D. Thiele

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Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase*

J. Hahn, D. Thiele, 2002, The Journal of Biological Chemistry.

Genome-Wide Analysis of the Biology of Stress Responses through Heat Shock Transcription Factor

V. Iyer, J. Hahn, D. Thiele, 2004, Molecular and Cellular Biology.

Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.

D. Thiele, K. Morano, Dennis J. Thiele, 1999, Gene expression.

The Mammalian HSF4 Gene Generates Both an Activator and a Repressor of Heat Shock Genes by Alternative Splicing*

D. Thiele, A. Nakai, K. Nagata, 1999, The Journal of Biological Chemistry.

Mechanisms for copper acquisition, distribution and regulation.

D. Thiele, Byung-Eun Kim, Tracy Nevitt, 2008, Nature chemical biology.

Copper-specific Transcriptional Repression of Yeast Genes Encoding Critical Components in the Copper Transport Pathway*

D. Thiele, S. Labbé, Zhiwu Zhu, 1997, The Journal of Biological Chemistry.

A trans-Activation Domain in Yeast Heat Shock Transcription Factor Is Essential for Cell Cycle Progression during Stress

D. Thiele, K. Morano, N. Santoro, 1999, Molecular and Cellular Biology.

Copper at the Front Line of the Host-Pathogen Battle

D. Thiele, Richard A. Festa, 2012, PLoS pathogens.

Pipes and wiring: the regulation of copper uptake and distribution in yeast.

D. Thiele, S. Labbé, D J Thiele, 1999, Trends in microbiology.

A stress regulatory network for co‐ordinated activation of proteasome expression mediated by yeast heat shock transcription factor

J. Hahn, D. Thiele, Ji-Sook Hahn, 2006, Molecular microbiology.

Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase.

S. Dorland, D. Stillman, D. Thiele, 1992, Genes & development.

Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways

D. Thiele, T. Sosinowski, D J Thiele, 1994, Molecular and cellular biology.

Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification.

D. Thiele, P. Zhou, Pengbo Zhou, 1993, Genes & development.

and Transcription Factor Stress Responses through Heat Shock Genome-Wide Analysis of the Biology of

V. Iyer, J. Hahn, D. Thiele, 2004 .

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

D. Thiele, L. Ellerby, J. Valentine, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Ctr 2 regulates mast cell maturation by affecting the storage and expression of tryptase 1 and proteoglycans 2 3

D. Thiele, L. Kjellén, G. Pejler, 2016 .

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

D. Thiele, L. Kjellén, G. Pejler, 2015, The Journal of Immunology.

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

D. Thiele, Byung-Eun Kim, S. Gleber, 2013, Proceedings of the National Academy of Sciences.

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

D. Thiele, H. Rockman, M. Casad, 2010, Cell metabolism.

How reliable and robust are current biomarkers for copper status?

D. Thiele, C. Keen, H. Mcardle, 2008, The British journal of nutrition.

From aging to virulence: forging connections through the study of copper homeostasis in eukaryotic microorganisms.

D. Thiele, E. Rees, 2004, Current opinion in microbiology.

Biochemical Characterization of the Human Copper Transporter Ctr1*

D. Thiele, M. M. Peña, Jaekwon Lee, 2002, The Journal of Biological Chemistry.

Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins.

D. Thiele, S. Vergara, 2008, Biochemical Society transactions.

Transcription factor–driven alternative localization of Cryptococcus neoformans superoxide dismutase

D. Thiele, D. Loiselle, T. Haystead, 2021, The Journal of biological chemistry.

Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency

D. Thiele, D. Toczyski, J. Wohlschlegel, 2018, mBio.

Early Recruitment of AU-Rich Element-Containing mRNAs Determines Their Cytosolic Fate during Iron Deficiency

D. Thiele, S. Puig, S. Vergara, 2010, Molecular and Cellular Biology.

The Cth2 ARE-binding Protein Recruits the Dhh1 Helicase to Promote the Decay of Succinate Dehydrogenase SDH4 mRNA in Response to Iron Deficiency*

D. Thiele, R. Parker, S. Rodríguez-Navarro, 2008, Journal of Biological Chemistry.

How reliable and robust are current biomarkers for copper status

D. Thiele, C. Keen, H. Mcardle, 2007 .

Negative Feedback Regulation of the Yeast Cth1 and Cth2 mRNA Binding Proteins Is Required for Adaptation to Iron Deficiency and Iron Supplementation

D. Thiele, M. Martínez-Pastor, S. Puig, 2013, Molecular and Cellular Biology.

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

D. Thiele, H. Öhrvik, Helena Öhrvik, 2014, Annals of the New York Academy of Sciences.

Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing

D. Thiele, Tracy Nevitt, 2011, PLoS pathogens.

Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1*

D. Thiele, Jaekwon Lee, M. Petris, 2003, The Journal of Biological Chemistry.

The Candida glabrata Amt1 copper‐sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification

D. Thiele, J. Côté, S. Allard, 2001, Molecular microbiology.

The ABCDs of periplasmic copper trafficking.

D. Thiele, S. Puig, E. Rees, 2002, Structure.

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans

J. Heitman, D. Thiele, Y. Bahn, 2016, Genetics.

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

S. Hubbard, D. Thiele, T. Hunter, 2016, eLife.

Reconstitution of a thermophilic Cu+ importer in vitro reveals intrinsic high-affinity slow transport driving accumulation of an essential metal ion

D. Thiele, Brandon L. Logeman, 2018, The Journal of Biological Chemistry.

Disulfiram (DSF) acts as a copper ionophore to induce copper‐dependent oxidative stress and mediate anti‐tumor efficacy in inflammatory breast cancer

F. Bertucci, D. Thiele, P. Finetti, 2015, Molecular oncology.

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

D. Thiele, Daniel W. Neef, Michelle L. Turski, 2010, PLoS biology.

Higher plants possess two different types of ATX1-like copper chaperones.

D. Thiele, J. Ecker, Antoni Garcia-Molina, 2007, Biochemical and biophysical research communications.

Metal-regulated transcription in eukaryotes.

D. Thiele, Dennis J. Thiele, D. J. Thiele, 1992, Nucleic acids research.

Metal accumulation and transport in the ovary of the lizard Podarcis sicula

D. Thiele, Jaekwon Lee, E. Parisi, 2004 .

Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron‐responsive gene transcription

D. Thiele, M. Szczypka, Zhiwu Zhu, 1997, Yeast.

A cysteine-rich nuclear protein activates yeast metallothionein gene transcription

D. Thiele, M. Szczypka, Dennis J. Thiele, 1989, Molecular and cellular biology.

Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene

D. Hamer, D. Thiele, 1986, Molecular and cellular biology.

Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences.

D. Thiele, D. Engelke, J. Huibregtse, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Mammalian metallothionein is functional in yeast.

D. Hamer, D. Thiele, M. Walling, 1986, Science.

Expression of alcohol-inducible rabbit liver cytochrome P-450 3a (P-450IIE1) in Saccharomyces cerevisiae with the copper-inducible CUP1 promoter.

M. J. Coon, D. Thiele, V. Fujita, 1990, DNA and cell biology.

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

D. Thiele, J. Prohaska, Jaekwon Lee, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism and regulation of intestinal copper absorption

D. Thiele, Y. Nose, 2010, Genes & Nutrition.

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cells in Vivo That Is Controlled at the Level of Protein Stability*

D. Thiele, Byung-Eun Kim, J. Prohaska, 2010, The Journal of Biological Chemistry.

Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture.

D. Thiele, E. Rees, Y. Nose, 2006, Trends in biochemical sciences.

Copper: An essential metal in biology

D. Thiele, Richard A. Festa, 2011, Current Biology.

The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis.

D. Thiele, O. Lockridge, K. Saito, 1991, The Journal of biological chemistry.

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain*♦

D. Thiele, T. Reinheckel, B. Turk, 2016, The Journal of Biological Chemistry.

A system for gene cloning and manipulation in the yeast Candida glabrata.

D. Thiele, M. Szczypka, R. Young, 1994, Gene.

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.

D. Thiele, A. Shawki, E. Niespodzany, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter

D. Thiele, Jaekwon Lee, M. Petris, 2002, The Journal of Biological Chemistry.

Trace metal uptake by Pichia spartinae, an endosymbiotic yeast in the salt marsh cord grass Spartina alterniflora

D. Thiele, S. Meyers, W. Catallo, 1996 .

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

D. Thiele, J. Gestwicki, Nicholas J. Rettko, 2018, Bioorganic & medicinal chemistry.

Separation and sequence of the 3' termini of M double-stranded RNA from killer yeast.

D. Thiele, M. Leibowitz, R. W. Wang, 1982, Nucleic acids research.

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2

D. Thiele, Jaekwon Lee, Brandon L. Logeman, 2017, The Journal of Biological Chemistry.

HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia

D. Thiele, C. Jordan, B. Boyce, 2022, Nature Communications.

New shuttle vectors for direct cloning in Saccharomyces cerevisiae.

D. Thiele, P. Silar, 1991, Gene.

Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance

D. Thiele, Corinna Probst, O. Baars, 2022, PLoS pathogens.

Regulation and Function of the Copper Ion Transport Machinery

D. Thiele, Jaekwon Lee, 2002 .

Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity.

D. Thiele, Alex M. Jaeger, Bushu Dong, 2019, Trends in pharmacological sciences.

Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis.

D. Thiele, Jia-Yi Li, Tao Wang, 2014 .

The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.

D. Thiele, H. Öhrvik, 2015, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

The Role of Ctr 1 and Ctr 2 in Mammalian Copper Homeostasis and Platinum-based Chemotherapy

D. Thiele, H. Öhrvik, 2015 .

Copper at the Fungal Pathogen-Host Axis*

D. Thiele, S. García-Santamarina, 2015, The Journal of Biological Chemistry.

Identiﬁcation of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

Philip F. Hughes, D. Thiele, David B. Darr, 2014 .

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

I. Herskowitz, D. Thiele, Jaekwon Lee, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A Copper-regulated Transporter Required for Copper Acquisition, Pigmentation, and Specific Stages of Development in Drosophila melanogaster*

D. Thiele, K. Cadigan, Hao Zhou, 2003, Journal of Biological Chemistry.

Integrating trace element metabolism from the cell to the whole organism.

D. Thiele, 2003, The Journal of nutrition.

Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins.

D. Thiele, K. Saito, V. Massey, 1993, The Journal of biological chemistry.

Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors.

D. Thiele, C. Ding, S. Atrian, 2014, Metallomics : integrated biometal science.

ACE2, an activator of yeast metallothionein expression which is homologous to SWI5

D. Thiele, G. Butler, 1991, Molecular and cellular biology.

Molecular mechanisms of copper uptake and distribution.

D. Thiele, S. Puig, Dennis J Thiele, 2002, Current opinion in chemical biology.

Characterization of the Saccharomyces cerevisiae High Affinity Copper Transporter Ctr3*

D. Thiele, S. Puig, M. Peña, 2000, The Journal of Biological Chemistry.

A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium.

P. A. Rea, D. Thiele, Z. S. Li, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor

D. Thiele, M. Szczypka, T. Sosinowski, 1992, Molecular and cellular biology.

The Drosophila Copper Transporter Ctr1C Functions in Male Fertility*

D. Thiele, W. Schaffner, M. Fetchko, 2010, The Journal of Biological Chemistry.

Charting the travels of copper in eukaryotes from yeast to mammals.

D. Thiele, Tracy Nevitt, H. Ohrvik, 2012, Biochimica et biophysica acta.

Toxic metal-responsive gene transcription.

D. Thiele, Z. Zhu, 1996, EXS.

Function and autoregulation of yeast copperthionein.

D. Hamer, D. Thiele, J. Lemontt, 1985, Science.

Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.

Kathryn L Haas, D. Thiele, K. Franz, 2011, Journal of the American Chemical Society.

Copper is required for oncogenic BRAF signaling and tumorigenesis

S. Knapp, D. Thiele, K. Xiao, 2013, Nature.

Copper-binding motifs in catalysis, transport, detoxification and signaling.

D. Thiele, K. Koch, M. Peña, 1997, Chemistry & biology.

Assembling the pieces.

D. Thiele, J. Gitlin, Dennis J Thiele, 2008, Nature chemical biology.

Copper in microbial pathogenesis: meddling with the metal.

D. Thiele, C. Ding, K. Darwin, 2012, Cell host & microbe.

Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.

D. Thiele, Richard A. Festa, K. Franz, 2014, Chemistry & biology.

Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant.

D. Thiele, J. Lee, T. Glover, 2000, Gene.

Dynamic Regulation of Copper Uptake and Detoxification Genes in Saccharomyces cerevisiae

D. Thiele, K. Koch, M. Peña, 1998, Molecular and Cellular Biology.

Biochemical and Genetic Analyses of Yeast and Human High Affinity Copper Transporters Suggest a Conserved Mechanism for Copper Uptake*

D. Thiele, S. Puig, Jaekwon Lee, 2002, The Journal of Biological Chemistry.

Identification of a Novel High Affinity Copper Transport Complex in the Fission Yeast Schizosaccharomyces pombe *

D. Thiele, Hao Zhou, 2001, The Journal of Biological Chemistry.

The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots.

D. Thiele, J. Ecker, S. Rodríguez-Navarro, 2006, The Plant journal : for cell and molecular biology.

New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease*

D. Thiele, Michelle L. Turski, 2009, Journal of Biological Chemistry.

The Arabidopsis Copper Transporter COPT1 Functions in Root Elongation and Pollen Development*

D. Thiele, S. Puig, L. Peñarrubia, 2004, Journal of Biological Chemistry.

Identification of a copper transporter family in Arabidopsis thaliana

D. Thiele, S. Puig, L. Peñarrubia, 2003, Plant Molecular Biology.

Regulation of heat shock transcription factors and their roles in physiology and disease

D. Thiele, Eileen T Burchfiel, Rocío Gómez-Pastor, 2017, Nature Reviews Molecular Cell Biology.

Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter*

D. Thiele, Jaekwon Lee, M. Petris, 2004, Journal of Biological Chemistry.

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99

D. Higgins, D. Thiele, D. Fitzpatrick, 2011, Molecular microbiology.

The Cu regulon of the human fungal pathogen Cryptococcus neoformans H99: Cuf1 activates distinct genes in response to both Cu excess and deficiency

D. Higgins, D. Thiele, D. Fitzpatrick, 2011 .

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

D. Thiele, C. Ross, D. Lo, 2017, Nature Communications.

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

D. Thiele, Daniel W. Neef, Dennis J. Thiele, 2011, Nature Reviews Drug Discovery.

A delicate balance: homeostatic control of copper uptake and distribution.

D. Thiele, J. Lee, D J Thiele, 1999, The Journal of nutrition.

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

D. Thiele, D. Winge, C. Counter, 2012, Molecular and Cellular Biology.

Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation

Michael J. Guertin, D. Thiele, Anniina Vihervaara, 2020, The Journal of biological chemistry.

Autoactivation by a Candida glabrata copper metalloregulatory transcription factor requires critical minor groove interactions

D. Thiele, K. Koch, 1996, Molecular and cellular biology.

A widespread transposable element masks expression of a yeast copper transport gene.

D. Thiele, D. Kosman, D. Kosman, 1996, Genes & development.

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

D. Thiele, J. Valentine, E. B. Gralla, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Genetic Selection for Constitutively Trimerized Human HSF1 Mutants Identifies a Role for Coiled-Coil Motifs in DNA Binding

D. Thiele, Daniel W. Neef, Alex M. Jaeger, 2013, G3: Genes, Genomes, Genetics.

Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF

D. Thiele, Xiao-Dong Liu, N. Santoro, 1997, The EMBO journal.

A Specialized Nucleosome Modulates Transcription Factor Access to a C. glabrata Metal Responsive Promoter

Zhiwu Zhu, D. Thiele, Zhiwu Zhu, 1996, Cell.

Mobilization of Intracellular Copper Stores by the Ctr2 Vacuolar Copper Transporter*

D. Thiele, E. Rees, Jaekwon Lee, 2004, Journal of Biological Chemistry.

Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1.

D. Thiele, J. Wemmie, M. Szczypka, 1994, The Journal of biological chemistry.

Heat shock transcription factor activates transcription of the yeast metallothionein gene

D. Thiele, G. Butler, P. Silar, 1991, Molecular and cellular biology.

Transcriptional Activation in Yeast in Response to Copper Deficiency Involves Copper-Zinc Superoxide Dismutase*

D. Thiele, L. K. Wood, 2009, Journal of Biological Chemistry.

Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis.

D. Thiele, Phillip C. C. Liu, P. C. Liu, 2001, Molecular biology of the cell.

Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.

D. Thiele, Sang‐Gun Ahn, 2003, Genes & development.

The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress.

D. Thiele, R. Morimoto, S. Ahn, 2001, Genes & development.

Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.

D. Thiele, D. Egli, W. Schaffner, 2005, Genes & development.

Protein chaperones and the heat shock response in Saccharomyces cerevisiae.

D. Thiele, K. Morano, D J Thiele, 1998, Current opinion in microbiology.

The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo

D. Thiele, K. Morano, 1999, The EMBO journal.

Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae

D. Thiele, Daniel W. Neef, 2009, Molecular microbiology.

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

Judith Frydman, Felix Willmund, D. Thiele, 2014, Cell reports.

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

C. Rodrigues-Pousada, D. Thiele, Phillip C. C. Liu, 2011, PloS one.

The Yeast Hsp110 Family Member, Sse1, Is an Hsp90 Cochaperone*

D. Thiele, K. Morano, Xiao-Dong Liu, 1999, The Journal of Biological Chemistry.

Modulation of Human Heat Shock Factor Trimerization by the Linker Domain*

D. Thiele, Phillip C. C. Liu, D J Thiele, 1999, The Journal of Biological Chemistry.

Heat Shock Element Architecture Is an Important Determinant in the Temperature and Transactivation Domain Requirements for Heat Shock Transcription Factor

Nina Johansson, D. Thiele, N. Johansson, 1998, Molecular and Cellular Biology.

Drosophila Ctr1A Functions as a Copper Transporter Essential for Development*

D. Thiele, Michelle L. Turski, 2007, Journal of Biological Chemistry.

Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function.

D. Thiele, Byung-Eun Kim, Y. Nose, 2006, Cell metabolism.

Saccharomyces cerevisiae killer virus transcripts contain template-coded polyadenylate tracts

D. Thiele, E. M. Hannig, M. Leibowitz, 1984, Molecular and cellular biology.

Genome structure and expression of a defective interfering mutant of the killer virus of yeast.

D. Thiele, E. M. Hannig, M. Leibowitz, 1984, Virology.

Multiple L double-stranded RNA species of Saccharomyces cerevisiae: evidence for separate encapsidation

D. Thiele, E. M. Hannig, M. Leibowitz, 1984, Molecular and cellular biology.

Copper ion inducible and repressible promoter systems in yeast.

D. Thiele, S. Labbé, 1999, Methods in enzymology.

A Copper-sensing Transcription Factor Regulates Iron Uptake Genes in Schizosaccharomyces pombe *

D. Thiele, S. Labbé, A. R. Fernandes, 1999, The Journal of Biological Chemistry.

ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene

D. Thiele, 1988, Molecular and cellular biology.

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Philip F. Hughes, D. Thiele, Jiaoti Huang, 2020, Science Translational Medicine.

High affinity copper transport protein in the lizard Podarcis sicula: molecular cloning, functional characterization and expression in somatic tissues, follicular oocytes and eggs.

D. Thiele, Jaekwon Lee, E. Parisi, 2002, Biochimica et biophysica acta.

Coordinated Remodeling of Cellular Metabolism during Iron Deficiency through Targeted mRNA Degradation

D. Thiele, S. Puig, E. Askeland, 2005, Cell.

Activation of the Saccharomyces cerevisiae Heat Shock Transcription Factor Under Glucose Starvation Conditions by Snf1 Protein Kinase*

J. Hahn, D. Thiele, Ji-Sook Hahn, 2004, Journal of Biological Chemistry.

X-ray structures of the high-affinity copper transporter Ctr1

D. Thiele, Yongjian Liu, Xiaohui Zhang, 2019, Nature Communications.

A Lytic Polysaccharide Monooxygenase-like protein functions in fungal copper import and meningitis

N. Grishin, D. Thiele, L. Kinch, 2019, Nature Chemical Biology.

Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein

D. Thiele, D. Kosman, K. Tamai, 1994, Molecular and cellular biology.

The Yeast Cadmium Factor Protein (YCF1) Is a Vacuolar Glutathione S-Conjugate Pump (*)

P. A. Rea, D. Thiele, Zesheng Li, 1996, The Journal of Biological Chemistry.

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

D. Thiele, J. Wemmie, M. Szczypka, 1994, The Journal of biological chemistry.

Cti6 Is an Rpd3-Sin3 Histone Deacetylase-associated Protein Required for Growth under Iron-limiting Conditions in Saccharomyces cerevisiae*

D. Thiele, S. Puig, Miranda Lau, 2004, Journal of Biological Chemistry.

De Novo Appearance and “Strain” Formation of Yeast Prion [PSI+] Are Regulated by the Heat-Shock Transcription Factor

J. Hahn, D. Thiele, Liming Li, 2006, Genetics.

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Philip F. Hughes, D. Thiele, David B. Darr, 2014, Chemistry & biology.

Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription.

D. Thiele, Xiao-Dong Liu, X. Liu, 1996, Genes & development.

Genomic Heat Shock Element Sequences Drive Cooperative Human Heat Shock Factor 1 DNA Binding and Selectivity*

D. Thiele, J. Gestwicki, L. Makley, 2014, The Journal of Biological Chemistry.

Inhibition of DNA Binding by Differential Sumoylation of Heat Shock Factors

D. Thiele, L. Sistonen, K. Denessiouk, 2006, Molecular and Cellular Biology.

Yeast Metallothionein Gene Regulation

D. Thiele, K. Koch, S. Knight, 1998 .

Structures of HSF2 Reveal Mechanisms for Differential Regulation of Human Heat Shock Factors

D. Thiele, L. Sistonen, Alex M. Jaeger, 2016, Nature Structural &Molecular Biology.

Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency.

D. Thiele, S. Puig, S. Vergara, 2008, Cell metabolism.

Identification of a Vacuole-associated Metalloreductase and Its Role in Ctr2-mediated Intracellular Copper Mobilization*

D. Thiele, E. Rees, 2007, Journal of Biological Chemistry.

ACE1 transcription factor produced in Escherichia coli binds multiple regions within yeast metallothionein upstream activation sequences

D. Thiele, D. Engelke, C. Evans, 1990, Molecular and cellular biology.

Functional Analysis of a Homopolymeric (dA-dT) Element That Provides Nucleosomal Access to Yeast and Mammalian Transcription Factors*

D. Thiele, K. Koch, D J Thiele, 1999, The Journal of Biological Chemistry.

Thiele for Heat Shock Transcription Factor and Transactivation Domain Requirements Important Determinant in the Temperature Heat Shock Element Architecture Is an

D. Thiele, N. Johansson, N. Santoro, 1998 .

Copper Acquisition and Utilization in Fungi.

D. Thiele, A. Smith, Brandon L. Logeman, 2017, Annual review of microbiology.

Genome‐wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans

D. Thiele, H. Madhani, J. Perfect, 2018, Molecular Microbiology.

X-ray structures of the high-affinity copper transporter Ctr1

D. Thiele, Yongjian Liu, Xiaohui Zhang, 2019, Nature Communications.

Expression of spinach glycolate oxidase in Saccharomyces cerevisiae: purification and characterization.

D. Thiele, P. Macheroux, V. Massey, 1991, Biochemistry.

Biochemical evidence of both copper chelation and oxygenase activity at the histidine brace

Morten H. H. Nørholm, D. Thiele, L. Olsson, 2020, Scientific Reports.

Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions.

D. Thiele, J. Beaudoin, S. Labbé, 2011, Microbiology.

X-ray structures of the high-affinity copper transporter Ctr1

D. Thiele, Xiaohui Zhang, Brandon L. Logeman, 2019, Nature Communications.

The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism.

D. Thiele, J. Valentine, C. Switzer, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

D. Thiele, P. Zhou, Dennis J. Thiele, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Copper Differentially Regulates the Activity and Degradation of Yeast Mac1 Transcription Factor*

D. Thiele, S. Labbé, Zhiwu Zhu, 1998, The Journal of Biological Chemistry.

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence.

J. Heitman, D. Thiele, C. Ding, 2013, Cell host & microbe.

Yeast metallothionein gene expression in response to metals and oxidative stress.

D. Thiele, X. Liu, 1997, Methods.

Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress

Marta A. Uzarska, D. Thiele, R. Lill, 2017, mBio.

Structural and functional analysis of separated strands of killer double-stranded RNA of yeast.

D. Thiele, M. Leibowitz, 1982, Nucleic Acids Research.

Yeast protective response to arsenate involves the repression of the high affinity iron uptake system.

C. Rodrigues-Pousada, D. Thiele, M. Tolédano, 2013, Biochimica et biophysica acta.

Adaptive changes in the fungal cell wall mediate copper homeostasis

D. Thiele, Corinna Probst, J. Alspaugh, 2021, bioRxiv.

Iron and copper transport activities of the mammalian metal‐ion transporters DMT1 and CTR1

D. Thiele, A. Shawki, B. Mackenzie, 2020, The FASEB Journal.

Function and regulation of yeast copperthionein.

D. Hamer, D. Thiele, M. Walling, 1987, Experientia. Supplementum.

Abstract IA09: Copper is required for oncogenic BRAF signaling and tumorigenesis

S. Knapp, D. Thiele, K. Xiao, 2014 .

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

D. Thiele, H. Rockman, M. Casad, 2010, Cell metabolism.

Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.

Kathryn L Haas, D. Thiele, K. Franz, 2011, Journal of the American Chemical Society.

Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis

D. Thiele, Tao Wang, Zhan-You Wang, 2014, Nature Communications.

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence.

J. Heitman, D. Thiele, C. Ding, 2013, Cell host & microbe.

Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide.

D. Thiele, J. Valentine, C. Switzer, 2000, Archives of biochemistry and biophysics.

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans

J. Heitman, D. Thiele, A. Idnurm, 2016, Genetics.

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.

D. Thiele, A. Shawki, E. Niespodzany, 2015, American Journal of Physiology - Gastrointestinal and Liver Physiology.