D. Vaux

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Toward an understanding of the molecular mechanisms of physiological cell death.

D. Vaux, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Replicates and repeats—what is the difference and is it significant?

D. Vaux, G. Cumming, F. Fidler, 2012, EMBO reports.

Error bars in experimental biology

D. Vaux, G. Cumming, F. Fidler, 2007, The Journal of Cell Biology.

Cell Death in Development

S. Korsmeyer, D. Vaux, Stanley J Korsmeyer, 1999, Cell.

Caspase inhibitors: viral, cellular and chemical

D. Vaux, B. Callus, 2007, Cell Death and Differentiation.

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

David L. Vaux, Suzanne Cory, D. Vaux, 1988, Nature.

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Robert L Moritz, Richard J Simpson, Lisa M Connolly, 2000, Cell.

TRAF proteins and meprins share a conserved domain.

D. Vaux, A. Uren, 1996, Trends in biochemical sciences.

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division.

R van Driel, D. Vaux, T. Lithgow, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Error bars in experimental biology

D. Vaux, G. Cumming, F. Fidler, 2007, The Journal of cell biology.

CARP2 deficiency does not alter induction of NF-κB by TNFα

D. Vaux, Afsar U. Ahmed, J. Silke, 2009, Current Biology.

Recent advances in understanding inhibitor of apoptosis proteins

D. Vaux, N. Lalaoui, 2018, F1000Research.

IAPs and Necroptotic Cell Death

D. Vaux, J. Silke, 2014 .

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

D. Vaux, W. Alexander, P. Ekert, 2014, Cell.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

D. Vaux, L. Gangoda, W. Alexander, 2014, eLife.

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

D. Vaux, J. Murphy, T. Okamoto, 2013, Cell Death and Disease.

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it

D. Vaux, B. Callus, J. Lluis, 2011, Cell Death and Differentiation.

IAPs, RINGs and ubiquitylation

David L. Vaux, D. Vaux, J. Silke, 2005, Nature Reviews Molecular Cell Biology.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

D. Vaux, K. Schroder, Tan A Nguyen, 2017, Cell reports.

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization*

D. Vaux, C. Day, J. Silke, 2011, The Journal of Biological Chemistry.

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.

D. Vaux, J. Silke, R. Brink, 2011, Blood.

Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

D. Vaux, C. Day, J. Silke, 2010, The Journal of Biological Chemistry.

Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer

D. Vaux, 2009, F1000 biology reports.

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Erinna F. Lee, D. Vaux, C. Day, 2009, The Journal of Biological Chemistry.

Inhibitor of Apoptosis (IAP) and BIR‐containing Proteins

D. Vaux, 2009 .

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.

D. Vaux, P. Ekert, C. Day, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites

D. Vaux, P. Ekert, C. Day, 2002, The Journal of cell biology.

Apoptosis Timeline

D. Vaux, 2002, Cell Death and Differentiation.

Direct inhibition of caspase 3 is dispensable for the anti‐apoptotic activity of XIAP

D. Vaux, P. Ekert, C. Day, 2001, The EMBO journal.

Signalling by CD95 and TNF receptors: Not only life and death

D. Vaux, C. Magnusson, 1999, Immunology and cell biology.

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.

D. Vaux, A. Uren, E. Coulson, 1998, Trends in biochemical sciences.

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells

D. Vaux, P. Ekert, A. Uren, 1998, Cell Death and Differentiation.

Viral inhibitors of apoptosis.

D. Vaux, A. Uren, 1997, Vitamins and hormones.

Feature Signalling by CD 95 and TNF receptors : Not only life and death

D. Vaux, C. Magnusson, 2022 .

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Stefan P. Glaser, D. Vaux, G. Salvesen, 2016, Science Translational Medicine.

Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice.

D. Vaux, A. Strasser, A. W. Harris, 1990, Current topics in microbiology and immunology.

Apoptosis genes and autoimmunity.

D. Vaux, R. Flavell, 2000, Current opinion in immunology.

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim

D. Vaux, J. Heraud, A. Strasser, 2009, Cell Death and Differentiation.

Rapid recovery of DNA from agarose gels.

D. Vaux, 1992, Trends in genetics : TIG.

Cell death regulation by the mammalian IAP antagonist Diablo/Smac

D. Vaux, A. Verhagen, 2002, Apoptosis.

Scientific Misconduct: Falsification, Fabrication, and Misappropriation of Credit

D. Vaux, 2015 .

RIPK3 promotes cell death NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL

D. Vaux, W. Alexander, I. Wicks, 2017 .

Programmed Cell Death

D. Vaux, A. Strasser, 2006 .

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

D. Vaux, P. Ekert, J. Silke, 2001, The Journal of cell biology.

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

D. Vaux, J. Vince, James M. Murphy, 2019, Journal of Cell Science.

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2

I. Weissman, D. Vaux, 1993, Molecular and cellular biology.

Basic statistics in cell biology.

D. Vaux, 2014, Annual review of cell and developmental biology.

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO‐1)‐transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

D. Vaux, A. Strasser, K. G. Smith, 1996, The EMBO journal.

Caspases and apoptosis – biology and terminology

D. Vaux, 1999, Cell Death and Differentiation.

Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10.

D. Vaux, L. Montaner, junwei sun, 1999, Journal of immunology.

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

D. Vaux, S. Kaufmann, 2003, Oncogene.

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

J. Tschopp, D. Vaux, K. Hofmann, 1997, FEBS letters.

Transgenic mouse models for hematopoietic tumorigenesis.

D. Vaux, I. Hariharan, W. Alexander, 1988, Current topics in microbiology and immunology.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

D. Vaux, M. Gaestel, G. Brumatti, 2016, Cancer cell.

IAP gene deletion and conditional knockout models.

D. Vaux, J. Silke, 2015, Seminars in cell & developmental biology.

TRAF 2 regulates TNF and NF-κB signalling to suppress apoptosis and skin 1 inflammation independently of Sphingosine kinase-1 2 3

D. Vaux, G. Smyth, S. Nutt, 2015 .

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*

D. Vaux, J. Silke, J. Lluis, 2011, The Journal of Biological Chemistry.

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

David L. Vaux, D. Vaux, A. Strasser, 2016, Nature Reviews Cancer.

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.

I. Weissman, D. Vaux, H. Aguila, 1992, International immunology.

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

D. Vaux, P. Ekert, Sharad Kumar, 2004, The Journal of cell biology.

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

C. Borner, D. Vaux, J. Heraud, 2006, Blood.

Apoptosis and Autoimmunity: Lymphoproliferative Syndromes

D. Vaux, 2006 .

HtrA2/Omi, a Sheep in Wolf's Clothing

D. Vaux, J. Silke, 2003, Cell.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

D. Vaux, K. Schroder, L. Whitehead, 2017, Proceedings of the National Academy of Sciences.

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

D. Vaux, A. Strasser, J. Allison, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Immunopathology of apoptosis —introduction and overview

D. Vaux, 2004, Springer Seminars in Immunopathology.

OVERVIEW: THE MACROPHAGE IN CELL BIOLOGY

D. Vaux, S. Gordon, 1981 .

IAPs must limit activation of RIP kinases by TNF Receptor 1 to prevent embryonic lethality

D. Vaux, A. Voss, T. Thomas, 2018 .

Recent advances in understanding inhibitor of apoptosis proteins [version 1; referees: 2 approved]

D. Vaux, N. Lalaoui, 2018 .

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

D. Vaux, A. Strasser, P. Ekert, 2002, Cell Death and Differentiation.

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose

D. Vaux, A. Elefanty, Elizabeth S. Ng, 2019, Cell Death & Differentiation.

In the Absence of Apoptosis, Myeloid Cells Arrest When Deprived of Growth Factor, But Remain Viable by Consuming Extracellular Glucose

D. Vaux, A. Elefanty, B. Reljić, 2017, bioRxiv.

A biased comment on double‐blind review

D. Vaux, 2011, The British journal of dermatology.

Easy multiple sequential CRISPR/Cas9 knockouts in cell lines using a Cre/LoxP re-cyclable vector

D. Vaux, N. Etemadi, Li Dong, 2021, bioRxiv.

Macrophage Endocytosis: Differential Type 1 and Type 2 Cytokine Regulation of

D. Vaux, S. Gordon, L. Montaner, 2013 .

Activation by IL-4 / IL-13 as Opposed to IFN-Macrophage Endocytosis : Differential Type 1 and Type 2 Cytokine Regulation of Siamon

D. Vaux, L. Montaner, junwei sun, 1999 .

Analysis of the Role of bcl‐2 in Apoptosis

D. Vaux, C. Hawkins, 1994, Immunological reviews.

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

D. Vaux, P. Ekert, M. Finch-Edmondson, 2016, PloS one.

Apoptosis, haemopoiesis and leukaemogenesis.

D. Vaux, P. Ekert, 1997, Bailliere's clinical haematology.

Ways around rejection

D. Vaux, 1995, Nature.

Viral, worm and radical implications for apoptosis.

D. Vaux, G. Haecker, 1994, Trends in biochemical sciences.

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland

D. Vaux, J. Visvader, M. Olayioye, 2005, Cell Death and Differentiation.

In vivo expression of interleukin 5 induces an eosinophilia and expanded Ly-1B lineage populations.

D. Vaux, S. Cory, G. Johnson, 1990, International immunology.

Enforced BCL 2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease ( oncogene / transgenic mice / lymphocyte lifespan / lupus mkce / glomerulonephritis )

D. Vaux, A. Strasser, A. W. Harris, 2022 .

Virological Synapse-Mediated Spread of Human Immunodeﬁciency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition (cid:1) †

D. Vaux, Q. Sattentau, J. Briggs, 2010 .

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes.

D. Vaux, J. Trapani, V. Sutton, 1997, Journal of immunology.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

D. Vaux, A. Strasser, W. Alexander, 2014, Blood.

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

Erinna F. Lee, W. D. Fairlie, D. Vaux, 2016, Autophagy.

The BCL-2 Family Proteins – Key Regulators and Effectors of Apoptosis

D. Vaux, 2009 .

Retraction: Immunology: Ways around rejection

D. Vaux, 1998, Nature.

Apoptosis: A sticky business

D. Vaux, G. Häcker, 1995, Current Biology.

The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system.

D. Vaux, C. Hawkins, 1997, Seminars in immunology.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

D. Vaux, A. Strasser, W. Alexander, 2014, EMBO reports.

Response to “The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory” DOI: 10.1002/bies.201100025

D. Vaux, 2011, BioEssays : news and reviews in molecular, cellular and developmental biology.

Early work on the function of Bcl-2, an interview with David Vaux

D. Vaux, 2004, Cell Death and Differentiation.

Transgenic Mice as Models for the Development of Haemopoietic Neoplasia

D. Vaux, A. W. Harris, S. Cory, 1989 .

Lymphoid neoplasia and the control of haemopoietic differentiation.

D. Vaux, I. Hariharan, W. Alexander, 1989, Ciba Foundation symposium.

Requirements for proteolysis during apoptosis

D. Vaux, G. Häcker, S. Wilhelm, 1997, Molecular and cellular biology.

Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells.

D. Vaux, G. Häcker, 1995, DNA and cell biology.

A tumour suppressor function of caspase-8?

D. Vaux, R. Knight, 2008, Cell Death and Differentiation.

Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis*

D. Vaux, P. Ekert, J. Silke, 2004, Journal of Biological Chemistry.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK 1-and RIPK 3-dependent manner

D. Vaux, A. Strasser, W. Alexander, 2014 .

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

D. Vaux, A. Strasser, D. Gray, 2019, Cell Death & Differentiation.

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1

D. Vaux, Li Dong, Li Dong, 2020, Cell Death & Disease.

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment*

D. Vaux, C. Day, J. Silke, 2008, Journal of Biological Chemistry.

Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.

D. Vaux, J. Schrader, G. Nossal, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Response to Heard et al

D. Vaux, A. Voss, T. Thomas, 2015, The EMBO journal.

Apoptosis in the development and treatment of cancer.

D. Vaux, David L Vaux, Robert Gerl, 2004, Carcinogenesis.

D. Vaux, L. Lindqvist, 2014, Autophagy.

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

D. Vaux, D. Huang, Melanie Heinlein, 2014, Proceedings of the National Academy of Sciences.

The molecular biology of apoptosis.

D. Vaux, A. Strasser, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion

D. Vaux, M. Lazarou, B. Kile, 2018, Cell Death & Differentiation.

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

David L. Vaux, Vinay Tergaonkar, Pascal Schneider, 2007, Cell.

The medical significance of physiological cell death

D. Vaux, Georg Häucker, 1995, Medicinal research reviews.

The mitochondrial death squad: hardened killers or innocent bystanders?

D. Vaux, P. Ekert, 2005, Current opinion in cell biology.

IAPs limit activation of RIP kinases by TNF receptor 1 during development

D. Vaux, A. Voss, T. Thomas, 2012, The EMBO journal.

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

D. Vaux, A. Strasser, A. W. Harris, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum.

D. Jewell, D. Vaux, P. Gionchetti, 1989, Gut.

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2.

I. Weissman, Stuart K. Kim, D. Vaux, 1992, Science.

Viewing BCL2 and cell death control from an evolutionary perspective

D. Vaux, A. Strasser, 2017, Cell Death and Differentiation.

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

Vinay Tergaonkar, Pascal Schneider, D. Vaux, 2007, Cell.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Maryam Rashidi, Warren S. Alexander, Seth L. Masters, 2015, Nature Communications.

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

D. Vaux, A. Strasser, A. W. Harris, 1999, Cancer research.

An evolutionary perspective on apoptosis

David L. Vaux, D. Vaux, A. Strasser, 1994, Cell.

Cell Death in the Origin and Treatment of Cancer.

D. Vaux, A. Strasser, 2020, Molecular cell.

Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice.

D. Vaux, W. Alexander, J. M. Adams, 1987, Journal of immunology.

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

D. Vaux, M. Pakusch, K. Choo, 2000, Current Biology.

Historical Perspective: The Seven Ages of Cell Death Research

D. Vaux, 2014 .

Another twist in the on and off affair between cell suicide and inflammation

D. Vaux, 2013, Cell Death and Differentiation.

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.

Paul G Ekert, D. Vaux, P. Ekert, 2008, Journal of molecular biology.

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation

D. Vaux, B. Callus, A. Verhagen, 2006, The FEBS journal.

Molecular mechanisms of apoptosis: an overview.

D. Vaux, A. Verhagen, 1999, Results and problems in cell differentiation.

The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy.

D. Vaux, A. Strasser, D. Huang, 1997, Biochimica et biophysica acta.

Apoptosis and the immune system.

D. Vaux, P. Ekert, P G Ekert, 1997, British medical bulletin.

Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999.

D. Vaux, A. Strasser, 2000, Biochimica et biophysica acta.

CED-4—The Third Horseman of Apoptosis

D. Vaux, D. Vaux, 1997, Cell.

Molecular and clinical aspects of apoptosis.

D. Vaux, A. Uren, 1996, Pharmacology & therapeutics.

Necroptosis induced by RIPK3 requires MLKL but not Drp1

D. Vaux, J. Murphy, James M. Murphy, 2014, Cell Death and Disease.

Expression of the integrin α4β1 on melanoma cells can inhibit the invasive stage of metastasis formation

I. Weissman, D. Vaux, Fang Qian, 1994, Cell.

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1

D. Vaux, Li Dong, 2020, Cell Death & Disease.

A Cinderella Caspase Takes Center Stage

D. Vaux, Sharad Kumar, 2002, Science.

Apoptosis. A cinderella caspase takes center stage.

D. Vaux, Sharad Kumar, 2002, Science.

In defense of the somatic mutation theory of cancer

D. Vaux, David L Vaux, 2011, BioEssays : news and reviews in molecular, cellular and developmental biology.

Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane.

D. Vaux, T. Lithgow, B. Callus, 2005, Molecular biology of the cell.

Apoptosis and toxicology--what relevance?

D. Vaux, 2002, Toxicology.

Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP.

D. Vaux, R. Medcalf, G. Häcker, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

D. Vaux, A. Verhagen, E. Coulson, 2001, Genome Biology.

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.

H. Horvitz, D. Vaux, E. Speliotes, 2000, Molecular cell.

A novel Apaf-1–independent putative caspase-2 activation complex

D. Vaux, P. Ekert, Sharad Kumar, 2002, The Journal of cell biology.

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion

D. Vaux, M. Lazarou, B. Kile, 2017, Cell Death & Differentiation.

Mammalian mitochondrial IAP binding proteins.

D. Vaux, J. Silke, 2003, Biochemical and biophysical research communications.

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*

R. Moritz, D. Vaux, P. Ekert, 2002, The Journal of Biological Chemistry.

A boom time for necrobiology

D. Vaux, 1993, Current Biology.

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

D. Vaux, M. Pakusch, A. Uren, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Apoptogenic factors released from mitochondria.

D. Vaux, 2011, Biochimica et biophysica acta.

Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: HYPOTHESIS: APOPTOSIS CAUSED BY CYTOTOXINS REPRESENTS A DEFENSIVE RESPONSE THAT EVOLVED TO COMBAT INTRACELLULAR PATHOGENS

D. Vaux, G. Häcker, 1995, Clinical and experimental pharmacology & physiology.

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Matthew E. Ritchie, D. Vaux, J. Visvader, 2020, Cell Death & Differentiation.

Cell Death and Cancer

D. Vaux, 2014 .

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

D. Vaux, P. Schneider, J. Silke, 2008, The Journal of cell biology.

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

D. Vaux, R. Norton, M. Hinds, 1999, Nature Structural Biology.

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Keisuke Kuida, Liam O'Connor, David L. Vaux, 2002, Nature.

Entamoeba histolytica: target cells killed by trophozoites undergo DNA fragmentation which is not blocked by Bcl-2.

D. Vaux, L. Ashley, W. Petri, 1994, Experimental parasitology.

CPD Damage Recognition by Transcribing RNA Polymerase II

S. Korsmeyer, D. Vaux, S. Lowe, 2007 .

The buzz about BAFF.

D. Vaux, 2002, The Journal of clinical investigation.

The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking

D. Vaux, E. C. Schirmer, C. Sewry, 2005, Journal of Molecular Histology.

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

David L. Vaux, D. Vaux, A. Strasser, 2004, The Journal of cell biology.

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

D. Vaux, J. Silke, B. Callus, 2010, PloS one.

Expression of candidate cell death genes in cell lines during apoptosis.

D. Vaux, G. Häcker, 1994, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Activation of physiological cell death mechanisms by a necrosis‐causing agent

I. Weissman, D. Vaux, Darlene Whitney, 1996, Microscopy research and technique.

RIPK1- and RIPK3-induced cell death mode is determined by target availability

D. Vaux, J. Murphy, S. N. Young, 2014, Cell Death and Differentiation.

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor*

D. Vaux, W. Craigen, G. Dewson, 2010, The Journal of Biological Chemistry.

Antibody production by single, hapten-specific B lymphocytes: an antigen-driven cloning system free of filler or accessory cells.

D. Vaux, G. Nossal, B. L. Pike, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A peptide from the C-terminal oligomerization domain of human synaptic (T-form) acetylcholinesterase forms classical amyloid fibrils

D. Vaux, M. Hollinshead, M. Cottingham, 2004 .

Proceedings of the 4th World Conference on Research Integrity

Logan L. Watts, Sophia Jui-An Pan, John M. Carfora, 2016, Research Integrity and Peer Review.

Research methods: Know when your numbers are significant

David L. Vaux, D. Vaux, 2012, Nature.

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

D. Vaux, P. Ekert, J. Silke, 1999, The EMBO journal.

Asymmetric recruitment of cIAPs by TRAF2.

D. Vaux, C. Day, J. Silke, 2010, Journal of molecular biology.

Effects of viral inhibitors of apoptosis in models of mammalian cell death.

D. Vaux, K. G. Smith, G. Häcker, 1996, Behring Institute Mitteilungen.

Proceedings of the 4th World Conference on Research Integrity

Logan L. Watts, James F. Johnson, Sophia Jui-An Pan, 2016, Research Integrity and Peer Review.

Identification of novel and known ovary‐specific genes including ZP2, in a marsupial, the stripe‐faced dunnart

D. Vaux, P. Au, L. Selwood, 2008, Molecular reproduction and development.

Single cell studies on hapten-specific B lymphocytes: differential cloning efficiency of cells of various sizes.

D. Vaux, G. Nossal, B. L. Pike, 1983, Journal of Immunology.

Correction to Supporting Information for Conos et al., Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

D. Vaux, K. Schroder, L. Whitehead, 2017, Proceedings of the National Academy of Sciences.

Tumor Necrosis Factor ( TNF ) Signaling , but Not TWEAK ( TNF-like Weak Inducer of Apoptosis )-triggered cIAP 1 ( Cellular Inhibitor of Apoptosis Protein 1 ) Degradation , Requires cIAP 1 RING Dimerization and E 2 Binding □

D. Vaux, C. Day, J. Silke, 2010 .

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1

D. Vaux, M. Lackmann, C. Day, 1999, Cell Death and Differentiation.

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

D. Vaux, P. Ekert, J. Silke, 2000, Cell Death and Differentiation.

Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis.

D. Vaux, J. Silke, D. Vaux, 2001, Journal of cell science.

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

D. Vaux, C. Smith, C. Day, 2008, Cell Death and Differentiation.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

D. Vaux, G. Smyth, S. Nutt, 2015, eLife.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

D. Vaux, C. Day, J. Silke, 2017, The Journal of Biological Chemistry.

DNA fragmentation in cytolysis.

D. Vaux, 1989, Immunology today (Amsterdam. Regular ed.).

A chronology of cell death

D. Vaux, G. Häcker, 2004, Apoptosis.

RIPK1 is not essential for TNFR1-induced activation of NF-κB

D. Vaux, J. Silke, D. Vaux, 2010, Cell Death and Differentiation.

Evolutionary divergence of the necroptosis effector MLKL

D. Vaux, J. Murphy, J. Hildebrand, 2016, Cell Death and Differentiation.

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

D. Vaux, D. Vaux, J. Vince, 2016, Cell Death and Differentiation.

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

D. Vaux, J. Silke, J. Lluis, 2016, The Journal of Biological Chemistry.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

D. Vaux, J. Silke, J. Vince, 2014, Blood.

In the Absence of Apoptosis, Myeloid Cells Arrest When Deprived of Growth Factor, But Remain Viable Without ATG5-dependent Autophagy or Uptake of Added Glucose or Glutamine

D. Vaux, A. Elefanty, Lisa M. Lindqvist, 2018 .

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

D. Vaux, P. Ekert, J. Silke, 2001, The Journal of cell biology.

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Erinna F. Lee, D. Vaux, C. Day, 2009, The Journal of Biological Chemistry.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

D. Vaux, G. Smyth, S. Nutt, 2017, eLife.

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D. Vaux, 2004, Nature.

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Stefan P. Glaser, D. Vaux, M. Gaestel, 2016 .

Cell death: Shadow Baxing

D. Vaux, J. Silke, 1998, Current Biology.

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

D. Vaux, P. Schneider, J. Silke, 2008, The Journal of cell biology.