J. Binley

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Fine Definition of the Epitope on the gp41 Glycoprotein of Human Immunodeficiency Virus Type 1 for the Neutralizing Monoclonal Antibody 2F5

C. E. Parker, L. Deterding, C. Hager-Braun, 2001, Journal of Virology.

Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries.

C. Barbas, J. Sodroski, J. Moore, 1997, Journal of molecular biology.

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.

A. Trkola, J. Moore, D. Ho, 1999, The Journal of clinical investigation.

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

Paul W. H. I. Parren, Erica Ollmann Saphire, Dennis R. Burton, 2001, Journal of Virology.

Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies

Renate Kunert, Bette Korber, Christos J. Petropoulos, 2004, Journal of Virology.

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.

Renate Kunert, Robyn L Stanfield, Ian A Wilson, 2005, Immunity.

Crystal structure , conformational fixation , and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016 .

Oligomeric and Conformational Properties of a Proteolytically Mature, Disulfide-Stabilized Human Immunodeficiency Virus Type 1 gp140 Envelope Glycoprotein

Min Lu, Paul W. H. I. Parren, Kenneth H. Roux, 2002, Journal of Virology.

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5

William C. Olson, A. Trkola, C. Cheng‐Mayer, 1996, Nature.

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

J. Binley, P. Poignard, M. Zwick, 2013, PloS one.

Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization.

J. Binley, N. Schülke, P. Moore, 2006, Human antibodies.

Inhibition of the HIV-1 Spike by Single-PG9/16-Antibody Binding Suggests a Coordinated-Activation Model for Its Three Protomeric Units

J. Binley, H. Garoff, Shang-Rung Wu, 2013, Journal of Virology.

Entry inhibition of HIV-1 subtype C isolates

J. Binley, L. Morris, P. Moore, 2007 .

Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered To Express High Levels of Env

J. Hoxie, J. Binley, M. Bendinelli, 2005, Journal of Virology.

Identification of a D-amino acid decapeptide HIV-1 entry inhibitor.

J. Binley, S. Blondelle, Hong Lu, 2006, Biochemical and biophysical research communications.

Improved induction of antibodies against key neutralizing epitopes by HIV-1 gp120 DNA prime-protein boost vaccination compared to gp120 protein only vaccination

J. Binley, D. Montefiori, Shixia Wang, 2021 .

Targeting HIV-1 envelope glycoprotein trimers to B cells using APRIL improves antibody responses

J. Moore, J. Binley, B. Berkhout, 2012, Retrovirology.

Improved Induction of Antibodies against Key Neutralizing Epitopes by Human Immunodeficiency Virus Type 1 gp120 DNA Prime-Protein Boost Vaccination Compared to gp120 Protein-Only Vaccination

J. Binley, D. Montefiori, Shixia Wang, 2008, Journal of Virology.

Protection against HIV‐1 infection in hu‐PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4‐binding site

C. Barbas, J. Binley, D. Burton, 1995, AIDS.

Type 1 diabetes pathogenesis is modulated by spontaneous autoimmune responses to endogenous retrovirus antigens in NOD mice

J. Binley, L. Sherman, Yang D. Dai, 2017, European journal of immunology.

HIV – host interactome revealed directly from infected cells

B. Chait, J. Binley, D. Fenyö, 2016 .

Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals

Feng Gao, Lynn Morris, John R. Mascola, 2011, Journal of Virology.

Safety and Immunogenicity of ALVAC vCP1452 and Recombinant gp160 in Newly Human Immunodeﬁciency Virus Type 1-Infected Patients Treated with Prolonged Highly Active Antiretroviral Therapy

D. Ho, J. Binley, X. Jin, 2002 .

Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeﬁciency Virus Type 1 Subtype (cid:1) †

J. Binley, L. Morris, J. Overbaugh, 2009 .

Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity

S. Zolla-Pazner, J. Binley, K. E. Follis, 1998, Journal of Virology.

HIV-cell fusion. The viral mousetrap.

J. Binley, J. Moore, 1997, Nature.

Role of Complex Carbohydrates in Human Immunodeﬁciency Virus Type 1 Infection and Resistance to Antibody Neutralization (cid:1)

J. Binley, Y. Ban, W. Schief, 2010 .

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

J. Binley, E. Crooks, P. Selhorst, 2013, Retrovirology.

HIV: Envelope's letters boxed into shape

J. Binley, J. Moore, 1998, Nature.

Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage

A. Trkola, J. Robinson, J. Binley, 1998, Journal of Virology.

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120

J. Binley, D. Burton, I. Wilson, 2006, Retrovirology.

Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Christoph Grundner, Christos J. Petropoulos, Terri Wrin, 2003, Journal of Virology.

Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies

C. Barbas, J. Sodroski, J. Binley, 1998, Journal of Virology.

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

J. Binley, Y. Ban, W. Schief, 2010, Journal of Virology.

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

J. Binley, E. Crooks, R. Sanders, 2021, Cell reports.

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

Lynn Morris, Gwo-Yu Chuang, David C Montefiori, 2017, PLoS pathogens.

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis

Sebastian Bonhoeffer, Alan S Perelson, John E Mittler, 1999, The Lancet.

HIV–host interactome revealed directly from infected cells

David Fenyö, Ileana M. Cristea, Michael P. Rout, 2016, Nature Microbiology.

Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein

J. Sodroski, J. Binley, R. Wyatt, 1997, Journal of virology.

Access of antibody molecules to th conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary HIV-1

J. Sodroski, J. Binley, R. Wyatt, 2009 .

Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex

A. Trkola, J. Moore, J. Robinson, 1997, Journal of virology.

Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries.

G R Pilkington, C. Barbas, N. Haigwood, 1993, Journal of molecular biology.

An investigation of the high-avidity antibody response to glycoprotein 120 of human immunodeficiency virus type 1.

J. Moore, J. Binley, T. Fouts, 1997, AIDS research and human retroviruses.

The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.

J. Moore, D. Ho, J. Binley, 1999, The Journal of infectious diseases.

Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 Pseudovirions

J. Binley, N. Schülke, D. Burton, 2003, Journal of Virology.

Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

Lynn Morris, Michael S. Seaman, John R. Mascola, 2008, Journal of Virology.

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

Daniel W. Kulp, J. Mascola, J. Binley, 2015, PLoS pathogens.

Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein.

J. Binley, T. Wrin, C. Petropoulos, 2009, Virology.

Broad Neutralization of Human Immunodeficiency Virus Type 1 Mediated by Plasma Antibodies against the gp41 Membrane Proximal External Region

Lynn Morris, John R. Mascola, Salim S. Abdool Karim, 2009, Journal of Virology.

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1.

J. Binley, John P. Moore, T. Parsons, 2009, Vaccine.

Antibody Specificities Associated with Neutralization Breadth in Plasma from Human Immunodeficiency Virus Type 1 Subtype C-Infected Blood Donors

Lynn Morris, Peter B. Gilbert, John R. Mascola, 2009, Journal of Virology.

An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

J. Binley, D. Burton, I. Wilson, 2007, Journal of Virology.

Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1

J. Binley, D. Burton, L. Morris, 2006, Journal of Virology.

Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1

J. Moore, D. Ho, J. Binley, 1997, Journal of virology.

Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia.

J. Moore, J. Binley, L. Sawyer, 2000, Virology.

Dhanier Ft Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp 41

J. Binley, H. Katinger, John P. Moore, 2009 .

Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

J. Binley, John P. Moore, D. Burton, 2002, Journal of Virology.

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface

Gwo-Yu Chuang, Peter D. Kwong, Richard T. Wyatt, 2014, Nature.

Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.

D R Burton, H J Ditzel, R. M. Hendry, 1995, Journal of immunology.

Temporal Analyses of Virus Replication, Immune Responses, and Efficacy in Rhesus Macaques Immunized with a Live, Attenuated Simian Immunodeficiency Virus Vaccine

D. Ho, J. Binley, John P. Moore, 1998, Journal of Virology.

The effect of highly active antiretroviral therapy on binding and neutralizing antibody responses to human immunodeficiency virus type 1 infection.

A. Trkola, D. Richman, J. Moore, 2000, The Journal of infectious diseases.

HIV-1 Antigen–specific and –nonspecific B Cell Responses Are Sensitive to Combination Antiretroviral Therapy

D. Ho, J. Binley, John P. Moore, 1998, The Journal of experimental medicine.

Virus‐like Particles Identify an HIV V1V2 Apex‐Binding Neutralizing Antibody that Lacks a Protruding Loop

T. Kepler, J. Mascola, J. Binley, 2017, Immunity.

Anti-HIV B Cell Lines as Candidate Vaccine Biosensors

J. Mascola, J. Binley, R. Wyatt, 2012, The Journal of Immunology.

UvA-DARE ( Digital Academic Repository ) Neutralizing antibodies to the HIV-1 envelope glycoproteins

C. Broder, J. Binley, D. Burton, 2009 .

Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

B. Haynes, J. Mascola, J. Binley, 2018, PLoS pathogens.

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.

Daniel W. Kulp, J. Binley, W. Schief, 2017, Virology.

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

J. Binley, E. Crooks, K. Osawa, 2011, Journal of Virology.

HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes

J. Binley, E. Crooks, K. Osawa, 2012, Journal of Virology.

Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1

A. Trkola, J. Binley, H. Katinger, 1998, Journal of Virology.

Safety and Immunogenicity of ALVAC vCP1452 and Recombinant gp160 in Newly Human Immunodeficiency Virus Type 1-Infected Patients Treated with Prolonged Highly Active Antiretroviral Therapy

D. Ho, J. Binley, A. Hurley, 2002, Journal of Virology.

Highly Active Antiretroviral Therapy 1-Infected Patients Treated with Prolonged Human Immunodeficiency Virus Type vCP 1452 and Recombinant gp 160 in Newly Safety and Immunogenicity of ALVAC

D. Ho, J. Binley, A. Hurley, 2002 .

A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.

J. Binley, N. Schülke, D. Burton, 2007, Virology.

A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure

J. Binley, John P. Moore, B. Clas, 2000, Journal of Virology.

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

J. Binley, L. Verkoczy, Y. Tsybovsky, 2021, bioRxiv.

Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype

J. Binley, L. Morris, J. Overbaugh, 2009, Journal of Virology.

Specificities of broadly neutralizing anti-HIV-1 sera

J. Binley, 2009, Current opinion in HIV and AIDS.

Antibody Responses Elicited in Macaques Immunized with Human Immunodeficiency Virus Type 1 (HIV-1) SF162-Derived gp140 Envelope Immunogens: Comparison with Those Elicited during Homologous Simian/Human Immunodeficiency Virus SHIVSF162P4 and Heterologous HIV-1 Infection

L. Stamatatos, J. Binley, Z. Kraft, 2006, Journal of Virology.

Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques.

J. Binley, C. Apetrei, E. Crooks, 2014, Virology.

Multi-Parameter Exploration of HIV-1 Virus-Like Particles as Neutralizing Antibody Immunogens in Guinea Pigs, Rabbits and Macaques.

J. Binley, C. Apetrei, E. Crooks, 2014, Virology.

Characterization by serial deletion competition ELISAs of HIV-1 V3 loop epitopes recognized by monoclonal antibodies.

S. Zolla-Pazner, M. Gorny, J. Binley, 1996, Molecular immunology.

The Cytoplasmic Tail Slows the Folding of Human Immunodeficiency Virus Type 1 Env from a Late Prebundle Configuration into the Six-Helix Bundle

J. Binley, Min Lu, L. Abrahamyan, 2005, Journal of Virology.

The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy.

J. Moore, J. Binley, G. M. Ortiz, 2000, The Journal of infectious diseases.

Targeting HIV-1 envelope glycoprotein trimers to B cells using APRIL improves antibody responses

J. Moore, J. Binley, B. Berkhout, 2011, Journal of Virology.

Topological Analysis of HIV-1 Glycoproteins Expressed In Situ on Virus Surfaces Reveals Tighter Packing but Greater Conformational Flexibility than for Soluble gp120

T. Tong, K. Osawa, J. E. Robinson, 2013, Journal of Virology.

Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.

J. Sodroski, J. Moore, J. Binley, 1998, AIDS research and human retroviruses.

Persistent Antibody Responses but Declining Cytotoxic T-Lymphocyte Responses to Multiple Human Immunodeficiency Virus Type 1 Antigens in a Long-Term Nonprogressing Individual with a Defective p17 Proviral Sequence and No Detectable Viral RNA Expression

D. Ho, J. Binley, John P. Moore, 1998, Journal of Virology.

Variable-Loop-Deleted Variants of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Can Be Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits

J. Binley, John P. Moore, R. Sanders, 2000, Journal of Virology.

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.

J. Hoxie, J. Binley, P. Moore, 2008, Virology.

Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques

J. Binley, K. Metzner, D. Nixon, 2006, Retrovirology.

Impact of Common Modifications on the Antigenic Profile and Glycosylation of Membrane-Expressed HIV-1 Envelope Glycoprotein

J. Binley, M. Crispin, T. Tong, 2023, bioRxiv.

Comparative Immunogenicity of Evolved V1V2-Deleted HIV-1 Envelope Glycoprotein Trimers

J. Binley, John P. Moore, B. Berkhout, 2013, PloS one.

Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus.

David C Montefiori, Xia Jin, J. Binley, 2005, The Journal of general virology.

Evaluation of CD 8 + T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live , attenuated simian immunodeficiency virus

J. Binley, K. Metzner, D. Montefiori, 2005 .

The viral mousetrap

J. Binley, J. Moore, 1997, Nature.

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

James B. Munro, Daniel S. Terry, Cinque S. Soto, 2015, Nature Structural &Molecular Biology.

L. Stamatatos, J. Binley, Z. Kraft, 2007, Journal of Virology.

Neutralizing antibodies to the HIV-1 envelope glycoproteins

C. Broder, J. Binley, D. Burton, 2004 .

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.

J. Hoxie, J. Binley, P. Moore, 2008, Virology.

J. Binley, John P. Moore, B. Clas, 2000, Journal of Virology.

Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein

J. Binley, M. Crispin, T. Tong, 2023, PLoS pathogens.

Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

J. Binley, D. Montefiori, R. Sanders, 2011, Journal of Virology.

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

J. Binley, H. Katinger, John P. Moore, 2001, Journal of Virology.

In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope

D R Burton, H J Ditzel, J. Binley, 1996, Journal of virology.

Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding.

C. Barbas, J. Sodroski, J. Binley, 1996, AIDS research and human retroviruses.