P. Reitsma

发表

F. R. Rosendaal, P. Reitsma, 2015, Journal of thrombosis and haemostasis : JTH.

Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity.

P. Reitsma, F. Bernardi, M. Monti, 2009, Thrombosis research.

Formation of platelet‐binding von Willebrand factor strings on non‐endothelial cells

P. Reitsma, J. Voorberg, J. W. Wang, 2012, Journal of thrombosis and haemostasis : JTH.

Analysis of Gene Expression Identifies Differentially Expressed Genes and Pathways Associated with Lymphatic Dissemination in Patients with Adenocarcinoma of the Esophagus

P. Reitsma, F. Baas, A. Zwinderman, 2008, Annals of surgical oncology.

Haemophilia B: database of point mutations and short additions and deletions.

P. Reitsma, K. High, R. Schwaab, 1990, Nucleic acids research.

Mutations in hemophilia Bm occur at the Arg180-Val activation site or in the catalytic domain of factor IX.

P. Reitsma, P. Mannucci, R. Bertina, 1990, The Journal of biological chemistry.

Eleven novel mutations in the factor VIII gene from Brazilian hemophilia A patients.

P. Reitsma, F. Costa, V. Arruda, 1995, Blood.

Screening for mutations in haemophilia A patients by multiplex PCR‐SSCP, Southern blotting and RNA analysis: the detection of a genetic abnormality in the factor VIII gene in 30 out of 35 patients

P. Reitsma, E. Briet, W. C. Pieneman, 1995, British journal of haematology.

Genetics of venous thrombosis

P. Reitsma, F. Rosendaal, P. Reitsma, 2009, Journal of thrombosis and haemostasis : JTH.

Mechanistic View of Risk Factors for Venous Thromboembolism

P. Reitsma, H. Versteeg, S. Middeldorp, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

K. Hao, P. Deloukas, P. Ridker, 2015, American journal of human genetics.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Sri V. V. Deevi, W. Ouwehand, A. Attwood, 2016, Blood.

Predators

P. Reitsma, F. Rosendaal, P. H. Reitsma, 2018, Journal of thrombosis and haemostasis : JTH.

Mutation in blood coagulation factor V associated with resistance to activated protein C

Pieter H. Reitsma, Bobby P. C. Koeleman, P. Reitsma, 1994, Nature.

Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity.

P. Reitsma, R. Bertina, C. Spek, 1999, The Biochemical journal.

Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity

P. Reitsma, R. Bertina, Spek Ca, 1999 .

Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression

P. Reitsma, P. Kuppen, H. Versteeg, 2015, Journal of thrombosis and haemostasis : JTH.

Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease

P. Reitsma, S. V. van Deventer, P. Stokkers, 1998, Gut.

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.

P. Reitsma, J. Voorberg, K. Valentijn, 2013, Blood.

THROMBOSIS AND HEMOSTASIS Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease

P. Reitsma, J. Voorberg, K. Valentijn, 2013 .

Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor.

P. Reitsma, J. Eikenboom, G. Castaman, 1996, Blood.

Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism

P. Reitsma, F. Rosendaal, S. Middeldorp, 2017, PloS one.

No evidence for a direct effect of von Willebrand factor's ABH blood group antigens on von Willebrand factor clearance

P. Reitsma, J. Eikenboom, G. Castaman, 2015, Journal of thrombosis and haemostasis : JTH.

Aspects of clearance of VWF

P. Reitsma, G. Castaman, R. Dirven, 2015 .

Biogenesis and exocytosis of Weibel-Palade bodies is affected by naturally occurring variants within the von Willebrand factor A1-A3 domains

P. Reitsma, J. Voorberg, K. Valentijn, 2012 .

Biogenesis of Weibel-Palade bodies in von Willebrand’s disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation

P. Reitsma, J. Voorberg, K. Valentijn, 2012, Haematologica.

Intracellular Storage and Regulated Secretion of Von Willebrand Factor in Quantitative Von Willebrand Disease*

P. Reitsma, A. Koster, J. Voorberg, 2011, The Journal of Biological Chemistry.

UvA-DARE ( Digital Academic Repository ) Factor VIII expression and regulation in health and disease

P. Reitsma, J. Meijers, M. J. Hollestelle, 2007 .

Recessive inheritance of von Willebrand's disease type I

P. Reitsma, J. Eikenboom, K. Peerlinck, 1993, The Lancet.

Multiple substitutions in the von Willebrand factor gene that mimic the pseudogene sequence.

P. Reitsma, J. Sixma, J. Eikenboom, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice

P. Reitsma, H. Versteeg, C. Spek, 2004, Journal of thrombosis and haemostasis : JTH.

Blood cell-derived tissue factor influences host response during murine endotoxemia.

P. Reitsma, C. Spek, S. Florquin, 2004, Blood cells, molecules & diseases.

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

B. Lämmle, P. Reitsma, H. Crijns, 2020, Thrombosis and Haemostasis.

Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients.

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1996, Blood.

Mechanisms of heparin induced anti-cancer activity in experimental cancer models.

P. Reitsma, H. Büller, C. V. van Noorden, 2007, Critical reviews in oncology/hematology.

Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats

P. Reitsma, O. Bijvoet, H. Verlinden-Ooms, 2006, Calcified Tissue International.

Overexpression of hepatic prothymosin alpha, a novel marker for human hepatocellular carcinoma.

P. Reitsma, R. Chamuleau, N. Habib, 1997, British Journal of Cancer.

Genetic risk factors for venous thrombosis.

P. Reitsma, C. Spek, 2000, Molecular genetics and metabolism.

Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk.

P. Reitsma, F. Rosendaal, R. Bertina, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families.

P. Reitsma, R. Bertina, B. Koeleman, 1994 .

High levels of protein C are determined by PROCR haplotype 3

P. Reitsma, F. Rosendaal, S. Middeldorp, 2011, Journal of thrombosis and haemostasis : JTH.

Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study)

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1995, Blood.

Mature

F. R. Rosendaal, P. Reitsma, F. R. Rosendaal, 2015, Journal of thrombosis and haemostasis : JTH.

Increased Risk of Venous Thrombosis in Oral-Contraceptive Users Who Are Carriers of Factor V Leiden Mutation

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1995 .

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

P. Reitsma, F. Rosendaal, R. Bertina, 1993 .

Protein C Deficiency: A Database of Mutations, 1995 Update

P. Reitsma, F. Bernardi, I. Witt, 1995, Thrombosis and Haemostasis.

Protein S Deficiency: A Database of Mutations – Summary of the First Update

P. Reitsma, D. Cooper, F. Bernardi, 2000, Thrombosis and Haemostasis.

Elevated anti-human factor Xa activity in rabbit and rodent plasma: Implications for preclinical assessment of human factor X in animal models of hemostasis.

P. Reitsma, K. Cheung, M. Bos, 2020, Thrombosis research.

Elevated coagulation factor levels affect the tissue factor-threshold in thrombin generation.

P. Reitsma, I. M. Rietveld, M. Bos, 2018, Thrombosis research.

Long‐term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis

P. Reitsma, H. Büller, C. V. van Noorden, 2009, Journal of thrombosis and haemostasis : JTH.

Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation.

P. Reitsma, M. Peppelenbosch, K. Borensztajn, 2009, Thrombosis research.

Differential effects of anticoagulants on tumor development of mouse cancer cell lines B 16 , K 1735 and CT 26 in

P. Reitsma, D. Richel, C. Spek, 2009 .

Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

P. Reitsma, H. Versteeg, C. Spek, 2008, Journal of cellular and molecular medicine.

Chapter 4 Metastasis promoting effects of thrombin inhibitors

P. Reitsma, H. Büller, D. Richel, 2008 .

Chapter In vivo analysis of the antimetastatic effects of anticoagulants on murine cancer cell lines B 16 , K 1735 and CT 26

P. Reitsma, D. Richel, C. Spek, 2008 .

High FVIIa levels do not promote tumor metastasis

P. Reitsma, H. Versteeg, C. Spek, 2008 .

Curated disease‐causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH

W. Ouwehand, K. Downes, P. Reitsma, 2019, Journal of thrombosis and haemostasis : JTH.

Modified two-step model for studying the inflammatory response during myocardial ischemia and reperfusion in mice.

Robbert J de Winter, P. Reitsma, R. D. de Winter, 2003, Comparative medicine.

Reduced acute myocardial ischemia–reperfusion injury in IL-6-deficient mice employing a closed-chest model

P. Reitsma, R. D. de Winter, A. Linnenbank, 2016, Inflammation Research.

A new diphosphonate: dissociation between effects on cells and mineral in rats and a preliminary trial in Paget's disease.

P. Reitsma, H. Lemkes, O. Bijvoet, 1978, Advances in experimental medicine and biology.

Assessment of coagulation and fibrinolysis in families with unexplained thrombophilia

P. Reitsma, H. Büller, F. Rosendaal, 2009, Thrombosis and Haemostasis.

The inheritance and molecular genetics of von Willebrand's disease

P. Reitsma, J. Eikenboom, E. Briët, 1995, Haemophilia : the official journal of the World Federation of Hemophilia.

Statins and Risk of Bleeding: An Analysis to Evaluate Possible Bias Due to Prevalent Users and Healthy User Aspects.

P. Reitsma, S. le Cessie, F. Rosendaal, 2016, American journal of epidemiology.

Genetic risk factors of venous thrombosis

P. Reitsma, R. Franco, 2001, Human Genetics.

Effectss of simvastatin on coagulation and fibrinolysis in relationn to intima-media thickness in patients with familia ll hypercholesterolemi a Submittedd for publication

P. Reitsma, M. Trip, B. Hutten, 2007 .

Arteriall wall thickness and the risk of recurrent ischemic events in carriers off the prothrombin G20210A mutation with clinical manifestations of atherosclerosis s

P. Reitsma, M. Prins, H. Büller, 2007 .

UvA-DARE ( Digital Academic Repository ) Atherosclerosis ; aspects of a multicultural disease

P. Reitsma, M. Prins, H. Büller, 2007 .

Mutations in Severe, Type III von Willebrand’s Disease in the Dutch Population: Candidate Missense and Nonsense Mutations Associated with Reduced Levels of von Willebrand Factor Messenger RNA

P. Reitsma, H. K. Ploos van Amstel, J. Eikenboom, 1992, Thrombosis and Haemostasis.

The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI

P. Reitsma, F. Rosendaal, P. Sandset, 2013, Thrombosis and Haemostasis.

Factor V Leiden (FV R506Q) in Families with Inherited Antithrombin Deficiency

P. Reitsma, F. Rosendaal, K. Bauer, 1996, Thrombosis and Haemostasis.

Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study

P. Reitsma, F. Rosendaal, P. Reitsma, 2004, Journal of thrombosis and haemostasis : JTH.

The 4G/5G Polymorphism in the Plasminogen Activator Inhibitor-1 Gene Is not Associated with Myocardial Infarction

P. Reitsma, F. Rosendaal, R. Bertina, 1999, Thrombosis and Haemostasis.

Objectives and Design of BLEEDS: A Cohort Study to Identify New Risk Factors and Predictors for Major Bleeding during Treatment with Vitamin K Antagonists

P. Reitsma, F. V. D. van der Meer, W. Lijfering, 2016, PloS one.

Circulating nucleosomes and elastase α1-antitrypsin complexes and the novel thrombosis susceptibility locus SLC44A2.

P. Reitsma, S. Middeldorp, B. V. van Vlijmen, 2016, Thrombosis research.

Is there still room for additional common susceptibility alleles for venous thromboembolism?

D. Chasman, P. Reitsma, D. Trégouët, 2016, Journal of thrombosis and haemostasis : JTH.

Updated analysis of gene variants associated with deep vein thrombosis.

P. Reitsma, F. Rosendaal, L. Bare, 2010, JAMA.

Geographic Distribution of the 20210 G to A Prothrombin Variant

P. Reitsma, D. Siscovick, F. Rosendaal, 1998, Thrombosis and Haemostasis.

Identification of polymorphisms in the 5'-untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis.

P. Reitsma, M. Zago, W. Silva, 2001, Haematologica.

Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes.

P. Reitsma, D. Sommeijer, H. ten Cate, 2004, Diabetes care.

Coagulation and inflammation in diabetes mellitus

P. Reitsma, J. Kuiper, H. Cate, 2007 .

Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice

P. Reitsma, D. Sommeijer, C. Spek, 2007, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.

P. Reitsma, C. Esmon, M. Aiach, 2007, American journal of respiratory and critical care medicine.

Major Haemorrhage during Vitamin K Antagonist Treatment: The Influence of Thyroid Hormone Levels

P. Reitsma, O. Dekkers, F. Rosendaal, 2014, European Thyroid Journal.

Prevalence of Protein C Deficiency in the Healthy Population

P. Reitsma, R. Bertina, R. Tait, 1995, Thrombosis and Haemostasis.

Relationship between in vitro lipopolysaccharide-induced cytokine response in whole blood, angiographic in-stent restenosis, and toll-like receptor 4 gene polymorphisms.

P. Reitsma, J. Tijssen, R. D. de Winter, 2005, Clinical chemistry.

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.

T. van der Poll, P. Reitsma, P. Speelman, 2004, Blood.

Interleukin 8 and venous thrombosis: evidence  for a role of inflammation in thrombosis

P. Reitsma, F. Rosendaal, B. V. van Aken, 2002, British journal of haematology.

Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation

P. Reitsma, M. Neumaier, P. Corbisier, 2005, Clinical chemistry and laboratory medicine.

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.

P. Reitsma, M. Peppelenbosch, H. Versteeg, 2006, Experimental cell research.

in a murine model of systemic inflammation Protease-activated receptor-4 inhibition protects from multiorgan failure

P. Reitsma, C. Spek, M. Bijlsma, 2013 .

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation.

P. Reitsma, C. Spek, H. ten Cate, 2007, Blood.

The contribution of DNA analysis to carrier detection and prenatal diagnosis of hemophilia A and B

P. Reitsma, G. Ommen, E. Bakker, 2005, Annals of Hematology.

Differential action of the bisphosphonates (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) and disodium dichloromethylidene bisphosphonate (Cl2MDP) on rat macrophage-mediated bone resorption in vitro.

P. Reitsma, S. Teitelbaum, A. Kahn, 1982, The Journal of clinical investigation.

Correlation of repressed transcription of α‐tocopherol transfer protein with serum α‐tocopherol during hepatocarcinogenesis

P. Reitsma, R. Chamuleau, S. V. van Deventer, 1997 .

Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events.

A. Zwinderman, R. Peters, P. Reitsma, 2004, American heart journal.

Thrombospondin-2 Polymorphism Is Associated With a Reduced Risk of Premature Myocardial Infarction

A. Zwinderman, R. Peters, J. Boer, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction.

P. Reitsma, F. Rosendaal, R. Bertina, 2009, Atherosclerosis.

A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

P. Reitsma, H. Büller, F. Rosendaal, 2005, PLoS medicine.

Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers.

P. Reitsma, S. Middeldorp, J. Meinardi, 2000 .

Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers

P. Reitsma, E. V. van Pampus, S. Middeldorp, 2000, British journal of haematology.

A Genetic Propensity to High Factor VII Is not Associated with the Risk of Myocardial Infarction in Men

P. Reitsma, F. Rosendaal, R. Bertina, 1998, Thrombosis and Haemostasis.

A Genetic Propensity to High Factor VII Is not Associated with the Risk of Myocardial Infarction in Men

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1998 .

Amino acid dimorphism in IL1A is detectable by PCR amplification.

P. Reitsma, P. A. van den Velden, P. Velden, 1993, Human molecular genetics.

Predators

P. Reitsma, F. Rosendaal, 2018, Journal of thrombosis and haemostasis : JTH.

respiratory pathogens and lipopolysaccharide Activated Protein C have an unaltered pulmonary immune response to Thrombomodulin mutant mice with a strongly reduced capacity to generate

P. Reitsma, C. Esmon, T. Poll, 2010 .

Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis

P. Reitsma, C. Ince, C. Spek, 2003, Basic Research in Cardiology.

Single Nucleotide Variants in the Protein C Pathway and Mortality in Dialysis Patients

W. Ouwehand, P. Reitsma, W. März, 2014, PloS one.

High Soluble Thrombomodulin Is Associated with an Increased Risk of Major Bleeding during Treatment with Oral Anticoagulants: A Case–Cohort Study

P. Reitsma, S. Cannegieter, F. V. D. van der Meer, 2020, Thrombosis and Haemostasis.

Multi‐dose drug dispensing as a tool to improve medication adherence: A study in patients using vitamin K antagonists

P. Reitsma, S. Cannegieter, F. V. D. van der Meer, 2018, Pharmacoepidemiology and drug safety.

Evaluation of the von Willebrand factor Y1584C polymorphism as a potential risk factor for bleeding in patients receiving anticoagulant treatment with vitamin K antagonists

P. Reitsma, J. Eikenboom, J. F. van der Heijden, 2005, Journal of thrombosis and haemostasis : JTH.

Factor V Leiden and Fatal Pulmonary Embolism

P. Reitsma, J. Vandenbroucke, R. Bertina, 1998, Thrombosis and Haemostasis.

Resistance to Activated Protein C and Factor V Leiden as Risk Factors for Venous Thrombosis

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1995, Thrombosis and Haemostasis.

High Plasma Concentration of Factor VIIIc Is a Major Risk Factor for Venous Thromboembolism

P. Reitsma, M. Prins, H. Büller, 2000, Thrombosis and Haemostasis.

Procoagulant protein levels are differentially increased during human endotoxemia

T. van der Poll, P. Reitsma, J. Meijers, 2003, Journal of thrombosis and haemostasis : JTH.

Diabetess mellitus does not increase thrombogenicityy of the arterial vessel wall in atheroscleroticc LDLr-/- mice

P. Reitsma, D. Sommeijer, J. Kuiper, 2007 .

Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.

T. van der Poll, P. Reitsma, C. Spek, 2004, The Journal of infectious diseases.

How to identify new genetic risk factors for VTE?

P. Reitsma, 2009, Thrombosis research.

A novel candidate mutation (Arg611→ His) in type I‘platelet discordant’von Willebrand's disease with desmopressin‐induced thrombocytopenia

P. Reitsma, J. Eikenboom, F. Rodeghiero, 1995, British journal of haematology.

Blood coagulation factors as inflammatory mediators.

P. Reitsma, C. Spek, S. Schoenmakers, 2005, Blood cells, molecules & diseases.

Recurrent Venous Thrombosis and Markers of Inflammation

P. Reitsma, M. den Heijer, S. V. van Deventer, 2000, Thrombosis and Haemostasis.

Use of "C9/11 Mismatch" Control Small Interfering RNA Reveals Sequence-Related Off-Target Effect on Coagulation of an Small Interfering RNA Targeting Mouse Coagulation Factor XII.

P. Reitsma, H. Versteeg, B. V. van Vlijmen, 2019, Nucleic acid therapeutics.

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils.

T. Renné, P. Reitsma, D. Kirchhofer, 2019, Blood.

Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice.

P. Reitsma, E. Laghmani, G. Wagenaar, 2016, Blood.

Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors

P. Reitsma, B. V. van Vlijmen, J. V. van Diepen, 2015, PloS one.

Phylogeny of renal phosphate transport in the vertebrates.

P. Reitsma, O. Bijvoet, 1977, Advances in experimental medicine and biology.

Is hypercoagulability an issue in arterial thrombosis? No

P. Reitsma, P. Reitsma, 2004, Journal of thrombosis and haemostasis : JTH.

Thrombospondin gene polymorphisms and the risk of angiographic coronary in-stent restenosis.

R. Peters, P. Reitsma, J. Tijssen, 2004, The American journal of medicine.

Functional implications of the unique disulfide bond in venom factor V from the Australian common brown snake Pseudonaja textilis

P. Reitsma, R. Camire, M. Bos, 2014 .

Factor V Leiden: An Additional Risk Factor for Thrombosis in Protein S Deficient Families?

P. Reitsma, R. Bertina, B. Koeleman, 1995, Thrombosis and Haemostasis.

Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide

P. Reitsma, H. Versteeg, S. Osanto, 2013, Haematologica.

Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

P. Reitsma, S. Teitelbaum, L. Pegg, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Human protein S cDNA encodes Phe‐16 and Tyr 222 in consensus sequences for the post‐translational processing

P. Reitsma, R. Bertina, H. K. V. van Amstel, 1987, FEBS letters.

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia*

T. van der Poll, P. Reitsma, C. Spek, 2006, Critical care medicine.

Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation.

P. Reitsma, C. Spek, A. Groot, 2007, American journal of respiratory and critical care medicine.

factor-factor Vil a pathway in murinee pneumococcal pneumonia

P. Reitsma, P. Bresser, T. Poll, 2007 .

Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice*

P. Reitsma, C. Spek, S. Schoenmakers, 2006, Critical care medicine.

Role of the FV Leiden mutation in septic peritonitis assessed in FV Leiden transgenic mice

P. Reitsma, C. Spek, A. Groot, 2006 .

Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.

P. Carmeliet, T. van der Poll, P. Reitsma, 2003, Blood.

Apolipoprotein A-V A NOVEL APOLIPOPROTEIN ASSOCIATED WITH AN EARLY PHASE OF LIVER REGENERATION*

P. Reitsma, R. Chamuleau, W. Boers, 2001 .

August Editorial: impact factors

P. Reitsma, F. Rosendaal, 2013, Journal of thrombosis and haemostasis : JTH.

Reversibility of vitamin D-induced human leukemia cell-line maturation.

P. Reitsma, S. Teitelbaum, A. Kahn, 1986, Endocrinology.

Platelet reactivity in patients with venous thrombosis who use rosuvastatin: a randomized controlled clinical trial

P. Reitsma, M. Kruip, S. Cannegieter, 2016, Journal of thrombosis and haemostasis : JTH.

The putative factor IX gene promoter in hemophilia B Leyden.

P. Reitsma, R. Bertina, J. K. Ploos van Amstel, 1988, Blood.

Two novel point mutations correlate with an altered developmental expression of blood coagulation factor IX (hemophilia B Leyden phenotype).

P. Reitsma, R. Bertina, C. Kasper, 1989, Blood.

Hemophilia B Leyden: substitution of thymine for guanine at position -21 results in a disruption of a hepatocyte nuclear factor 4 binding site in the factor IX promoter.

P. Reitsma, R. Bertina, K. Peerlinck, 1993, Blood.

Factor XIII Val34Leu Is a Genetic Factor Involved in the Aetiology of Venous Thrombosis

P. Reitsma, M. Zago, C. Piccinato, 1999, Thrombosis and Haemostasis.

A Frequent Thrombomodulin Amino Acid Dimorphism Is not Associated with Thrombophilia

P. Reitsma, R. Bertina, P. A. van der Velden, 1991, Thrombosis and Haemostasis.

Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation*

P. Reitsma, C. Spek, W. Buurman, 2005, Critical care medicine.

Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.

T. van der Poll, P. Reitsma, S. Deventer, 2003, The Journal of infectious diseases.

New editorial crew

P. Reitsma, F. Rosendaal, 2013, Journal of thrombosis and haemostasis : JTH.

Familial thrombophilia: a complex genetic disorder.

P. Reitsma, R. Bertina, B. Koeleman, 1997, Seminars in hematology.

APD in Paget's disease of bone. Role of the mononuclear phagocyte system?

P. Reitsma, C. Meijer, O. Bijvoet, 1980, Arthritis and rheumatism.

Genetics in thrombophilia.

P. Reitsma, 2015, Hamostaseologie.

Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans

P. Reitsma, J. Kastelein, E. Stroes, 2005, Circulation research.

VKORC1 and the vitamin K cycle.

P. Reitsma, A. A. Garcia, A. Garcia, 2008, Vitamins and hormones.

Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis

P. Reitsma, F. Rosendaal, H. L. Vos, 2011, Thrombosis and Haemostasis.

UvA-DARE ( Digital Academic Repository ) Interaction between inflammation , coagulation and fibrinolysis during infection

P. Reitsma, M. Levi, S. Florquin, 2007 .

Inhalation of activated protein C inhibits endotoxin‐induced pulmonary inflammation in mice independent of neutrophil recruitment

P. Reitsma, C. Spek, A. Groot, 2006, British journal of pharmacology.

The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation.

T. van der Poll, P. Reitsma, E. de Jonge, 2000, Blood.

Risk Factor Profiles in Patients with Different Clinical Manifestations of Venous Thromboembolism: A Focus on the Factor V Leiden Mutation

P. Reitsma, R. Westendorp, F. Rosendaal, 1996, Thrombosis and Haemostasis.

High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor

P. Reitsma, S. Cessie, F. Rosendaal, 2018, Journal of thrombosis and haemostasis : JTH.

Five novel intragenic dimorphisms in the human interleukin-1 genes combine to high informativity.

P. Reitsma, R. Bertina, J. F. Guasch, 1996, Cytokine.

LPS induced translocation of NF-κB occurs only in a subpopulation of CD14-positive mononuclear cells

P. Reitsma, S. V. van Deventer, P. Dekkers, 1999 .

The Interaction of Protein S with the Phospholipid Surface Is Essential for the Activated Protein C-independent Activity of Protein S

P. Reitsma, R. Bertina, J. Meijers, 1996, Thrombosis and Haemostasis.

Genetic Heterogeneity in Hereditary Thrombophilia

P. Reitsma, 2001, Pathophysiology of Haemostasis and Thrombosis.

Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells.

P. Reitsma, S. V. van Deventer, B. V. van Aken, 2000, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Plasma cytokine and P‐selectin levels in advanced malignancy

P. Reitsma, M. Di Nisio, H. Buller, 2005, Cancer.

Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A)

T. Raghunathan, P. Reitsma, B. Psaty, 1998, Stroke.

Protein S Deficiency: A Database of Mutations

P. Reitsma, D. Cooper, F. Bernardi, 1997, Thrombosis and Haemostasis.

The mutational demography of protein C deficiency

P. Reitsma, D. Cooper, M. Krawczak, 1995, Human Genetics.

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inﬂammation

P. Reitsma, M. Bijlsma, C. Spek, 2007 .

FOXA1 in Mouse Hepatic Estrogen Receptor α Signaling

P. Reitsma, H. L. Vos, P. E. Thijssen, 2014 .

Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice

P. Reitsma, F. Gonzalez, Y. Inoue, 2013, PloS one.

Factor V Leiden (FVQ 506) is common in a Brazilian population

P. Reitsma, F. Costa, V. Arruda, 1995, American journal of hematology.

Venous Thrombosis: Genetics

P. Reitsma, 2006 .

Molecular Basis of Thrombophilia

P. Reitsma, 1995 .

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1994, The Lancet.

Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk.

P. Reitsma, F. Rosendaal, H. L. Vos, 2017, European journal of internal medicine.

Evaluation of activated protein C resistance in stored plasma

P. Reitsma, F. Rosendaal, C. Legnani, 1994, The Lancet.

Tetranucleotide repeat polymorphism in the vWF gene.

P. Reitsma, H. K. V. van Amstel, 1990, Nucleic acids research.

Cardiovascular , Pulmonary and Renal Pathology Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

P. Reitsma, M. Peppelenbosch, K. Borensztajn, 2010 .

Early death of factor v leiden hemizygous mice : a fatal absence of wild type FV anticoagulant function

P. Reitsma, R. Westrick, D. Ginsburg, 2011 .

Severe coagulation factor V deficiency caused by a 4 bp deletion in the factor V gene

P. Reitsma, R. Bertina, S. Cannegieter, 1998, British journal of haematology.

Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation.

P. Reitsma, R. Bertina, C. P. van der Logt, 1991, Biochemistry.

Brave real world

P. Reitsma, F. Rosendaal, P. Reitsma, 2016, Journal of thrombosis and haemostasis : JTH.

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

S. Diamond, P. Reitsma, R. Nieuwland, 2015, Thrombosis research.

17α‐Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α

P. Reitsma, G. Wagenaar, B. V. van Vlijmen, 2010, Journal of thrombosis and haemostasis : JTH.

Tissue Factor Expression during Monocyte-Macrophage Differentiation

P. Reitsma, R. Bertina, M. M. van den Eijnden, 1997, Thrombosis and Haemostasis.

Microvascular coagulopathy and disseminated intravascular coagulation

P. Reitsma, C. Spek, H. ten Cate, 2001, Critical care medicine.

When is cardiovascular genomics delivering on its promise?

P. Reitsma, P. Reitsma, 2006, Journal of thrombosis and haemostasis : JTH.

High hematocrit as a risk factor for venous thrombosis. Cause or innocent bystander?

P. Reitsma, S. Cannegieter, A. Schreijer, 2010, Haematologica.

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994.

P. Reitsma, R. Schwaab, G. Brownlee, 1994, Nucleic acids research.

Factor V levels and risk of venous thrombosis: The MEGA case‐control study

P. Reitsma, F. Rosendaal, R. Li-Gao, 2018, Research and practice in thrombosis and haemostasis.

Protein C Deficiency: A Database of Mutations

P. Reitsma, D. Cooper, F. Bernardi, 1993, Thrombosis and Haemostasis.

Modifiedd vascular response to endotoxin in streptozotocin-inducedd diabetic mice

P. Reitsma, D. Sommeijer, H. Cate, 2007 .

TF:FVIIa‐specific activation of CREB upregulates proapoptotic proteins via protease‐activated receptor‐2

P. Reitsma, M. Peppelenbosch, H. Versteeg, 2008, Journal of thrombosis and haemostasis : JTH.

Factor VII and Fibrinogen Levels as Risk Factors for Venous Thrombosis

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1994, Thrombosis and Haemostasis.

Hemophiliaa and thrombophili a shape host defense during septicc peritoniti s in mice without affecting survival

P. Reitsma, S. Schoenmakers, Lois W. Briiggemann, 2007 .

Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes

P. Reitsma, D. Sommeijer, R. van Oerle, 2005, Thrombosis journal.

Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain.

P. Reitsma, R. Bertina, J. Meijers, 1998, The Biochemical journal.

Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation.

P. Reitsma, R. D. de Winter, J. Piek, 1998, Catheterization and cardiovascular diagnosis.

Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae

P. Reitsma, J. Drijfhout, C. Spek, 2006, Journal of thrombosis and haemostasis : JTH.

Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg593 to Cys substitution

P. Reitsma, R. V. van Lier, J. Voorberg, 2006, Thrombosis and Haemostasis.

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families.

P. Reitsma, R. Bertina, B. Koeleman, 1994, Blood.

Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor

P. Reitsma, H. Versteeg, W. Ruf, 2011, Blood.

World distribution of factor V Leiden mutation

P. Reitsma, P. Morel, J. Jespersen, 1996, The Lancet.

Role of coagulation FVIII in septic peritonitis assessed in hemophilic mice

P. Reitsma, C. Spek, S. Schoenmakers, 2005, Journal of thrombosis and haemostasis : JTH.

Expression of tissue factor and tissue factor pathway inhibitor in monocytes in response to bacterial lipopolysaccharide and phorbolester

P. Reitsma, R. Bertina, R. Dirven, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Three novel mutations in five unrelated subjects with hereditary protein S deficiency type I.

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1994, The Journal of clinical investigation.

Transgenic Mouse Models of Venous Thrombosis: Fulfilling the Expectations?

P. Reitsma, B. V. van Vlijmen, A. Cleuren, 2007, Seminars in thrombosis and hemostasis.

Reversal Agents for the Direct Factor Xa Inhibitors: Biochemical Mechanisms of Current and Newly Emerging Therapies

P. Reitsma, M. Bos, Mark Schreuder, 2020, Seminars in Thrombosis and Hemostasis.

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.

P. Reitsma, F. Rosendaal, R. Bertina, 1996, Blood.

Haemophilia B: database of point mutations and short additions and deletions, 7th edition

M. Goossens, P. M. Green, S. S. Sommer, 1990, Nucleic Acids Res..

Haemophilia B: database of point mutations and short additions and deletions--eighth edition

M. Goossens, F. Giannelli, P. M. Green, 1998, Nucleic Acids Res..

PROTHROMBIN 20210 G: A MUTATION AND FACTOR V LEIDEN MUTATION IN WOMEN WITH A HISTORY OF SEVERE PREECLAMPSIA AND (H)ELLP SYNDROME*

P. Reitsma, H. Buller, H. Wolf, 2001, Hypertension in pregnancy.

Major bleeding risks of different low‐molecular‐weight heparin agents: a cohort study in 12 934 patients treated for acute venous thrombosis

P. Reitsma, M. Kruip, S. Cannegieter, 2017, Journal of thrombosis and haemostasis : JTH.

Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden.

P. Reitsma, F. Sladek, R. Bertina, 1992, Proceedings of the National Academy of Sciences of the United States of America.

New fundamentals in hemostasis.

P. Reitsma, H. Versteeg, M. Levi, 2013, Physiological reviews.

Treatment with an Anti-CD14 Monoclonal Antibody Delays and Inhibits Lipopolysaccharide-Induced Gene Expression in Humans in Vivo

P. Reitsma, J. Schouten, C. Mcelgunn, 2003, Journal of Clinical Immunology.

Evolutionary Adaptations in Pseudonaja Textilis Venom Factor X Induce Zymogen Activity and Resistance to the Intrinsic Tenase Complex

P. Reitsma, K. Cheung, M. Bos, 2020, Thrombosis and Haemostasis.

Tolerance to human factor VIII in a mouse transgenic for human factor VIII-R593C

P. Reitsma, J. Voorberg, Jan, 2003 .

Haemophilia B (sixth edition): a database of point mutations and short additions and deletions

M. Goossens, F. Giannelli, P. M. Green, 1996, Nucleic Acids Res..

Haemophilia B: database of point mutations and short additions and deletions--second edition.

P. Reitsma, K. High, D. Lillicrap, 1991, Nucleic acids research.

Two Mutations of the Factor IX Gene Including a Donor Splice Consensus Deletion and a Point Mutation in a Dutch Patient with Severe Hemophilia B

P. Reitsma, R. Bertina, E. Briët, 1990, Thrombosis and Haemostasis.

Localization of transcription initiation sites in the human coagulation factor IX gene

P. Reitsma, R. Bertina, M. Reijnen, 1990, FEBS letters.

Genetic variants associated with deep vein thrombosis: the F11 locus

P. Reitsma, J. Catanese, F. Rosendaal, 2009, Journal of thrombosis and haemostasis : JTH.

Determination of the allelic and haplotype frequencies of three polymorphisms in the promoter region of the human protein C gene.

P. Reitsma, R. Bertina, C. Spek, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Haemophilia B: database of point mutations and short additions and deletions--third edition, 1992.

P. Reitsma, K. High, D. Lillicrap, 1992, Nucleic acids research.

Apposition and resorption of bone during oral treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

P. Reitsma, O. Bijvoet, Lianne J. A. Wee-Pals, 1983, Calcified Tissue International.

Influence of treatment with APD‐bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma

P. Reitsma, J. Croese, J. Radl, 1985, Cancer.

Pharmacology of disodium (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate.

P. Reitsma, F. Vismans, O. Bijvoet, 1980, Advances in experimental medicine and biology.

F9 Malmö, factor IX and deep vein thrombosis

P. Reitsma, J. Catanese, F. Rosendaal, 2009, Haematologica.

Increased risk of major bleeding after a minor bleed during treatment with vitamin K antagonists is determined by fixed common risk factors

P. Reitsma, S. Cessie, S. Cannegieter, 2016, Journal of thrombosis and haemostasis : JTH.

disulfide-deficient tissue factor Complete abolishment of coagulant activity in monomeric

P. Reitsma, H. Versteeg, W. Ruf, 2013 .

Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.

P. Reitsma, R. Chamuleau, S. V. van Deventer, 1997, International journal of cancer.

IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study

R. Peters, P. Reitsma, N. Day, 2004, Arteriosclerosis, thrombosis, and vascular biology.

The relationship between tissue factor and cancer progression: insights from bench and bedside.

P. Reitsma, H. Versteeg, S. Osanto, 2012, Blood.

Alternatively spliced tissue factor induces angiogenesis through integrin ligation

E. Jordanova, P. Reitsma, H. Versteeg, 2009, Proceedings of the National Academy of Sciences.

Genetics in thrombophilia

P. Reitsma, 2014, Hämostaseologie.

Citations from the Literature

P. Reitsma, F. Rosendaal, R. Bertina, 2003 .

Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner

P. Reitsma, P. Kuppen, C. V. D. van de Velde, 2013, Proceedings of the National Academy of Sciences.

The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects.

P. Reitsma, R. Bertina, E. Briët, 1991, Blood.

Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460.

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1990, Blood.

RNA profiling and the genetics of myocardial infarction

P. Reitsma, E. Paffen, A. Felice, 2007 .

Apolipoprotein A-V

P. Reitsma, R. Chamuleau, W. Boers, 2001, The Journal of Biological Chemistry.

Tissue factor associates with survival and regulates tumour progression in osteosarcoma

P. Reitsma, A. Cleton-Jansen, H. Gelderblom, 2016, Thrombosis and Haemostasis.

Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite

P. Reitsma, P. Rothberg, S. Astrin, 1983, Nature.

Cerebral small vessel disease genomics and its implications across the lifespan

N. Eriksson, P. Matthews, M. Fornage, 2020, Nature Communications.

Storage and secretion of naturally occurring von Willebrand factor A domain variants

P. Reitsma, J. Voorberg, K. Valentijn, 2014, British journal of haematology.

Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein.

P. Reitsma, J. Griffin, J. A. Fernandez, 1998, Blood cells, molecules & diseases.

Type I Protein C Deficiency Caused by Disruption of a Hepatocyte Nuclear Factor (HNF)-6/HNF-1 Binding Site in the Human Protein C Gene Promoter*

P H Reitsma, P. Reitsma, R. Bertina, 1998, The Journal of Biological Chemistry.

Two Mutations in the Promoter Region of the Human Protein C Gene Both Cause Type I Protein C Deficiency by Disruption of Two HNF-3 Binding Sites (*)

P. Reitsma, J. Griffin, R. Bertina, 1995, The Journal of Biological Chemistry.

Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis.

P. Reitsma, R. Chamuleau, S. V. van Deventer, 1997, Carcinogenesis.

Seeming homozygosity in type-IIB von Willebrand's disease due to a polymorphism within the sequence of a commonly used primer

P. Reitsma, J. Eikenboom, E. Briët, 1994, Annals of Hematology.

Hyperhomocysteinemia as a risk factor for deep-vein thrombosis.

P. Reitsma, J. Vandenbroucke, H. Blom, 1996, The New England journal of medicine.

High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells.

P. Reitsma, F. Rosendaal, C. Spek, 2005, Blood.

Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice.

P. Reitsma, G. Boeckxstaens, W. D. de Jonge, 2003, Gastroenterology.

Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity

P. Reitsma, P. D. de Groot, Y. Henskens, 2014, Journal of thrombosis and haemostasis : JTH.

Interaction of factor V Leiden with inherited anti-thrombin deficiency

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1995 .

Hereditary antithrombin deficiency: heterogeneity of the molecular basis and mortality in Dutch families.

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1994, Blood.

HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis

P. Reitsma, S. V. van Deventer, P. Stokkers, 1999, Gut.

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

P. Reitsma, J. Vandenbroucke, F. Rosendaal, 1995, Blood.

Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice.

P. Reitsma, G. Boeckxstaens, W. D. de Jonge, 2004, Gastroenterology.

Partial protein S gene deletion in a family with hereditary thrombophilia

P. Reitsma, R. Bertina, M. Huisman, 1989 .

Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene.

T. Raghunathan, P. Reitsma, B. Psaty, 1997, Circulation.

Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study.

P. Reitsma, F. Rosendaal, C. Doggen, 2013, Blood.

Twelve novel and two recurrent mutations in 14 Austrian families with hereditary protein C deficiency

P. Reitsma, R. Bertina, C. Mannhalter, 1993, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

A CCA/CCG neutral dimorphism in the codon for Pro 626 of the human protein S gene PSα (PROS1)

P. Reitsma, R. Bertina, C. M. Diepstraten, 1991 .

Studies of the Interaction between Human Protein S and Human C4b-Binding Protein Using Deletion Variants of Recombinant Human Protein S

P. Reitsma, R. Bertina, B. Bouma, 1994, Thrombosis and Haemostasis.

A CCA/CCG neutral dimorphism in the codon for Pro 626 of the human protein S gene PS alpha (PROS1).

P. Reitsma, R. Bertina, C. M. Diepstraten, 1991, Nucleic acids research.

Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution.

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1990, Biochemistry.

Somatic origin of inherited haemophilia A

P. Reitsma, P. Pearson, J. Dreesen, 1990, Human Genetics.

Healthy Men and Women : The EPIC-Norfolk Prospective Population Study IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in

Sheila, R. Peters, P. Reitsma, 2004 .

Characterization of a large chromosomal deletion in the PROS1 gene of a patient with protein S deficiency type I using long PCR

P. Reitsma, R. Bertina, Zandra Holmes, 1996, British journal of haematology.

Homzygous Protein S Deficiency due to a One Base Pair Deletion that Leads to a Stop Codon in Exon III of the Protein S Gene

P. Reitsma, C. Pegelow, R. Bertina, 1994, Thrombosis and Haemostasis.

Location on the Human Genetic Linkage Map of 26 Genes Involved in Blood Coagulation

P. Reitsma, E. Bakker, R. Bertina, 1997, Thrombosis and Haemostasis.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis

H. Crijns, U. Schotten, T. Renné, 2018, Thrombosis and Haemostasis.

Protein C deficiency: summary of the 1995 database update

Pieter H. Reitsma, P. Reitsma, 1996, Nucleic Acids Res..

Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors

P. Reitsma, D. Geerke, K. Visscher, 2017, Nature Communications.

Gene polymorphisms of the haemostatic system and the risk of arterial thrombotic disease

P. Reitsma, R. Franco, 2001, British journal of haematology.

Reduced acute myocardial ischemia–reperfusion injury in IL-6-deficient mice employing a closed-chest model

P. Reitsma, R. D. de Winter, A. Linnenbank, 2016, Inflammation Research.

Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2-tribromoethanol in mice.

P. Reitsma, R. D. de Winter, C. Ince, 2002, Contemporary topics in laboratory animal science.

HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis

P. Reitsma, S. Deventer, G. Tytgat, 1999, Gut.

Differential Gene Expression Changes in Children with Severe Dengue Virus Infections

Pieter H. Reitsma, Albert D. M. E. Osterhaus, P. Reitsma, 2008, PLoS neglected tropical diseases.

Whole exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease.

D. Goldstein, Jun Z. Li, P. Reitsma, 2020, Blood.

Refined regional assignment of the human tissue factor pathway inhibitor (TFPI) gene to chromosome band 2q32 by non-isotopic in situ hybridization

P. Reitsma, J. Wiegant, J. Landegent, 1992, Human Genetics.

Multiple SNP testing improves risk prediction of first venous thrombosis.

P. Reitsma, S. le Cessie, F. Rosendaal, 2012, Blood.

A comprehensive high-throughput sequencing test for the diagnosis of inherited bleeding , thrombotic and platelet disorders

Sri V. V. Deevi, W. Ouwehand, J. Jolley, 2015 .

Inflammatory Cytokines as Risk Factors for a First Venous Thrombosis: A Prospective Population-Based Study

Frits R Rosendaal, P. Reitsma, F. Rosendaal, 2006, PLoS medicine.

Expression of inflammation-related genes in endothelial cells is not directly affected by microparticles from preeclamptic patients.

P. Reitsma, R. Nieuwland, J. V. D. van der Post, 2006, The Journal of laboratory and clinical medicine.

Identification of Eight Point Mutations in Protein S Deficiency Type I – Analysis of 15 Pedigrees

P. Reitsma, R. Bertina, S. Poort, 1995, Thrombosis and Haemostasis.

Variants of Toll-Like Receptor 4 Modify the Efficacy of Statin Therapy and the Risk of Cardiovascular Events

A. Zwinderman, R. Peters, P. Reitsma, 2003, Circulation.

High factor VIIa levels do not promote tumor metastasis

P. Reitsma, H. Versteeg, C. Spek, 2008, Thrombosis and Haemostasis.

Alternative Splicing Is Responsible for the Presence of Two Tissue Factor mRNA Species in LPS Stimulated Human Monocytes

P. Reitsma, R. Bertina, C. Paul, 1992, Thrombosis and Haemostasis.

Identification of coagulation gene 3′UTR variants that are potentially regulated by microRNAs

P. Reitsma, J. Corral, B. Koeleman, 2017, British journal of haematology.

Dichloromethylene diphosphonate and calcium and phosphate metabolism.

P. Reitsma, O. Bijvoet, W. Frijlink, 1980, The New England journal of medicine.

xpression of inflammation-related genes in ndothelial cells is not directly affected by icroparticles from preeclamptic patients

P. Reitsma, K. Boer, A. Böing, 2006 .

Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4α and C/EBPα

P. Reitsma, F. Gonzalez, Y. Inoue, 2012, PloS one.

Pravastatin reduces fibrinogen receptor gpIIIa on platelet‐derived microparticles in patients with type 2 diabetes

P. Reitsma, D. Sommeijer, D. W. SOMMEIJER, 2005, Journal of thrombosis and haemostasis : JTH.

Genomics and Proteomics: Implications for Inflammatory Bowel Diseases

P. Reitsma, P. Stokkers, K. Kok, 2004, Inflammatory bowel diseases.

1 Inherited Thrombophilia : Past , Present , and Future Research

P. Reitsma, J. S. Koenderman, 2017 .

Inherited Thrombophilia: Past, Present, and Future Research

P. Reitsma, J. S. Koenderman, 2011 .

World distribution of factor V Leiden mutation.

P. Reitsma, A. Naipal, D. Gou, 1996, Lancet.

Two Genes Homologous with Human Protein S cDNA Are Located on Chromosome 3

P. Reitsma, E. Bakker, R. Bertina, 1987, Thrombosis and Haemostasis.

Fundamental

F. R. Rosendaal, P. Reitsma, F. R. Rosendaal, 2015, Journal of thrombosis and haemostasis : JTH.

Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung

P. Reitsma, D. Richel, C. Spek, 2009, Clinical & Experimental Metastasis.

Pulmonary embolism

P. Reitsma, M. Rodger, A. Noordegraaf, 2018, Nature Reviews Disease Primers.

Gene variants associated with deep vein thrombosis.

P. Reitsma, J. Catanese, F. Rosendaal, 2008, Journal of the American Medical Association (JAMA).

Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women.

T. Raghunathan, P. Reitsma, B. Psaty, 1997, Blood.

Genetic Variations Associated With Recurrent Venous Thrombosis

P. Reitsma, F. Rosendaal, S. Cannegieter, 2014, Circulation. Cardiovascular genetics.

Malmö , factor IX and deep vein thrombosis

P. Reitsma, J. Catanese, F. Rosendaal, 2009 .

F 9 Malmö , factor IX and deep vein thrombosis

P. Reitsma, J. Catanese, F. Rosendaal, 2022 .

Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department

P. Reitsma, P. Bossuyt, C. Spek, 2010, Critical care medicine.

Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.

R. Peters, P. Reitsma, N. Day, 2004, The American journal of medicine.

Homozygosity for a Novel Missense Mutation in the Prothrombin Gene Causing a Severe Bleeding Disorder

P. Reitsma, R. Bertina, S. Poort, 1994, Thrombosis and Haemostasis.

Arterial wall thickness and the risk of recurrent ischemic events in carriers of the prothrombin G20210A mutation with clinical manifestations of atherosclerosis.

P. Reitsma, M. Prins, H. Büller, 2002, Atherosclerosis.

Construction and Characterization of Thrombin-resistant Variants of Recombinant Human Protein S

P. Reitsma, R. Bertina, T. Hackeng, 1994, Thrombosis and Haemostasis.

Two novel mutations in the prothrombin gene identified in a patient with compound heterozygous type 1/2 prothrombin deficiency

P. Reitsma, G. Nicolaes, N. Dors, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Polymorphisms in the protein C gene as risk factor for venous thrombosis

P. Reitsma, F. Rosendaal, C. Doggen, 2008, Thrombosis and Haemostasis.

Protein C Deficiency: from Gene Defects to Disease

P. Reitsma, 1997, Thrombosis and Haemostasis.

Homozygous protein C deficiency with late onset and recurrent coumarin-induced skin necrosis

P. Reitsma, M. Samama, R. Bertina, 1992, The Lancet.

PTX3 predicts severe disease in febrile patients at the emergency department.

P. Reitsma, C. Garlanda, A. Mantovani, 2010, The Journal of infection.

Identification of Evolutionarily Invariant Sequences in the Protein C Gene Promoter

P. Reitsma, R. Bertina, C. Spek, 1998, Journal of Molecular Evolution.

The role of hepatocyte nuclear factor 4α in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels

P. Reitsma, B. V. van Vlijmen, H. Safdar, 2010, Journal of thrombosis and haemostasis : JTH.

Application of Two Neutral Mspl DNA Polymorphisms in the Analysis of Hereditary Protein C Deficiency

P. Reitsma, R. Bertina, P. A. van der Velden, 1990, Thrombosis and Haemostasis.

Identification of polymorphisms in the TAFI gene promoter: Relationship with plasma TAFI levels and risk of venous thrombosis.

P. Reitsma, M. Zago, W. Silva, 2000 .

Partial Reconstitution of Factor VIII Activity from a Mild Crm+ Hemophilia A Patient by Replacement of the Defective A2 Domain

P. Reitsma, R. Bertina, E. Briët, 1998, Thrombosis and Haemostasis.

Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons.

A. Reiner, T. Raghunathan, P. Reitsma, 2002, The American journal of cardiology.

Renal Tissue Factor Expression Is Increased in Streptozotocin-Induced Diabetic Mice

P. Reitsma, D. Sommeijer, H. ten Cate, 2005, Nephron Experimental Nephrology.

Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency

P. Reitsma, C. Spek, D. Borgel, 2009, Human Genetics.

BISPHOSPHONATES AND PAGET'S DISEASE

P. Reitsma, O. Bijvoet, W. Frijlink, 1980, The Lancet.

The Effect of Levothyroxine on Expression of Inflammation-Related Genes in Healthy Subjects: A Controlled Randomized Crossover Study

P. Reitsma, O. Dekkers, C. Spek, 2014, Hormone and Metabolic Research.

Silencing of Anticoagulant Protein C Evokes Low-Incident but Spontaneous Atherothrombosis in Apolipoprotein E–Deficient Mice—Brief Report

P. Reitsma, B. V. van Vlijmen, M. Gijbels, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.

P. Reitsma, H. Versteeg, E. Laghmani, 2013, Blood.

Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice

P. Reitsma, B. V. van Vlijmen, M. Gijbels, 2018, Scientific Reports.

Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice

P. Reitsma, B. V. van Vlijmen, M. Gijbels, 2018, Scientific Reports.

Coagulation Factor XII Does Not Contribute to Mouse Venous Thrombosis Induced By Silencing of Antithrombin and Protein C

T. Renné, K. Nickel, P. Reitsma, 2018 .

Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

P. Reitsma, H. Blom, M. Heijer, 1998, Thrombosis and Haemostasis.

Suspected survivor bias in case-control studies: stratify on survival time and use a negative control.

P. Reitsma, F. Rosendaal, S. Cannegieter, 2014, Journal of clinical epidemiology.

Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding

P. Reitsma, M. Bos, Mark Schreuder, 2019, Journal of thrombosis and haemostasis : JTH.

Differential expression of tissue factor mRNA and protein expression in murine sepsis

P. Reitsma, V. de Waard, H. ten Cate, 2006, Thrombosis and Haemostasis.

The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis.

P. Reitsma, M. Prins, M. Trip, 1998, Atherosclerosis.

Quantitative trait locus for protein C in a family with thrombophilia

P. Reitsma, H. Büller, S. Middeldorp, 2010, Thrombosis and Haemostasis.

ptFVa (Pseudonaja Textilis Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C

P. Reitsma, Xiaosong Liu, G. Nicolaes, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model

J. Hamming, P. Reitsma, P. Quax, 2013, PloS one.

Freeloading in biomedical research

P. Reitsma, T. V. Leeuwen, F. Rosendaal, 2019, Scientometrics.

A Pstl RFLP of the LACl gene

P. Reitsma, R. Bertina, C. V. D. Logt, 1990 .

Expression and Characterization of Recombinant Human Protein S in Heterologous Cells - Studies of the Interaction of Amino Acid Residues Leu-608 to Glu-612 with Human C4b-Binding Protein

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1992, Thrombosis and Haemostasis.

A Mutation in the Protein S Pseudogene Is Linked to Protein S Deficiency in a Thrombophilic Family

P. Reitsma, P. Mannucci, R. Bertina, 1989, Thrombosis and Haemostasis.

The human protein S locus: identification of the PS alpha gene as a site of liver protein S messenger RNA synthesis.

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1988, Biochemical and biophysical research communications.

Type-I protein-C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein-C gene promoter.

P. Reitsma, A. Spek, 1999, Trends in cardiovascular medicine.

VKORC1 gene variation and venous thrombosis: ‘another one bites the dust’?

P. Reitsma, 2007, Journal of thrombosis and haemostasis : JTH.

Chapter 8-Disulfide switching : a conserved mechanism in Tissue Factor decryption ?

P. Reitsma, M. Bos, Y. Berg, 2013 .

PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype–phenotype associations

P. Reitsma, P. Terpstra, M. Platteel, 2008, Human mutation.

Two RFLPS ˜ 7kb 5′ of the human protein C gene

P. Reitsma, R. Bertina, W. T. L. Hekkert, 1988 .

Partial protein S gene deletion in a family with hereditary thrombophilia.

P. Reitsma, R. Bertina, H. K. Ploos van Amstel, 1989, Blood.

Two RFLPS approximately 7 kb 5' of the human protein C gene.

P. Reitsma, R. Bertina, W. te Lintel Hekkert, 1988, Nucleic acids research.

Fibrinogen Aα312 and Bβ448 polymorphisms are not related to bleeding during oral vitamin K-antagonist treatment

P. Reitsma, A. Groot, T. Boellaard, 2007, Thrombosis and Haemostasis.

Chapter 6-Alternatively spliced and full-length tissue factor have dissimilar properties in breast cancer

P. Reitsma, C. Velde, H. Versteeg, 2013 .

Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice

P. Reitsma, B. V. van Vlijmen, M. Gijbels, 2018, Scientific Reports.

Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-Á receptor 1

K. de Heer, P. Reitsma, S. V. van Deventer, 1999, International Journal of Colorectal Disease.

Double Strand Conformation Polymorphism (DSCP) Detects Two Point Mutations at Codon 280 (AAC→ATC) and at Codon 431 (TAC→AAC) of the Blood Coagulation Factor VIII Gene

P. Reitsma, E. Briët, W. C. Pieneman, 1993, Thrombosis and Haemostasis.

Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-gamma receptor 1.

K. de Heer, P. Reitsma, S. V. van Deventer, 1999, International journal of colorectal disease.

Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans

P. Reitsma, J. Kastelein, E. Stroes, 2005, Circulation research.

The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers

P. Reitsma, H. Blom, M. den Heijer, 2007, Clinical chemistry and laboratory medicine.

Angiogenic characteristics of blood outgrowth endothelial cells from patients with von Willebrand disease

P. Reitsma, J. Voorberg, J. Eikenboom, 2015, Journal of thrombosis and haemostasis : JTH.

Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors

P. Reitsma, D. Geerke, K. Visscher, 2015, Nature Communications.

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

P. Reitsma, F. Rosendaal, R. Bertina, 1993, The Lancet.

THROMBOSIS AND HEMOSTASIS A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders