D. Brough

D. Brough, M. Praetorius, H. Staecker, 2007, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Bcl-2 Gene Therapy Prevents Aminoglycoside-Induced Degeneration of Auditory and Vestibular Hair Cells

D. Brough, P. Plinkert, M. Praetorius, 2009, Audiology and Neurotology.

Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo

D. Brough, I. Kovesdi, L. J. Cantolupo, 1997, Journal of virology.

Persistent expression of PEDF in the eye using high-capacity adenovectors.

D. Brough, R. S. MacGill, J. Bruder, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting

D. Brough, D. Curiel, I. Dmitriev, 2020, Journal of Virology.

Adenoviral vectors for gene transfer.

D. Brough, I. Kovesdi, T. Wickham, 1997, Current opinion in biotechnology.

Ocular Localization and Transduction by Adenoviral Vectors Are Serotype-Dependent and Can Be Modified by Inclusion of RGD Fiber Modifications

D. Brough, S. Yoneya, L. Wei, 2014, PloS one.

Improved production of adenovirus vectors expressing apoptotic transgenes.

D. Brough, I. Kovesdi, J. Tian, 2000, Human gene therapy.

Repeated administration of adenovector in the eye results in efficient gene delivery.

D. Brough, D. McVey, J. Bruder, 2006, Investigative ophthalmology & visual science.

E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells.

S. Rafii, D. Brough, R. Crystal, 1999, Blood.

Restricted changes in the adenovirus DNA-binding protein that lead to extended host range or temperature-sensitive phenotypes

D. Brough, D. Klessig, S. Sell, 1985, Journal of virology.

Adenovirus Type 5 Early Region 4 Is Responsible for E 1 A-Induced p 53-Independent Apoptosis

D. Brough, P. Branton, J. G. Teodoro, 1996 .

Adenovirus vector library: an approach to the discovery of gene and protein function.

D. Brough, D. McVey, I. Kovesdi, 2003, The Journal of general virology.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY E1 2 E4 1 Adenoviral Gene Transfer Vectors Function as a ''Pro-Life'' Signal to Promote Survival of Primary Human Endothelial Cells

S. Rafii, D. Brough, R. Crystal, 2016 .

Characterization of human adenovirus 35 and derivation of complex vectors

D. Brough, G. Nabel, J. Gall, 2010, Virology Journal.

to Promote Survival of Primary Human Endothelial Cells E1-E4+ Adenoviral Gene Transfer Vectors Function as a "Pro-Life" Signal

S. Rafii, D. Brough, R. Crystal, 2010 .

Rescue and production of vaccine and therapeutic adenovirus vectors expressing inhibitory transgenes

D. Brough, J. Gall, D. McVey, 2007, Molecular biotechnology.

Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.

D. Brough, B. Graham, D. Rangel, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Repeat administration of proteins to the eye with a single intraocular injection of an adenovirus vector.

D. Brough, D. McVey, L. Wei, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

D. Brough, L. Zsak, J. Neilan, 2018, BMC Veterinary Research.

Preclinical study of a novel therapeutic vaccine for recurrent respiratory papillomatosis

D. Brough, J. Schlom, H. Sabzevari, 2021, NPJ vaccines.

Adenovirus Vectors Hexon-Modified That Improves the Yields of Identification of a Suppressor Mutation

D. Brough, J. Gall, D. McVey, 2014 .

Identification of a Suppressor Mutation That Improves the Yields of Hexon-Modified Adenovirus Vectors

D. Brough, J. Gall, D. McVey, 2013, Journal of Virology.

Identiﬁcation of a Suppressor Mutation That Improves the Yields of Hexon-Modiﬁed Adenovirus Vectors

D. Brough, J. Gall, D. McVey, 2013 .

Restricted Changes intheAdenovirus DNA-Binding Protein That LeadtoExtended HostRangeorTemperature-Sensitive Phenotypes

D. Brough, D. Klessig, 1985 .

Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival

D. Brough, N. DeLuca, I. Kovesdi, 2001, Journal of Virology.

Novel adenovirus vaccine vectors based on the enteric-tropic serotype 41.

D. Brough, G. Nabel, J. Gall, 2007, Vaccine.

Construction, characterization, and utilization of cell lines which inducibly express the adenovirus DNA-binding protein.

D. Brough, D. Klessig, V. Cleghon, 1992, Virology.

Construction of an adenovirus type 7a E1A- vector

D. Brough, R. Crystal, E. Falck-Pedersen, 1997, Journal of virology.

Adenovirus serotype 5-vectored foot-and-mouth disease subunit vaccines: the first decade

D. Brough, M. Grubman, M. Moraes, 2010 .

Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge.

D. Brough, G. Mayr, L. Zsak, 2016, Vaccine.

Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine.

D. Brough, W. Hurtle, J. Neilan, 2018, Vaccine.

Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle.

D. Brough, M. Colby, J. Neilan, 2018, Transboundary and emerging diseases.

Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine.

D. Brough, M. Grubman, J. Neilan, 2018, Vaccine.

The Coxsackievirus-Adenovirus Receptor Protein Can Function as a Cellular Attachment Protein for Adenovirus Serotypes from Subgroups A, C, D, E, and F

D. Brough, J. Bergelson, I. Kovesdi, 1998, Journal of Virology.

An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation

D. Brough, M. Cole, K. Ellwood, 1995, Molecular and cellular biology.

Characterization of adenovirus type 5 insertion and deletion mutants encoding altered DNA binding proteins.

D. Brough, D. Klessig, J. Sussenbach, 1989, Virology.

Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell

D. Brough, D. Klessig, V. Cleghon, 1984, Molecular and cellular biology.

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Christopher A. Lazarski, D. Brough, J. Aguiar, 2017, Molecular therapy. Methods & clinical development.

Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins

D. Brough, I. Kovesdi, T. Wickham, 1997, Journal of virology.

Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization

P. Campochiaro, D. Zack, D. Brough, 2001, Journal of cellular physiology.

Phosphorylation of the adenovirus DNA-binding protein and epitope mapping of monoclonal antibodies against it.

D. Brough, D. Klessig, V. Cleghon, 1993, Virology.

Rapid Construction of Adenoviral Vectors by Lambda Phage Genetics

D. Brough, D. McVey, I. Kovesdi, 2002, Journal of Virology.

A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4

D. Brough, I. Kovesdi, C. Hsu, 1996, Journal of virology.

Drug delivery to the inner ear using gene therapy.

D. Brough, M. Praetorius, H. Staecker, 2004, Otolaryngologic clinics of North America.

Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model.

E. Topol, D. Brough, M. Kibbe, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

D. Brough, D. Kufe, I. Kovesdi, 2000, The Journal of clinical investigation.

Adenoviruses isolated from wild gorillas are closely related to human species C viruses.

D. Brough, D. Rangel, J. Gall, 2013, Virology.

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy

D. Brough, D. Fremont, M. Diamond, 2019, Cell reports.

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model

D. Brough, J. Bruder, Ping Chen, 2017, Malaria Journal.

The Presence of Alpha Interferon at the Time of Infection Alters the Innate and Adaptive Immune Responses to Porcine Reproductive and Respiratory Syndrome Virus

D. Brough, T. Nicholson, E. Nelson, 2012, Clinical and Vaccine Immunology.

TNFerade Biologic: Preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene

D. Brough, R. Weichselbaum, C. King, 2002, Cancer Gene Therapy.

Therapeutic potential of adenovirus-mediated delivery of β-defensin 2 for experimental otitis media

D. Brough, S. Moon, D. Lim, 2015, Innate immunity.

Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

Ryosei Minoda, Yehoash Raphael, K. Kawamoto, 2005, Nature Medicine.

Characterization of recombinant gorilla adenovirus HPV therapeutic vaccine PRGN-2009

D. Brough, J. Schlom, H. Sabzevari, 2021, JCI insight.

Adenovirus-mediated expression of interferon-alpha delays viral replication and reduces disease signs in swine challenged with porcine reproductive and respiratory syndrome virus.

D. Brough, P. Gauger, K. Lager, 2009, Viral immunology.

Preclinical study of a novel therapeutic vaccine for recurrent respiratory papillomatosis

D. Brough, J. Schlom, H. Sabzevari, 2021, npj Vaccines.

Optimizing atoh1‐induced vestibular hair cell regeneration

D. Brough, M. Praetorius, H. Staecker, 2014, The Laryngoscope.

Adenoviral vectors for improved gene delivery to the inner ear

D. Brough, P. Plinkert, M. Praetorius, 2009, Hearing Research.

Adenovector-mediated hair cell regeneration is affected by promoter type

D. Brough, P. Plinkert, M. Praetorius, 2010, Acta oto-laryngologica.

Multiple functions of the adenovirus DNA-binding protein are required for efficient viral DNA synthesis.

D. Brough, D. Klessig, G. Droguett, 1993, Virology.

Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research

D. Brough, M. Praetorius, H. Staecker, 2011, Hearing Research.

The immunoregulatory role of IL‐35 in patients with interstitial lung disease

D. Brough, H. Sabzevari, S. Vidal, 2022, Immunology.

Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications

D. Brough, H. Staecker, A. Warnecke, 2022, Frontiers in Bioengineering and Biotechnology.

Alternate serotype adenovector provides long-term therapeutic gene expression in the eye

D. Brough, J. Gall, L. Wei, 2008, Molecular vision.

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model

D. Brough, J. Vulule, J. Bruder, 2017, Malaria Journal.

Repair of the vestibular system via adenovector delivery of Atoh1: a potential treatment for balance disorders.

D. Brough, H. Staecker, Kim Baker, 2009, Advances in oto-rhino-laryngology.

Identification of a high-molecular-weight cellular protein complex containing the adenovirus DNA binding protein.

D. Brough, D. Klessig, J. Ricigliano, 1994, Virology.

Activation of Gene Expression from Silenced Adenovector Genomes

D. Brough, D. McVey, C. King, 2004 .

Impaired Regulation by IL-35 in Systemic Sclerosis

D. Brough, H. Sabzevari, M. A. Ortiz, 2023, International Journal of Molecular Sciences.

Preclinical Evaluation of Prgn-3007, a Non-Viral, Multigenic, Autologous ROR1 Ultracar-T ® Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

D. Brough, H. Sabzevari, T. Chan, 2021, Blood.

Developing a Molecular Therapeutic for Hearing Loss

D. Brough, H. Staecker, L. Klickstein, 2016 .

Comprehensive characterization of the 293-ORF6 cell line.

D. Brough, R. Sheets, A. Lizonová, 2006, Developments in biologicals.

Human adenovirus-vectored foot-and-mouth disease vaccines: establishment of a vaccine product profile through in vitro testing.

D. Brough, T. Burrage, M. McIlhaney, 2012, Developments in biologicals.

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis

D. Brough, P. Branton, J. G. Teodoro, 1996, Journal of virology.

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

D. Brough, H. Sabzevari, Ke-Chun Bai, 2023, Science Translational Medicine.

Adenovector-mediated hair cell regeneration is affected by promoter type

D. Brough, P. Plinkert, M. Praetorius, 2010, Acta oto-laryngologica.

Repeat administration of proteins to the eye with a single intraocular injection of an adenovirus vector.

D. Brough, D. McVey, L. Wei, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.