J. Eeckhoute

发表

Model-based Analysis of ChIP-Seq (MACS)

Clifford A. Meyer, C. Nusbaum, R. Myers, 2008, Genome Biology.

Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1

Clifford A. Meyer, P. Silver, Wei Li, 2005, Cell.

B in Waldenstrom macroglobulinemia κ Targeting NF

D. Carrasco, K. Anderson, J. Eeckhoute, 2013 .

Targeting NF-kappaB in Waldenstrom macroglobulinemia.

D. Carrasco, K. Anderson, J. Eeckhoute, 2008, Blood.

1 Targeting NF-κ B in Waldenstrom Macroglobulinemia

D. Carrasco, K. Anderson, J. Eeckhoute, 2008 .

Genome-wide analysis of estrogen receptor binding sites

Clifford A. Meyer, Jun S. Song, P. Silver, 2006, Nature Genetics.

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

Clifford A. Meyer, Wei Li, Yong Zhang, 2008, Cell.

Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

Swneke D. Bailey, Jason H. Moore, J. Eeckhoute, 2012, Nature Genetics.

Pioneer factors: directing transcriptional regulators within the chromatin environment.

J. Eeckhoute, L. Magnani, M. Lupien, 2011, Trends in genetics : TIG.

Glucose sensing O‐GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

J. Eeckhoute, T. Lefebvre, B. Staels, 2014, Hepatology.

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

J. Eeckhoute, B. Staels, V. Dubois, 2020, Cells.

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

J. Eeckhoute, P. Froguel, R. Métivier, 2012, Nucleic acids research.

Dynamic Estrogen Receptor Interactomes Control Estrogen-Responsive Trefoil Factor (TFF) Locus Cell-Specific Activities

J. Eeckhoute, R. Métivier, E. Watrin, 2014, Molecular and Cellular Biology.

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation

J. Eeckhoute, B. Staels, Céline Gheeraert, 2014, Nucleic acids research.

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

J. Eeckhoute, D. Lacroix, J. Edmé, 2018, The Lancet.

Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner

J. Eeckhoute, A. Gabory, J. Lesage, 2017, Molecular metabolism.

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

J. Eeckhoute, S. Lancel, D. Dombrowicz, 2017, Gastroenterology.

Organizing combinatorial transcription factor recruitment at cis-regulatory modules

J. Eeckhoute, M. Lupien, B. Staels, 2018, Transcription.

FOXA1 Is a Potential Oncogene in Anaplastic Thyroid Carcinoma

M. Loda, J. Eeckhoute, Myles A Brown, 2009, Clinical Cancer Research.

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

J. Eeckhoute, S. Cianférani, T. Lefebvre, 2018, Proceedings of the National Academy of Sciences.

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.

J. Eeckhoute, J. Carroll, M. Lupien, 2017, Genome research.

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.

J. Eeckhoute, Myles A Brown, M. Lupien, 2011, Genome research.

Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis.

J. Eeckhoute, R. Bataller, S. Truant, 2021, Journal of hepatology.

Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β‐cells

J. Eeckhoute, B. Staels, Wahiba Berrabah, 2013, FEBS letters.

Palmitate increases Nur 77 expression by modulating ZBP 89 and Sp 1 binding to the Nur 77 proximal promoter in pancreatic

J. Eeckhoute, B. Staels, Wahiba Berrabah, 2013 .

Mutations in hepatocyte nuclear factor 4α (HNF4α) gene associated with diabetes result in greater loss of HNF4α function in pancreatic β-cells than in nonpancreatic β-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells

J. Eeckhoute, B. Laine, P. Formstecher, 2002, Journal of Molecular Medicine.

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

G. Van den Berghe, J. Eeckhoute, S. Lancel, 2020, Molecular systems biology.

Peroxisome Proliferator-activated Receptor γ Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes*

J. Eeckhoute, P. Froguel, E. Durand, 2013, The Journal of Biological Chemistry.

Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

J. Eeckhoute, F. Pattou, T. Bouckenooghe, 2003, Endocrinology.

Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity.

J. Eeckhoute, B. Laine, P. Lefebvre, 2003, Nucleic acids research.

Perspectives on the use of super-enhancers as a defining feature of cell/tissue-identity genes.

J. Eeckhoute, B. Staels, V. Dubois, 2020, Epigenomics.

The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells.

J. Eeckhoute, F. Pattou, V. Gmyr, 2012, Molecular endocrinology.

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

J. Eeckhoute, F. Pattou, S. Cianférani, 2022, Nature Communications.

Unique ER Cistromes Control Cell Type-Specific Gene Regulation

J. Eeckhoute, Myles A Brown, J. Carroll, 2008 .

Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator.

J. Eeckhoute, B. Laine, P. Formstecher, 2001, Molecular endocrinology.

Functional properties of the R154X HNF‐4α protein generated by a mutation associated with maturity‐onset diabetes of the young, type 1

J. Eeckhoute, G. Bell, H. Furuta, 2000, FEBS letters.

Timed use of digoxin prevents heart ischemia–reperfusion injury through a REV-ERBα–UPS signaling pathway

J. Eeckhoute, S. Cianférani, B. Staels, 2022, Nature Cardiovascular Research.

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

J. Eeckhoute, B. Staels, P. Lefebvre, 2018, Cells.

Differential Estrogen-Regulation of CXCL12 Chemokine Receptors, CXCR4 and CXCR7, Contributes to the Growth Effect of Estrogens in Breast Cancer Cells

J. Eeckhoute, G. Flouriot, François le Dily, 2011, PloS one.

Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor α Expression in Breast Cancer

Jérôme Eeckhoute, Mathieu Lupien, Jason S. Carroll, 2007 .

Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.

J. Eeckhoute, J. Carroll, M. Lupien, 2007, Cancer research.

Dynamic ER Interactomes Control the Estrogen-Responsive Trefoil Factor (TFF) Locus Cell-Specific Activities.

J. Eeckhoute, R. Métivier, A. Sérandour, 2018 .

Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.

Jérôme Eeckhoute, Mathieu Lupien, Clifford A. Meyer, 2010, Genes & development.

Defining specificity of transcription factor regulatory activities

J. Eeckhoute, R. Métivier, G. Salbert, 2009, Journal of Cell Science.

Coactivator Function Defines the Active Estrogen Receptor Alpha Cistrome

Clifford A. Meyer, J. Eeckhoute, X. Liu, 2009, Molecular and Cellular Biology.

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.

Clifford A. Meyer, J. Eeckhoute, X. Liu, 2008, Genome research.

Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies.

Jérôme Eeckhoute, Mathieu Lupien, Myles Brown, 2009, Methods in molecular biology.

of FOXA 1-bound enhancers Cell-type selective chromatin remodeling defines the active subset Material Supplemental

Clifford A. Meyer, J. Eeckhoute, X. Liu, 2009 .

Unique ERalpha cistromes control cell type-specific gene regulation.

J. Eeckhoute, J. Carroll, M. Lupien, 2008, Molecular endocrinology.

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.

J. Eeckhoute, S. Cianférani, B. Staels, 2018, Journal of hepatology.

Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.

Wei Li, J. Eeckhoute, Jindan Yu, 2011, Cancer research.

A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer.

Jérôme Eeckhoute, Myles Brown, J. Eeckhoute, 2006, Genes & development.

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

J. Eeckhoute, B. Staels, P. Lefebvre, 2012, PPAR research.

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

J. Eeckhoute, B. Laine, P. Formstecher, 2006, Journal of molecular biology.

The ubiquitous transcription factor CTCF promotes lineage-specific epigenomic remodeling and establishment of transcriptional networks driving cell differentiation

J. Eeckhoute, B. Staels, P. Lefebvre, 2015, Nucleus.

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

J. Eeckhoute, C. Dani, S. Lancel, 2019, Cell reports.

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

J. Eeckhoute, B. Staels, V. Dubois, 2017, The Journal of clinical investigation.

Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring

J. Eeckhoute, J. Lesage, P. Legrand, 2019, International Journal of Obesity.

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.

J. Eeckhoute, G. Hubens, L. V. Van Gaal, 2017, JCI insight.

Cell-specific dysregulation of microRNA expression in obese white adipose tissue.

J. Eeckhoute, F. Pattou, D. Dombrowicz, 2014, The Journal of clinical endocrinology and metabolism.

A cell-type-specific transcriptional network required for estrogen regulation of cyclin D 1 and cell cycle progression in breast cancer

Jérôme Eeckhoute, Jason S. Carroll, Myles Brown, 2006 .

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

J. Eeckhoute, S. Lancel, R. Neviere, 2013, Nature Medicine.

GIANT: galaxy-based tool for interactive analysis of transcriptomic data

Jérôme Eeckhoute, Bart Staels, Céline Gheeraert, 2020, Scientific Reports.

Hepatic Molecular Signatures Highlight the Sexual Dimorphism of Nonalcoholic Steatohepatitis (NASH)

J. Eeckhoute, F. Pattou, D. Thuillier, 2020, Hepatology.

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ

J. Eeckhoute, F. Pattou, T. Lefebvre, 2017, Scientific Reports.

A time- and space-resolved nuclear receptor atlas in mouse liver

J. Eeckhoute, D. Dombrowicz, B. Staels, 2023, bioRxiv.

Reduced PPARγ2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications

J. Eeckhoute, A. Gabory, J. Lesage, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals.

J. Eeckhoute, C. Martinez-Jimenez, I. Talianidis, 2017, ACS chemical biology.

PPARalpha regulates the production of serum Vanin‐1 by liver

J. Eeckhoute, B. Staels, P. Naquet, 2013, FEBS letters.

GIANT: Galaxy-based Interactive tools for ANalysis of Transcriptomic data

Jérôme Eeckhoute, Jimmy Vandel, Céline Gheeraert, 2018 .

Hepatocyte Nuclear Factor 4α enhances the Hepatocyte Nuclear Factor 1α‐mediated activation of transcription

Jérôme Eeckhoute, J. Eeckhoute, B. Laine, 2004 .

Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription.

J. Eeckhoute, B. Laine, P Formstecher, 2004, Nucleic acids research.

The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype.

J. Eeckhoute, S. Haulon, B. Jude, 2015, Atherosclerosis.

Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity

J. Eeckhoute, S. Haulon, Z. Massy, 2017, Circulation research.

Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis: Molecular and Multicellular Control of Evolving Diseased States

J. Eeckhoute, 2022, Cells.

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients

J. Eeckhoute, P. Froguel, A. Bonnefond, 2023, bioRxiv.

Transducin‐like enhancer of split‐1 is expressed and functional in human macrophages

J. Eeckhoute, S. Haulon, F. Pattou, 2016, FEBS letters.

Peroxisome Proliferator–Activated Receptor-&ggr; Activation Induces 11&bgr;-Hydroxysteroid Dehydrogenase Type 1 Activity in Human Alternative Macrophages

J. Eeckhoute, J. Seckl, M. Bouhlel, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Roux-en-Y gastric bypass induces hepatic transcriptomic signatures and plasma metabolite changes indicative of improved cholesterol homeostasis.

J. Eeckhoute, D. Dombrowicz, E. Dirinck, 2023, Journal of hepatology.

An extended transcription factor regulatory network controls hepatocyte identity

J. Eeckhoute, L. Dubuquoy, B. Staels, 2023, EMBO reports.

J. Eeckhoute, B. Laine, P. Formstecher, 2001, Molecular endocrinology.

The conundrum of the functional relationship between transcription factors and chromatin.

J. Eeckhoute, B. Staels, A. Sérandour, 2022, Epigenomics.

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ

J. Eeckhoute, F. Pattou, T. Lefebvre, 2017, Scientific Reports.

Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation.

J. Eeckhoute, D. Dombrowicz, F. Geissmann, 2023, Journal of the American College of Cardiology.

Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming

J. Eeckhoute, P. Froguel, A. Bonnefond, 2023, iScience.

Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

J. Eeckhoute, S. Lancel, R. Neviere, 2019 .