R. Wyatt

发表

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies

J. Sodroski, Q. Sattentau, J. Moore, 1994, Journal of virology.

Proof of principle for epitope-focused vaccine design

David Baker, Eric Stevens, Man Chen, 2014, Nature.

High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site

J. Mascola, R. Wyatt, Yuxing Li, 2012, Science Translational Medicine.

Elicitation of structure-specific antibodies by epitope scaffolds

D. Baker, R. Wyatt, W. Schief, 2010, Proceedings of the National Academy of Sciences.

Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.

François Stricher, Wayne A Hendrickson, Peter D Kwong, 2005, Structure.

Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

Peter D. Kwong, John R. Mascola, Hermann Katinger, 2004, Journal of Virology.

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

J. Sodroski, R. Wyatt, W. Hendrickson, 1998, Nature.

The antigenic structure of the HIV gp120 envelope glycoprotein

Peter D. Kwong, Wayne A. Hendrickson, J. Sodroski, 1998, Nature.

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

Ying Sun, J. Sodroski, R. Wyatt, 1998, Science.

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.

W A Hendrickson, R W Sweet, J. Sodroski, 2000, Structure.

Structure of a V3-Containing HIV-1 gp120 Core

Bette Korber, Peter D. Kwong, Robyn L. Stanfield, 2005, Science.

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

Peter D. Kwong, Robyn L. Stanfield, Ian A. Wilson, 2007, Science.

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2009, Proceedings of the National Academy of Sciences.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Mario Roederer, Tongqing Zhou, Gary J. Nabel, 2010, Science.

Diverse Antibody Genetic and Recognition Properties Revealed following HIV-1 Envelope Glycoprotein Immunization

J. Mascola, R. Wyatt, Yuxing Li, 2015, The Journal of Immunology.

Particulate Array of Well‐Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

Richard T. Wyatt, John R. Mascola, J. Mascola, 2017, Immunity.

Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity.

R. Wyatt, G. B. Karlsson Hedestam, K. Tran, 2020, Cell reports.

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

R. Wyatt, S. Sharma, Richard Wilson, 2018, Front. Immunol..

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

R. Wyatt, S. Sharma, A. Ward, 2018, Front. Immunol..

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

R. Wyatt, I. Wilson, A. Ward, 2017, Immunity.

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

R. Wyatt, Richard Wilson, M. Zwick, 2017, Journal of Virology.

HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates

J. Mascola, R. Wyatt, N. Doria-Rose, 2017, Journal of Virology.

Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein

J. Mascola, R. Wyatt, P. Kwong, 2008, Journal of Virology.

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

Richard Wilson, Richard T. Wyatt, Robyn L. Stanfield, 2014, Proceedings of the National Academy of Sciences.

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

R. Wyatt, S. Sharma, A. Ward, 2015, Journal of Virology.

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2007, Nature.

HIV vaccine design and the neutralizing antibody problem

Wayne C Koff, Ian A Wilson, Dennis R Burton, 2004, Nature Immunology.

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Daniel W. Kulp, D. Irvine, R. Wyatt, 2019, Immunity.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

Daniel W. Kulp, D. Irvine, R. Wyatt, 2018 .

HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

J. Mascola, R. Wyatt, M. Connors, 2012, Journal of Virology.

The Envelope Glycoprotein Ectodomains Determine the Efficiency of CD4+ T Lymphocyte Depletion in Simian– Human Immunodeficiency Virus–Infected Macaques

J. Manola, J. Sodroski, R. Wyatt, 1998, The Journal of experimental medicine.

The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens.

J. Sodroski, R. Wyatt, R Wyatt, 1998, Science.

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

R. Wyatt, A. Ward, Richard Wilson, 2016, PLoS pathogens.

Sundling the HIV Primary Receptor Binding Site High-Resolution Definition of Vaccine-Elicited B Cell Responses Against

J. Mascola, R. Wyatt, Yuxing Li, 2012 .

Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2008, Structure.

Characterization of antibody responses to purified HIV-1 gp120 glycoproteins fused with the molecular adjuvant C3d.

J. Sodroski, R. Wyatt, M. Koch, 2005, Virology.

Structure of the Core of the HIV-1 gp 120 Exterior Envelope Glycoprotein

J. Sodroski, R. Wyatt, W. Hendrickson, 1999 .

CD4-independent binding of SIV gp120 to rhesus CCR5.

J. Sodroski, J. Robinson, R. Wyatt, 1997, Science.

Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S.

R. Wyatt, J. Coburn, D. Gill, 1989, The Journal of biological chemistry.

Selective Interactions of Polyanions with Basic Surfaces on Human Immunodeficiency Virus Type 1 gp120

J. Sodroski, Q. Sattentau, R. Wyatt, 2000, Journal of Virology.

Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry

R. Wyatt, D. Burton, D. Sok, 2018, Journal of Virology.

CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization.

R. Wyatt, C. Sundling, G. B. Karlsson Hedestam, 2008, The Journal of general virology.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Daniel W. Kulp, D. Irvine, R. Wyatt, 2017, Immunity.

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

R. Wyatt, I. Wilson, S. Sharma, 2018, Nature Communications.

Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category.

R. Wyatt, D. Dimitrov, Wei-zao Chen, 2018, Virology.

Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus

J. Mascola, R. Wyatt, C. Sundling, 2010, Journal of Virology.

HIV-1 Envgp140 trimers elicit neutralizing antibodies without efficient induction of conformational antibodies.

R. Wyatt, Yuxing Li, T. Ross, 2006, Vaccine.

Resource Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches Graphical Abstract Highlights

Daniel W. Kulp, D. Irvine, R. Wyatt, 2022 .

Glycoprotein Immunization Plasma Cell Responses upon HIV-1 Envelope Independent Expansion of Epitope-Specific

R. Wyatt, P. Dosenovic, M. Forsell, 2013 .

Dense Array of Spikes on HIV-1 Virion Particles

R. Wyatt, A. Olson, D. Leaman, 2017, Journal of Virology.

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

R. Wyatt, E. Saphire, J. Guenaga, 2019, mBio.

A Blueprint for HIV Vaccine Discovery.

Adam Godzik, Hendrik Streeck, M Juliana McElrath, 2012, Cell host & microbe.

147 Rational Design of Envelope Surface Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

J. Mascola, R. Wyatt, M. Connors, 2011 .

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

R. Wyatt, Lai-Xi Wang, J. Orwenyo, 2017, Chemical Communications.

Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease

R. Wyatt, J. Billingsley, D. Kaufmann, 2019, Nature Immunology.

HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies.

J. Mascola, R. Wyatt, K. Mckee, 2011, AIDS research and human retroviruses.

Analysis of Neutralization Speciﬁcities in Polyclonal Sera Derived from Human Immunodeﬁciency Virus Type 1-Infected Individuals (cid:1)

J. Mascola, R. Wyatt, S. Migueles, 2008 .

Influence of Novel CD4 binding-defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T Cell Responses in Non- human Primates Running title: Novel CD4 binding-defective HIV-1 Env immunogens

J. Mascola, R. Wyatt, Yuxing Li, 2009 .

Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes

R. Wyatt, Y. Xiong, J. O. Wertheim, 2018, The Journal of Biological Chemistry.

Phosphoserine acidic cluster motifs in the cytoplasmic domains of transmembrane proteins bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes

R. Wyatt, Y. Xiong, J. O. Wertheim, 2018, bioRxiv.

Tyrosine Sulfation of the Amino Terminus of CCR5 Facilitates HIV-1 Entry

Joseph Sodroski, J. Sodroski, R. Wyatt, 1999, Cell.

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

R. Wyatt, Richard Wilson, Yu Feng, 2017, Front. Immunol..

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

R. Fuller, R. Wyatt, D. Burton, 2018, Cell reports.

Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.

R. Wyatt, Yu Feng, G. B. Karlsson Hedestam, 2013, Virology.

Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation

R. Wyatt, R. Koup, G. B. Karlsson Hedestam, 2013, The Journal of Immunology.

Glycoproteins via CD4 for Antigen Efficiently Capture HIV-1 Envelope Human Plasmacytoid Dendritic Cells

R. Wyatt, R. Koup, K. Loré, 2013 .

Glycoproteins via CD 4 for Antigen Efficiently Capture HIV-1 Envelope Human Plasmacytoid Dendritic Cells

R. Wyatt, R. Koup, K. Loré, 2013 .

Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help

R. Wyatt, K. Überla, M. Epple, 2019, Nanomaterials.

Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.

J. Sodroski, R. Wyatt, W. Hendrickson, 1999, Biochemistry.

Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with CD4.

J. Sodroski, R. Wyatt, I. Chaiken, 2001, Biochemistry.

Translocation Is Mediated by a x-like Consensus By

A. Zelenetz, R. Wyatt, R. DeLellis, 1992 .

Human Immunodeﬁciency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein (cid:1) †

J. Mascola, R. Wyatt, P. Kwong, 2008 .

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

R. Wyatt, K. Überla, V. Temchura, 2022, Pharmaceutics.

Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.

R. Wyatt, C. Bewley, P. Acharya, 2008, Bioorganic & medicinal chemistry.

Resistance to Argentine stem weevil in perennial ryegrass infected with endophytes producing different alkaloids.

R. Wyatt, A. Popay, 1995 .

Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Christoph Grundner, Christos J. Petropoulos, Terri Wrin, 2003, Journal of Virology.

Enhanced Expression, Native Purification, and Characterization of CCR5, a Principal HIV-1 Coreceptor*

J. Sodroski, R. Wyatt, N. Bannert, 1999, The Journal of Biological Chemistry.

A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5

J. Sodroski, L. Vaca, R. Wyatt, 1998, Journal of Virology.

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

Joseph Sodroski, Cristina Parolin, J. Sodroski, 1996, Nature.

Inhibition of HIV‐1 entry by antibodies: potential viral and cellular targets

R. Wyatt, G. B. Karlsson Hedestam, S. Phogat, 2007, Journal of internal medicine.

Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Mark Connors, John R Mascola, J. Mascola, 2007, Nature Medicine.

Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.

J. Sodroski, Q. Sattentau, J. Hoxie, 1998, Virology.

BCL2 oncogene translocation is mediated by a chi-like consensus

A. Zelenetz, R. Wyatt, R. DeLellis, 1992, The Journal of experimental medicine.

A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly.

R. Wyatt, Yuxing Li, I. Ghosh, 2010, ACS chemical biology.

Selective Interactions of Polyanions with Basic Surfaces on Human Immunodeficiency Virus Type 1 gp120

J. Sodroski, Q. Sattentau, R. Wyatt, 2000, Journal of Virology.

Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.

R. Wyatt, W. Hendrickson, P. Kwong, 2007, Journal of medicinal chemistry.

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2012, Nature.

Direct Antibody Access to the HIV-1 Membrane-Proximal External Region Positively Correlates with Neutralization Sensitivity

R. Wyatt, D. Burton, L. Walker, 2011, Journal of Virology.

Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region

J. Mascola, R. Wyatt, G. Nabel, 2009, Journal of Virology.

Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain

J. Sodroski, R. Wyatt, J. Kuhn, 1998, Journal of Virology.

Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein

J. Sodroski, J. Binley, R. Wyatt, 1997, Journal of virology.

Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions

J. Sodroski, D. Ho, J. Robinson, 1993, Journal of virology.

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

J. Sodroski, R. Wyatt, D. Burton, 2008, Nature Reviews Microbiology.

Access of antibody molecules to th conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary HIV-1

J. Sodroski, J. Binley, R. Wyatt, 2009 .

Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

J. Sodroski, J. Moore, J. Robinson, 1995, Journal of virology.

Improved Elicitation of Neutralizing Antibodies against Primary Human Immunodeficiency Viruses by Soluble Stabilized Envelope Glycoprotein Trimers

J. Sodroski, R. Wyatt, Xinzhen Yang, 2001, Journal of Virology.

Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design.

R. Wyatt, S. Sharma, A. Ward, 2015, Cell reports.

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

Christoph Grundner, Wayne A Hendrickson, Marie Pancera, 2003, Virology.

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples.

D. Irvine, R. Wyatt, D. Burton, 2010, Journal of immunological methods.

Immunogenicity of HIV-1 envelope glycoprotein oligomers

R. Wyatt, W. Schief, M. Forsell, 2009, Current opinion in HIV and AIDS.

Selective Expansion of HIV-1 Envelope Glycoprotein-Specific B Cell Subsets Recognizing Distinct Structural Elements Following Immunization1

J. Hoxie, R. Wyatt, Yuxing Li, 2009, The Journal of Immunology.

Following Immunization Recognizing Distinct Structural Elements Glycoprotein-Specific B Cell Subsets Selective Expansion of HIV-1 Envelope

J. Hoxie, R. Wyatt, Yuxing Li, 2009 .

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.

J. Mascola, R. Wyatt, I. Wilson, 2016, Immunity.

Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

Richard T. Wyatt, John R. Mascola, Mark Connors, 2012, Journal of Virology.

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

J. Mascola, R. Wyatt, C. Sundling, 2010, The Journal of experimental medicine.

Characterization of Antibody Responses Elicited by Human Immunodeficiency Virus Type 1 Primary Isolate Trimeric and Monomeric Envelope Glycoproteins in Selected Adjuvants

J. Mascola, R. Wyatt, Yuxing Li, 2006, Journal of Virology.

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

L. Stamatatos, R. Wyatt, D. Montefiori, 2019, Cell reports.

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2009, Science.

Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables

Richard T. Wyatt, Bette T. Korber, John R. Mascola, 2009, Journal of Virology.

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

Peter D. Kwong, Wayne A. Hendrickson, Michael L. Doyle, 2002, Nature.

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

Daniel W. Kulp, J. Mascola, J. Binley, 2015, PLoS pathogens.

PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4

Tongqing Zhou, Terri Wrin, Peter D. Kwong, 2012, Journal of Virology.

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

Barney S. Graham, Richard T. Wyatt, John R. Mascola, 2011, Journal of Virology.

Mechanism of Human Immunodeficiency Virus Type 1 Resistance to Monoclonal Antibody b12 That Effectively Targets the Site of CD4 Attachment

Tongqing Zhou, Peter D. Kwong, Richard T. Wyatt, 2009, Journal of Virology.

Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals

John R. Mascola, Mark K. Louder, Mark Connors, 2008, Journal of Virology.

Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies

J. Mascola, R. Wyatt, C. Hallahan, 2008, Journal of Virology.

, Epitope 1 Antibody 2 F 5 in Complex with Its gp 41 Anti-Human Immunodeficiency Virus Type Structure and Mechanistic Analysis of the

J. Mascola, H. Katinger, R. Wyatt, 2004 .

Studies with monoclonal antibodies to the V3 region of HIV-1 gp120 reveal limitations to the utility of solid-phase peptide binding assays.

J. Moore, D. Ho, J. Robinson, 1994, Journal of acquired immune deficiency syndromes.

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

J. Mascola, R. Wyatt, R. Bailer, 2019, Immunity.

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

J. Mascola, R. Wyatt, C. Bewley, 2016, PLoS pathogens.

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

J. Mascola, R. Wyatt, C. Bewley, 2016, PLoS pathogens.

Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis

J. Mascola, R. Wyatt, K. Mckee, 2015, mBio.

ResponsesImpacts HIV Env-Induced Antibody BLyS-Mediated Modulation of Naive B Cell

J. Mascola, R. Wyatt, N. Pelletier, 2017 .

BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses

J. Mascola, R. Wyatt, S. O'dell, 2012, The Journal of Immunology.

Subsets Impacts HIV Env-Induced Antibody BLyS-Mediated Modulation of Naive B Cell Cancro and

J. Mascola, R. Wyatt, N. Pelletier, 2012 .

Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region

J. Sodroski, D. Ho, J. Robinson, 1992, Journal of virology.

THE HIV VACCINE PROBLEM : WHY HAVE PAST APPROACHES TO DEVELOP AN HIV VACCINE FAILED ?

Walker, A. Godzik, B. Walker, 2022 .

Soluble Mimetics of Human Immunodeficiency Virus Type 1 Viral Spikes Produced by Replacement of the Native Trimerization Domain with aHeterologous Trimerization Motif: Characterization and Ligand Binding Analysis

J. Sodroski, R. Wyatt, E. Freire, 2005, Journal of Virology.

Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

Christoph Grundner, Joseph Sodroski, J. Sodroski, 2005, Virology.

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface

Gwo-Yu Chuang, Peter D. Kwong, Richard T. Wyatt, 2014, Nature.

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.

Wayne A Hendrickson, Peter D Kwong, Joseph Sodroski, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation

J. Mascola, R. Wyatt, C. Sundling, 2015, Scientific Reports.

Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.

J. Sodroski, R. Wyatt, M. Pancera, 2004, Virology.

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Richard T. Wyatt, Michael S. Seaman, John R. Mascola, 2009, Nature.

B Cells from Knock-in Mice Expressing Broadly Neutralizing HIV Antibody b12 Carry an Innocuous B Cell Receptor Responsive to HIV Vaccine Candidates

R. Wyatt, D. Burton, W. Schief, 2013, The Journal of Immunology.

HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

J. Mascola, R. Wyatt, K. Mckee, 2014, PLoS pathogens.

Characterization of Human Immunodeficiency Virus Type 1 Monomeric and Trimeric gp120 Glycoproteins Stabilized in the CD4-Bound State: Antigenicity, Biophysics, and Immunogenicity

Peter D. Kwong, John R. Mascola, Marie Pancera, 2007, Journal of Virology.

Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein

J. Sodroski, R. Wyatt, M. Doyle, 2002, Journal of Virology.

Energetics of the HIV gp120-CD4 binding reaction.

W A Hendrickson, R W Sweet, D G Myszka, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Migration ofAntigen-Specific T Cells Away from CXCR4-Binding Human ImmunodeficiencyVirus Type 1gp120

B. Walker, R. Wyatt, A. Trocha, 2004, Journal of Virology.

Virus‐like Particles Identify an HIV V1V2 Apex‐Binding Neutralizing Antibody that Lacks a Protruding Loop

T. Kepler, J. Mascola, J. Binley, 2017, Immunity.

An Aptamer That Neutralizes R5 Strains of Human Immunodeficiency Virus Type 1 Blocks gp120-CCR5 Interaction

Antu K. Dey, Susan M. Lea, R. Wyatt, 2005, Journal of Virology.

Anti-HIV B Cell Lines as Candidate Vaccine Biosensors

J. Mascola, J. Binley, R. Wyatt, 2012, The Journal of Immunology.

Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

J. Mascola, R. Wyatt, M. Connors, 2016, Journal of Virology.

A method for identification of HIV gp140 binding memory B cells in human blood.

F. Pereyra, B. Walker, J. Mascola, 2009, Journal of immunological methods.

Characterization of Stable, Soluble Trimers Containing Complete Ectodomains of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

J. Sodroski, R. Wyatt, M. Farzan, 2000, Journal of Virology.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

R. Fuller, R. Wyatt, D. Burton, 2017, Cell reports.

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

R. Wyatt, A. Ward, Yu Feng, 2017, PLoS pathogens.

Selective recognition of oligomeric HIV-1 primary isolate envelope glycoproteins by potently neutralizing ligands requires efficient precursor cleavage.

R. Wyatt, M. Pancera, 2005, Virology.

Oligomeric Modeling and Electrostatic Analysis of the gp120 Envelope Glycoprotein of Human Immunodeficiency Virus

J. Sodroski, Q. Sattentau, R. Wyatt, 2000, Journal of Virology.

Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function

R. Wyatt, J. Guenaga, 2012, PLoS pathogens.

Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

R. Wyatt, P. Dosenovic, M. Forsell, 2013, The Journal of Immunology.

Probability Analysis of Variational Crystallization and Its Application to gp120, The Exterior Envelope Glycoprotein of Type 1 Human Immunodeficiency Virus (HIV-1)*

J. Sodroski, R. Wyatt, J. Culp, 1999, The Journal of Biological Chemistry.

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

R. Wyatt, S. Sharma, D. Nemazee, 2016, Cell reports.

Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility

Young Do Kwon, Tongqing Zhou, Lei Chen, 2009 .

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

J. Mascola, R. Wyatt, L. Shapiro, 2019, The Journal of experimental medicine.

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

R. Wyatt, I. Wilson, S. Sharma, 2018, Nature Communications.

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization

R. Wyatt, A. Ward, Yuxing Li, 2019, Cell reports.

An HIV-1 Env–Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes

J. Mascola, R. Wyatt, Yuxing Li, 2016, The Journal of Immunology.

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

R. Wyatt, A. Ward, Yu Feng, 2015, PLoS pathogens.

Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles.

J. Mascola, R. Wyatt, I. Berkower, 2008, Virology.

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

J. Diedrich, J. Yates, R. Wyatt, 2018, Nature Communications.

J. Mascola, R. Wyatt, A. Mileant, 2021, bioRxiv.

Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein

J. Sodroski, J. Robinson, R. Wyatt, 1997, Journal of virology.

Biochemical and Immunogenic Characterization of Soluble Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers Expressed by Semliki Forest Virus

J. Mascola, R. Wyatt, Yuxing Li, 2005, Journal of Virology.

HIV-1 Envelope Glycoprotein Clone BG505 delCT N332T in complex with broadly neutralizing antibody Fab PGT151

J. Diedrich, J. Yates, R. Wyatt, 2018 .

Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

D. Baker, R. Wyatt, W. Schief, 2011, PloS one.

Energetics of the HIV gp 120-CD 4 binding reaction

J. Sodroski, R. Wyatt, M. Doyle, 2000 .

Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin

J. Sodroski, R. Wyatt, P. Kwong, 2002, Journal of Virology.

Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates

J. Mascola, R. Wyatt, D. Montefiori, 2013, Journal of Virology.

Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2009, PLoS pathogens.

Immunization with Recombinant HLA Classes I and II, HIV-1 gp140, and SIV p27 Elicits Protection against Heterologous SHIV Infection in Rhesus Macaques

R. Wyatt, Yufei Wang, E. Bunnik, 2011, Journal of Virology.

A biosensor-based approach toward purification and crystallization of G protein-coupled receptors.

David G Myszka, Marie Pancera, R. Wyatt, 2006, Analytical biochemistry.

HIV-1 envelope glycoprotein trimer immunogenicity elicited in the presence of human CD4 alters the neutralization profile.

J. Mascola, R. Wyatt, K. Mckee, 2014, AIDS research and human retroviruses.

Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates

J. Mascola, R. Wyatt, Yuxing Li, 2009, Journal of Virology.

B Cell Recognition of the Conserved HIV-1 Co-Receptor Binding Site Is Altered by Endogenous Primate CD4

J. Mascola, R. Wyatt, G. Shaw, 2008, PLoS pathogens.

Rational modifications of HIV-1 envelope glycoproteins for immunogen design.

R. Wyatt, S. Phogat, R Wyatt, 2007, Current pharmaceutical design.

Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs

R. Wyatt, Yuxing Li, K. Tran, 2019, Front. Microbiol..

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

H. Liao, J. Sodroski, B. Haynes, 2014, Journal of Virology.

Small-Molecule CD 4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp 120

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2018 .

Evolution of B cell analysis and Env trimer redesign

R. Wyatt, M. Corcoran, J. Guenaga, 2017, Immunological reviews.

Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140.

R. Doms, R. Wyatt, D. Burton, 2008, AIDS research and human retroviruses.

Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.

J. Sodroski, J. Moore, J. Binley, 1998, AIDS research and human retroviruses.

Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site*

J. Mascola, R. Wyatt, K. Mckee, 2011, The Journal of Biological Chemistry.

Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization

J. Mascola, R. Wyatt, Zhenhai Zhang, 2014, The Journal of Immunology.

IgG-Switched Macaque B Cells Reveal a Single-Cell and Deep Sequencing of Karlsson Hedestam

J. Mascola, R. Wyatt, Zhenhai Zhang, 2014 .

Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5

William R Schief, R. Wyatt, Y. Ban, 2014, Proteins.

Solid-Phase Proteoliposomes Containing Human Immunodeficiency Virus Envelope Glycoproteins

J. Sodroski, R. Wyatt, T. Mirzabekov, 2002, Journal of Virology.

HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

J. Mascola, R. Wyatt, K. Mckee, 2016, Scientific Reports.

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

L. Stamatatos, R. Wyatt, D. Nemazee, 2023, Frontiers in Immunology.

Modifications That Stabilize Human Immunodeficiency Virus Envelope Glycoprotein Trimers in Solution

J. Sodroski, R. Wyatt, P. Kwong, 2000, Journal of virology.

High-Resolution Longitudinal Study of HIV-1 Env Vaccine–Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

J. Mascola, R. Wyatt, Yuxing Li, 2016, The Journal of Immunology.

Symbiotic Nitrogen Fixation in the Fungus Gardens of Leaf-Cutter Ants

David M. Stevenson, Paul J. Weimer, Cameron R. Currie, 2009, Science.

Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions.

J. Sodroski, R. Wyatt, D. Montefiori, 1998, AIDS research and human retroviruses.

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

John R Yates, James C Paulson, Zachary Berndsen, 2018, Nature Communications.

HIV-1 Envelope Glycoprotein Clone BG505 delCT N332T in complex with broadly neutralizing antibody Fab PGT151

J. Diedrich, J. Yates, R. Wyatt, 2018 .

A method for identification of HIV gp140 binding memory B cells in human blood.

F. Pereyra, B. Walker, J. Mascola, 2009, Journal of immunological methods.

Hyperglycosylated Stable Core Immunogens Designed To Present the CD4 Binding Site Are Preferentially Recognized by Broadly Neutralizing Antibodies

J. Mascola, R. Wyatt, W. Schief, 2014, Journal of Virology.

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

J. Sodroski, B. Haynes, R. Wyatt, 2014, Journal of Virology.

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

J. Mascola, R. Wyatt, C. Sundling, 2010, The Journal of experimental medicine.

Characterization of Antibody Responses Elicited by Human Immunodeficiency Virus Type 1 Primary Isolate Trimeric and Monomeric Envelope Glycoproteins in Selected Adjuvants

J. Mascola, R. Wyatt, Yuxing Li, 2006, Journal of Virology.