J. Kemp

J. Kemp, R. Hargreaves, R. Gill, 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures

J. Kemp, R. Mckernan, T. Priestley, 1990, Brain Research.

Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex.

J. Kemp, T. Priestley, 1994, Molecular pharmacology.

Neurobiology. Glycine maintains excitement.

J. Kemp, A. Foster, 1989, Nature.

THE MPTP-TREATED PRIMATE AS A MODEL FOR ASSESSING NOVEL ANTIPARKINSONUN AGENTS

S. Iversen, L. Iversen, J. Kemp, 2006 .

S. Iversen, L. Iversen, J. Kemp, 1992, Annals of the New York Academy of Sciences.

Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324

J. Kemp, R. Hill, T. Priestley, 1996, Neuropharmacology.

Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABAA receptors

J. Kemp, U. Kristiansen, P. Krogsgaard‐Larsen, 1997 .

3′‐(Arylmethyl)‐ and 3′‐(Aryloxy)‐3‐phenyl‐4‐hydroxyquinolin‐2(1H)‐ ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor.

J. Kemp, P. Leeson, M. Tricklebank, 2010 .

Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.

J. Kemp, P. Whiting, K. Wafford, 1993, Molecular pharmacology.

Noradrenaline-stimulated inositol phospholipid breakdown in rat dorsal lateral geniculate nucleus neurones

J. Kemp, C. Downes, 1986, Brain Research.

β‐Amyloid‐Induced Cell Toxicity: Enhancement of 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide‐Dependent Cell Death

J. Kemp, B. Seilheimer, C. Hertel, 1996, Journal of neurochemistry.

Cryopreservation of Human Fetal Pancreas

J. Kemp, S. Hurt, W. Clark, 1980, Diabetes.

Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility.

J. Kemp, D. Veber, M. Bock, 1994, Journal of medicinal chemistry.

Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

J. Kemp, P. Whiting, K. Wafford, 1993, Molecular pharmacology.

Glutamate- and GABA-based CNS therapeutics.

J. Kemp, A. Foster, 2006, Current opinion in pharmacology.

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

J. Kemp, J. Kew, P. Malherbe, 1997, The Journal of pharmacology and experimental therapeutics.

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

L. Iversen, E. Wong, J. Kemp, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

J. Kemp, P. Leeson, M. Tricklebank, 1993 .

2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.

J. Kemp, P. Leeson, A. Foster, 1992, Journal of medicinal chemistry.

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

S. Iversen, L. Iversen, J. Kemp, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The glycine site of the NMDA receptor--five years on.

J. Kemp, P. Leeson, 1993, Trends in pharmacological sciences.

Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists

J. Kemp, P. Leeson, I. Stansfield, 1993 .

Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor

J. Kemp, P. Leeson, Brett Williams, 1993 .

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

J. Kemp, P. Leeson, A. Foster, 1992, Molecular pharmacology.

Non-competitive antagonists of excitatory amino acid receptors

E. Wong, J. Kemp, A. Foster, 1987, Trends in Neurosciences.

4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.

J. Kemp, P. Leeson, M. Hudson, 1997, Journal of medicinal chemistry.

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex.

J. Kemp, P. Leeson, I. Stansfield, 1993, Journal of medicinal chemistry.

Modulation of cyclic AMP formation by putative metabotropic receptor agonists

Stephen P. H. Alexander, J. Kemp, H. Shinozaki, 1994, British journal of pharmacology.

Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.

J. Kemp, R. Faull, J. Kew, 2002, Brain research. Molecular brain research.

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

J. Kemp, L. Lovat, T. Hoffmann, 2002, Nature.

In Vitro Binding Properties in Rat Brain of [3H]Ro 25‐6981, a Potent and Selective Antagonist of NMDA Receptors Containing NR2B Subunits

J. Kemp, V. Mutel, Z. Bleuel, 1998, Journal of Neurochemistry.

Systemic administration of MK-801 prevents N-methyl-d-aspartate-induced neuronal degeneration in rat brain

J. Kemp, A. Foster, G. Woodruff, 1987, Neuroscience Letters.

Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity.

J. Kemp, J. Seelig, C. Hertel, 1997, Proceedings of the National Academy of Sciences of the United States of America.

State‐dependent NMDA receptor antagonism by Ro 8‐4304, a novel NR2B selective, non‐competitive, voltage‐independent antagonist

J. Kemp, J. Kew, G. Trube, 1998, British journal of pharmacology.

Block of voltage‐dependent sodium currents by the substance P receptor antagonist (±)‐CP‐96,345 in neurones cultured from rat cortex

J. Kemp, G. Seabrook, M. Caeser, 1993, British journal of pharmacology.

Ionotropic and metabotropic glutamate receptor structure and pharmacology

J. Kemp, J. Kew, 2005, Psychopharmacology.

High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.

J. Kemp, J. G. Neduvelil, S. Freedman, 1994, Journal of medicinal chemistry.

The role of GABAergic inhibition in the cortical effects of monocular deprivation

Colin Blakemore, Adam M. Sillito, C. Blakemore, 1981, Nature.

The pharmacological specificity of N‐methyl‐d‐aspartate receptors in rat cerebral cortex: correspondence between radioligand binding and electrophysiological measurements

J. Kemp, A. Foster, S. Grimwood, 1991, British journal of pharmacology.

Controlling Polymerization of β-Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands*

J. Kemp, L. Tjernberg, B. Bohrmann, 2000, The Journal of Biological Chemistry.

Role of Caspase-3 Activation in Cerebral Ischemia-Induced Neurodegeneration in Adult and Neonatal Brain

K. Blomgren, J. Kemp, H. Loetscher, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

J. Kemp, H. Loetscher, R. Gill, 2001, Drug discovery today.

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

J. Kemp, J. Kew, G. Higgins, 2003, The Journal of Neuroscience.

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition

J. Kemp, G. Higgins, T. Ballard, 2003, Neuropharmacology.

Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat

J. Kemp, G. Higgins, T. Ballard, 2005, Psychopharmacology.

Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket

J. Kemp, J. Kew, P. Malherbe, 2003, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological Characterization of Ro 63-1908 (1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a Novel Subtype-SelectiveN-Methyl-d-Aspartate Antagonist

J. Kemp, J. Kew, E. Pinard, 2002, Journal of Pharmacology and Experimental Therapeutics.

Severe Impairment of NMDA Receptor Function in Mice Carrying Targeted Point Mutations in the Glycine Binding Site Results in Drug-Resistant Nonhabituating Hyperactivity

J. Kemp, J. Kew, G. Higgins, 2002, The Journal of Neuroscience.

Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

J. Kemp, J. Kew, V. Mutel, 2000, The Journal of Neuroscience.

NMDA Receptor Antagonists and Their Potential as Neuroprotective Agents

J. Kemp, J. Kew, R. Gill, 1999 .

Developmental Changes in NMDA Receptor Glycine Affinity and Ifenprodil Sensitivity Reveal Three Distinct Populations of NMDA Receptors in Individual Rat Cortical Neurons

J. Kemp, J. Kew, V. Mutel, 1998, The Journal of Neuroscience.

MK-801, NMDA receptors and ischaemia-induced neurodegeneration

J. Kemp, A. Foster, G. Woodruff, 1987 .

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice

J. Kemp, J. Kew, V. Mutel, 2002, Neuropharmacology.

Block of human voltage‐sensitive Na+ currents in differentiated SH‐SY5Y cells by lifarizine

J. Kemp, G. Seabrook, N. Brown, 1994, British journal of pharmacology.

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

S. Nakanishi, J. Kemp, J. Kew, 2004, Neuropharmacology.

The interaction between MK-801 and receptors for n-methyl-d-aspartate : Functional consequences

L. Iversen, E. Wong, J. Kemp, 1987, Neuropharmacology.

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition

S. Nakanishi, J. Kemp, W. Spooren, 2004, Psychopharmacology.

L‐687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective

J. Kemp, R. Hill, T. Priestley, 1998, British journal of pharmacology.

Characterization of [3H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([3H]‐DCG IV) binding to metabotropic mGlu2 receptor‐transfected cell membranes

F. Monsma, J. Kemp, G. Adam, 1998, British journal of pharmacology.

Inhibitory interactions contributing to the ocular dominance of monocularly dominated cells in the normal cat striate cortex

A. Sillito, J. Kemp, H. Patel, 2004, Experimental Brain Research.

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

L. Iversen, J. Kemp, P. Leeson, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The cholinergic influence on the function of the cat dorsal lateral geniculate nucleus (dLGN)

A. Sillito, J. Kemp, N. Berardi, 1983, Brain Research.

The nature of the excitatory transmitter mediating X and Y cell inputs to the cat dorsal lateral geniculate nucleus

A. Sillito, J. Kemp, 1982, The Journal of physiology.

Modulation of Voltage-Gated Calcium Channels by Orphanin FQ in Freshly Dissociated Hippocampal Neurons

J. Kemp, F. Knoflach, O. Civelli, 1996, The Journal of Neuroscience.

Characterization of (2S,2′R,3′R)‐2‐(2′,3′‐[3H]‐Dicarboxycyclopropyl)glycine Binding in Rat Brain

J. Kemp, T. Woltering, G. Adam, 1998, Journal of neurochemistry.

In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain.

J. Kemp, T. Woltering, V. Mutel, 1998, Molecular pharmacology.

Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures

J. Kemp, G. Adam, V. Mutel, 1998, Brain Research.

The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia

J. Kemp, G. Woodruff, C. Brazell, 1991, British journal of pharmacology.

Non-competitive NMDA antagonists as drugs

L. Iversen, J. Kemp, 1995 .

The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.

J. Kemp, P. Whiting, P. C. Harkness, 1993, British journal of pharmacology.

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

J. Sikela, J. Kemp, C. Ragan, 1993, Molecular pharmacology.

Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1

J. Kemp, J. Kew, V. Mutel, 2001, Neuropharmacology.

A novel allosteric modulatory site on the GABAA receptor β subunit

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.

J. Kemp, P. Whiting, P. Krogsgaard‐Larsen, 1994, Molecular pharmacology.

A novel allosteric modulatory site on the GABAA receptor beta subunit.

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

Glycine maintains excitement

J. Kemp, A. Foster, 1989, Nature.

Human C-Reactive Protein Increases Cerebral Infarct Size after Middle Cerebral Artery Occlusion in Adult Rats

J. Kemp, C. Sabin, M. Pepys, 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The distribution of putative neurotransmitters in the lateral geniculate nucleus of the rat

J. Kemp, P. Mantyh, Patrick W. Mantyh, 1983, Brain Research.

SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement

J. Kemp, K. D'ostilio, S. Sunaert, 2023, Frontiers in Pharmacology.

RECOVERY AND FUNCTION OF HUMAN FETAL PANCREAS FROZEN TO −196 C

J. Kemp, S. Hurt, W. Clark, 1981, Transplantation.

Reversal of diabetes in rats using fetal pancreases stored at -196 C.

J. Kemp, Y. Mullen, W. Clark, 1978, Transplantation.

The glycine site on the NMDA receptor: pharmacology and involvement in NMDA receptor-mediated neurodegeneration.

J. Kemp, C. Willis, A. Foster, 1990, Advances in experimental medicine and biology.

Further studies on the action of 5-hydroxytryptamine in the dorsal lateral geniculate nucleus of the cat

A. Sillito, J. Kemp, H. Roberts, 1982, Brain Research.