P. Piper

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Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors.

I. Seymour, P. Piper, Peter W. Piper, 1999, Microbiology.

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

L. Pearl, P. Piper, J. Ladbury, 1997, Cell.

Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

L. Pearl, P. Piper, S. Roe, 2006, Nature.

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

L. Pearl, P. Piper, J. Ladbury, 1999, Journal of medicinal chemistry.

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

L. Pearl, P. Piper, C. Prodromou, 2009, The FEBS journal.

The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37

L. Pearl, P. Piper, S. Roe, 2004, Cell.

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

Paul Workman, Rainer Cramer, Chrisostomos Prodromou, 2002, Molecular cell.

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.

Chrisostomos Prodromou, Bin Hu, Philippe Meyer, 2003, Molecular cell.

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.

L. Pearl, P. Piper, W. Stetler-Stevenson, 2010, Molecular cell.

Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x‐ray diffraction studies of the amino‐terminal domain

L. Pearl, P. Piper, C. Prodromou, 1996, Proteins.

Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae.

Mehdi Mollapour, Karl Kuchler, P. Piper, 2003, Molecular biology of the cell.

The Pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast

Rudy Pandjaitan, Ralf Egner, Karl Kuchler, 1998, The EMBO journal.

Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50 cdc37 *

L. Pearl, P. Piper, D. Woolfson, 2002, The Journal of Biological Chemistry.

A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta.

P. Piper, C. Prodromou, S. Millson, 2010, Biochemical pharmacology.

The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae

P. Piper, M. Mollapour, S. Millson, 2009, Yeast.

The C‐terminus of yeast plasma membrane H+‐ATPase is essential for the regulation of this enzyme by heat shock protein Hsp30, but not for stress activation

P. Piper, R. Braley, 1997, FEBS letters.

Primary structure of a mouse myeloma cell initiator transfer RNA

B. Clark, P. Piper, 1974, Nature.

Yeast superoxide dismutase mutants reveal a pro-oxidant action of weak organic acid food preservatives.

P. Piper, Peter W. Piper, 1999, Free radical biology & medicine.

War1p, a Novel Transcription Factor Controlling Weak Acid Stress Response in Yeast

P. Piper, K. Kuchler, M. Mollapour, 2003, Molecular and Cellular Biology.

Activity of the yeast zinc‐finger transcription factor War1 is lost with alanine mutation of two putative phosphorylation sites in the activation domain

P. Piper, M. Mollapour, 2012, Yeast.

Resistance of yeasts to weak organic acid food preservatives.

P. Piper, 2011, Advances in applied microbiology.

Chapter 10 Weak organic acid resistance of spoilage yeasts

P. Piper, M. Mollapour, 2008 .

Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives

P. Piper, M. Mollapour, Andrew Shepherd, 2008, Yeast.

Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae.

P. Piper, M. Mollapour, J. Phelan, 2006, The Biochemical journal.

Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants.

P. Piper, K. Kuchler, M. Mollapour, 2003, European journal of biochemistry.

Loss of Cmk1 Ca2+–calmodulin‐dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post‐transcriptional activation of the Pdr12 ATP‐binding cassette transporter

P. Piper, K. Kuchler, B. Bauer, 2000, Molecular microbiology.

The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives

P. Piper, M. Mollapour, Mehdi Mollapour, 2001, Molecular microbiology.

Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor

P. Piper, S. Millson, 2014, Oncotarget.

A correlation between a recessive lethal amber suppressor mutation in Saccharomyces cerevisiae and an anticodon change in a minor serine transfer RNA.

P. Piper, 1978, Journal of molecular biology.

Separation of Saccharomyces cerevisiae tRNAs on two-dimensional polyacrylamide gels as applied to investigations on the mutational alterations of tRNA that produce nonsense suppressors.

P. Piper, M. Wasserstein, 1977, European journal of biochemistry.

Weak acid preservatives block the heat shock response and heat-shock-element-directed lacZ expression of low pH Saccharomyces cerevisiae cultures, an inhibitory action partially relieved by respiratory deficiency.

P. Piper, L. Cheng, 1994, Microbiology.

The primary structure of the major cytoplasmic valine tRNA of mouse myeloma cells.

P. Piper, 1975, European journal of biochemistry.

The nucleotide sequence of the cytoplasmic initiator transfer RNA of a mouse myeloma cell.

P. Piper, F. Clark, 1974, European journal of biochemistry.

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics

P. Piper, S. Millson, 2012, Open Biology.

Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice.

P. Piper, J. Burnie, R. Matthews, 1996, FEMS immunology and medical microbiology.

Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase activation loop are essential for catalytic, but not non-catalytic, Slt2-mediated transcription in yeast

P. Piper, A. Truman, S. Millson, 2022, Cell stress & chaperones.

Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector. Influences of overexpression of HSP90 protein on high temperature growth and thermotolerance.

P. Piper, L. Cheng, K. Hirst, 1992, Biochimica et biophysica acta.

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival

P. Piper, S. Millson, Susana Gomez-Escalante, 2016, Cell Stress and Chaperones.

Identifying stress genes.

W. H. Mager, P. Piper, K. Maurer, 1997 .

Induction of heat shock proteins and thermotolerance.

P. Piper, 1996, Methods in molecular biology.

Plasma-membrane ATPase action affects several stress tolerances of Saccharomyces cerevisiae and Schizosaccharomyces pombe as well as the extent and duration of the heat shock response

P. Piper, B. Panaretou, 1990 .

Saccharomyces cerevisiae mRNA populations of different intrinsic stability in unstressed and heat shocked cells display almost constant m7GpppA:m7GpppG 5′‐cap structure ratios

P. Piper, B. Curran, K. Hirst, 1987, FEBS letters.

Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.

L. Pearl, P. Piper, A. Truman, 2003, Gene.

Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37

L. Pearl, P. Piper, L. Neckers, 2008, Molecular cell.

Catabolite control of the elevation of PGK mRNA levels by heat shock in Saccharomyces cerevisiae

P. Piper, M. Davies, B. Curran, 1988, Molecular microbiology.

Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells

P. Piper, D. Bringloe, 2002, Mechanisms of Ageing and Development.

Potential Safety Issues Surrounding the Use of Benzoate Preservatives

P. Piper, 2018 .

Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate.

P. Piper, Joseph D. Piper, 2017, Comprehensive reviews in food science and food safety.

UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM

P. Piper, S. Millson, Susana Gómez Escalante, 2017, Cell Stress and Chaperones.

Growth rate influences MFα1 promoter activity in MATαSaccharomyces cerevisiae

P. Piper, N. Kirk, 1994, Applied Microbiology and Biotechnology.

Isolation of yeast plasma membranes.

P. Piper, B. Panaretou, 1996, Methods in molecular biology.

A minor class of 5S rRNA genes in Saccharomyces cerevisiae X2180-1B, one member of which lies adjacent to a Ty transposable element.

P. Piper, N. Patel, A. Lockheart, 1984, Nucleic acids research.

When a glycolytic gene on a yeast 2μORI-STB plasmid is made essential for growth its expression level is a major determinant of plasmid copy number

P. Piper, B. Curran, 1990, Current Genetics.

The Hsp90 chaperone as a promising drug target.

P. Piper, 2001, Current opinion in investigational drugs.

Methanol as a convenient inducer of heat shock element-directed heterologous gene expression in yeast

P. Piper, N. Kirk, 1991, Biotechnology Letters.

Starvation for His-tRNAHis in yeast causes translational arrest without a high level of misincorporation of glutamine at histidine codons

P. Piper, K. Hirst, 1992, Current Genetics.

Transcription of the phosphoglycerate kinase gene of Saccharomyces cerevisiae increases when fermentative cultures are stressed by heat-shock.

M. W. Davies, P. Piper, B. Curran, 1986, European journal of biochemistry.

The determinants of heat‐shock element‐directed lacZ expression in Saccharomyces cerevisiae

P. Piper, N. Kirk, 1991, Yeast.

A temperature-sensitive mutant of Sacchromyces cerevisiae defective in the specific phosphatase of trehalose biosynthesis

P. Piper, A. Lockheart, 1988 .

Isolation of the ribosomal RNA gene from Tetrahymena in the state of transcriptionally active chromatin.

P. Piper, O. Westergaard, O. Nielsen, 1976, Biochemical and biophysical research communications.

3′‐End formation of transcripts from the yeast rRNA operon.

R. Planta, P. Piper, H. Offenberg, 1986, The EMBO journal.

Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae

P. Piper, P. Parker, J. Phelan, 2006, Journal of Cell Science.

UCS Chaperone Folding of the Myosin Head: A Function That Evolved before Animals and Fungi Diverged from a Common Ancestor More than a Billion Years Ago

P. Piper, S. Millson, Julia Elizabeth Scott, 2022, Biomolecules.

Mentha piperita essential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage.

P. Piper, M. Sousa, T. Cardoso, 2014, FEMS yeast research.

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

P. Piper, L. Cheng, R. Watt, 1994, Molecular and General Genetics MGG.

Structural basis of the radicicol resistance displayed by a fungal hsp90.

L. Pearl, P. Piper, P. Workman, 2009, ACS chemical biology.

Effects of medium composition on MFα1 promoter-directed secretion of a small protease inhibitor in Saccharomyces cerevisiae batch fermentation

P. Piper, N. Kirk, Yaping Chen, 1993, Biotechnology Letters.

Regulation of Hsp 90 ATPase Activity by the Co-chaperone Cdc 37 p / p 50 cdc 37

L. Pearl, P. Piper, D. Woolfson, 2002 .

Nonsense suppressors of Saccharomyces cerevisiae can be generated by mutation of the tyrosine tRNA anticodon

P. Piper, J. Zeuthen, F. Sherman, 1976, Nature.

The effects of protein synthesis inhibition, and of mutations rna1.1 and rna82.1, on the synthesis of small RNAs in yeast

P. Piper, J. Bellatin, A. Lockheart, 1987, FEBS letters.

Nonsense suppressors in eukaryotes

P. Piper, J. Celis, 1981 .

The influence of cell ploidy on the thermotolerance of Saccharomyces cerevisiae

M. W. Davies, P. Piper, M. Tuite, 1987, Current Genetics.

The incorporation of uridine label into the RNA of mouse embryo cells does not always reflect the labelling of the major cellular UTP pool

P. Piper, 1981, FEBS letters.

Differential role of Hsps and trehalose in stress tolerance.

P. Piper, 1998, Trends in microbiology.

Weak organic acid treatment causes a trehalose accumulation in low-pH cultures of Saccharomyces cerevisiae, not displayed by the more preservative-resistant Zygosaccharomyces bailii.

P. Piper, J. Moghraby, L. Cheng, 1999, FEMS microbiology letters.

Molecular events associated with acquisition of heat tolerance by the yeast Saccharomyces cerevisiae.

P. Piper, 1993, FEMS microbiology reviews.

Location of a platinum binding site in the structure of yeast phenylalanine transfer RNA.

B. Clark, P. Piper, D. Rhodes, 1974, Journal of molecular biology.

The Saccharomyces cerevisiae Weak-Acid-Inducible ABC Transporter Pdr12 Transports Fluorescein and Preservative Anions from the Cytosol by an Energy-Dependent Mechanism

P. Piper, K. Kuchler, C. Holyoak, 1999, Journal of bacteriology.

Targeted gene deletion in Zygosaccharomyces bailii

P. Piper, M. Mollapour, M Mollapour, 2001, Yeast.

The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap.

P. Piper, 1995, FEMS microbiology letters.

Chaperone ligand-discrimination by the TPR-domain protein Tah1

L. Pearl, P. Piper, C. Prodromou, 2008, The Biochemical journal.

Weak acid adaptation: the stress response that confers yeasts with resistance to organic acid food preservatives.

P. Piper, M. Mollapour, K. Hatzixanthis, 2001, Microbiology.

Hog1 Mitogen-Activated Protein Kinase Phosphorylation Targets the Yeast Fps1 Aquaglyceroporin for Endocytosis, Thereby Rendering Cells Resistant to Acetic Acid

Mehdi Mollapour, P. Piper, M. Mollapour, 2007, Molecular and Cellular Biology.

Lack of Tpψp in loop IV of a mammalian initiator transfer RNA

B. Clark, P. Piper, 1973 .

Yeast ochre suppressor SUQ5-ol is an altered tRNA Ser UCA

C. Waldron, B.S. Cox, N. Wills, 1981, Nucleic Acids Res..

The nucleotide sequences of cytoplasmic methionine and valine tRNAs from mouse myeloma cells

B. Clark, P. Piper, 1974, FEBS letters.

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1)

P. Piper, M. Siderius, A. Truman, 2014, Cell Stress and Chaperones.

A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p)

L. Pearl, P. Piper, A. Truman, 2005, Eukaryotic Cell.

Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold.

P. Piper, H. Boucherie, B. Panaretou, 1994, Microbiology.

The molecular defences against reactive oxygen species in yeast

P. Piper, V. Costa, P. Moradas‐Ferreira, 1996, Molecular microbiology.

Hsp30, the integral plasma membrane heat shock protein of Saccharomyces cerevisiae, is a stress-inducible regulator of plasma membrane H(+)-ATPase.

P. Piper, C. Holyoak, P. Coote, 1997, Cell stress & chaperones.

UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is a heat shock gene that is also subject to catabolite derepression control

P. Piper, R. Watt, 1997, Molecular and General Genetics MGG.

Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP‐binding cassette transporter

Mehdi Mollapour, Ian Seymour, Karl Kuchler, 2003, Yeast.

Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms

P. Piper, M. MacLean, N. Harris, 2001, Yeast.

The plasma membrane of yeast acquires a novel heat-shock protein (hsp30) and displays a decline in proton-pumping ATPase levels in response to both heat shock and the entry to stationary phase.

P. Piper, B. Panaretou, Peter W. Piper, 1992, European journal of biochemistry.

Screening the yeast deletant mutant collection for hypersensitivity and hyper‐resistance to sorbate, a weak organic acid food preservative

P. Piper, K. Kuchler, M. Mollapour, 2004, Yeast.

War1p, a Novel Transcription Factor Controlling Weak Acid Stress Response in Yeast

P. Piper, K. Kuchler, M. Mollapour, 2003, Molecular and Cellular Biology.

Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges

P. Piper, S. Millson, 2011, Pharmaceuticals.

Hypoxia abolishes transience of the heat-shock response in the methylotrophic yeast Hansenula polymorpha.

P. Piper, E. Berardi, E. Guerra, 2005, Microbiology.

Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.

Chrisostomos Prodromou, Mehdi Mollapour, Giuliano Siligardi, 2003, European journal of biochemistry.

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections.

L. Pearl, P. Piper, B. Panaretou, 1999, Microbiology.

A small influence of HSP90 levels on the trehalose and heat shock element inductions of the yeast heat shock response.

P. Piper, N. Kirk, L. Cheng, 1993, Biochemical and biophysical research communications.

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

L. Pearl, P. Piper, J. Ladbury, 1998, The EMBO journal.

The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells

P. Piper, M. Mollapour, D. Bringloe, 2002, Aging cell.

The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains

Chrisostomos Prodromou, Ronan O'Brien, Giuliano Siligardi, 2000, The EMBO journal.

Transfer of tRNAs to somatic cells mediated by Sendai-virus-induced fusion.

P. Piper, J. Zeuthen, J. Celis, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90

L. Pearl, P. Piper, S. Roe, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cloning and sequencing of a gene from the archaeon Pyrococcus furiosus with high homology to a gene encoding phosphoenolpyruvate synthetase from Escherichia coli.

P. Piper, J. Littlechild, D. Cowan, 1995, Gene.

Altered maturation of sequences at the 3′ terminus of 5S gene transcripts in a Saccharomyces cerevisiae mutant that lacks a RNA processing endonuclease.

P. Piper, J. Bellatin, A. Lockheart, 1983, The EMBO journal.

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones

Chrisostomos Prodromou, Lynne Regan, Ronan O'Brien, 1999, The EMBO journal.

Yeast mutation thought to arrest mRNA transport markedly increases the length of the 3' poly(A) on polyadenylated RNA.

P. Piper, J. L. Aamand, 1989, Journal of molecular biology.

Processing of transcripts of a dimeric tRNA gene in yeast uses the nuclease responsible for maturation of the 3′ termini upon 5 S and 37 S precursor rRNAs

P. Piper, K. B. Straby, K. B. Stråby, 1989, FEBS letters.

Processing of the 3' sequence extensions upon the 5S rRNA of a mutant yeast in Xenopus laevis germinal vesicle extract.

P. Piper, N. Patel, A. Lockheart, 1984, European journal of biochemistry.

The selective reaction of methoxyamine with cytidine residues in mammalian initiator transfer ribonucleic acid.

B. Clark, P. Piper, B F Clark, 1974, Nucleic acids research.

Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast

P. Piper, M. MacLean, N. Harris, 2006, Mechanisms of Ageing and Development.

Expressed in the Yeast Saccharomyces cerevisiae, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase

L. Pearl, P. Piper, A. Truman, 2006, Eukaryotic Cell.

Expressed in yeast , human ERK 5 is a client of the Hsp 90 chaperone that complements loss of the Slt 2 ( Mpk 1 ) p cell integrity stress-activated protein kinase

L. Pearl, P. Piper, A. Truman, 2006 .

Hog1p mitogen-activated protein kinase determines acetic acid resistance in Saccharomyces cerevisiae.

Mehdi Mollapour, P. Piper, M. Mollapour, 2006, FEMS yeast research.

Only one of two closely related yeast suppressor tRNA genes contains an intervening sequence

M. Olson, A. Sentenac, P. Piper, 1981, Nature.

Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast.

P. Piper, M. Mollapour, Andrew Shepherd, 2009, Microbiology.

Long‐lived yeast as a model for ageing research

P. Piper, 2006, Yeast.

Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach

L. Pearl, P. Piper, A. Truman, 2004, Cell stress & chaperones.

Understanding of the Hsp90 molecular chaperone reaches new heights

P. Piper, L. Neckers, C. Vaughan, 2010, Nature Structural &Molecular Biology.

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

Laurence H. Pearl, Chrisostomos Prodromou, L. Pearl, 1997, Nature Structural Biology.

Tetrahymena ribosomal RNA gene chromatin is digested by micrococcal nuclease at sites which have the same regular spacing on the DNA as corresponding sites in the bulk nuclear chromatin.

P. Piper, J. Celis, O. Westergaard, 1976, Nucleic acids research.

Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.

P. Piper, M. Mollapour, Vítor Costa, 2003, Free radical biology & medicine.

Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp104 and in the absence of protein synthesis

P. Piper, T. Boller, C. De Virgilio, 1991, FEBS letters.

In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity

P. Piper, A. Truman, C. Prodromou, 2007, Eukaryotic Cell.

Overexpression of the Gene for Polyubiquitin in Yeast Confers Increased Secretion of a Human Leucocyte Protease Inhibitor

P. Piper, Yaping Chen, D. Pioli, 1994, Bio/Technology.

Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu2+‐deficient or an active Cu,Zn‐superoxide dismutase

P. Piper, M. Mollapour, Vítor Costa, 2005, Aging cell.

Base excision repair activities required for yeast to attain a full chronological life span

E. Seeberg, P. Piper, M. Bjørås, 2003, Aging cell.

Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle*

L. Pearl, P. Piper, C. Prodromou, 2004, Journal of Biological Chemistry.

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

L. Pearl, P. Piper, C. Liao, 2004, The EMBO journal.

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.

L. Pearl, P. Piper, L. Neckers, 2011, Molecular cell.

Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol

P. Piper, A. Truman, B. Panaretou, 2007 .

Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.

P. Piper, A. Truman, B. Panaretou, 2007, The FEBS journal.

Structural and Functional Analysis of the Middle Segment of Hsp 90 : Implications for ATP Hydrolysis and Client

L. Pearl, P. Piper, S. Roe, 2003 .

Maximising the yeast chronological lifespan.

P. Piper, 2012, Sub-cellular biochemistry.

Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex

L. Pearl, P. Piper, C. Liao, 2005, Molecular microbiology.

Detection of sequences homologous to the highly-conserved HSP70 gene of eukaryotes in thermophilic eubacteria and archaebacteria

P. Piper, D. Cowan, E. Lambert, 1988 .

A heat shock element in the phosphoglycerate kinase gene promoter of yeast.

M. W. Davies, P. Piper, A. Kingsman, 1988, Nucleic acids research.

Vectors for N- or C-terminal positioning of the yeast Gal4p DNA binding or activator domains.

P. Piper, A. Truman, S. Millson, 2003, BioTechniques.

Consequences of the overexpression of ubiquitin in yeast: elevated tolerances of osmostress, ethanol and canavanine, yet reduced tolerances of cadmium, arsenite and paromomycin.

P. Piper, P W Piper, Y Chen, 1995, Biochimica et biophysica acta.

Complementation of a pgk deletion mutation in Saccharomyces cerevisiae with expression of the phosphoglycerate-kinase gene from the hyperthermophilic Archaeon Sulfolobus solfataricus

P. Piper, J. Littlechild, D. Cowan, 1996, Current Genetics.

The nucleotide sequence of a methionine tRNA which functions in protein elongation in mouse myeloma cells.

P. Piper, 1975, European journal of biochemistry.

Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells

P. Piper, B. Panaretou, M. MacLean, 2001, Molecular Genetics and Genomics.

The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-bp. Isolation, sequencing of the genes and expression in Escherichia coli.

P. Piper, J. Littlechild, D. Cowan, 1995, European journal of biochemistry.

Complementation of apgk deletion mutation inSaccharomyces cerevisiae with expression of the phosphoglycerate-kinase gene from the hyperthermophilic ArchaeonSulfolobus solfataricus

P. Piper, J. Littlechild, D. Cowan, 2006, Current Genetics.

Hsp90 chaperone control over transcriptional regulation by the yeast Slt2(Mpk1)p and human ERK5 mitogen-activated protein kinases (MAPKs).

P. Piper, A. Truman, S. Millson, 2006, Biochemical Society transactions.

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival

P. Piper, S. Millson, Susana Gomez-Escalante, 2016, Cell Stress and Chaperones.

The Phosphoglycerate Kinase and glsyceraldehyde‐3‐phosphate Dehydrogenase Genes from the Thermophilic Archaeon Sulfolobus Solfataricus Overlap by 8‐bp

P. Piper, J. Littlechild, D. Cowan, 1995 .

Characterization, crystallization and preliminary X-ray investigation of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

P. Piper, J. Littlechild, M. Isupov, 1998, Acta crystallographica. Section D, Biological crystallography.

Isolation of yeast DNA.

P. Piper, 1996, Methods in molecular biology.

Stress proteins ‐ induction and function

P. Piper, 1992 .