J. Champness

发表

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.

L. Kuyper, B. Roth, D. Baccanari, 1982, Journal of medicinal chemistry.

The structure of the protein disk of tobacco mosaic virus to 5 Å resolution

G. Bricogne, A. Klug, J. Champness, 1976, Nature.

L. Kuyper, B. Roth, D. Baccanari, 1982, Journal of medicinal chemistry.

A rational approach to the design of antihypertensives: X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors

T. Blundell, C. Harris, J. Champness, 1991 .

Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses.

J. Champness, D. Selwood, S. Challand, 1993, Journal of medicinal chemistry.

X-ray and optical diffraction studies of bacterial flagella.

J. Champness, 1971, Journal of molecular biology.

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

J. Champness, D. Stammers, P. K. Bryant, 1997, Nature Structural Biology.

5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.

J. Champness, E. De Clercq, P. Herdewijn, 1998, Journal of medicinal chemistry.

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim.

L. Kuyper, D. Baccanari, C. Beddell, 1996, Bioorganic & medicinal chemistry.

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

P K Bryant, J. Champness, D. Stammers, 1994, Structure.

Protein disk of tobacco mosaic virus at 2.8 Å resolution showing the interactions within and between subunits

R. Staden, G. Bricogne, A. Klug, 1978, Nature.

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

J M Burridge, C. Beddell, J. Champness, 1985, The Journal of biological chemistry.

Exploring the active site of herpes simplex virus type‐1 thymidine kinase by X‐ray crystallography of complexes with aciclovir and other ligands

Frank Wien, Piet Herdewijn, Tomasz Ostrowski, 1998, Proteins.

Herpesviral thymidine kinases: laxity and resistance by design.

J. Champness, W. Summers, J. Evans, 1998, The Journal of general virology.

Structure to 1.9 Å resolution of a complex with herpes simplex virus type‐1 thymidine kinase of a novel, non‐substrate inhibitor: X‐ray crystallographic comparison with binding of aciclovir

J. Champness, Hongmao Sun, W. Summers, 1999, FEBS letters.

The structure of mouse L1210 dihydrofolate reductase‐drug complexes and the construction of a model of human enzyme

C. Beddell, J. Champness, D. Stammers, 1987, FEBS letters.

The binding of trimethoprim to bacterial dihydrofolate reductase

P J Goodford, C. Beddell, J. Champness, 1981, FEBS letters.

A single‐crystal oscillation camera for large unit cells

J. Champness, R. P. Phizackerley, A. Wonacott, 1973 .

Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase

C. Beddell, J. Champness, D. Stammers, 1986, FEBS letters.

Crystal structure of Escherichia coli UvrB C‐terminal domain, and a model for UvrB‐UvrC interaction

J. Champness, J. Fontecilla-Camps, X. Vernède, 2000, FEBS letters.

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes.

R. M. Hyde, B. Roth, D. Baccanari, 1987, Journal of medicinal chemistry.

The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures

R. M. Hyde, L. Kuyper, B. Roth, 1983 .

A new automatic flat-bed microdensitometer for use in x-ray crystallography.

T. H. Gossling, J. Champness, A. R. Faruqi, 1977, Journal of physics E: Scientific instruments.

The hand of the stacked-disk aggregate of tobacco mosaic virus protein.

J. Champness, A. Bloomer, P. Unwin, 1976, Journal of molecular biology.

2.0 Å X‐ray structure of the ternary complex of 7,8‐dihydro‐6‐hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

J. Champness, D. Stammers, P. K. Bryant, 1999, FEBS letters.