. Laduron, 1978 .

Reduction of a distinct pool of monoamines by ketanserin in peripheral tissues

J. Leysen, P. Janssen, J. Wynants, 1990 .

Evaluation of the tetracycline‐ and ecdysone‐inducible systems for expression of neurotransmitter receptors in mammalian cells

J. Leysen, G. Haegeman, K. Van Craenenbroeck, 2001, The European journal of neuroscience.

Functional characterisation of a 5-HT2 receptor cDNA cloned from Lymnaea stagnalis.

R. Planta, J. Leysen, E. Vreugdenhil, 1996, European journal of pharmacology.

Depolarization of chick myotubes triggers the appearance of (+)-[3H]PN 200-110-binding sites.

J. Leysen, P. Pauwels, H. P. van Assouw, 1987, Molecular Pharmacology.

[3H]Batrachotoxinin A 20-alpha-benzoate binding to sodium channels in rat brain: characterization and pharmacological significance.

J. Leysen, P. Pauwels, P. Laduron, 1986, European journal of pharmacology.

Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors

J. Leysen, A. Megens, W. Luyten, 2005, Psychopharmacology.

Optimized expression of serotonin receptors in mammalian cells using inducible expression systems

J. Leysen, G. Haegeman, P. Vanhoenacker, 1999 .

Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.

J. Leysen, P. Laduron, Josée E. Leysen, 1979, Biochemical pharmacology.

Differentiation between Stereospecific Binding Sites on a Dopamine Receptor Complex: Effects of Proteolytic Enzymes

J. Leysen, P. Gompel, 1982 .

Effects of lesions on 3H-apomorphine and 3H-spiperone stereospecific binding sites in subcellular fractions of rat striatum

J. Leysen, W. Gommeren, P. Gompel, 1981, Neurochemistry International.

Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells.

J. Leysen, W. Luyten, J. Vanhauwe, 1999, The Journal of pharmacology and experimental therapeutics.

Effects of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signaling in Chinese hamster ovary cells

M. Jurzak, J. Leysen, J. Vanhauwe, 2000, Psychopharmacology.

Receptor cloning and heterologous expression--towards a new tool for drug discovery.

J. Leysen, W. Luyten, 1993, Trends in biotechnology.

Serotoninergic receptors in brain tissue: properties and identification of various 3H-ligand binding sites in vitro.

J. Leysen, 1981, Journal de physiologie.

Is the low incidence of extrapyramidal side‐effects of antipsychotics associated with antimuscarinic properties?

J. Leysen, P. M. Laduron, 1978, The Journal of pharmacy and pharmacology.

The signal transducing system coupled to serotonin-S2 receptors

J. Leysen, F. Clerck, D. Courcelles, 1988, Experientia.

Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs.

J. Leysen, P. Janssen, W. Gommeren, 1988, The Journal of pharmacology and experimental therapeutics.

Demonstration of S2-receptor binding sites on cat blood platelets using [3H]ketanserin.

J. Leysen, F. De Clerck, W. Gommeren, 1983, European journal of pharmacology.

THE INFLUENCE OF DIAZEPAM AND DROPERIDOL ON CNS RECEPTOR BINDING

J. Leysen, T. Stanley, C. Niemegers, 1980 .

Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding.

J. Leysen, D. Ashton, C. Waterkeyn, 1981, Life sciences.

The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors.

J. C. Stoof, A. Cools, J. Leysen, 1999, European journal of pharmacology.

Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine.

J. Leysen, P. Janssen, P. Pauwels, 1991, Life sciences.

Molecular cloning and pharmacological characterization of a molluscan octopamine receptor.

R. Planta, J. Leysen, E. Vreugdenhil, 1997, Molecular pharmacology.

The involvement of 5-HT2-receptor sites in the activation of cat platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Thrombosis research.

Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography

J. Leysen, A. Megens, A. Schotte, 1993, Brain Research.

Biochemical profile of risperidone, a new antipsychotic.

J. C. Stoof, J. Leysen, P. Janssen, 1988, The Journal of pharmacology and experimental therapeutics.

N-methylation of indolealkylamines in the brain with a new methyl donor.

J. Leysen, P. Laduron, 1974, Advances in biochemical psychopharmacology.

Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat

J. Leysen, A. Megens, J. Heykants, 1994, Psychopharmacology.

Functional study of rat 5‐HT2A receptors using antisense oligonucleotides

Theo Meert, J. Leysen, A. Megens, 2003, Journal of neurochemistry.

Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.

J. Leysen, A. Lesage, L. Peeters, 1996, The Journal of pharmacology and experimental therapeutics.

Subchronic treatment with phencyclidine in adolescence leads to impaired exploratory behavior in adult rats without altering social interaction or N‐methyl‐D‐aspartate receptor binding levels

J. Leysen, A. Windhorst, A. Metaxas, 2014, Journal of neuroscience research.

Binding of [3H]paroxetine to platelets of depressed patients: seasonal differences and effects of diagnostic classification.

J. Leysen, M. Maes, P. Cosyns, 1994, Journal of affective disorders.

MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

J. Leysen, X. Langlois, A. Lesage, 2005, Neuroreport.

Receptor profile of antipsychotics

J. Leysen, 2000 .

Does phenylethylamine act as an endogenous amphetamine in some patients?

J. Leysen, A. Megens, P. Janssen, 1999, The international journal of neuropsychopharmacology.

Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.

J. Leysen, A. Megens, P. Janssen, 1994, The Journal of clinical psychiatry.

Regional distribution of serotonin-2 receptor binding sites in the brain and effects of neuronal lesions.

J. Leysen, W. Gommeren, P. van Gompel, 1982, Archives internationales de pharmacodynamie et de therapie.

In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.

J. Leysen, P. Pauwels, P. Janssen, 1992, Molecular pharmacology.

Spiperone: a ligand of choice for neuroleptic receptors. 3. Subcellular distribution of neuroleptic drugs and their receptors in various rat brain areas.

J. Leysen, P. Laduron, P. Janssen, 1978, Biochemical pharmacology.

The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat

J. Leysen, C. Dugovic, A. Wauquier, 1989, Pharmacology Biochemistry and Behavior.

[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

J. Leysen, D. Knol, A. Lammertsma, 2013, EJNMMI Research.

Radiosynthesis and biological evaluation of the M1 muscarinic acetylcholine receptor agonist ligand [11C]AF150(S)

J. Leysen, A. Lammertsma, R. Schuit, 2012 .

Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.

J. Leysen, P. Pauwels, P. van Gompel, 1993, Biochemical pharmacology.

Radiosynthesis and preclinical evaluation of ( 11 C)

Albert D. Windhorst, Adriaan Lammertsma, Marc Huisman, 2013 .

The discovery of a series of new non-indole 5HT1D agonists

J. Leysen, W. Janssens, W. Verschueren, 1995 .

The Receptor Binding Profile of the New Antihypertensive Agent Nebivolol and its Stereoisomers Compared with Various β-Adrenergic Blockers

J. Leysen, P. Janssen, P. Pauwels, 1988, Molecular pharmacology.

Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i) and G(o) proteins in Spodoptera frugiperda 9 cells.

M. Jurzak, J. Leysen, W. Luyten, 2000, Molecular pharmacology.

Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2′-iodospiperone

P. Seeburg, J. Leysen, P. Pauwels, 2005, Psychopharmacology.

Non-serotonergic [3H]ketanserin binding sites in striatal membranes are associated with a dopac release system on dopaminergic nerve endings.

J. Leysen, P. Janssen, W. Gommeren, 1987, European journal of pharmacology.

Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells.

J. Leysen, H. Lavreysen, L. Dillen, 2002, Molecular pharmacology.

Abstracts of papers and posters Meeting on Pharmaceutical Sciences

S. W. F. Omta, Gert Luurtsema, John Urquhart, 1993, Pharmacy World and Science.

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor.

J. Leysen, G. Haegeman, H. V. Van Tol, 2006, Life sciences.

BTK抑制剂联合苯达莫司汀、利妥昔单抗一线治疗慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的疗效及安全性

P. Shizgal, R. Bevins, L. Wilkinson, 2023, Chinese Journal of Hematology.

Further characterization of neurotensin binding in the rat brain: levocabastine-displaceable neurotensin binding sites are not histamine-H1 receptors.

J. Leysen, A. Schotte, 1989, Biochemical pharmacology.

Neuroprotective sigma ligands interfere with the glutamate‐activated NOS pathway in hippocampal cell culture

J. Leysen, A. Lesage, L. Peeters, 1995, Synapse.

Use of 5-HT Receptor Agonists and Antagonists for the Characterization of Their Respective Receptor Sites

J. Leysen, J. E. Leysen, 1989 .

Comparison of the In‐vitro Receptor Selectivity of Substituted Benzamide Drugs for Brain Neurotransmitter Receptors

J. Leysen, P. Jenner, P. Jenner, 1988, The Journal of pharmacy and pharmacology.

Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand.

A Schotte, P. Bonaventure, J. Leysen, 1997, Receptors & channels.

Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat

J. Leysen, P. Janssen, C. Dugovic, 2004, Psychopharmacology.

Synthesis and biological activities of linear and cyclic enkephalin analogues containing a psi (E,CH = CH) or psi (CH2CH2) isosteric replacement.

J. Leysen, T. Burks, H. Yamamura, 2009, International journal of peptide and protein research.

Stimulation of D2-receptors in rat nucleus accumbens slices inhibits dopamine and acetylcholine release but not cyclic AMP formation

J. C. Stoof, J. Leysen, P. Verheijden, 1987, Brain Research.

Mapping of serotonin 5‐HT4 receptor mRNA and ligand binding sites in the post‐mortem human brain

P. Bonaventure, M. Jurzak, J. Leysen, 2000, Synapse.

Restricted usefulness of tetraethylammonium and 4‐aminopyridine for the characterization of receptor‐operated K+ ‐channels

J. C. Stoof, J. Leysen, K. Kits, 1989, British journal of pharmacology.

Subcellular localization of dopamine-sensitive adenylate cyclase in rat brain striatum.

J. Leysen, P. Laduron, P. Janssen, 1976, Life sciences.

5-HT2 receptors.

J. Leysen, Josée E. Leysen, J. Leysen, 2004, Current drug targets. CNS and neurological disorders.

The serotonin‐S2 Receptor: A receptor‐transducer coupling model to explain insurmountable antagonist effects

J. Leysen, H. van Belle, P. Roevens, 1986 .

Problems in in vitro receptor binding studies and identification and role of serotonin receptor sites

J. Leysen, 1984, Neuropharmacology.

Receptor occupancy by ritanserin and risperidone measured using ex vivo autaradiography

J. Leysen, A. Schotte, P. Janssen, 1989, Brain Research.

Intermittent morphine treatment causes long-term desensitization of functional dopamine D2 receptors in rat striatum.

J. Leysen, B. Drukarch, A. Schoffelmeer, 1995, European journal of pharmacology.

Role of 5-HT2 receptors in the tryptamine-induced 5-HT syndrome in rats

J. Leysen, A. Megens, T. Meert, 2002, Behavioural pharmacology.

Symposium on: Receptors of dopamine antagonists: New biochemical approaches: July 6–8, 1978 Beerse, Belgium

J. Leysen, P. Laduron, 1978 .

Role and localization of serotonin2 (S2)-receptor-binding sites: effects of neuronal lesions.

J. Leysen, C. Niemegeers, P. van Gompel, 1983, Advances in biochemical psychopharmacology.

Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus

J. Leysen, P. Pauwels, 1992, Neuroscience Letters.

Binding properties of 3H-lofentanil at the opiate receptor.

J. Leysen, W. Gommeren, 1982, Archives internationales de pharmacodynamie et de therapie.

Substance dependence.

John F. G. Atack, C. McDougle, D. Posey, 1998, Harvard women's health watch.

The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.

M. Jurzak, J. Leysen, W. Luyten, 1998, European journal of pharmacology.

Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.

M. Jurzak, J. Leysen, X. Langlois, 2001, The Journal of pharmacology and experimental therapeutics.

The importance of a disulphide bond in the binding of dopamine to the D2 receptor: A molecular modelling study

J. Leysen, H. Moereels, 1993 .

Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.

J. Leysen, P. Janssen, P. Pauwels, 1989, Molecular pharmacology.

Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system.

J. Leysen, G. Haegeman, W. Luyten, 1997, Receptors & channels.

Bilateral control of brain activity by dopamine D1 receptors: Evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats

H. Groenewegen, J. Leysen, X. Langlois, 2005, Neuroscience.

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain

H. Groenewegen, M. Jurzak, J. Leysen, 2002, Neuroscience.

Initial evaluation of123|-5-|-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects

J. Leysen, R. Kerwin, M. Travis, 2006, European Journal of Nuclear Medicine.

Radiosynthesis of a new radiobrominated ligand for 5HT2A receptors, a potential tracer for PET.

J. Leysen, A. Hermanne, J. Mertens, 1997 .

5HT1B and 5HT1D receptor mRNA differential co‐localization with peptide mRNA in the guinea pig trigeminal ganglion

P. Bonaventure, J. Leysen, W. Luyten, 1998, Neuroreport.

Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function

P. Bonaventure, M. Jurzak, J. Leysen, 1997, Neuroscience.

Radioligand binding profile of enantiomers of tifluadom analogues for opioid, CCK and central benzodiazepine receptors: Versatility of the benzodiazepine skeleton

J. Leysen, L. Heylen, C. D. Ranter, 1994, Regulatory Peptides.

Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations.

M. Jurzak, J. Leysen, M. P. Castelli, 2000, Molecular pharmacology.

Efficient expression of neurotransmitter receptors in mammalian cells: use of inducible expression systems.

J. Leysen, G. Haegeman, W. Luyten, 1998, Annals of the New York Academy of Sciences.

Synthesis and biological activities of psi (CH2NH) pseudopeptide analogues of the C-terminal hexapeptide of neurotensin.

J. Leysen, D. Tourwé, J. Couder, 2009, International journal of peptide and protein research.

Erratum: Initial evaluation of 123 I-5-I-R91150, a selective 5-HT(2A) ligand for single-photon emission tomography, in healthy human subjects (European Journal of Nuclear Medicine (1997) 24 (119-124))

J. Leysen, R. Kerwin, M. Travis, 1997 .

Neurotransmitters and receptor binding in amygdaloid kindled rats: serotonergic and noradrenergic modulatory effects.

J. Leysen, A. Wauquier, D. Ashton, 1980, Life sciences.

Distinct autoradiographic labelling of serotonin 5-HT2 receptors, alpha 1-adrenoceptors and histamine-H1 receptors and of tetrabenazine-displaceable ketanserin binding sites in rodent brain with [125I]7-amino-8-iodo-ketanserin.

J. Leysen, A. Schotte, 1988, European journal of pharmacology.

Subtype

Husseini K. Manji, John F. G. Atack, D. Posey, 2020, Definitions.

Epival

P. Shizgal, R. Bevins, L. Wilkinson, 1997, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo

J. Leysen, E. Kidd, C. Marsden, 1990, Journal of Neuroscience Methods.

Synthesis of cisapride, a gastrointestinal stimulant derived from cis‐4‐amino‐3‐methoxypiperidine

F. Sommen, J. Leysen, C. Niemegeers, 1986 .

Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin.

J. Leysen, J. van Dun, W. Wouters, 1985, The Journal of biological chemistry.

Quantification of the neurokinin 1 receptor ligand [11C]R116301

R. Boellaard, J. Leysen, D. Veltman, 2011, Nuclear medicine communications.

Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization.

P. Bonaventure, M. Bakker, J. Leysen, 1999, Molecular pharmacology.

Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors.

J. Leysen, D. Charney, M. Laruelle, 1997, European journal of pharmacology.

Comparative Study of the Binding Properties of Cloned Human β1- and β2-Adrenergic Receptors Expressed in Escherichia coli

J. Leysen, P. Pauwels, A. Strosberg, 1991 .

Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors.

R. Boellaard, J. Leysen, R. Schuit, 2015, Nuclear medicine and biology.

Striatal dopamine receptors in rats displaying long‐term behavioural sensitization to morphine

J. Leysen, L. Vanderschuren, A. Schoffelmeer, 1997, Synapse.

Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3).

P. Bonaventure, J. Leysen, M. Pangalos, 1998, European journal of biochemistry.

G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure.

A. Driessen, J. Leysen, W. Luyten, 2000, The Journal of pharmacology and experimental therapeutics.

Receptor binding properties in vitro and in vivo of some long-acting opiates.

J. Leysen, P. Laduron, 1978, Archives internationales de pharmacodynamie et de therapie.

MENTAL DISORDERS

C. Buhusi, P. Shizgal, R. Beninger, 1969 .

Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.

J. Leysen, P. Pauwels, L. Peeters, 1990, The Journal of pharmacology and experimental therapeutics.

Reconstitution of human 5-hydroxytryptamine5A receptor--G protein coupling in E. coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins.

M. Jurzak, J. Leysen, W. Luyten, 2001, Receptors & channels.

Agonist-induced desensitization of 5-HT2 receptors on cultured calf aortic smooth muscle cells

J. Leysen, P. Pauwels, P. Gompel, 1988, Neurochemistry International.

Human beta 1- and beta 2-adrenergic receptor binding and mediated accumulation of cAMP in transfected Chinese hamster ovary cells. Profile of nebivolol and known beta-adrenergic blockers.

J. Leysen, P. Pauwels, P. van Gompel, 1991, Biochemical pharmacology.