D. Constam

发表

Automated design of ligands to polypharmacological profiles

Maria F. Sassano, G. R. Bickerton, Jérémy Besnard, 2012, Nature.

Cripto Localizes Nodal at the Limiting Membrane of Early Endosomes

D. Constam, J. Klumperman, V. Oorschot, 2008, Science Signaling.

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

D. Constam, J. Klumperman, V. Oorschot, 2008, The EMBO journal.

Extraembryonic proteases regulate Nodal signalling during gastrulation

D. Constam, J. A. Le Good, F. Beermann, 2002, Nature Cell Biology.

Riding Shotgun: A Dual Role for the Epidermal Growth Factor‐Cripto/FRL‐1/Cryptic Protein Cripto in Nodal Trafficking

D. Constam, 2009, Traffic.

Intracellular trafficking and signaling in development

D. Constam, 2009, F1000 biology reports.

Modulation of the immune response by transforming growth factor beta.

D. Constam, K. Frei, H. Pfister, 1992, International archives of allergy and immunology.

A gene network establishing polarity in the early mouse embryo.

D. Constam, S. Ang, 2004, Seminars in cell & developmental biology.

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

D. Constam, C. Bellanné-Chantelot, A. Grapin-Botton, 2012, Human mutation.

The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.

D. Constam, F. Naef, N. Ben-Haim, 2006, Developmental cell.

Cripto promotes A–P axis specification independently of its stimulatory effect on Nodal autoinduction

D. Constam, J. A. Le Good, G. Minchiotti, 2008, The Journal of cell biology.

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

D. Constam, J. Rougemont, P. Jacquemin, 2015, Development.

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

D. Constam, D. Peters, W. Leonhard, 2015, Journal of Translational Medicine.

Epiblast-speci fi c loss of HCF-1 leads to failure in anterior-posterior axis speci fi cation

D. Constam, W. Herr, Sylvain Bessonnard, 2016 .

Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.

D. Constam, W. Herr, Sylvain Bessonnard, 2016, Developmental biology.

Transforming growth factor‐β2 induces apoptosis of murine T cell clones without down‐regulating bcl‐2 mRNA expression

D. Constam, M. Weller, A. Fontana, 1994, European journal of immunology.

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

N. Seidah, D. Constam, A. Roulin, 2018, bioRxiv.

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst

D. Constam, D. Mesnard, 2010, The Journal of cell biology.

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis

D. Constam, M. Calfon, E. Robertson, 1996, The Journal of cell biology.

Cloning of the Human Puromycin‐Sensitive Aminopeptidase and Evidence for Expression in Neurons

D. Constam, R. Schlapbach, A. Fontana, 1997, Journal of neurochemistry.

Paracrine Activin-A signaling promotes melanoma growth and metastasis through immune evasion

D. Constam, P. Müller, K. Muehlethaler, 2017, bioRxiv.

Paracrine Activin-A signaling promotes melanoma growth and metastasis through immune evasion

D. Constam, K. Muehlethaler, D. Rimoldi, 2017, bioRxiv.

Puromycin-sensitive Aminopeptidase

L. Hersh, D. Constam, A. Tobler, 1995, The Journal of Biological Chemistry.

Pathogen-free husbandry conditions alleviate behavioral deficits and neurodegeneration in AD10 anti-NGF mice.

D. Constam, I. Arisi, R. Brandi, 2013, Journal of Alzheimer's disease : JAD.

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10*

Annik Prat, Daniel Constam, Marie-Claude Asselin, 2011, The Journal of Biological Chemistry.

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

D. Constam, julien Faget, S. Nassiri, 2022, Journal for ImmunoTherapy of Cancer.

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

D. Constam, Benjamin Rothé, Simon Fortier, 2018, PLoS genetics.

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

D. Constam, N. Ben-Haim, M. Shen, 2015, Development.

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

D. Constam, C. Fuerer, M. Nostro, 2014, The Journal of Biological Chemistry.

Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO‐1/CD95) pathway

J. Tschopp, D. Constam, M. Irmler, 1996, European journal of immunology.

Faculty Opinions recommendation of Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.

D. Constam, 2004 .

Dual modulation of phase-transitioning licenses the Bicc1 network of ciliopathy proteins to bind specific target mRNAs

D. Constam, Benjamin Rothé, Simon Fortier, 2021, bioRxiv.

Immune response to brain tumors

D. Constam, K. Frei, D. Piani, 1992 .

Purification and partial characterization of an intracellular NADH: quinone oxidoreductase from Phanerochaete chrysosporium

W. Zimmermann, D. Constam, A. Fiechter, 1991 .

Evolution of the mechanisms and molecular control of endoderm formation

D. Constam, A. Grapin-Botton, 2007, Mechanisms of Development.

KAP1 controls endogenous retroviruses in embryonic stem cells

Helen M. Rowe, D. Constam, J. Rougemont, 2010, Nature.

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.

D. Constam, E. Robertson, 2000, Development.

Regulation of TGFβ and related signals by precursor processing.

D. Constam, 2014, Seminars in cell & developmental biology.

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.

D. Constam, N. Ben-Haim, Séverine Beck, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

D. Constam, D. Mesnard, Marcela Guzman-Ayala, 2006, Development.

Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes

D. Constam, A. Fontana, M Moos, 1991, The Journal of cell biology.

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements

D. Constam, D. Norris, E. Robertson, 2004, Mechanisms of Development.

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.

D. Constam, S. Rotman, Nathalie Piazzon, 2012, Journal of molecular cell biology.

Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases

D. Constam, E. Robertson, 1999, The Journal of cell biology.

Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia.

D. Constam, M. Schachner, P. Dijke, 1992, Journal of immunology.

A novel cell‐based sensor detecting the activity of individual basic proprotein convertases

N. Seidah, D. Constam, A. Roulin, 2019, The FEBS Journal.

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes*

A. Prat, N. Seidah, D. Constam, 2013, The Journal of Biological Chemistry.

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

D. Constam, J. Anders, A. Radenović, 2021, ACS nano.

Time-resolved scanning ion conductance microscopy for three-dimensional tracking of nanoscale cell surface dynamics

D. Constam, J. Anders, A. Radenović, 2021, bioRxiv.

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.

Steve D. M. Brown, J. Ragoussis, A. Prat, 2008, Genes & development.

5 malformations in mice with mutation in the proprotein convertase VACTERL / caudal regression / Currarino syndrome-like data

Steve D. M. Brown, J. Ragoussis, A. Prat, 2008 .

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

D. Constam, Philipp André, M. Blum, 2009, Development.

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.

D. Constam, E. Robertson, 2000, Genes & development.

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells is Revealed by the ShcD/RaLP Adaptor Protein

D. Constam, A. Simeone, A. Sciullo, 2012, Stem cells.

Transient Production of TGF‐β2 by Postnatal Cerebellar Neurons and its Effect on Neuroblast Proliferation

D. Constam, A. Aguzzi, M. Schachner, 1994, The European journal of neuroscience.

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7.

D. Constam, Sylvain Bessonnard, B. Filippi, 2018, Cell reports.

D. Constam, D. Mesnard, Sylvain Bessonnard, 2015, The Journal of cell biology.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

H. Kiyonari, D. Constam, H. Hamada, 2021, Nature Communications.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires Bicc1-Ccr4 RNA degradation complex

H. Kiyonari, D. Constam, H. Hamada, 2020, bioRxiv.

Serum-Independent Nodal · Gdf 1 Heterodimers with Bound Pro Signal Transduction :

D. Constam, C. Fuerer, M. Nostro, 2014 .

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases.

D. Constam, Benjamin Rothé, Céline Gagnieux, 2019, Cellular signalling.

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.

D. Constam, J. Bowie, D. Cascio, 2017, Structure.

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

D. Constam, T. Weimbs, Justyna Iwaszkiewicz, 2015, Molecular and Cellular Biology.

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

D. Constam, A. Roebroek, W. V. D. Van de Ven, 1998, Development.

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

R. Rodriguiz, A. Prat, N. Seidah, 2013, Proceedings of the National Academy of Sciences.

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

D. Constam, D. Peters, W. Leonhard, 2015, Journal of Translational Medicine.

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

D. Constam, Benjamin Rothé, Simon Fortier, 2023, iScience.

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal.

D. Constam, 2009, Current opinion in genetics & development.

Nodal Stability Determines Signaling Range

A. Schier, D. Constam, N. Ben-Haim, 2005, Current Biology.

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.

D. Constam, P. Pfeffer, M. Donnison, 2011, Genes & development.

Watch thy neighbor: Proprotein convertases activate TGFß-related signals across tissue boundaries

D. Constam, 2003 .

Macrophages in the Brain: Friends or Enemies?

Adriano Fontana, D. Constam, K. Frei, 1994 .