D. Gisselsson

H. Svensson, D. Gisselsson, E. Hansson, 2020, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Mitotic instability associated with late genomic changes in bone and soft tissue tumours.

Christina Y. Yu, D. Gisselsson, F. Mertens, 2004, Cancer letters.

Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

J. Karlsson, D. Gisselsson, Kristina Aaltonen, 2022, bioRxiv.

Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p.

D. Gisselsson, F. Mitelman, S. Knuutila, 2000, Cancer genetics and cytogenetics.

Tumor biology, biomarkers, and liquid biopsy in pediatric renal tumors

D. Gisselsson, B. Crompton, M. Gessler, 2023, Pediatric blood & cancer.

Ring Y chromosome in an azoospermic male with short stature: additional evidence for a distinct ring Y syndrome in non‐mosaic patients?

D. Gisselsson, A. Giwercman, U. Kristoffersson, 2003, Clinical genetics.

Connecting mitotic instability and chromosome aberrations in cancer--can telomeres bridge the gap?

D. Gisselsson, M. Höglund, 2005, Seminars in cancer biology.

Abnormal nuclear shape in solid tumors reflects mitotic instability.

D. Gisselsson, P. D. Dal Cin, M. Höglund, 2001, The American journal of pathology.

Clonal evolution through genetic bottlenecks and telomere attrition: Potential threats to in vitro data reproducibility

J. Karlsson, D. Gisselsson, E. Manor, 2018, Genes, chromosomes & cancer.

Differential Activation of Immune Effector Processes in Mature Compared to Immature Sacrococcygeal Teratomas

J. Karlsson, D. Gisselsson, L. Hagander, 2020, Fetal and pediatric pathology.

Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers

D. Gisselsson, M. Höglund, D. Lindgren, 2007, Clinical Cancer Research.

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study

M. O'sullivan, D. Gisselsson, M. Kool, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA‐FISH

H. Tanke, D. Gisselsson, M. Höglund, 2001, Genes, chromosomes & cancer.

Chromosome instability in cancer: how, when, and why?

D. Gisselsson, 2003, Advances in cancer research.

Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum

D. Gisselsson, S. Påhlman, C. Persson, 2017, Scientific Reports.

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

N. Rahman, D. Gisselsson, J. Clayton-Smith, 2011, Nature Genetics.

Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.

Mattias Höglund, Mef Nilbert, David Gisselsson, 2002, Cancer research.

Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

D. Gisselsson, F. Speleman, R. Versteeg, 2012, Genes, chromosomes & cancer.

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors

D. Gisselsson, M. Kool, K. Sakaguchi, 2020, bioRxiv.

snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

D. Gisselsson, R. Versteeg, D. Lindgren, 2013, Translational oncology.

Intratumor diversity and clonal evolution in cancer--a skeptical standpoint.

D. Gisselsson, 2011, Advances in cancer research.

Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice

D. Gisselsson, Å. Petersén, M. Björkqvist, 2005, BMC Cell Biology.

Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification.

D. Gisselsson, M. Höglund, F. Mitelman, 2004, Cancer genetics and cytogenetics.

Tumors of endocrine glands

D. Gisselsson, J. Bullerdiek, 2015 .

Prevalence of germline TP53 mutations and history of Li–Fraumeni syndrome in families with childhood adrenocortical tumors, choroid plexus tumors, and rhabdomyosarcoma: A population‐based survey

D. Gisselsson, Å. Borg, H. Olsson, 2012, Pediatric blood & cancer.

Anti-tumor effects of rigosertib in high-risk neuroblastoma

J. Karlsson, D. Gisselsson, K. Pietras, 2021, Translational oncology.

Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma.

J. Karlsson, D. Gisselsson, D. Lindgren, 2018, Cancer research.

Title : Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma Running title : Intratumor heterogeneity in neuroblastoma

Noguera, J. Karlsson, D. Gisselsson, 2018 .

High‐resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors

D. Gisselsson, F. Mertens, J. Merks, 2008, Genes, chromosomes & cancer.

Tracing the evolution of aneuploid cancers by multiregional sequencing with CRUST

Jenny Karlsson, Natalie Andersson, Subhayan Chattopadhyay, 2021, Briefings Bioinform..

Tracing the evolution of aneuploid cancers from multiregional sequencing

J. Karlsson, D. Gisselsson, S. Chattopadhyay, 2020, bioRxiv.

Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cells

D. Gisselsson, M. Ehrlich, D. Smeets, 2005, Chromosoma.

Intratumour Diversity of Chromosome Copy Numbers in Neuroblastoma Mediated by On-Going Chromosome Loss from a Polyploid State

D. Gisselsson, R. Versteeg, I. Øra, 2013, PloS one.

Clonal competition within complex evolutionary hierarchies shapes AML over time

D. Gisselsson, T. Fioretos, G. Juliusson, 2020, Nature Communications.

High levels of HIF‐2α highlight an immature neural crest‐like neuroblastoma cell cohort located in a perivascular niche

D. Gisselsson, S. Navarro, I. Øra, 2007, The Journal of pathology.

Whole chromosome gain does not in itself confer cancer-like chromosomal instability

D. Gisselsson, B. Baldetorp, Yuesheng Jin, 2013, Proceedings of the National Academy of Sciences.

Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma

D. Gisselsson, E. Lindberg, E. Englund, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Mechanisms of Whole Chromosome Gains in Tumors – Many Answers to a Simple Question

D. Gisselsson, 2010, Cytogenetic and Genome Research.

Elevated Tolerance to Aneuploidy in Cancer Cells: Estimating the Fitness Effects of Chromosome Number Alterations by In Silico Modelling of Somatic Genome Evolution

D. Gisselsson, Yuesheng Jin, Anders Valind, 2013, PloS one.

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

D. Gisselsson, M. Höglund, F. Mitelman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution

D. Gisselsson, M. Höglund, B. Johansson, 2001, Genes, chromosomes & cancer.

Ring chromosomes: vicious circles at the end and beginning of life

D. Gisselsson, 2011 .

Defective Chromosome Segregation and Telomere Dysfunction in Aggressive Wilms' Tumors

D. Gisselsson, A. Meeker, I. Øra, 2007, Clinical Cancer Research.

PLAG1 (Pleomorphic adenoma gene 1)

D. Gisselsson, 2011 .

Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics.

D. Gisselsson, M. Höglund, F. Mertens, 1999, The American journal of surgical pathology.

Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near‐haploidization and loss of the RB1 gene

D. Gisselsson, F. Mertens, Jakob Hofvander, 2016, Histopathology.

Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.

Thoas Fioretos, Jenny Karlsson, Henrik Lilljebjörn, 2015, Cancer letters.

Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing

D. Gisselsson, F. Mertens, C. Fletcher, 2015, Laboratory Investigation.

The fetal thymus has a unique genomic copy number profile resulting from physiological T cell receptor gene rearrangement

D. Gisselsson, M. Johansson, B. Baldetorp, 2016, Scientific Reports.

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

D. Gisselsson, C. Lassen, T. Fioretos, 2010, Blood.

Statistical behavior of complex cancer karyotypes

Mattias Höglund, Attila Frigyesi, David Gisselsson, 2005, Genes, chromosomes & cancer.

Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data.

Mattias Höglund, David Gisselsson, D. Gisselsson, 2004, Cancer genetics and cytogenetics.

Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas

D. Gisselsson, M. Höglund, L. Gorunova, 2004, British Journal of Cancer.

Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours.

D. Gisselsson, S. Navarro, I. Øra, 2016, Cancer letters.

Chromosomal instability in cancer: Causes and consequences

David Gisselsson, D. Gisselsson, 2011 .

Genetic intratumour heterogeneity in high‐grade brain tumours is associated with telomere‐dependent mitotic instability

D. Gisselsson, L. Salford, E. Englund, 2007, Neuropathology and applied neurobiology.

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.

D. Gisselsson, M. Höglund, F. Mitelman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Classification of chromosome segregation errors in cancer

D. Gisselsson, 2008, Chromosoma.

When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses

D. Gisselsson, A. Rosengren, I. Panagopoulos, 2008, PloS one.

Building a precision medicine infrastructure at a national level: The Swedish experience

D. Gisselsson, T. Fioretos, L. Cavelier, 2023, Cambridge prisms. Precision medicine.

Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome

D. Gisselsson, V. Shanmugasundaram, F. Alkuraya, 2020, The Journal of experimental medicine.

Array‐based genotype–phenotype correlation in a case of supernumerary ring chromosome 12

D. Gisselsson, J. Davidsson, A. Collin, 2007, Clinical genetics.

Chemotherapy, host response and molecular dynamics in periampullary cancer: the CHAMP study

D. Gisselsson, K. Jirström, J. Eberhard, 2020, BMC Cancer.

Tumorigenesis and Neoplastic Progression Deletions of 16 q in Wilms Tumors Localize to Blastemal-Anaplastic Cells and Are Associated with Reduced Expression of the IRXB Renal Tubulogenesis Gene Cluster

J. Karlsson, D. Gisselsson, D. Lindgren, 2010 .

Binomial Mitotic Segregation of MYCN-Carrying Double Minutes in Neuroblastoma Illustrates the Role of Randomness in Oncogene Amplification

D. Gisselsson, A. Rosengren, S. Påhlman, 2008, PloS one.

Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis

Nazneen Rahman, Johan Persson, Sandra Hanks, 2010, Proceedings of the National Academy of Sciences.

Telomere‐mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma

D. Gisselsson, M. Höglund, S. Tsao, 2005, Genes, chromosomes & cancer.

Alternative lengthening of telomeres—An enhanced chromosomal instability in aggressive non‐MYCN amplified and telomere elongated neuroblastomas

D. Gisselsson, S. Navarro, I. Øra, 2011, Genes, chromosomes & cancer.

Telomere dysfunction and telomerase activation in cancer – a pathological paradox?

D. Gisselsson, O. Calcagnile, 2007, Cytogenetic and Genome Research.

Coping with complexity. multivariate analysis of tumor karyotypes.

Mattias Höglund, David Gisselsson, D. Gisselsson, 2002, Cancer genetics and cytogenetics.

Multiple mechanisms of MYCN dysregulation in Wilms tumour

D. Gisselsson, M. Kool, M. Gessler, 2015, Oncotarget.

Histopathological dimensions differ between aganglionic and ganglionic bowel wall in children with Hirschsprung’s disease

D. Gisselsson, T. Jansson, M. Cinthio, 2022, BMC pediatrics.

Ultra high frequency ultrasonography to distinguish ganglionic from aganglionic bowel wall in Hirschsprung disease: A first report.

D. Gisselsson, T. Jansson, M. Cinthio, 2021, Journal of pediatric surgery.

Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

J. Karlsson, Linda Holmquist Mengelbier, D. Gisselsson, 2018, Nature Genetics.

BCOR internal tandem duplication and YWHAE–NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney

J. Karlsson, D. Gisselsson, Anders Valind, 2016, Genes, chromosomes & cancer.

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

J. Karlsson, D. Gisselsson, A. Ameur, 2015, Nature Communications.

Immune checkpoint inhibitors in Wilms' tumor and Neuroblastoma: What now?

D. Gisselsson, Anders Valind, 2021, Cancer reports.

Dissecting karyotypic patterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution

Mattias Höglund, David Gisselsson, D. Horsman, 2004, International journal of cancer.

Locus‐specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia

D. Gisselsson, M. Höglund, L. Gorunova, 2000, Genes, chromosomes & cancer.

Trailblazing Precision Medicine in Europe: a joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany.

S. Fröhling, L. Levin, D. Gisselsson, 2021, Seminars in cancer biology.

A model for karyotypic evolution in testicular germ cell tumors

D. Gisselsson, M. Höglund, F. Mitelman, 2004, Genes, chromosomes & cancer.

Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy

J. Karlsson, D. Gisselsson, Kristina Aaltonen, 2023, Oncoimmunology.

2. Cytogenetic Methods

D. Gisselsson, 2010 .

Cryptic terminal chromosome rearrangements in colorectal carcinoma cell lines detected by subtelomeric FISH analysis

H. Tanke, D. Gisselsson, J. Wiegant, 2006, Cytogenetic and Genome Research.

Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres

D. Gisselsson, F. Mertens, J. Wiegant, 2002, British Journal of Cancer.

Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study.

D. Gisselsson, M. Höglund, B. Johansson, 2000, Medical and pediatric oncology.

A case of Cornelia de Lange syndrome from Sudan

D. Gisselsson, T. Nilsson, M. Ellaithi, 2007, BMC pediatrics.

Refined characterisation of chromosome aberrations in tumours by multicolour banding and electronic mapping resources.

D. Gisselsson, 2001, Methods in cell science : an official journal of the Society for In Vitro Biology.

Confined trisomy 8 mosaicism of meiotic origin: A rare cause of aneuploidy in childhood cancer

Anders Valind, David Gisselsson, Linda Holmquist Mengelbier, 2014, Genes, chromosomes & cancer.

Genetic bottlenecks and the hazardous game of population reduction in cell line based research.

D. Gisselsson, D. Lindgren, H. Yeger, 2010, Experimental cell research.

Implementing precision medicine in a regionally organized healthcare system in Sweden

L. Levin, D. Gisselsson, T. Fioretos, 2022, Nature Medicine.

Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression

J. Karlsson, M. O'sullivan, D. Gisselsson, 2016, Oncotarget.

Inactivation of RB1 , CDKN2A , and TP53 have distinct effects on genomic stability at side‐by‐side comparison in karyotypically normal cells

J. Karlsson, D. Gisselsson, L. Magnusson, 2022, Genes, chromosomes & cancer.

Chromosomal Instability in Cancer : Causes and Consequences Gisselsson

D. Gisselsson, 2011 .

Mitotic Instability in Cancer: Is There Method in the Madness?

D. Gisselsson, 2005, Cell cycle.

Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma.

Mattias Höglund, David Gisselsson, D. Gisselsson, 2004, Cancer genetics and cytogenetics.

Changes in the Prevalence of Embryologic Remnants in Umbilical Cord With Gestational Age

D. Gisselsson, Emma Grottling, 2018, Pediatric and Developmental Pathology.

Diagnostic Efficacy of Rectal Suction Biopsy with Regard to Weight in Children Investigated for Hirschsprung’s Disease

D. Gisselsson, K. Hagelsteen, P. Stenström, 2022, Children.

Next-Generation Biowarfare: Small in Scale, Sensational in Nature?

D. Gisselsson, 2022, Health security.

The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis

S. Hopyan, J. Karlsson, Linda Holmquist Mengelbier, 2018, The Journal of pathology.

Tumor-initiating cells in childhood neuroblastoma--letter.

D. Gisselsson, M. Andäng, I. Ora, 2012, Cancer Research.

Clonal competition within complex evolutionary hierarchies shapes AML over time

D. Gisselsson, T. Fioretos, G. Juliusson, 2020, Nature Communications.

Absence of epstein–barr and cytomegalovirus infection in neuroblastoma cells by standard detection methodologies

J. Karlsson, D. Gisselsson, J. Dillner, 2013, Pediatric blood & cancer.

Genetic heterogeneity in rhabdomyosarcoma revealed by SNP array analysis

D. Gisselsson, F. Mertens, N. Mandahl, 2016, Genes, chromosomes & cancer.

Wilms tumors develop through two distinct karyotypic pathways.

D. Gisselsson, M. Höglund, F. Mitelman, 2004, Cancer genetics and cytogenetics.

Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer.

P. Grillner, D. Gisselsson, A. Nordgren, 2023, JCO precision oncology.

Chemotherapy, host response and molecular dynamics in periampullary cancer: the CHAMP study

D. Gisselsson, K. Jirström, J. Eberhard, 2020, BMC Cancer.

Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas

D. Gisselsson, M. Höglund, I. Øra, 2007, Journal of carcinogenesis.

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric Cancers

J. Karlsson, Linda Holmquist Mengelbier, D. Gisselsson, 2020, Cancer Research.

Reply to Duesberg: Stability of peritriploid and triploid states in neoplastic and nonneoplastic cells

D. Gisselsson, Anders Valind, 2014, Proceedings of the National Academy of Sciences.

Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression

J. Karlsson, D. Gisselsson, Anders Valind, 2016, Oncotarget.

Coping with complexity: multivariate analysis of tumor karyotypes

D. Gisselsson, M. Höglund, F. Mitelman, 2002 .

Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours

D. Gisselsson, M. Höglund, F. Mitelman, 2005, International journal of cancer.

SIX1 as a Novel Immunohistochemical Marker in the Differential Diagnosis of Rhabdomyosarcoma

D. Gisselsson, Daniel Ehinger, Hanna Frostberg, 2023, Fetal and pediatric pathology.

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

D. Gisselsson, S. Hanks, Elise Ruark, 2011, Nature Genetics.

HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

D. Gisselsson, E. Fredlund, S. Navarro, 2009, Proceedings of the National Academy of Sciences.

Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

D. Gisselsson, F. Speleman, R. Versteeg, 2012, Genes, chromosomes & cancer.

Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin

J. Karlsson, Linda Holmquist Mengelbier, A. Naranjo, 2014, Genes, chromosomes & cancer.

Wargaming cancer: a strategy for future precision oncology?

D. Gisselsson, Tony Ingesson, 2023, Trends in cancer.

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

J. Karlsson, D. Gisselsson, A. Ameur, 2015, Nature Communications.

Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.

J. Karlsson, D. Gisselsson, D. Lindgren, 2010, American Journal of Pathology.

Hallmark discoveries in the biology of Wilms tumour.

D. Gisselsson, R. Williams, J. Drost, 2023, Nature reviews. Urology.

Elevated Tolerance to Aneuploidy in Cancer Cells: Estimating the Fitness Effects of Chromosome Number Alterations by In Silico Modelling of Somatic Genome Evolution

D. Gisselsson, Yuesheng Jin, Anders Valind, 2013, PloS one.

Regarding human cytomegalovirus in neuroblastoma

Linda Holmquist Mengelbier, D. Gisselsson, O. Forslund, 2014, Cancer medicine.

Gradual transition towards anaplasia in Wilms tumor through tolerance to genetic damage.

Linda Holmquist Mengelbier, D. Gisselsson, D. Perotti, 2023, Modern Pathology.

Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

J. Karlsson, Linda Holmquist Mengelbier, D. Gisselsson, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.

High levels of HIF‐2α highlight an immature neural crest‐like neuroblastoma cell cohort located in a perivascular niche

D. Gisselsson, S. Navarro, I. Øra, 2007, The Journal of pathology.