D. Leak

发表

The Path Forward for Biofuels and Biomaterials

Charlotte K. Williams, A. Ragauskas, B. Davison, 2006, Science.

Translational Arrest Due to Cytoplasmic Redox Stress Delays Adaptation to Growth on Methanol and Heterologous Protein Expression in a Typical Fed-Batch Culture of Pichia pastoris

Gregory D. Tredwell, D. Leak, Bryn Edwards-Jones, 2015, PloS one.

Global sensitivity analysis and meta-modeling of an ethanol production process

Nilay Shah, Cleo Kontoravdi, David J. Leak, 2014 .

Improving Power Production in Acetate-Fed Microbial Fuel Cells via Enrichment of Exoelectrogenic Organisms in Flow-Through Systems

D. Leak, T. Vishnivetskaya, A. Borole, 2009 .

Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production.

D. Leak, T. Atkinson, B. Rudd, 2009, Metabolic engineering.

Application of pheB as a Reporter Gene for Geobacillus spp., Enabling Qualitative Colony Screening and Quantitative Analysis of Promoter Strength

D. Leak, K. Eley, Jeremy Bartosiak-Jentys, 2012, Applied and Environmental Microbiology.

The genus Geobacillus and their biotechnological potential.

D. Leak, A. Hussein, B. Lisowska, 2015, Advances in applied microbiology.

Degradation of cyclohexylamine by a new isolate of Pseudomonas plecoglossicida

D. Leak, Xiang-Qun Chi, Da-zhong Yan, 2008 .

Simultaneous saccharification and lactic acid fermentation of the cellulosic fraction of municipal solid waste using Bacillus smithii

D. Leak, Micaela G Chacón, C. Ibenegbu, 2020, Biotechnology Letters.

The Development of Metabolomic Sampling Procedures for Pichia pastoris, and Baseline Metabolome Data

Gregory D. Tredwell, D. Leak, Bryn Edwards-Jones, 2011, PloS one.

Methylotrophs, Industrial Applications

D. Leak, 2010 .

An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates.

D. Leak, N. Shah, S. Ignatova, 2017, Faraday discussions.

34. Aromatic Oxidations

D. Leak, Jun-Jie Zhang, N. Zhou, 2012 .

Alteration of the stereo- and regioselectivity of alkene monooxygenase based on coupling protein interactions

D. Leak, Young-Jun Choi, V. Champreda, 2006, Applied Microbiology and Biotechnology.

Comparison of Nile Red and Cell Size Analysis for High‐Throughput Lipid Estimation Within Oleaginous Yeast

D. Leak, C. Chuck, D. Henk, 2019, European Journal of Lipid Science and Technology.

Minimisation of biomass in an extractive membrane bioreactor

D. Leak, L. M. Santos, A. Livingston, 1996 .

Insights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris

D. Leak, Rochelle Aw, G. Barton, 2017, Applied Microbiology and Biotechnology.

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

M. Coma, D. Leak, T. Arnot, 2019, Molecules.

Centrifugal partition chromatography in a biorefinery context: Optimisation and scale-up of monosaccharide fractionation from hydrolysed sugar beet pulp.

Joseph P. Adams, D. Leak, S. Ignatova, 2017, Journal of chromatography. A.

Xylo-Oligosaccharide Utilization by Engineered Saccharomyces cerevisiae to Produce Ethanol

D. Leak, A. Damasio, Yong‐Su Jin, 2022, Frontiers in Bioengineering and Biotechnology.

Pilot-scale production of xylo-oligosaccharides and fermentable sugars from Miscanthus using steam explosion pretreatment

D. Leak, J. Clifton-Brown, J. Gallagher, 2019, Bioresource technology.

Dielectric barrier discharge plasma microbubble reactor for pretreatment of lignocellulosic biomass

D. Leak, W. Zimmerman, F. Iza, 2018, AIChE journal. American Institute of Chemical Engineers.

Xylo-oligosaccharides, fermentable sugars, and bioenergy production from sugarcane straw using steam explosion pretreatment at pilot-scale.

D. Leak, S. C. Rabelo, T. Franco, 2022, Bioresource technology.

Continuous removal of ethanol from dilute ethanol-water mixtures using hot microbubbles

D. Leak, W. Zimmerman, J. Calverley, 2021, Chemical Engineering Journal.

Hot Microbubble Air Stripping of Dilute Ethanol–Water Mixtures

D. Leak, W. Zimmerman, H. Bandulasena, 2020 .

Nanofiltration and reverse osmosis membranes for purification and concentration of a 2,3-butanediol producing gas fermentation broth

D. Leak, C. Davey, D. Patterson, 2016 .

Fermentation of a wheat straw acid hydrolysate by Bacillus stearothermophilus T-13 in continuous culture with partial cell recycle

D. Leak, S. Amartey, N. Baghaei-Yazdi, 1999 .

Copper stress underlies the fundamental change in intracellular location of methane mono-oxygenase in methane-oxidizing organisms: Studies in batch and continuous cultures

D. Leak, H. Dalton, S. H. Stanley, 2004, Biotechnology Letters.

Enzymatic generation of short chain cello-oligosaccharides from Miscanthus using different pretreatments.

D. Leak, J. Gallagher, R. Bhatia, 2022, Bioresource technology.

Heterologous expression of pyruvate decarboxylase in Geobacillus thermoglucosidasius

A. H. Thompson, D. Leak, D. Studholme, 2008, Biotechnology Letters.

Production of oligosaccharides and biofuels from Miscanthus using combinatorial steam explosion and ionic liquid pretreatment

J. Hallett, D. Leak, T. Franco, 2020, Bioresource technology.

Enrichment of mixed cultures capable of aerobic degradation of 1,2-dibromoethane

D. Leak, A. Livingston, L. M. Freitas dos Santos, 1996, Applied and environmental microbiology.

Rapid screening of cellular stress responses in recombinant Pichia pastoris strains using metabolite profiling

Gregory D. Tredwell, D. Leak, Bryn Edwards-Jones, 2017, Journal of Industrial Microbiology & Biotechnology.

Development of an efficient technique for gene deletion and allelic exchange in Geobacillus spp.

D. Leak, M. Danson, C. Hamley-Bennett, 2017, Microbial Cell Factories.

Expression of benzene dioxygenase from Pseudomonas putida ML2 in cis-1,2-cyclohexanediol-degrading pseudomonads

D. Leak, J. Mason, D. Widdowson, 2001, Applied Microbiology and Biotechnology.

Adjusting Organic Load as a Strategy to Direct Single-Stage Food Waste Fermentation from Anaerobic Digestion to Chain Elongation

M. Coma, D. Leak, T. Arnot, 2020, Processes.

Biotechnological and Applied Aspects of Methane and Methanol Utilizers

D. Leak, 1992 .

Genetic and biochemical analyses of chlorobenzene degradation gene clusters in Pandoraea sp. strain MCB032

D. Leak, Hong Liu, N. Zhou, 2009, Archives of Microbiology.

Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase

D. Leak, V. Arcus, S. Crennell, 2018, Acta Crystallographica Section F Structural Biology Communications.

Expoxidation of styrene and substituted styrenes by whole cells of Mycobacterium sp. M156.

C. S. Matthews, D. Leak, S. R. Rigby, 1994, Bioorganic & medicinal chemistry.

Novel thermostable antibiotic resistance enzymes from the Atlantis II Deep Red Sea brine pool

Ali H. A. Elbehery, Ali H A Elbehery, D. Leak, 2016, Microbial biotechnology.

The ribR gene encodes a monofunctional riboflavin kinase which is involved in regulation of the Bacillus subtilis riboflavin operon.

D. Leak, R. A. Kreneva, D. A. Perumov, 1999, Microbiology.

The heterologous production of terpenes by the thermophile Parageobacillus thermoglucosidasius in a consolidated bioprocess using waste bread.

D. Leak, M. Ortenzi, Matthew Q Styles, 2020, Metabolic engineering.

Microbial Alkene Epoxidation—Merits and Limitations

C. S. Matthews, D. Leak, M. P. Woodland, 1994 .

The microbial production of epoxides

D. Leak, P. Aikens, Mahmoud Seyed-mahmoudian, 1992 .

Cloning, Expression, and Site-Directed Mutagenesis of the Propene Monooxygenase Genes from Mycobacterium sp. Strain M156

D. Leak, S. Askew, C. Chan Kwo Chion, 2005, Applied and Environmental Microbiology.

Growth yields of methanotrophs

D. Leak, H. Dalton, 1986, Applied Microbiology and Biotechnology.

Cloning and expression of the genes encoding the propene monooxygenase from Xanthobacter, Py2

D. Leak, N. Zhou, C. Chan Kwo Chion, 2004, Applied Microbiology and Biotechnology.

Cloning and Expression of the α-Pinene Monooxygenase Gene from Pseudomonas fluorescens NCIMB 11671

D. Leak, A. Colocousi, 1995 .

Are eucalyptus harvest residues a truly burden-free biomass source for bioenergy? A deeper look into biorefinery process design and Life Cycle Assessment

D. Leak, M. McManus, T. Franco, 2021 .

Studies On The Regioselectivity And Stereoselectivity Of The Soluble Methane Monooxygenase From Methylococcus Capsulatus (Bath)

D. Leak, H. Dalton, 1987 .

Characterisation of a catabolic epoxide hydrolase from a Corynebacterium sp.

D. Leak, N. Zhou, D. Widdowson, 1998, European journal of biochemistry.

Growth yields of methanotrophs 2. A theoretical analysis

D. Leak, H. Dalton, 1986, Applied Microbiology and Biotechnology.

Mutants of Pseudomonas fluorescens NCIMB 11671 defective in the catabolism of α-pinene

D. Leak, K. M. Saqib, A. Colocousi, 1996, Applied Microbiology and Biotechnology.

Removing carbon catabolite repression in Parageobacillus thermoglucosidasius DSM 2542

D. Leak, R. van Kranenburg, A. Bolhuis, 2022, Frontiers in Microbiology.

The Geobacillus plasm id set: a m odular toolkit for therm ophile engineering

D. Leak, T. Ellis, Joachim De Jonghe, 2016 .

Simultaneous saccharification and ethanologenic fermentation (SSF) of waste bread by an amylolytic Parageobacillus thermoglucosidasius strain TM333

D. Leak, Christopher C. Ibenegbu, 2022, Microbial Cell Factories.

Bioleaching and bioprecipitation of nickel and iron from laterites

D. Leak, A. Dudeney, K. Alibhai, 1993 .

Brown rot fungal early stage decay mechanism as a biological pretreatment for softwood biomass in biofuel production

Richard J. Murphy, David J. Leak, D. Leak, 2010 .

Optimisation Of The Kinetics Of The Stereoselective Reduction Of Geraniol To Citronellol In A Two Liquid Phase System

D. Leak, D. Stuckey, A. Livingston, 1998 .

Biocatalysts for selective introduction of oxygen

John M. Woodley, David J. Leak, Roger A. Sheldon, 2009 .

Opportunities in microbial biotransformation of monoterpenes

D. Leak, M. J. van der Werf, M. Werf, 1997 .

Biotransformations in the Flavour Industry

D. Leak, F. Keulen, C. Larroche, 1999 .

Mechanistic Studies on the Mode of Action of Methane Monooxygenase

D. Leak, H. Dalton, 1985 .

The Alkene Monooxygenase from Xanthobacter Strain Py2 Is Closely Related to Aromatic Monooxygenases and Catalyzes Aromatic Monohydroxylation of Benzene, Toluene, and Phenol

D. Leak, N. Zhou, C. Chan Kwo Chion, 1999, Applied and Environmental Microbiology.

Heterologous expression of alkene monooxygenase components from Xanthobacter autotrophicus Py2 and reconstitution of the active complex.

D. Leak, V. Champreda, N. Zhou, 2004, FEMS microbiology letters.

The treatment of iron oxalate leach liquors in a UASB with sulfate reduction

D. Leak, D. Stuckey, A. Dudeney, 1997 .

Polymers from sugars and unsaturated fatty acids: ADMET polymerisation of monomers derived from d-xylose, d-mannose and castor oil

D. Leak, C. Chuck, A. Buchard, 2020 .

Crystal structure of pyruvate decarboxylase from Zymobacter palmae

D. Leak, V. Arcus, S. Crennell, 2016, Acta crystallographica. Section F, Structural biology communications.

Alkene Monooxygenase-Catalyzed Whole Cell Epoxidation in a Two-Liquid Phase System

D. Leak, D. Stuckey, S. Prichanont, 1998 .

Continuous enzymatic hydrolysis of sugar beet pectin and l-arabinose recovery within an integrated biorefinery.

D. Leak, G. Lye, Max Cárdenas‐Fernández, 2018, Bioresource technology.

In vivo studies of primary alcohols, aldehydes and carboxylic acids as electron donors for the methane mono-oxygenase in a variety of methanotrophs

D. Leak, H. Dalton, 1983 .

Phylogenetic analysis of transformable strains of thermophilic Bacillus species.

D. Leak, D. Studholme, R. A. Jackson, 1999, FEMS microbiology letters.

The solubilisation of mycobacterium in a water in oil microemulsion for biotransformations: System selection and characterisation

D. Leak, D. Stuckey, S. Prichanont, 2000 .

Metabolic engineering of Saccharomyces cerevisiae for second-generation ethanol production from xylo-oligosaccharides and acetate

F. Squina, D. Leak, S. C. Rabelo, 2023, bioRxiv.

Selecting fermentation products for food waste valorisation with HRT and OLR as the key operational parameters.

M. Coma, D. Leak, T. Arnot, 2021, Waste management.

Ionic liquid pretreatment of lignocellulosic biomass with ionic liquid–water mixtures

D. Leak, T. Welton, A. Brandt, 2011 .

The effect of the ionic liquid anion in the pretreatment of pine wood chips

J. Hallett, D. Leak, T. Welton, 2010 .

Development and optimization of a defined medium for aerobic growth ofBacillus stearothermophilus LLD-15

D. Leak, S. Amartey, B. Hartley, 1991, Biotechnology Letters.

Arg169 is essential for catalytic activity of 3-hydroxybenzoate 6-hydroxylase from Klebsiella pneumoniae M5a1.

D. Leak, N. Zhou, D. Q. Liu, 2005, Microbiological research.

Production of ethanol by thermophilic oligosaccharide utilising Geobacillus thermoglucosidasius TM242 using palm kernel cake as a renewable feedstock

D. Leak, V. Champreda, C. Ibenegbu, 2016 .

Selective fractionation of Sugar Beet Pulp for release of fermentation and chemical feedstocks; optimisation of thermo-chemical pre-treatment.

D. Leak, G. Lye, C. Hamley-Bennett, 2016, Bioresource technology.

Chemoenzymic resolution and deracemisation of (±)-1-methyl-1,2-epoxycyclohexane: the synthesis of (1-S, 2-S)-1-methylcyclohexane-1,2-diol

D. Leak, D. Widdowson, I. Archer, 1996 .

Faraday Discussions

Stefan Metzger, David C. Carslaw, Alastair C. Lewis, 2016 .

Esterification of geraniol as a strategy for increasing product titre and specificity in engineered Escherichia coli

D. Leak, A. Marriott, E. Kendrick, 2019, Microbial Cell Factories.

Genome-scale metabolic modeling of P. thermoglucosidasius NCIMB 11955 reveals metabolic bottlenecks in anaerobic metabolism.

Markus J. Herrgård, Benjamín J. Sánchez, D. Leak, 2021, Metabolic engineering.

Genome-scale metabolic modelling of P. thermoglucosidasius NCIMB 11955 reveals metabolic bottlenecks in anaerobic metabolism

Markus J. Herrgård, Benjamín J. Sánchez, D. Leak, 2021 .

Stability and Performance of Xanthobacter autotrophicus GJ10 during 1,2-Dichloroethane Biodegradation

D. Leak, A. Mantalaris, A. Livingston, 2006, Applied and Environmental Microbiology.

Genetic tool development underpins recent advances in thermophilic whole‐cell biocatalysts

D. Leak, D. Cowan, M. Taylor, 2011, Microbial biotechnology.

Engineering Escherichia coli for the production of butyl octanoate from endogenous octanoyl-CoA

D. Leak, E. Kendrick, Micaela G. Chacón, 2019, PeerJ.

Development of a versatile shuttle vector for gene expression in Geobacillus spp.

D. Leak, M. Taylor, C. D. Esteban, 2008, Plasmid.

Integrating engineering design improvements with exoelectrogen enrichment process to increase power output from microbial fuel cells

Brian H. Davison, Abhijeet P. Borole, Martin Keller, 2009 .

The Geobacillus Plasmid Set: A Modular Toolkit for Thermophile Engineering.

D. Leak, T. Ellis, Benjamin Reeve, 2016, ACS synthetic biology.

Modular system for assessment of glycosyl hydrolase secretion in Geobacillus thermoglucosidasius.

David J. Leak, D. Leak, Jeremy Bartosiak-Jentys, 2013, Microbiology.

Synthetic microbial consortia bioprocessing integrated with pyrolysis for efficient conversion of cellulose to valuables

D. Leak, S. K. Masakapalli, Neil MacKinnon, 2022, Bioresource Technology Reports.

Optimization of cello-oligosaccharides production by enzymatic hydrolysis of hydrothermally pretreated sugarcane straw using cellulolytic and oxidative enzymes

D. Leak, S. C. Rabelo, G. Pastore, 2020 .

Evidence of species succession during chlorobenzene biodegradation

D. Leak, A. Mantalaris, A. Livingston, 2008, Biotechnology and bioengineering.

Heterologous microcompartment assembly in Bacillaceae: establishing the components necessary for scaffold formation.

D. Leak, R. Daniel, Yana Wade, 2019, ACS synthetic biology.

Metabolic characterization and modeling of fermentation process of an engineered Geobacillus thermoglucosidasius strain for bioethanol production with gas stripping

D. Leak, N. Shah, C. Kontoravdi, 2015 .

Changes in Pre-Formed Granule Composition and Structure in a Sulphidogenic UASB Treating a Synthetic Ferric Oxalate Wastewater

D. Leak, D. Stuckey, J. Teer, 2000 .

Hybrid and Mixed Matrix Membranes for Separations from Fermentations

D. Leak, C. Davey, D. Patterson, 2016, Membranes.

Effect of nutrient limitation on product formation during continuous fermentation of xylose with Thermoanaerobacter ethanolicus JW200 Fe(7)

D. Leak, D. Stuckey, H. Hild, 2003, Applied Microbiology and Biotechnology.

Characterization of the first naturally thermostable terpene synthases and development of strategies to improve thermostability in this family of enzymes

Scott Marr, D. Leak, David J Leak, 2017, The FEBS journal.

The biosynthesis of a choline nucleotide by a cell-free extract from Streptococcus pneumoniae.

D. Leak, I. Poxton, 1977, Journal of general microbiology.

Pathways of ethanol production from sucrose by a mutant thermophilic Bacillus in continuous culture

Ricardo San Martin, D. Leak, B. Hartley, 1993 .

Development of a synthetic medium for continuous anaerobic growth and ethanol production with a lactate dehydrogenase mutant of Bacillus stearothermophilus.

D. Leak, B. Hartley, R. San Martín, 1992, Journal of general microbiology.

Effects of temperature and medium composition on the ethanol tolerance ofBacillus stearothermophilus LLD-15

D. Leak, S. Amartey, B. Hartley, 1991, Biotechnology Letters.

Cultivation of an L‐lactate dehydrogenase mutant of Bacillus stearothermophilus in continuous culture with cell recycle

D. Leak, B. Hartley, R. Martín, 1994, Biotechnology and bioengineering.

OnpA, an Unusual Flavin-Dependent Monooxygenase Containing a Cytochrome b5 Domain

D. Leak, Hong Liu, Huiru Tang, 2012, Journal of bacteriology.

The effect of pretreatment choice on cellulosic ethanol production from sugarcane straw: An insight into environmental impact profile and GHG emissions mitigation potential in Brazil

D. Leak, M. Chagas, T. Junqueira, 2023, Biomass and Bioenergy.

Production of cello‐oligosaccharides through the biorefinery concept: A technical‐economic and life‐cycle assessment

D. Leak, T. Franco, C. Cavaliero, 2021, Biofuels, Bioproducts and Biorefining.

Integration of synthetic microbial consortia based bioprocessing with pyrolysis for efficient conversion of cellulose to valuables

D. Leak, S. K. Masakapalli, Neil MacKinnon, 2022, bioRxiv.

The alkene monooxygenase from Xanthobacter Py2 is a binuclear non‐haem iron protein closely related to toluene 4‐monooxygenase

D. Leak, N. Zhou, Alistair Jenkins, 1998, FEBS letters.

OnpA, an Unusual Flavin-Dependent Monooxygenase Containing a Cytochrome b5 Domain

D. Leak, Hong Liu, Huiru Tang, 2012, Journal of bacteriology.