D. Lamb

发表

Functional profiling of the Saccharomyces cerevisiae genome

Ronald W. Davis, J. Hegemann, P. Philippsen, 2002, Nature.

The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity*

Brian C. Baldwin, Steven L. Kelly, D. Kelly, 1997, The Journal of Biological Chemistry.

Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains

D. Kelly, S. Kelly, D. Lamb, 1998, Antimicrobial Agents and Chemotherapy.

Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem.

D. Kelly, S. Kelly, D. Lamb, 1999, FEMS microbiology letters.

The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.

D. Kelly, S. Kelly, D. Lamb, 1999, Biochemical and biophysical research communications.

Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans.

S. Kelly, D. Lamb, B. Maresca, 2013, The Journal of antimicrobial chemotherapy.

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site*

Li Lei, Bin Zhao, S. Kelly, 2009, The Journal of Biological Chemistry.

Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14α‐demethylase (CYP51; P45014DM)

D. Kelly, S. Kelly, D. Lamb, 1998 .

Molecular diversity of sterol 14α‐demethylase substrates in plants, fungi and humans

D. Kelly, S. Kelly, D. Lamb, 1998, FEBS letters.

Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents*

D. Kelly, S. Kelly, D. Lamb, 1997, The Journal of Biological Chemistry.

Cytochrome P450 biodiversity and biotechnology.

D. Kelly, S. Kelly, D. Lamb, 2006, Biochemical Society transactions.

The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2)*

Colin J Jackson, Douglas B Kell, D. Kell, 2002, The Journal of Biological Chemistry.

An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae

S. Kelly, D. Lamb, N. Burton, 2011, Antimicrobial Agents and Chemotherapy.

Streptomyces coelicolor A3(2) CYP102 Protein, a Novel Fatty Acid Hydroxylase Encoded as a Heme Domain without an N-Terminal Redox Partner

S. Kelly, D. Lamb, M. Waterman, 2010, Applied and Environmental Microbiology.

Cytochrome P450105D1 (CYP105D1) from Streptomyces griseus: heterologous expression, activity, and activation effects of multiple xenobiotics.

S. Kelly, D. Lamb, M. Dawson, 1999, Biochemical and biophysical research communications.

An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance.

D. Kelly, S. Kelly, D. Lamb, 2001, Biochemical Society transactions.

Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis

D. Kelly, S. Kelly, D. Lamb, 2003 .

Metabolic arsenal of giant viruses: Host hijack or self-use?

S. Kelly, D. Lamb, B. La Scola, 2022, eLife.

Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals

D. Kelly, S. Kelly, D. Lamb, 1999 .

Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism

D. Kelly, S. Kelly, D. Lamb, 1997, FEBS letters.

Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes

S. Kelly, D. Lamb, M. Waterman, 2012, The FEBS journal.

Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)

D. Kelly, S. Kelly, D. Lamb, 2010, Antimicrobial Agents and Chemotherapy.

The First Virally Encoded Cytochrome P450

S. Kelly, D. Lamb, M. Waterman, 2009, Journal of Virology.

Expression and Characterization of CYP51, the Ancient Sterol 14-demethylase Activity for Cytochromes P450 (CYP), in the White-Rot Fungus Phanerochaete chrysosporium

D. Kelly, S. Kelly, D. Lamb, 2008, Lipids.

Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis.

D. Kelly, S. Kelly, D. Lamb, 2007, Molecular biology and evolution.

Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.

D. Kelly, S. Kelly, D. Lamb, 2002, The Biochemical journal.

Export of Cytochrome P450 105D1 to the Periplasmic Space of Escherichia coli

S. Kelly, D. Lamb, M. Kaderbhai, 2001, Applied and Environmental Microbiology.

Engineering of heterologous cytochrome P450 in Acinetobacter sp.: application for pollutant degradation.

D. Kelly, S. Kelly, D. Lamb, 2000, Biochemical and biophysical research communications.

Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli.

D. Kelly, S. Kelly, D. Lamb, 1998, Biochemical and biophysical research communications.

The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51) (*)

D. Kelly, S. Kelly, D. Lamb, 1996, The Journal of Biological Chemistry.

Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol Δ 22‐desaturase

L. W. Parks, D. Kelly, S. Kelly, 1995, FEBS letters.

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51).

D. Kelly, S. Kelly, D. Lamb, 1996, The Journal of biological chemistry.

THE HISTONES OF CHICKEN ERYTHROCYTE NUCLEI.

D. Lamb, P. Callahan, K. Murray, 1964, Canadian journal of biochemistry.

Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

D. Kelly, S. Kelly, D. Lamb, 1996, The Lancet.

Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity

S. Kelly, D. Lamb, M. Allen, 2022, Biomolecules.

Mode of Action and Resistance to Azole Antifungals Associated with the Formation of 14α-Methylergosta-8,24(28)-dien-3β,6α-diol

D. Kelly, S. Kelly, D. Lamb, 1995 .

Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363.

D. Kelly, S. Kelly, D. Lamb, 1997, FEMS microbiology letters.

Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans.

D. Kelly, S. Kelly, D. Lamb, 2004, Biochemical and biophysical research communications.

Differential inhibition of Candida albicans CYP51 with azole antifungal stereoisomers.

W. Richards, D. Kelly, S. Kelly, 1997, FEMS microbiology letters.

Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

D. Kelly, S. Kelly, D. Lamb, 1995, Biochemical and biophysical research communications.

Components of royal jelly : 10-hydroxy-trans-dec-2-enoic acid

A. B. Foster, D. Lamb, S. A. Barker, 1962 .

Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics

S. Kelly, D. Lamb, Z. Wawrzak, 2022, Scientific Reports.

Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.

D. Kelly, S. Kelly, D. Lamb, 2000, FEMS microbiology letters.

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

D. Kelly, S. Kelly, D. Lamb, 2015, Antimicrobial Agents and Chemotherapy.

Generation of a complete, soluble, and catalytically active sterol 14 alpha-demethylase-reductase complex.

D. Kelly, S. Kelly, D. Lamb, 1999, Biochemistry.

Streptomyces cytochromes P450: applications in drug metabolism

D. Lamb, M. Waterman, Bin Zhao, 2013, Expert opinion on drug metabolism & toxicology.

Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery

F Peter Guengerich, S. Kelly, D. Lamb, 2006, Expert opinion on drug metabolism & toxicology.

Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents.

D. Kelly, S. Kelly, D. Lamb, 2000, Chemico-biological interactions.

Resistance to fluconazole and cross‐resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6‐desaturation

D. Kelly, S. Kelly, D. Lamb, 1997, FEBS letters.

The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

T. C. White, D. Kelly, S. Kelly, 2000, Antimicrobial Agents and Chemotherapy.

Purification, Reconstitution, and Inhibition of Cytochrome P-450 Sterol Δ22-Desaturase from the Pathogenic Fungus Candida glabrata

D. Kelly, S. Kelly, D. Lamb, 1999, Antimicrobial Agents and Chemotherapy.

Molecular aspects of azole antifungal action and resistance.

D. Kelly, S. Kelly, D. Lamb, 1999, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole.

D. Kelly, S. Kelly, D. Lamb, 2003, Biochemical and biophysical research communications.

Fifty Years of Cytochrome P450 Research: Examples of What We Know and Do Not Know

D. Lamb, M. Waterman, 2014 .

The Diversity and Importance of Microbial Cytochromes P450

D. Kelly, S. Kelly, D. Lamb, 2005 .

The biodiversity of microbial cytochromes P450.

D. Kelly, S. Kelly, D. Lamb, 2003, Advances in microbial physiology.

Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase.

D. Kelly, S. Kelly, D. Lamb, 2001, Biochemical and biophysical research communications.

Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients

S. Kelly, D. Lamb, B. C. Baldwin, 1995, FEBS letters.

Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

S. Kelly, D. Lamb, W. Powderly, 1994, FEMS microbiology letters.

Biodiversity of the P450 catalytic cycle: yeast cytochrome b 5/NADH cytochrome b 5 reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction

D. Kelly, S. Kelly, D. Lamb, 1999, FEBS letters.

Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase.

D. Lamb, J. Goldstone, J. Stegeman, 2014, Biochimica et biophysica acta.

Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans

S. Kelly, D. Lamb, B. C. Baldwin, 1997, Antimicrobial agents and chemotherapy.

Stereoselective Interaction of Tetraconazole with 14α-Demethylase in Fungi

S. Kelly, D. Lamb, R. Carzaniga, 1995 .

A sterol biosynthetic pathway in Mycobacterium

D. Kelly, S. Kelly, D. Lamb, 1998, FEBS letters.

S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole

D. Kelly, S. Kelly, D. Lamb, 2012, Antimicrobial Agents and Chemotherapy.

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs*

D. Lamb, Z. Wawrzak, F. Guengerich, 2015, The Journal of Biological Chemistry.

Characteristics of the heterologously expressed human lanosterol 14α‐demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents

D. Kelly, S. Kelly, D. Lamb, 1999, Yeast.

Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5

D. Kelly, S. Kelly, D. Lamb, 2001 .

Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5).

D. Kelly, S. Kelly, D. Lamb, 2001, Archives of biochemistry and biophysics.

Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?

D. Lamb, D. Raoult, B. La Scola, 2020, The ISME Journal.

Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).

H. Ikeda, S. Ōmura, S. Kelly, 2003, Biochemical and biophysical research communications.

Biological Origin and Configuration of 10-Hydroxy-Δ2-decenoic Acid

A. B. Foster, D. Lamb, S. A. Barker, 1959, Nature.

Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways

S. Kelly, D. Lamb, M. Waterman, 2004, Protein science : a publication of the Protein Society.

The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1

Benjamin A. Neely, S. Kelly, D. Lamb, 2003, The Journal of Biological Chemistry.

CYP56 (Dit2p) in Candida albicans: Characterization and Investigation of Its Role in Growth and Antifungal Drug Susceptibility

D. Kelly, S. Kelly, D. Lamb, 2008, Antimicrobial Agents and Chemotherapy.

Genome-Wide Generation of Yeast Gene Deletion Strains

Steven L. Kelly, D. Kelly, S. Kelly, 2001, Comparative and functional genomics.

Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).

S. Kelly, D. Lamb, M. Waterman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

On the occurrence of cytochrome P450 in viruses

S. Kelly, D. Lamb, T. Poulos, 2019, Proceedings of the National Academy of Sciences.

Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution.

D. Lamb, M. Waterman, J. Goldstone, 2016, Molecular phylogenetics and evolution.

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.

Robert L. Tanguay, D. Lamb, J. Goldstone, 2016, Toxicology and applied pharmacology.

Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish

D. Lamb, J. Goldstone, J. Stegeman, 2021, Scientific Reports.

Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor.

D. Lamb, F. Guengerich, Zhenhua Tian, 2013, Archives of biochemistry and biophysics.

Cytochrome P450 immobilisation as a route to bioremediation/biocatalysis

S. Kelly, D. Lamb, D. Stuckey, 1998, FEBS letters.

A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.

S. Kelly, D. Lamb, M. Waterman, 2006, Structure.

Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

S. Kelly, D. Lamb, M. Waterman, 2020, Molecular biology and evolution.

OP-MOLB200261 1..16

S. Kelly, D. Lamb, M. Waterman, 2020 .

Functional and structural characterisation of a viral cytochrome b5

S. Kelly, D. Lamb, M. Allen, 2013, FEBS letters.

Electron Transport Pathway for a Streptomyces Cytochrome P450

S. Kelly, D. Lamb, M. Waterman, 2007, Journal of Biological Chemistry.

Unusual properties of the cytochrome P450 superfamily

D. Lamb, M. Waterman, David C Lamb, 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

The N-Terminal Membrane Domain of Yeast NADPH-Cytochrome P450 (CYP) Oxidoreductase Is Not Required for Catalytic Activity in Sterol Biosynthesis or in Reconstitution of CYP Activity*

D. Kelly, S. Kelly, D. Lamb, 1998, The Journal of Biological Chemistry.

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)*

S. Kelly, D. Lamb, D. Cane, 2008, Journal of Biological Chemistry.

The cytochrome P450 gene family CYP157 does not contain EXXR in the K‐helix reducing the absolute conserved P450 residues to a single cysteine

S. Kelly, D. Lamb, M. Waterman, 2006, FEBS letters.

A Novel Sterol 14α-Demethylase/Ferredoxin Fusion Protein (MCCYP51FX) from Methylococcus capsulatusRepresents a New Class of the Cytochrome P450 Superfamily*

D. Kelly, S. Kelly, D. Lamb, 2002, The Journal of Biological Chemistry.

Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin

S. Kelly, D. Lamb, M. Waterman, 2012, International journal of molecular sciences.

Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction.

S. Kelly, D. Lamb, F. Guengerich, 2010, Journal of the American Chemical Society.

Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2.

S. Kelly, D. Lamb, M. Waterman, 2007, Biochemistry.

Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus.

D. Lamb, J. Goldstone, M. E. Hahn, 2018, Biochimica et biophysica acta. Proteins and proteomics.

Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.

D. Kelly, S. Kelly, D. Lamb, 2003, Biochemical and biophysical research communications.

Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae

D. Kelly, S. Kelly, D. Lamb, 2008, Antimicrobial Agents and Chemotherapy.

Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2*

Bradley S Moore, F Peter Guengerich, Tsutomu Shimada, 2005, Journal of Biological Chemistry.

Identification , characterization and azole-binding properties of 1 Mycobacterium smegmatis CYP 164 A 2 , a homolog of ML 2088 , 2 the sole cytochrome P 450 gene of Mycobacterium leprae 3 4

D. Kelly, S. Kelly, D. Lamb, 2009 .

Cytochromes P450 and drug discovery.

F Peter Guengerich, S. Kelly, D. Lamb, 2007, Current opinion in biotechnology.

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.

S. Kelly, D. Lamb, M. Botta, 2008, Journal of medicinal chemistry.

Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1).

S. Kelly, D. Lamb, M. Dawson, 2000, Biochemical and biophysical research communications.

Purification and characterization of a benzo[a]pyrene hydroxylase from Pleurotus pulmonarius.

S. Kelly, D. Lamb, S. Maspahy, 1999, Biochemical and biophysical research communications.

Plant sterol 14 alpha-demethylase affinity for azole fungicides.

D. Kelly, S. Kelly, D. Lamb, 2001, Biochemical and biophysical research communications.

Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism.

D. Kelly, S. Kelly, D. Lamb, 2002, Biochemical and biophysical research communications.

Role of Sterol Δ5(6) Desaturase in Azole Antifungal Mode of Action and Resistance

D. Kelly, S. Kelly, D. Lamb, 1996 .

Structural modeling of cytochrome P450 51 from a deep-sea fish points to a novel structural feature in other CYP51s.

S. Kelly, D. Lamb, J. Goldstone, 2023, Journal of inorganic biochemistry.

Targeting of active human cytochrome P4501A1 (CYP1A1) to the periplasmic space of Escherichia coli.

S. Kelly, D. Lamb, M. Kaderbhai, 2000, Biochemical and biophysical research communications.

Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus.

D. Lamb, J. Goldstone, M. E. Hahn, 2018, Biochimica et biophysica acta. Proteins and proteomics.

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

D. Kelly, S. Kelly, D. Lamb, 2015, Antimicrobial Agents and Chemotherapy.

Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?

D. Lamb, B. La Scola, E. Chabrière, 2021, The ISME Journal.