S. Kazmirski

发表

Analysis methods for comparison of multiple molecular dynamics trajectories: applications to protein unfolding pathways and denatured ensembles.

S. Kazmirski, A. Li, V. Daggett, 1999, Journal of molecular biology.

Loss of a metal-binding site in gelsolin leads to familial amyloidosis–Finnish type

A. Fersht, S. Kazmirski, V. Daggett, 2002, Nature Structural Biology.

Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors.

S. Kazmirski, A. Cheng, F. Féru, 2010, Bioorganic & medicinal chemistry letters.

P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy

S. Kazmirski, L. Ronco, A. Cacace, 2019, bioRxiv.

p38α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy

S. Kazmirski, L. Ronco, A. Cacace, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Modulating Antibody Structure and Function through Directed Mutations and Chemical Rescue.

J. Karanicolas, S. Kazmirski, M. P. Castaldi, 2018, ACS synthetic biology.

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

David A. Scott, S. Kazmirski, A. Ferguson, 2015, Bioorganic & medicinal chemistry letters.

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.

S. Kazmirski, Nancy Su, D. Ogg, 2015, ACS medicinal chemistry letters.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

J. A. Hendricks, David M. Wilson, S. Kazmirski, 2018, Nature Communications.

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2005, Nature Structural &Molecular Biology.

Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).

S. Kazmirski, M. Hickey, G. Alton, 2011, Journal of medicinal chemistry.

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

S. Kazmirski, J. Cate, A. Ferguson, 2016, Proceedings of the National Academy of Sciences.

Protein Dynamics: A Theoretical Perspective

S. Kazmirski, V. Daggett, 1997 .

Elucidating the mechanism of familial amyloidosis- Finnish type: NMR studies of human gelsolin domain 2.

A. Fersht, S. Kazmirski, R. Isaacson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.

David A. Scott, S. Kazmirski, P. Lyne, 2016, Bioorganic & medicinal chemistry letters.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Anthony D. Keefe, Christoph E. Dumelin, S. Kazmirski, 2017, ACS medicinal chemistry letters.

Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation.

F. Cohen, S. Prusiner, S. Kazmirski, 1995, Chemistry & biology.

The conformational consequences of mutations to the H1 helix of the prion protein explored by molecular dynamics simulations

F. Cohen, S. Prusiner, S. Kazmirski, 1996 .

Non-native interactions in protein folding intermediates: molecular dynamics simulations of hen lysozyme.

S. Kazmirski, V. Daggett, 1998, Journal of molecular biology.

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2009, Cell.

Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen.

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG‐out Conformation of p38α for High Throughput Screening Binding Assay

S. Kazmirski, A. Cheng, Qing Cao, 2009, Chemical biology & drug design.

Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex.

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex.

J. Gulbis, S. Kazmirski, J. Kuriyan, 2004, European journal of biochemistry.

Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.

S. Kazmirski, C. Eyermann, G. Breault, 2016, ACS infectious diseases.

Abstract 1262: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ex19del, L858R) and C797S resistance mutations in metastatic NSCLC

S. Kazmirski, Ayşegül Özen, K. Hoeflich, 2021, Experimental and Molecular Therapeutics.

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

S. Kazmirski, J. Penzotti, H. Tecle, 2009, Bioorganic & medicinal chemistry letters.

Protein folding from a highly disordered denatured state: The folding pathway of chymotrypsin inhibitor 2 at atomic resolution

Valerie Daggett, Alan R. Fersht, A. Fersht, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Simulations of the structural and dynamical properties of denatured proteins: the "molten coil" state of bovine pancreatic trypsin inhibitor.

S. Kazmirski, V. Daggett, 1998, Journal of molecular biology.

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

S. Kazmirski, D. Hargreaves, P. Rawlins, 2019, Acta crystallographica. Section D, Structural biology.

DNA polymerase clamp loaders and DNA recognition

John Kuriyan, Mike O'Donnell, S. Kazmirski, 2005, FEBS letters.

Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers

S. Kazmirski, J. Tyner, D. Hargreaves, 2017 .